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NEWS OUT Prurisol enrollment complete!!!!!!
//finance.yahoo.com/news/innovation-pharmaceuticals-completes-full-patient-110000597.html
4-12.....
Not good enough for prime time?:)
You can bank on the fact that Dartmouth took on the Kevetrin OC trial because they know the results from Cohort A at MaryCrowley...GUARANTEED!!!!!!!!!!!!!!!!!!!!!
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Hey Bunny KABOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!!!!
Another site now recruiting for Kevetrin OC.
https://clinicaltrials.gov/ct2/show/NCT03042702?term=cellceutix&rank=1
You people are crazy if you don't think B-UP will get a >$200M up front deal THIS year.
10 of 15 patients (67%) with remission along WITH ENDOSCOPIC PROOF!!!
$50m given to a Pre-clinical. Not a phase1....Not a phase2a with no endoscopy...A freaking PRE-CLINICAL!!!!!!
TIC TOC KABOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!!!!
With 20,000,000 stock options between Menon and Leo expiring
in 2019, I can guarantee you they are going to run trial after trial and get deal after deal the next 2 years or sell the entire company in 2018 for a bundle.
TIC TOC KABOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO!!
Does this mean that "P" interim results could include subjects that have completed more than 6 weeks and even completed the trial? It doesn't sound like it's a 6 week cutoff.
"Our planned interim analysis, which targets the majority of patients who have completed at least six weeks"
KarinCA There are 22,000 new cases of OC every year.
We are only looking for 10 patients.
There has to be a reason they(IPIX and BP) picked marycrowley and I'm sure it wasn't for their slow enrollment of OC patients.
Do you know something we all don't know?
"Being a tough one to enroll, this one may fall behind schedule."
George Prurisol could also be used for Atopic Dermititis(Eczema)
"It was suggested by the physician investigators of the Prurisol Phase 2a trial."
That 20% of all children WORLDWIDE.
That's quote is From Leo in an email I sent him back in March.
So Prurisol and Brilacidin for AD. May the best drug win!!!
Does everyone realize that if B-OM gets approved in 2018 which is a VERY high probability then JNJ(yes it's jnj) can then use B as a biofilm for their medical devices division. They are NOT required to run any clinical trials. All they have to do is file some paperwork.
WOW!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Hmmmmmmmmmmmmmmm...................
https://www.fool.com/investing/2017/08/13/why-has-2017-been-a-horrible-year-so-far-for-biote.aspx
With BTD you can also bank on more than $100,000,000
up front..
TIC TOC KABOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!!!
C'mon sox that JNJ deal for >$900M had a sample size of 320
mice,6 rats,3 squirrels and 1 BUNNY with no butthole pics!!!
We only had 19 humans with endoscopic results:)
The completed enrollment of B-OM has caught the bad guys off guard. With only 19 patients completing the trial in 2 years as of March,they did not see this coming and have come out in force!!! They did not expect OM to be completed with results in NOVEMBER of this year. OMG 1st they had to worry about UP,now OM and soon P. Please Leo don't put out any news on K or it may kill some of these guys. Their very little hearts won't be able to take it!!
TIC TOC KABOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!!!
B-OM will become part of the protocol for treating head and neck cancers.
550,000 cases worldwide. $10k-25k a pop?
You do the MATH!!!! MONSTER BLOCKBUSTER!!!!
TIC TOC KAOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!!!
24 months to enroll 30 patients.................................
Then only 4 months to enroll the final 31 after great interim results were announced.
Cancer institutions now know B-OM works and enrollment will be quick.
Phase 3 will fly by especially with BP running it.
With BTD B-OM approval in late 2018.....
B-OM is going to be a MONSTER...an ABSOLUTE MONSTER
TIC TOC KABOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!!!!!
100% enrollment for B-OM trial!!!!
WOOOOOOHOOOOOOOOOO!!!!!!!!!!!!!
TIC TOC...KABOOOOOOOOOOOOOOOOOOOOOOOOM!!
http://www.ipharminc.com/new-blog/2017/8/7/brilacidin-for-oral-mucositis
With a "minimum" of 2 weeks to collect and analyze data that would mean the enrollment would have to be 100% complete "today" for an interim 6 week data read out by 9/30.
Biohedge you said "I know for a fact that CELG had no idea who Leo or Cellceutix was until late last year.
So who is not telling the truth here. You or Karin CA?
SO did Celgene know Leo and Cellceutix since 2012 or 2016?
I await your response...
At the 2012, J.P. Morgan Health Care Conference, Celgene's (CELG) CEO Bob Hugin heralded the company's psoriatic compound as a potential blockbuster that appeared destined to become a primary drug in the psoriatic area of dermatology for which it is in trials to address. However, several weeks later, the compound was reported as having difficulty in phase three clinicals and appeared to be unlikely to generate as promising of an advance as indicated. Expectations for Apremilast have been halved and Celgene now touts that its safety profile instead of its once speculated superior efficacy will be the agent of its market penetration. That said, the once diminished hopes for Apremilast have been bolstered by the latest announcement. However strong the recent announcement, Celgene quickly added a need for increased therapeutic advancement in treating the disease.
In an interview with KarinCA, Cellceutix (CTIX.OB) CEO, Leo Ehrlich, said that Celgene called Cellceutix and requested publicly available documents from the company. Cellceutix's two primary compounds are Kevetrin and Prurisol (KM 133).
Tomorrow will be interesting:)
Tomorrow will be interesting:)
B-OM will be the 1st partnership announced.
There is a reason additional data was not presented by Innovation like they said they would. Time to gather the data was not a factor. IPIX had plenty of that. I believe the BP with the nda on OM did not want the data on 15 more patients announced to the world.
With Leo's intent to apply for BTD I believe BP is salivating over B-OM and a deal is near and before the completion of the trial.
"big pharmaceutical" company ENDO"
$2.7b MC is NOT A BIG PHARMACEUTICAL COMPANY.not even close.....sheeeeeesh
34 sites now recruiting for Prurisol
added another Los Angeles California location. Must be a hot spot.
https://clinicaltrials.gov/ct2/show/NCT02949388?term=cellceutix&rank=4
Xeljanz was already rejected once by the FDA for Plaque Psoriasis because of concerns over serious side effects.
The LARGEST Phase2 trial for Otezla was 352 patients 5 arms. That's 70 per arm.
https://clinicaltrials.gov/ct2/show/NCT00773734?term=apremilast+phase+2+psoriasis&recrs=e&cond=psoriasis&phase=1&rank=3
UNTOHIM Interim data results for Prurisol trial is 6 week data not 12 week,
so the 6 weeks was up in the 3rd week of June for the OVER 70% enrolled.
3-4 weeks to analyze data you say?
TIC TOC ANY DAY NOW!!!!
KABOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!!!!
I wonder which European BP clinical trial site
the UP trial was held at:)
and we won't have to wait til Sept-December for a Deal either...
TIC TOC KABOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!!!!!!!!!!!!
Groton show me where Leo said his 1st choice to partner was "P"
Wonder why the UP blog was pulled? It was there for 5+ hours before being noticed here. I saw it earlier in the day, but didn't want to waste my 1 post. I figured someone else would see it but a little sooner than they did.
If I have a CDA for B-UP and now the WORLD is about to hear the stunning results this Thursday afternoon what do I do? What do I do? What do I do?
So what additional data then?
"Second, the Company will be presenting topline findings from the Brilacidin-UP/UPS trial as well as additional interim data from its Phase 2 trial of Brilacidin for Oral Mucositis at Drug Discovery and Therapy World Congress 2017, to be held July 10 – 13, 2017, in Boston. More details to come."
Addition data from the OM trial
will be BLOWOUT data results from 15 or so more patients.
BREAKTHROUGH THERAPY DESIGNATION
You can bank on that.
This message board isn't going to stop the science nor the SP once these results come pouring in.
tic toc KABOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!!!!
I'm gonna miss you guys.
From the Innovation Website Blog.
http://www.ipharminc.com/new-blog/2017/7/3/growing-interest-in-novel-non-biologic-treatments-for-inflammatory-bowel-disease
CHA CHING!!!!!!!!!!!!
BP will pay an enormous upfront payment for the B franchise and IPIX will receive BIG royalty payments for all current and future indications.
With having only scratched the surface for B there is no way you just sell the entire franchise. It is idiotic to even think that.
P may indeed be the 1st deal and I think right after the 6 week data read out.
If Leo does not disclose where the UP trial was run after
presenting final results then you can bank on it that it was run at a BP site in Europe at their request.
TIC TOC
KABOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!!
I'm actually more interested in the ADDITIONAL data for OM in the presentation.
We know UP is already a hit. More good OM data and there will NO stopping IPIX.
TIC TOC
KABOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!!!
BIG DEALS are made over long holiday weekends.
I remember my husband leaving work from Smithkline on Friday 12/29/2000 and returning to work at GlaxoSmithkline on Tuesday 1/2/2001.
An absolute shocker to all!!!!!
With UP and OM results coming up I wouldn't be surprised to hear a deal announced next week. BP with CDA already know the results.
Early bird gets the worm.
It's just a matter of when..
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KABOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!
BiotecM How can you peg Om sub $1B?
It's not only and anti-inflammatory but a Pro-Inflammatory.
B-OM will be the standard of care for ALL head and neck and probably more.
It can PREVENT SOM. That's HUGE!
Those pharma's with the confidential agreements don't need to wait til 7/13 to see the results.
Clock is ticking.....
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KABOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!!!!