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Your logic and this quote agree.
"Everything should be made as simple as possible, but no simpler."
Just realized I've checked the price of AVXL thousands of times over the years.
Now I'm depressed.
"he is ready to move quickly"
Now I know you're pulling my leg.
Any thoughts on why the rare disease is undisclosed?
Seems an odd thing not to disclose.
[I’m wondering if his position is a prerequisite for getting some favorable expedited path.]
Same thing was said about Faridan.
Never quite understood the excitement over each new hire.
If we hired an ex plumber or a lumberjack I think a discussion is warranted.
But maybe the FDA guy or the Hammond guy was offered an opportunity and just jumped at it.
Many job changes involve a measure of hope and few are a sure thing.
Or maybe we encountered a roadblock and we're throwing everything against the wall to see what sticks.
I always thought they would license IP to established BP’s who in turn would combine it with a drug in their own pipeline.
Let's say their drug immediately works on the symptoms while A2-73 in due course fixes the upstream problem.
This would also curtail off label movement into other indications as there is another targeted drug involved.
"Reclecta"
Hat tip.
It's not my intent to downplay the one million dollars, but assuming static numbers that's less than one percent of total funding.
So those who suggest Mr. Fox is much improved and attribute it to A2-73 would need to explain why the MJFF didn't throw much more in our direction.
https://viewer.joomag.com/the-michael-j-fox-foundation-annual-report-2018-impact-innovation/0816034001561062113?short&
Gotcha, thanks for the clarification.
Good point.
I hadn't thought of it that way.
But now that I am, and assuming Needham has some type of game since they have investment banking and institutional accounts, wouldn't it behoove independent investors to listen in and gain quality ideas?
And if it would, and since I'm never the first guy to think of a new good idea, where are the views and comments?
One thing that caught my eye.
There are 149 views and virtually no comments.
I'm not inferring it was a lackluster video, just that it's no surprise
AVXL remains unknown to the masses.
The subject matter simply has zero broad appeal at the present.
"It's like the 3 trials starting by end of year...He said that as late in December when there was no way possible to do so."
That really bugged me at the time.
I've wondered lately if our nearly unknown name and MOA makes it harder to recruit trial participants.
We have a few professionals in our corner but not that many.
I hate to say it but if I was bad sick and was offered a choice of trial spots, I'd probably go with a Pfizer before an unknown.
In regard to voting, I say give Dr. Missling everything he wants.
I'm quite incapable of generating the kind of money we're talking about by myself.
I'm hoping Anavex can.
I have no desire to hinder or dictate terms as if I know better than him.
The word "proudly" seems inappropriate.
I believe the first person who said "No guts no glory" died young and somewhat violently.
I think there's also considerable career risk for any CEO who would want to go after almost unknown Anavex with it's almost unknown MOA.
But as you say, things are changing.
I was thinking of it in the context of the shareholders rights plan, the 20 million preferred shares and now the requested authorization for 100 million more shares.
Someone with a friend in the money industry once posted that the first two would be insufficient to thwart a takeover which got me wondering.
I once owned a company that developed a novel antibiotic.
From the beginning they made it clear they wanted to be bought out.
As the near certain positive trial results approached and the offers were too low the company issued shares and raised 115 million under the guise of funding a sales force and manufacturing capabilities.
The fair priced buyout quickly followed.
The transparent bluff worked.
I'm not suggesting this is Anavex's plan, just saying the ability to access a bunch of money can be a powerful tool.
I'm with falconer in that I'll vote yes to all proposals.
And I was pleased the 20 million preferred thing passed a while back.
I'm guessing her addition to the team isn't a major "dot' as far as us laymen are concerned.
Blasphemy!!!
Question for you long timers.
In the shareholder rights thing it refers to a date.
As in "shareholders as of...".
Could someone tell me that date?
Good question.
I find myself unable to even make something up.
The new energy transition?
Excerpt from an article:
"Genova, a neuroscientist by training, has spent most of her working life writing fiction about characters with various neurological maladies. Her novel “Still Alice,” from 2007, centered on a Harvard psychology professor who is diagnosed with early-onset Alzheimer’s. In “Remember,” her first nonfiction work, Genova assures her readers that only two per cent of Alzheimer’s cases are of the strictly inherited, early-onset kind. For most of us, our chances of developing the disease are highly amenable to interventions, as it takes fifteen to twenty years for the amyloid plaque that is mounting in our brains to reach a tipping point, “triggering a molecular cascade that causes tangles, neuroinflammation, cell death, and pathological forgetting.” What do those interventions look like? Genova’s guidance is backed by current science, but is mostly just parental: exercise, avoid chronic stress, adopt a Mediterranean diet, and enjoy your morning coffee—but not so much as to compromise deep sleep, which is when “your glial cells flush away any metabolic debris that has accumulated in your synapses.”
One of the more interesting studies that Genova cites followed six hundred and seventy-eight elderly nuns over two decades, subjecting them to all manner of physical and cognitive tests. When a nun died, her brain was collected for autopsy. Curiously, a number of the nuns whose brains showed plaques, tangles, and shrinkage exhibited “no behavioral signs” of Alzheimer’s disease. The researchers theorized that these nuns had a high degree of “cognitive reserve”; they tended to have more years of formal education, active social lives, and mentally stimulating hobbies. Even as many old neural pathways collapsed, they were paving “new neural roads” and taking detours along as-yet undamaged connections, thereby masking, if not postponing, the onset of the disease. All pretty straightforward. Now all we have to do is build a society in which everyone has the time and resources for adequate sleep, exercise, nutrition, self-care, and a few good hobbies."
To be honest, I wouldn't miss this for the world.
For me, my investment in AVXL is like a lottery ticket.
All my other individual stocks are mature, dividend paying companies.
AVXL is my one shot at wealth.
But if the ship sinks I stand to lose quite a bit as I also sell covered calls on AVXL.
Humorously, I write these risky calls to lower my risk by reducing the cost basis on my core shares.
Win or lose, this is my last big stock market gamble.
If I lose I hope I take it stoically, as I knew the risks going in.
And yet, this is the type of ineptitude we face.
https://academictimes.com/surprise-and-shock-was-a-key-guideline-for-screening-autism-wrong-for-years/
[ Hoping the reviews of the video were spot on and we see MJF at the Oscars next month ... in Alex Keaton-style ... in his 50's!]
My problem with that line of thought is if MJF were indeed taking A2-73 and improving wouldn't he throw his full weight and resources into accelerating the push toward approval, not just the 1 million currently offered?
I noticed(not for the first time) there was a 2 day delay before they told us they sold in the high $20's.
Only after the stock dropped back to the mid teens did they humbly announce their exploits.
Makes me wonder what we would have heard if the stock had continued on up to $35.
I kinda feel like calling you coach.
I had no idea when I first bought AVXL but I just remembered I have a folder labeled AVXL to show my wife some time in the future.
This is the very first link from Nov. 2015.
https://seekingalpha.com/instablog/40909465-jdlambert/4565296-backgrounder-on-epilepsy-and-anavex-life-sciences
That's very possible.
But that doesn't disqualify Steady's excellent answer to your question.
Whenever I find myself feeling like this I'm reminded of one of my favorite book titles "Being Right or Making Money" by Ned Davis.
Timeline?
Could anyone give a ballpark guess on a timeline for when we should expect the next step in regard to PDD?
Nice to put a face on Rett.
I want to be the guy who discovered AVXL in late '18 and bought my fill at $1.50.
7813 views in one day?
Cool.
AVXL is a no revenue biotech startup with no approved drugs and no stand-alone phase 3 trials.
Thought about your post whilst out walking.
Yes, I too would "like being talked about on CNBC by analysts as other successful bio cos. are".
But mostly to quiet the nagging little voice in my head that says "Bullet, are you sure this isn't another of those compelling biotech "story stocks" you seem determined to chase despite knowing better".
So, sadly, I would like conformation from those whose opinions I do not value that I'm right.
And yet, I'm a student of the game.
Two legendary investors, Warren Buffet and Jesse Livermore stressed that patience was the real key to winning, and I would guess those thoughts were born in situations we believe ourselves to be in now.
Most of us on this board are in the black.
I know that helps me sleep better.
Cheers
I'd be ok with it.
My average cost is @ $5 so a $25 buyout would be a 500% gain in 5 or 6 years.
That would be the largest percentage and dollar amount gain of my entire life.
At age 62 this is also my last big stock market gamble, and while millions would be nice I'd also take a solid win.
But what if, as some here have postulated, we're just a small fish(presently) that could not avoid being taken over?
In the future might not more shareholders(both retail and institutions) see the enormous potential we think we see, and dig in their heels and say "no thanks" to a lowball offer?