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Pyrr, thanks again for taking time to put together a very well written and on topic article! You laid it out quite nicely with thorough substantiation of your position!! Wish we could all do that
Last post for the day given my last few didn't make it through the auger. Can someone please explain posting rules to me in a public forum b/c I am being told to stay within vary narrow margins by simply challenging another posters position. I thought this was an open forum in which were allowed to dialogue and dispute as long as we weren't attacking each other? I in no way have been attacking just wanting some substantiation of certain positions from others? I hope you all have a great weekend and lets keep the constructive battle alive!
OK, this is what I would refer to as "skirting" the issue! You are saying NWBO CEO hyped the early results of the Direct trial. I am referring you to the PR that came out on 06/11/14 regarding the PR that supposedly "hyped" the results. Please look at my last post taken directly from the PR and quotes LP saying
TOB, in the PR released on 06/11/14 Linda is quoted as saying
TOB, I think it's best to simply say we agree to disagree. I have tempered my initial emotions and as stated before, I think it's fair to simply try to better understand the double standard being played out here as well as questionable position the Buzdar takes with NWBO's technology and making a public statement about it. GLTA
SPOT ON FLIP!!!
TOB, you may not have any skin in this game and that may be why you take the stance you take but I hope you are not so naive to understand the timing of this "direct hit" as well stated by Basin Street:
Olive, just quoted you on MDA facebook homepage. Sorry for taking liberties but you brought up an very interesting valid point. I will be including your findings along with further instances of double standards being played out here in a email to LG, Laura Sussman, Dr Dephino, Dr Dmitrovsky and of course I have cc'd good ole Dr Buzdar on all my emails to date. TIA
Sentiment, I am not seeing your post on MDA homepage?
Jack, I'm with you on this:
RRR, I have to say I am in agreement with you after mulling this over last night and getting some sleep. It looks as though MDA is discrediting themselves and lowering their standards just fine on their own. NWBO came out with a PR addressing the issue today and we know their will be more PR's coming out soon on the Direct trial results. We have Germany to look forward to as well as DMC. I think some continued well thought out hand grenades exposing MDA and more specifically Buzdar's double standard are in order. Given the writing talents of some on the board here, I would love to see a piece addressing all of this come out next week. We need MDA for the time being so putting them in front of our firing line may not be OUR best approach.
Thanks Dok! I am going to try and call LG tomorrow regarding this as well as legal action but like he discussed with me before, AF is the proverbial pimple on our butt for now and isn't worth the Co's time or resources to go after legally. I still plan on working the angle with MDA and putting persistent heat on them for Buzdar's comments
RRR, spot on!! I think we have enough dedicated investors on this board to see this through and make sure appropriate actions are taken.
Trading, great additions! I plan to stay on top of this BS til it gets settled!Thanks to all the members who most likely had much better things to do on a Thurs. than dealing with the aftermath of this fiasco! Soon we will all look back on this, have a good laugh and realize we were part of this cancer breakthrough therapy and its journey. I may have to even enjoy a wee scotch on that occasion
TZOR, I would have to agree and taking ALL emotion out of it, I still have to agree Still have not had any response from TOB on his "hard" stance on this BS. Flip found some great info related to Buzdar releasing preliminary positive date for other Big Pharma Co's in their PI/II trial but I guess in the case of NWBO, "it is very unusual and inappropriate." TOB just disregarded this info. so I guess we all know where he stands on this..Flush....
Pyrr, I like ChartHunter5's suggestion. Any spare time or are you working double overtime to put more $ into NWBO? Hope you are well friend!
Bio, great stuff and we need to keep a full court press on this issue! Here is my email to LSussman:
Laura~
I left you a VM today and I am certain you have been inundated with calls and emails regarding Dr Buzdar's questionable comments regarding the ongoing DCVac Direct PI/II trial and the legitimate release of PR's from Northwest Biotherapeutics on the early trial results. Here are my concerns as should be the concerns of MDA regarding comments made by Dr. Buzdar's position on NWBO releasing early date from their trial:
What is interesting is that the first phase of a trial is to determine the best dose.
One determines the best dose by looking at toxicity and tumor response.
Not surprisingly, toxicity (safety) and tumor response are the primary and secondary outcome measures in the trial.
In his "ongoing" Phase I Taxol trial, Dr. Buzdar shared "preliminary ongoing" efficacy data and even compared it with competitors. He admitted he really should wait for further verification but he just had to tell world about HIS CHEMOTHERAPY PHASE I trial. Now remember, he shared this info directly as an employee of MDAnderson, and did it on behalf of Bristol Myer Squibb.
On the other hand, he does not want Dr Vivek or NWBO, the first not an employee of MDAnderson, the second conducting a trial Buzdar is not working on, to share any efficacy information. Not one shred.
MDAnderson will only share safety data, even though phase I is to determine dosage based upon safety and TUMOR RESPONSE. Imagine that, phase I is not over, but they are willing to share safety data? But this is a phase I dose trial, the other half is which dose creates the best tumor response. Nope, they will not share the secondary outcome.
How is this fair? Why does MDAnderson apparently want to spread ongoing phase I trial efficacy (tumor response) data to the public themselves on chemotherapy phase I trials; and yet, not only will they not share (tumor response) efficacy data on immunotherapy trials to the public in ongoing phase I trials, but they will not let the sponsor share this data to the public?
I also find it alarming in Dr Buzdar's quote that came out this morning that he discusses the investors perspective related to the early trial PR's that NWBO has put out. Why would the VP of clinical research at the prestigious MD Anderson be discussing anything related to an investment perspective in a Company who MDA is sponsoring their trial? I would also like to know why Dr Buzdar who from my understanding in not even involved in this Phase I/II trial is making comments on it?
Dr. Buzdar's comments were used as slanderous campaign against NWBO today which affected the share price of the stock over 20% and a large group of investors who believe in the science behind what NWBO is doing do not plan on letting such comments just pass. As a business owner myself I truly hope MDA is prepared to really take a look at the repercussions of the statements that Dr Buzdar made.
Thank you for your time in this matter and my hope is that it will be handled appropriately.
Regards,
Scott Hammons
I emailed as well as left a VM for Laura Sussman with MDA today and I just emailed this to NWBO:
Les~
What a shit show to say the least! Quote from Dr. Buzdar in AF's article this am : "I have read the information that the company has put in the public domain. It is extremely unusual and inappropriate," said Dr. Aman Buzdar, vice president of clinical research at MD Anderson, a unit of the University of Texas system. Buzdar, an oncologist by training, spoke by phone about Northwest Bio on Wednesday. He then goes on to say: "If you flip the coin and the trial results were negative, do you think the company would be disclosing this type of information? No, the company is trying to create tremendous hype about its product, which is very concerning to me as an academic oncologist," said Buzdar.
"A patient or an investor may read these press releases and see a rosy picture, which may not be so rosy when the entire dataset is analyzed," he added.
So this is tenured professor/Dr. and VP of clinical research with MDA who is not directly working with the Direct PI/II trial and is making these statements and even more alarming, he even goes on to comment about an investors point of view, really? Is this his place to be speaking about the investment perspective of a trial being conducted at his facility? Please, someone explain to me who this gentleman is and why is speaking on behalf of MDA regarding the NWBO trial? So you know, your investors plan on taking legal action! Dr. Buzdar goes out of his way to say "it is extremely unusual and inappropriate for NWBO to be releasing PR's regarding the status of its Direct trial. Well he obviously spoke out of turn:
Budzar releases ongoing phase 1 data for chemotherapy
But he will not let immunotherapy see the light of day.
You are busted Budzar!
Quote:
SAN ANTONIO?Preliminary results from an ongoing clinical trial suggest that neoadjuvant chemotherapy of breast cancer with paclitaxel (Taxol) alone produces response rates comparable to those achieved with the three-drug FAC (fluorouracil, Adriamycin, cyclophosphamide) regimen. Speaking at a satellite symposium held in conjunction with the 21st Annual San Antonio Breast Cancer Symposium, Aman Buzdar, MD, expressed optimism for neoadjuvant use of paclitaxel….With longer follow-up, we will know the true value of paclitaxel in neoadjuvant breast cancer therapy,? said Dr. Buzdar, a breast medical oncologist at M.D. Anderson Cancer Center.
- See more at: http://www.cancernetwork.com/articles/paclitaxel-seems-equivalent-fac-neoadjuvant-chemo#sthash.mxIrPR79.dpuf
I would have expected some action to be taken by MDA regarding these extremely misleading comments by Dr Buzdar but instead we get this: Jim Newman, a spokesman for M.D. Anderson, said Northwest Biotherapeutics had released bits and pieces of data from the ongoing trial in a series of recent press releases that had the potential to provide an inaccurate picture of results from the Phase I/II study.
Jim Newman of MDAnderson is lying to the public.
He is calling phase I only a safety issue, and only allowing Vivek Subbiah to comment on toxicity, when in fact the phase I trial also tests for tumor response.
Quote:Secondary Outcome Measures
"Number of patients with tumor response [ Time Frame: 18 months ] [ Designated as safety issue: No ]"
Maybe a PR refuting this from NWBO? Instead we get Dr Subbiah stating this:
"We are testing for toxicity, and we haven't seen any toxicity" from the drug so far, Dr. Vivek Subbiah, an oncologist who is conducting the DCVax-Direct studies at the prominent Houston center, told Reuters. The trials have been underway since last autumn.
Investigators at the hospital and at several other research sites are testing whether DCVax-Direct can successfully treat a wide range of solid tumors so advanced or inaccessible that they are deemed inoperable.
The ongoing first phase of the study is focusing on whether the injectable drug is safe. The primary goal of a subsequent Phase II part of the study, if the drug proves safe, would assess whether it can actually shrink or eliminate tumors.
As you are also aware from an investors perspective, there are now 4 Law Firms "Investigating" NWBO for fraudulent claims. I truly hope action is taken by NWBO given the >20% loss of share value today. The sentiment is not so great from the investor perspective right now and I know that is not necessarily the fault of NWBO but when you have a Dr who works for MDA who is sponsoring your trial come out and make these comments and damage your reputation, action must be taken. I can tell you that us investors will not stand by and do nothing and I would be appalled if NWBO didn't do something as well!
I realize your time is limited but a personal reply or public PR regarding this would be most appreciated.
Regards,
Scott
Just called Laura Sussman and left a VM. Also talked with Secretary at Dr. Depino's office and they are very aware of what is going on a she said that Laura is handling it. This is going to get very interesting indeed!
TOB, can you please explain your position as requested?
Very nice "silver lining" indeed!
Pyrr, have you been head down in writing mode and remodeling modeAny new article submissions coming our way?
STT, keep making me $, I love it when I'm able to sell high and buy low. Please proceed
TOB,
There is nothing wrong with appropriately disclosed data from trial in progress. Even a million examples of appropriate disclosure do not make an inappropriate and premature promotional PR appropriate.
Nice work iclight! Sold shares at 8.85 last night and just loaded back up at 7.80. Pyrr must have gone into writing mode?
Wow..nice satisfaction survey! I'd be out of a job with those kind of reviews
POP goes your weasel May be time to set your "new" short position STT!
Ditto...sold a chunk at $4.72
RRR, that is powerful!!!!! God willing, NWBO has a large piece of the puzzle solved. Prayers out to ALL those like Rico and Ariel who's lives have been tossed into the vicious medical cycle of treating "currently" and untreatable disease!
As I recall, things were getting a little heated btwn the good DOK and some of the other posters here. Not sure if this was a BBKing kind of thing but hope he is still out there and has hung onto his shares! Good stuff on Cramer Sentiment and btw, I never heard bk from LG. Emailed him about 3 more times but I think the questions I posed were simply ones that he could not answer. I'm thinking we have another big PR coming in the next week or let's hope soGLTU
Sentiment, thanks for the post from Sarc Alliance!!
Jack, this is what I would call "Market Awareness" of our little Gem! Playing this one now, buying on dips with small sells for profit If you truly believe is our direction, start playing the options!
Will email him today! Loading up our trailer from a weekend at the Rodeo What a great way to start the week!
Hope all the stress and uncertainty is paying off for all. Loaded up more first thing this am at $7.65...thank god Did sell a chunk of my $4.90 buyin back at $7.15...wish I hadn't but was playing it safe. GLTU Afford
LTT, I mean STT...is your new short position $8.25 or are you still evaluating the momentum of the "weak" results for Direct?
A squeeeeezzzeee of EPIC proportions coming on! Crazy to go from $11k down last Monday to over $2K up in one week..luv it. Guess this is what LG was hinting to in our discussion, we still ain't seen nothin' yet
LTT, I will take the "good news" that has lifted us up over 20% in 2 days. Thank goodness for your "short" position that this wasn't "great" news BTW, that will be coming very soon, better cover up!
Poor LTT....All the subpar, poor Direct results really are having an effect on the pps. You nailed this one and I really do applaud your new "long-short position" Whatever it takes huh? What's your next short position...$8.25??