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Austin
You celebrate Canada Day as well? I'm fortunate enough to have married an amazing Ottawa girl but now am forced to watch the Senators (only if Don Cherry is commentating), Downton Abbey and of course celebrate Canada Day Happy 4th to you all and may we continue to recognize what an opportunity this life is!!
I'll take that as your approval? Remember...focus on the TICK
Trust me when I say, I understand but also think lines have been crossed here big time! With all the positive news and positive PR's you could sticky isn't it ironic that the one bold sticky that remains is a speculative rant by an absolute joke of a "journalist" who apparently hit a homerun with timing on this one? Just sayin'
Hope you have a great 4th weekend and get that nosebleed under control. I also hope you saved some scratch in this game, it will pay off big time!
B/c you are the light we all seek and are ever consuming. How can one ignore the "tick." Keep it real "tick"
When you are the supposed BMOC (only self acknowledged) you better hope your hide is thick. Expose yourself and take whats coming!A fool thinks himself to be wise, but a wise man knows himself to be a fool. GLTA
Rabbit, good analogy and thank goodness our lil' elk is starting to get her legs underneath her! It won't be long before this little one won't be able to be caught by the big bad wolf
You must have the biggest..."balls of them all!"
Me doesn't care as long as the path is one of incline grasshopper!
Homework, I think this is simply a timing issue. The FDA more recently is much more open to fast track status as well as AA. Given how long ago NWBO's PI/II trial started, it was a different time for the FDA. I still believe DCVax L will get AA from FDA quite soon. GLTU
What a quiet day on the board! Not that I mind, in fact its kinda nice! Big news coming right around the corner. GLTA and those in MNKD as well...won that battle!
Mapman, thanks for your reply and you can email me personally at asportsdoc@juno.com
Mav, a very scary semblance indeed. I take LP to be quite savvy and is well aware of the "battle" that lies ahead. Her background and connections if you have not looked it up give me some peace of mind. As has been stated in numerous posts before, validation by Germany and the extensive infrastructure already executed also helps ALOT! GLTU
Mapman, good god, what a twisted coerce manipulation. It is almost unfathomable that this stuff is allowed to happen but as so eloquently stated in this article, it's about winning the game. Is it your assertion that we find ourselves in a similar situation with our "David?" Corruption even at the expense of saving lives, god am I naive!!
Doesn't sway my position at all but did open my eyes a bit more to the whispers in the background!
Mapman, w/out having done any research on what you stated, can you expound further?
Completely understood, I was just poking a little fun We are all big kids here and at the end of the day we better have done our own DD and not simply rely on posts on any forum. GLTU
Great post Mav! Hopefully its get clearance from Afford Just poking fun at the lack of gears btwn 1st-5th..all good!!
Terry, you said:
Maybe some day someone will be able to make me understand why anyone would think poisoning, burning, cutting people to make them well is a good thing. I can understand why chemo and radiation and surgery may be necessary considering the primitive state of our technology but not so much why that conundrum should persist.
Evaluate, I for one find value in many of these videos/articles referring to Immuno Oncology even if the focus is not specifically on NWBO's product. It just further validates the science and technology and where treatment is heading. You couple this with how much work has been done by NWBO over the past 10+ yrs and the infrastructure they have already set up over in Germany and UK. We are the frontrunners (Other cancer vaccines are also forecast to hit the glioblastoma market by 2019, including Celldex Therapeutics' Rindopepimut and Peregrine Pharmaceuticals' targeted therapy Cotara) in the pack and that I why I think we (NWBO) is being attacked so viciously right now!Who else has what we have in Germany? We will begin to see $$$$$ coming in by Q3/Q4 which will take some pressure off our balance sheet. I truly hope we don't partner and go at this alone b/c the payoff will be that much better and I am certain that is the way LP sees it.
Huge GBM market with most other immuno vaccine Co's far behind us!
http://www.fiercevaccines.com/story/northwest-bio-leads-german-cancer-vax-trial-glioblastoma-market-poised-doub/2014-06-12
Once again, if this had already been posted my apologies for the redundancy
Very interesting highlight from: LIBTC / St. Francis Hospital Symposium Educates Health Professionals On Brain Cancer Clinical Trials
“Our goal with this symposium was to use it as a showcase, so that members of the regions medical community could better understand the importance of clinical trials to the future of neuro-oncology,” said Dr. Tessler. “That is why we decided to provide a platform to so many of these innovative companies and researchers.”
The symposiums distinguished faculty included: Marnix L. Bosch, M.B.A., Ph.D., Chief Technical Officer, Northwest Biotherapeutics, Inc.; Juliann Chmielecki, Ph.D., Senior Scientist II, Cancer Genomics, Foundation Medicine; Alan Ezrin, Ph.D., President and CEO, NX PharmaGen; George Farmer, Ph.D., CEO, Cortice Biosciences; Stuart Grossman, M.D., Professor of Oncology, Medicine and Neurosurgery, Johns Hopkins University School of Medicine; Al Musella, D.P.M., President, Musella Foundation for Brain Tumor Research and Information, Inc.; Jamey R. Skillings, M.D., Senior Vice President and Chief Medical Officer, Tocagen Inc.; Uri Weinberg, M.D., Ph.D., VP, Research and Development, Novocure GmbH; and Michael Yellin, M.D., VP, Clinical Science, Celldex.
“Now more than ever, participation in clinical trials offers brain tumor patients cutting edge technology, while advancing our knowledge of disease treatment,” said Dr. Tessler. Remarkable advances in immunotherapy and drug delivery options, as well as the drugs themselves, have allowed us to break down the blood-brain barrier and begin fighting these tumors head on.
Dr. Tessler added that, until recently, medical treatment of brain tumors was somewhat limited by this barrier, which prevented most drugs from affecting tumors within the brain.
Great article from back in Jan. but thought I would post it. Focus has been on Direct but keep in mind all the progress that has been made with L and the fact that we will have revenue #'s coming very soon!! http://nursing.advanceweb.com/Features/Articles/Brain-Cancer-Vaccine-Breakthrough.aspx
Amazing video Evaluate!! Thnx for sharing
Thanks Pyrr and GLTU!! As you helped call Flipper back from the depths of the ocean I do hope you will return at some point soon as your input has always been a valuable contribution to this board!!
I guess we are still not able to post anything pertaining to questioning other board members position. This is laughable at best! Given this post is not directed at any board member in particular I would hope there would not be an issue. Oh the power of ego, I guess its in us all
Afford, AF definitely represent the "shorter" side of things. Must have started in his adolescence I can guarantee that LP will not change her course due to the likes of AF. In fact, I think she takes great pleasure in making him look like an a**. As LG stated to me on the phone, they don't give a rats batooty what AF is doing. They know what they have and that is ALL that matters to them!
Dok, Subbiah never brought it up b/c as he clearly stated at ASCO, NWBO was free to PR their results. This is NOT some little misunderstanding! This was "manipulation" at its finest! Regardless of sponsoring the Direct trial, Direct is absolutely 100% disruptive technology that some would hope would never see the day of light! NWBO got thrown under the bus as did Subbiah by MDA. We may not get a formal apology but MDA has been made painfully aware of their "mistake." Posts continue to go up on their FB page and I will continue to email L Sussman for some basic answers. My tone on emails to her and my points are one of concern and confusion and not anger which I think is important for us to make any headway.
I agree safin. LP doesn't strike me as one to "hold back" on anything. As more data is accumulated they will release the PR's appropriately regardless of the double standard being spouted by MDA. I sure would like MDA to comment on why their lead Dr. in the Direct trial (Subbiah)stated at ASCO that the Co was free to comment on the trial results? Guess this shouldn't surprise me, big business is like the government, the right foot has no clue where the left is!
Spot On Sometimes being the BMOC or in this case BLOC ain't as glamorous as one would assume! Overall I think LP has handled herself with poise and leadership!! God knows if this was me running the ship I'd find out what AF's favorite watering hole was and pay him a little visit (working the anger management steps as we speak)
Great post Flip!
CSF, haven't you posted on this board before, say 4-5 months ago?
Sentiment, Terry Hallinan answered this question on investors village: "Phase I trials are open trials and need no unblinding."
Sentiment, I sent LG an email this morning making him aware of the activity all the investor were doing as well as posting on MDA's FB page, emails to L Sussman etc... I did ask him to please let me know if by doing this it would affect/harm the trial with MDA or their relationship (if not tarnished already)? Will let you all know his response when I get one
BJoel, great idea especially if you are able to obtain info. You probably know best how to go about it but I did just look up this site for info., http://www.foia.gov/report-makerequest.html
As you are probably aware, MD Anderson is deleting all posts on their FB Page related to this issue.
RRR, start with http://www.exposeadam.com/ as I think you will get some info. there. Also look at http://www.benzinga.com/topic/adam-feuerstein
Here is my list:
ARNA
AGEN
GNBT
AVNR
VNDA
MNKD
Did a brief google search and will do more later tomorrow. Cheers
Bingo!! Great find Dan. Just posted it on MDA's FB page. They are going to have to respond to this at some point
Sentiment, here ya go: Sussman,Laura M; externalcomm@mdanderson.org
Great work btw. Did you see that MDA took down all of our posts from yesterday?? I just posted my response to Sussman again and it did go live. Family day for me but will check in later.
Bravo Iclight!! We need to use MD Anderson's own PR against them. Not in a malicious way but in such a way that sheds light on their lack of transparency and obvious double standard policy. My feeling is this all has to do with NWBO being such a disruptive technology and the billions at stake. Good ole AF knows this of course and as stated by others, he when after the obvious target, VP of clinical research who only deals with the "Big Boys." It certainly was no coincidence that he got Buzdar on the line! We certainly got one hell of a team here
MD Anderson just emailed me regarding my post on their FB Homepage. Here is what they said:
Scott, thanks for giving us the chance to respond. You can read our statement here: www.mdanderson.org/newsroom/news-releases/2014/statement-regarding-release-of-data-prior-to-study-conclusion.html
Thanks for your reply and I wish that all the dots connected on this but they just don't and for obvious reasons. I take issue with part of your press release today, specifically, "MD Anderson was not involved in the decision to disclose the study information prior to the completion of the research. Therefore, we felt it was important to state that fact. We also felt it was important to state our belief that releasing incomplete research data is not accepted practice in our field."
If this were the case then how can you explain this: 2011 "MDAnderson" announces phase I results despite on-going enrollment expansion.
Threshold Pharmaceuticals Announces Promising Phase 1 Clinical Trial Results in Patients With Advanced Leukemias
SOUTH SAN FRANCISCO, CA -- (MARKET WIRE) -- 12/14/11 -- Threshold Pharmaceuticals, Inc. (NASDAQ: THLD) today announced clinical trial results of the Phase 1 study of TH-302 in patients with advanced leukemias conducted at MD Anderson's Cancer Center in Houston, Texas.
Thirty-two patients with either acute myelogenous leukemia (AML) or acute lymphoblastic leukemia (ALL) have been enrolled in the trial to date. The starting dose in the trial was 120mg/m2 daily for 5 days of a 21-day cycle and the highest dose investigated in the study was 550 mg/m2. At this dose two patients developed dose limiting mucosal toxicity. The maximum tolerated daily dose (MTD) of TH-302 was established at 460 mg/m2. Efficacy assessments have demonstrated TH-302 activity in multiple subjects with relapsed/refractory AML and ALL as evidenced by stabilization or reduction of bone marrow and peripheral blast counts. One patient had a complete response with incomplete platelet recovery (CRp) with resolution of leukemia cutis. A dose expansion with 10 additional evaluable patients is ongoing at the MTD.
"With the establishment of the MTD, we look forward to better defining the safety and efficacy of single agent TH-302 in patients with advanced leukemias," said Dr. Marina Konopleva, M.D., Associate Professor in the Department of Leukemia at MD Anderson Cancer Center.
As well as this: Sunesis Announces Presentation of Positive Results From Ongoing MD Anderson-Sponsored Trial of Vosaroxin in AML and High-Risk MDS
Data Presented at AACR 2014 Annual Meeting
Company to Host Conference Call Today at 8:00 AM Pacific Time
SOUTH SAN FRANCISCO, Calif., April 8, 2014 (GLOBE NEWSWIRE) -- Sunesis Pharmaceuticals, Inc. (Nasdaq:SNSS) today announced the presentation of results from an ongoing Phase 1b/2 University of Texas MD Anderson Cancer Center-sponsored trial of vosaroxin in combination with decitabine in older patients with previously untreated acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). The results will be presented today at the Phase II/III Clinical Trials Poster Session of the American Association for Cancer Research Annual Meeting 2014 (AACR) in San Diego, California. The poster (Poster #7, Hall A-E, Poster Section 38) is titled "Phase I/II study of vosaroxin and decitabine in older patients with acute myeloid leukemia (AML) and high risk myelodysplastic syndrome (MDS)."
Patients in the ongoing trial are being followed for rate of response, leukemia-free survival, overall survival and safety. To date, the combination of vosaroxin and decitabine has been found to be effective and well tolerated in older patients with AML and high-risk MDS. Twenty four patients are evaluable for response; 9 (38%) achieved complete response (CR), 5 (21%) achieved CR with incomplete platelet recovery (CRp), and 2 (8%) achieved CR with incomplete peripheral blood count recovery (CRi), for an overall response rate of 67%. The main grade = 3 toxicity was mucositis in 6 (6/29, 21%) patients. No patients died during the initial 30-day induction period.
Just to make sure I am not misunderstanding MD Anderson's position on this can you please explain this quote from Dr. Vivek Subbiah at ASCO this year regarding the DCVax Direct trial with NWBO: At ASCO this year, Dr Vivek Subbiah of MD Anderson who is leading the DCVax Direct trial said, "I will not be reporting data on patient tumor response while the study is underway, although the company is free to do so, he said."
I would like to know MD Anderson's official position on releasing data given they themselves have done this and Dr Subbiah himself stated the Company was allowed to release data? Something is not making sense here especially given the latest PR from MD Anderson stating that this sort of thing is "not accepted practice in the field."
If I along with many others are confused then please do set the record straight because this is all looking a little disingenuous to me. Once again, I would appreciate any input you may have on this matter. I would also like to reiterate that your latest PR is not acceptable and will not just go away until some sense is made of this debacle.
Trading, there is a reason this young man was accepted into an accelerated pre-med program at a young age! Hope I didn't skew the facts but I think this is the case. Very talented to say the least