Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
DHA is not an essential fatty acid. Stuffing your body with it is probably unneeded. EPA is an essential fatty acid.
I meant to write DHA.
"Docosahexaenoic acid synthesis
DHA is synthesized in the body by ALA metabolism.
It is synthesized from eicosapentaenoic acid (EPA) via docosapentaenoic acid as an intermediate.
By the Sprecher's shunt pathway EPA is elongated twice to yield 24:5 ?-3.
It is then desaturated to 24:6 ?-3.
24:6 ?-3, via beta oxidation is shortened to 22:6 ?-3 (DHA)."
I'm expecting an Amarin hit article on SA from him soon.
Body metabolizes EPA to DPA.
I'm wondering if the "skeptic" is polishing an Amarin hit piece for SA.
Yeah, I know. My post was intended to be a LMAO at the "skeptic's" post you were responding to.
Apparently iHub doesn't recognize emojis, lol.
As part of the 1A settlement, Amarin can petition for promotion of 10 off-label indications the next 5 years through 2020, Max of 2 per year. Pls correct me if I'm wrong (I'm sure that won't be a problem). Less than 5 months left in 2016. So, why negotiate for something you know you don't need? Like the heart attack study, there are several diseases that can be trialled with relatively few patients in a short period of time (RA, DES, Depression). Any one of these would create news and demand for scripts.
Perhaps true, but actual people mostly don't do that.
I noticed it too. To quote Princess Leia: "I recognized your foul stench when I was brought on board."
He as an agenda (figuring out when to short). Nothing else.
Glad to hear it's your last point. Sleep tight.
PBYI went from $59 to $275 in space of few days in 2014. Trading around $49 now.
Well, that's a happy little hummer!
Omegavia EPA 500 probably better choice IMO. > 6 mo for my wife and me @ 4 gm/day with no problems.
Thanks. The dietitian's discussion was superficial but she did relate omega 3 fatty acids to anti-inflammatory effects. Is the blood thinning concerns she mentioned valid?
Anyone aware of omega 3 treatment being tried for Sarcoidosis?
Agree. Peter Attia also has an excellent TED Talk, June 2013, on obesity and diabetes. ~15 minutes.
The organizations for Big Disease benefit from increasing rates of disease. They include the American Heart Association, American Diabetes Association, the Arthritis Association, and the American Cancer Society. I don't send them money.
Ever increasing T2DM is an absolute panacea for the American Diabetes Association. They have no incentive to make the problem go away.
I get "SSL not enabled" message on my iPad when attempting to view your links.
Nissen was a clown before that.
Think I'll send the US government a thank you note that I won't have to be paying these jackass's taxes!
Fly. ClayTrader bungled his analysis on 3/31. He was called out on it but didn't correct it. Any comment?
There are some lurkers.
Been entertaining to read all the PR decoder ring chatter today. For those old enough to have watched, Amarin PR reminds me of the "Androgynous Pat" skits on Saturday Night Live.
Gosh, think how much fun we would be having now if he was a public face for Vascepa? And yes, had he been taking Vascepa perhaps he would have not had one, but the fact is, anyone can die suddenly of heart related issues.
Having a personality taking your phase 3 trial CVD drug is beyond stupid. No upside and risk of catastrophic downside.
An excellent reason for Amarin to end the Rick Harrison goofiness!
Sometimes better to be lucky than smart...
Had blood work recently which showed mildly elevated bilirubin. Had ultrasound scan (clear) and repeat blood test. Dr diagnosed Gilbert's Syndrome. (Also taking 4gr/day Omega 500). GS is negatively correlated with atherosclerotic disease. Surprised at lack of publicity about this.
http://www.ncbi.nlm.nih.gov/pubmed/23201182
http://www.ncbi.nlm.nih.gov/pubmed/25576848
Agree. Grew up on a farm so wading through BS (mostly CS actually) is a core competence for me. You don't even notice the smell after awhile. Went into ADCOM with 5k @ $6.40. Now 61k @ $2.00. Appreciate contributions from HD, JL, and Zum. Seems like folks are overdriving the gloom and doom and hurt feelings. Not sure but following may be significant:
"FDA has agreed to provide Amarin with an optional preclearance provision through 2020 for new off-label claims."
Regards.
This has been my speculation for awhile now.
I'm thinking that Zum's posts give a clue as to what the 1A negotiations are about. The whole enchilada, maybe a plate full of enchiladas.
Suppose the treatment arm death rate is lower due to pleiotropic influence on non-atherosclerotic disease processes. Does the DMC have visibility to differentiate and would it raise a flag?
I bought an Omron BP786 a few months ago. Data can be downloaded to a smartphone. Accumulates up to a year's results. Data can be emailed. Can be set to take 3 readings and average them. Works well.
Been following Amarin for over a year on iHub. Had 5k @ ~$7 basis going into ADCOM. Now at 60k @ $2 basis. Have learned a lot. Hope it pays off. Stents are about half of the $22B interventional cardiology market. This and other powerful constituencies will respond vigorously to threats from Vascepa IMO.
Another thing I learned from "The Widowmaker" documentary was about the COURAGE study that showed stents were not more effective than non-intervention treatment and lifestyle changes. Medscape article circa 2012...
http://www.medscape.com/viewarticle/775874
Quote:
In summary, during the 5 years since COURAGE was originally published, we continue to lack scientific evidence that PCI has any favourable clinical effects in patients with chronic angina and SIHD except for angina relief and, even then more recent data would suggest that the treatment effect on angina as compared with OMT alone is modest at best. Despite this, PCI continues to be performed increasingly without regard to the consistency of evidence which suggests, to the contrary, that PCI should be used more judiciously in many patients with SIHD and only after there has been an appropriately adequate trial of medical therapy as the initial treatment approach. It is perplexing that we cannot accept and embrace the scientific evidence that aggressive medical therapy, when applied intensively as secondary prevention and combined with lifestyle interventions such as diet and weight maintenance, smoking cessation and regular physical exercise, is an extremely safe and powerfully effective (and cost-effective) approach to reducing clinical events and improving prognosis in patients with CAD. Until we have data from ongoing or planned trials to support a different therapeutic approach, we should endeavour to base current treatment decisions in stable CAD patients with chronic angina on the best available evidence, and should recognise that there are three equally effective management approaches (PCI, CABG and OMT) that can (and should) be applied to individualise the best and most appropriate treatment for stable CAD patients.
Near as I can tell, it is a type of CT scan. According to one reference, electron beam computed tomography (EBCT) and multidetector computed tomography (MDCT). Probably more like $400 and may take ~10 minutes depending on machine used.