Stuart Tomc attending last weeks Anti aging medicine conference says new proline roll on products launching next month. Here is a clip of Stuart.
www.facebook.com/a4mconferences/videos/503711160792931

This may help DTC channel. Email marketing manager.
https://www.indeed.com/viewjob?jk=85d3d64d9d94b8ef&q=Cbd+Hemp+Oil&tk=1fm8n9eloo2al800&from=web&advn=7321969295799187&adid=379961381&ad=-6NYlbfkN0BFGdrbVN5W-uxf8UVb1lJZKP5iOo1jZvEfIAz8oYxJw63j9jqFkyb3MjPRl19y8fPYc34Xvxuott4kbzbDihg221F8BXSwOjz2VBsKg3pY-UMPK_lqoRMa1pDfwsGKV1A0nHjJENVxeH8BsuFVWonjeUP6Zazi0qOoI8qo9CB08zZYmhqDJemwfrHRLOgTTkb-_dFfOLHhqjoKETAZe5MB1CY4xbBaHI2zeWt2Rw89uHa_TbRbFXGZxqCjFbjfyN9nyODNYW9r-Qyla6oLpVnu0YTJmR8FWS_aG_T7YR1U4Zd9kr28lbjA3wgD5qK0K-qKuTkw0yuz-hEJo9yojHvrBvQq0yhytfU1mOavGU3LIXmqTXLf1WxL&pub=4a1b367933fd867b19b072952f68dceb&vjs=3

g247. here is the link verification for new U.S. patent to be issued this week.
https://globaldossier.uspto.gov/svc/doccontent/US/202016841834.A/1-1-US%20%20168418340JP1%20/1/PDF

This new patent seems to be a dosage patent which a possible partner could have required before committing to clinical trials. Maybe?

CVSI New patent #11191736 to be issued December 7,2021. Hopefully
with a pr and update.

looks like the inventor of cvsi-007 Jonnie Williams, is the brains behind
the Nasdaq listed company MYMD. Jonnie had the patents, then set up the company MYMD and then merged with Akers last April. Mymd is now developing
his patents products and has a market cap of 300m. Maybe this adds some credibility to patent cvsi-007.

A competitor is up premarket 20-50% on Amazon accepting cbd sometime soon.

“As an industry, this is the moment we’ve all been waiting for, and we believe we are close. When a global retailer like Amazon is ready to accept your products, you get your strategy prepared and perfected so you’re ready to go to market as soon as possible. That’s exactly what this partnership represents.

CVSI and Nuleaf CBD have similar yearly revenues. CVSI presently valued at 21M. Nuleaf bought by Canadian company today valued at 38M. This should hopefully be our bottom?
https://markets.businessinsider.com/news/stocks/high-tide-expands-us-reach-via-31-24m-acquisition-of-80-stake-in-nuleaf-naturals-1030994739

New Stuart Tomc podcast on reserve collection. Good stuff.
https://drhoffman.com/podcast/a-revolution-in-hemp-derived-nutraceuticals-part-1/

Looks like new Christmas items are already on the shelves. https://patch.com/new-jersey/lacey/calendar/event/20211027/1498574/limited-edition-holiday-survival-kit

Anyone else confused by new reserve product being offered online?
Thought this would be a dispensary product only?

AB 45 signed.
https://www.gov.ca.gov/2021/10/06/governor-newsom-issues-legislative-update-10-6-21/

Stuart Tomc comments on AB 45.
https://www.leafreport.com/news/the-worlds-largest-cannabis-market-is-setting-the-rules-for-cbd-products-13823

Still trying to ascertain the importance of the seven unannounced products
registered with the FDA. It seems they are part of a revamping of the OTC monograph reform bill which is derived from the CARES ACT. Today the FDA announced the final orders for four of the categories and will update the list as they are finalized. The seven new products only active ingredients contain camphor and menthol in different percentages. Listed under inactive
ingredients is cannabidiol implied on the label used to soften the skin.
If these products make it to market they assumable will be cheap and they
will differentiate themselves from the other products by their large labeling trade names PLUS CBD and PRO CBD. If you see a number of similar arthritis cream products with similar prices but only one will show CBD on the labeling even though the cbd is inconsequential.

https://www.accessdata.fda.gov/spl/data/ca398dfb-81f9-eee3-e053-2995a90ab1f7/ca398dfb-81f9-eee3-e053-2995a90ab1f7.xml

https://www.federalregister.gov/documents/2021/09/21/2021-20393/final-administrative-orders-for-over-the-counter-monographs-availability

Stuart says we are ready for a phase 1 clinical trial for cv-007.(around 18:30) Stuart is always a good listen. Says they will be following up on their published 5 million bottles sold safety data with a 10 million bottles sold safety data. https://www.thinkingoutsidethebud.com/podcast/288-stuart-tomc

On August 12 the patent office sent cv sciences a notice of allowance
for their second patent for cv-007.
This allows for higher doses of cbd for treatment which may be important to any potential partner.

NDI submissions from CW and Irwin Naturals.Is this new? https://www.regulations.gov/document/FDA-2021-S-0023-0054

Another web site which seems to be hosted from cv sciences but has yet to my knowledge been announced. CV sciences logo and link are on bottom of page. If you haven't seen "the scientist" (one of the links on this page"
try to watch sometime.
https://www.cvresearch.info/

They have owned the domain website www.plushemp.com since 2010 which leads nowhere. In June 2021 for some reason registered the domain www.plus-hemp.com which is active. Go figure.

Has anyone seen this packaging. Been out of the loop
https://www.plus-hemp.com/

There may be more to this than meets the eye. A new clinical study on Happy Lane.
https://clinicaltrials.gov/ct2/show/NCT04997616

Final report from NIST using cv sciences supplied oil. I imagine it would be hard to find a more looked into oil.
https://nvlpubs.nist.gov/nistpubs/ir/2021/NIST.IR.8385.pdf

Not sure if this has been reported but seven new products have been registered with fda. they seem to target specific audiences.

PROCBD PAIN CREAM (PENETRATING) 2OZ (camphor, menthol) cream CV Sciences, Inc. Tue, 24 Aug 2021

PROCBD PAIN CREAM (ARTHRITIS) 2OZ (camphor, menthol) cream CV Sciences, Inc. Tue, 24 Aug 2021

PROCBD PAIN CREAM (MUSCLE) 4OZ (camphor, menthol) cream CV Sciences, Inc. Tue, 24 Aug 2021

PLUSCBD PAIN CREAM (PENETRATING) 2OZ (camphor, menthol) cream CV Sciences, Inc. Tue, 24 Aug 2021

PLUSCBD PAIN CREAM (ARTHRITIS) 2OZ (camphor, menthol) cream CV Sciences, Inc. Tue, 24 Aug 2021

PLUSCBD PAIN CREAM (MUSCLE) 4OZ (camphor, menthol) cream CV Sciences, Inc. Tue, 24 Aug 2021

PLUSCBD SPORT RECOVERY STICK 1OZ (camphor, menthol) cream CV Sciences, Inc. Tue, 24 Aug 2021

https://fda.report/DailyMed/

In addition to the European patent office intentions to approve the cv-007 patent this initial publication of a cv-007 study in the european journal Psychopharmacology should be another PR.

https://link.springer.com/article/10.1007/s00213-021-05845-4

Funding suggest that money is available for cvsi to pursue this program.

"This work was supported by the National Institute on Drug Abuse (grant no. 1F31DA047113-01 to L.C.S.), National Institute on Alcohol Abuse and Alcoholism (grant no. AA022977 and AA006420 to O.G.), Tobacco-Related Disease Research Program (grant no. 27IR-0047 to O.G.), Tobacco-Related Disease Research Program (grant no. T31KT1859 to M.K.), and CV science (O.G.)."

Took a break from DD. So just wondering if anyone reported the European patent office decision to grant the patent on April 16th. CVSI may be waiting on formal issuance of patent # before announcing. Believe there are 30 countries that this patent can now be enforced in when and if cv007
happens.

I'll venture a guess that you are the host and producer of ACC. Thanks for the clarification
but is there a way to see the ad campaign commercial without subscribing to
Simultv,com. or is it on the cvsi youtube already. The new Fortifying Your Immune Defense with Dr. Michael Lewis has over 18k views its first week.

This seems to be a new extension of the w420 and cvsi "partnership". Last month w420 radio had a special report on the immune products.
This looks like a attempt to reach a larger audience although I can't find w420 radio listed.
https://www.einnews.com/pr_news/535446930/w420-announces-launch-on-simultv-com

Just noticed that before our discussion on the CVSI and Alaffia personnel connections they applied for a trademark to include cbd in their products November 6th. Hopefully cvsi is the provider.

From uspto,gov
Word Mark ALAFFIA
Goods and Services IC 003. US 001 004 006 050 051 052. G & S: Skin moisturizer; skin moisturizing gels; shea butter for cosmetic purposes; skin care preparations, namely, body balm; coconut oil for cosmetic purposes; neem oil for cosmetic purposes; skin cream; Non-medicated balms for use on lips and skin; lip balm; skin cream; facial cream; facial lotion; all of the foregoing containing CBD derived from hemp
Standard Characters Claimed
Mark Drawing Code (4) STANDARD CHARACTER MARK
Serial Number 90304466
Filing Date November 6, 2020
Current Basis 1B
Original Filing Basis 1B
Owner (APPLICANT) AGBANGA KARITE, INC. CORPORATION WASHINGTON 8109 RIVER DR SE Olympia WASHINGTON 98501
Attorney of Record Lynne E. Graybeal
Prior Registrations 3831468;5227205;5987106;AND OTHERS
Type of Mark TRADEMARK
Register PRINCIPAL
Live/Dead Indicator LIVE

Off topic but it was fun reading about Andrew Lefts Citron Research
getting out foxed on his attempted short of gamestop.

https://finance.yahoo.com/news/gamestop-halted-for-trading-after-70-jump-in-apparent-short-squeeze-192635040.html

I believe prop.65 in California kicked in Jan.3rd 2021.This should eliminate some of the competition. I see cvsi last month produced new batches of their biggest selling products that now have the new certificates of analysis that comply with california. COA's are now 5 pages
vs.2 pages

https://www.pluscbdoil.com/on/demandware.static/-/Sites-CVSCIENCES-Library/default/dwe17454dd/COAs/FP-20-0741%20J20035-1-60328%20Released.pdf

"With the addition of ?9 THC to the Proposition 65 list on January 3, 2020, hemp companies have a one year compliance period until January 3, 2021 to implement Proposition 65 warnings, if required, for any
products marketed in California. Subsequent to this date, and in the absence of OEHHA setting a
Maximum Daily Allowable Level (MADL) safe harbor value for ?9 THC, it is possible that some marketers
of hemp products containing detectable amounts of ?9 THC may need to provide a compliant
Proposition 65 warning."

http://www.ahpa.org/Portals/0/PDFs/Committee/CC/AHPA_Prop65_Guidance_Hemp_Products.pdf

I too have thought there may be a cvsi product line for Alaffia. I am leaning towards the cvsi trademark Potentia as the name.
CVSI brought in Shane Hart in October 2019 the same month as the registration for Potentia. Shane is our SVP of marketing. He was senior director of marketing and sales at Alaffia for five years.
Also worked 10 years as Flora Health North America marketing manager.

The cvsi trademark seems to cover every Alaffia product from body, face, hair, and babies
POTENTIA
Body care and toiletry products, namely, skin moisturizers, balms, ointments, lotions, skin cleansers, creams, body oils, massage oils, roll-on oils, baby lotion, baby oil, lip balms, and serums; shampoos and conditioners; cosmetics; anti-aging creams; mineral make-up; eye creams; foundation; all of the foregoing containing CBD derived from industrial hemp

The news to me was the substantial size of the award and that this was the
first awarded cbd study in the TRDRP history. Out of the 509 awards
over the last five years this one was higher than about 400 others. I was thinking it may be 50k-100k not 778k.

Just to address your repeated oversimplification that you and others would rather just self medicate by taking a otc nicotinic gum and your favorite cbd gummy that you can obtain for $45 for 60 10mg. pieces.
You must understand that based on the patent claims this medication
may contain up to 300mg per dosage so you may find yourself self medicating
with 30 gummies per dosage. Multiple daily dosages? Multiple weeks?
Looks like its getting expensive. See a doctor. Get prescribed cv-007(someday?) Save money?

In what appears to be a vote of confidence in the cv-007 initial study conducted by UCSD for cvsi, a extension of the study has been awarded a $777,900 grant from TRDRP.

https://www.trdrp.org/files/trdrp-legislative-report-2015-2020.pdf
Page 72.

New
Investigator
Award 2020*
Effect of CBD on nicotine
addiction: evidence from
translational models of nicotine
intake in rats Kallupi, Marsida
University of
California, San
Diego $777,900

About TRDRP.
The Tobacco-Related Disease Research Program (TRDRP) transforms tobacco taxes into cutting edge research to reduce commercial tobacco use and tobacco-related diseases and to inform public policy that benefits California’s diverse populations.

Another name appearing as a contributor to the study is Kate Hanham who may be of interest to the development of cv-007
http://www.mentara.com/founder/

Good to see Joe getting involved in the science behind cv-007.
ACNP 59th Annual Meeting: Poster Session I December 6-9
39. Cannabidiol Reduces Withdrawal Symptoms in Nicotine Dependent Rats
Marsida Kallupi*, Lauren Smith, Lani Tieu, Ray Suhandynata, Melissa Hoffman, Yadira Sepulveda, Jeremiah Momper, Robert Fitzgeral, Kate Hanham, Joseph Dowling, Olivier George

UCSD School of Medicine, La Jolla, California, United States
Background: Cannabidiol (CBD) reduces craving in animal models of alcohol and cocaine seeking and is known to modulate nicotinic receptor function, suggesting that it may alleviate symptoms of nicotine withdrawal; however, preclinical evaluation of its efficacy is still lacking.

Methods: Male and female Wistar rats were made dependent on nicotine using osmotic minipumps (3.15 mg/kg/day) for two weeks, after which minipumps were removed to induce spontaneous withdrawal. Three groups received CBD injections at doses of 7.5, 15, and 30 mg/kg/day for two weeks, starting one week into chronic nicotine infusion. The control group received vehicle injections of sesame oil instead of CBD. Finally, another control group received a saline minipump and sesame oil injections (double vehicle). Throughout the experiment, serum was collected for determination of CBD and nicotine concentrations, mechanical sensitivity threshold and withdrawal scores were measured, and body weight was recorded.

Results: CBD prevented rats from exhibiting somatic signs of withdrawal and hyperalgesia during acute and protracted abstinence. There was no dose-response observed for CBD, suggesting a ceiling effect at the doses used and the potential for lower effective doses of CBD.

Conclusions: This preclinical study suggests that using CBD as a strategy to alleviate the withdrawal symptoms upon nicotine-cessation may be beneficial.

"The Federal Trade Commission today announced the first law enforcement crackdown on deceptive claims in the growing market for cannabidiol (CBD) products." Fines were up to $85k to be paid to FTC
Hope this is a daily event.

https://www.ftc.gov/news-events/press-releases/2020/12/ftc-announces-crackdown-deceptively-marketed-cbd-products

Looks like Olympic silver medal cyclist winner Nelson Vails will be a influencer for Happy Lane. Maybe focusing on the thc free aspect for athletes
Stuart Tomc introduces Nelson Vails:

https://www.iheart.com/podcast/503-lets-talk-nutrition-28241942/#

https://nelsonvails.com/

Nice write up today in nutritional outlook.

“CV Sciences plans to expand its CBD and non-CBD offerings with innovative products. Our experienced team of nutrition industry executives is working closely with our medical advisory board on several exciting projects that will advance CV Sciences’ position as the most reliable and trusted CBD manufacturer for all sales channels,”

https://www.nutritionaloutlook.com/view/nutritional-outlooks-2020-best-of-the-industry-awards-retail-brand-product-cv-sciences

The business address of Tumim Stone Capital, LLC is 140 Broadway, 38th Floor, New York, NY 10005. Tumim Stone Capital, LLC’s principal business is that of a private investor. Maier Joshua Tarlow is the manager of 3i Management, LLC, the general partner of 3i LP, which is the sole member of Tumim Stone Capital LLC, and has sole voting control and investment discretion over securities beneficially owned directly by Tumim Stone Capital LLC and indirectly by 3i Management, LLC and 3i, LP. 3i Management, LLC is also the manager of Tumim Stone Capital LLC. We have been advised that none of Mr. Tarlow, 3i Management, LLC, 3i, LP or Tumim Stone Capital LLC is a member of the Financial Industry Regulatory Authority, or FINRA, or an independent broker-dealer, or an affiliate or associated person of a FINRA member or independent broker-dealer. The foregoing should not be construed in and of itself as an admission by Mr. Tarlow as to beneficial ownership of the securities beneficially owned directly by Tumim Stone Capital LLC and indirectly by 3i Management, LLC and 3i, LP.

Pet products for sale.
https://www.pluscbdoil.com/pluscbdforpets.html?utm_source=SFMC&utm_medium=Email&utm_campaign=Dec_PetLaunch