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2-73 effect on bdnf signaling could help dramatically in rett
Sold @ 6.26 but back @ 6.12
Got a feeling
$avxl long
Hippocampal volumes and atrophy rate matched severity index but posterior cortical atrophy markedly increased in 40ug samples
why?
Alkon continued we are excited to be able to anticipate the final data from the trial earlier than previously expected
maybe shouldn't have said that
$20m in the bank to settle
Bryo stores expire 2018
$ntrp short @ 6
Research supporting $avxl moa ad/pd 2017
Pmc5343785
dont taze me bro
$zgnx zx008 new moa $avxl validation in epileptic seizures dravets
$avxl leveraging lp
josh is giddy
$50m for p3
Been watching some 1.16s sail away
been picking under 2.4
$galt long @ 1.89
Is he a samson or a snape?
Always the ? In bios (stocks)
Some
Company
Almost
Made it
everyone has to play the game if you dont promote yourself youll never win
Sucssess is not black and white fact or not lots of approved drugs dont work miracles have been denied
does the plus patent mean nothing or was it the clincher?
I dont see another bio that has come from otc to fairly valued nasdaq issue with as much behind it
got some trading shares to start accumulating on house $
$avxl buy
Started reading about this cerebreal clearing during sleep
Interesting the relationship between vgca2+ channels and this action
could the sleep data be on to something?
seems to be a sleep correlation across many neurodegen conditions
otoh is 003 data looking bad and co trying to load the bases before a hard grounder?
Just need one strong conformity catalyst!
Er confirming. Stupid phone
I questioned the ind existance
do not need one for non us trial or nda submission
Just to human test in us
Could always be why they went to au failure to get ind
I referenced ucm294729.pdf
nice to see new outside sponsored study
j french powerful ally
no. 72s for me today
lol
Hey if 20 can finish the 3 years it should be fairly conclusive
A mounain of data with all the soms
avg mmse drop over 3 yr is -8.4 for mild to mod
If they avg -3.5 its a home run
Ctad pg 17
3 consent withdrawn (dropped out)
Ae delirium grade 2
Ae dizziness grade 1
Ae confusion disorientation lethargy grade 1
1 lost to follow up (unreachable)
Www.eurekaselect.com/95387/article
Download
Great board thanks!
I had not seen that
I understand now
wth are they going to inlicense?
Ill play my core
$avxl long
Scepticism yes why i was wondering
think pk/pd data is proprietary and ariana setting up kem for next trial
I thought 12 mo readout would provide clear guidance on investing but it raised more?s
so i share the anxiousness
Lot of irons in the fire though
Thanks
Can you point to an example of pk/pd analysis you are awaiting?
My research indicates pk/pd data is used to plan trials optimize dosing etc
ctad pres says in vivo receptor occupancy studies this is not layman translatable stuff
When/where did they state they would release this to the public?
Think you are mistaken
2-73-001 p1 human de study
2-73-002 p2a 52 wk saftey study
2-73-003 p2a 104 wk extension study
2-73-004 ???
I follow lane simonian on sa
shorted $ntrp @ 21 easy $$$
Read lanes ntrp piece
2-73 has been in patients for over a year and if any drug will be effective it will have to be cbronic low dose counter agent started early on
Pom was met and soms of exploratory extensions are well poweroed to project efficacy
Agree with jimbo50 silence is golden right now
missling gives clues sudden options was blatantly obvious imo
Yesterdays conf same as 2015?
Im excited and made some good $ to put here next week
still going to wait for the next readout to make any firm commitment
that sa piece was just stupid hope they slam it down too!
What will happen if 18 mo mmse and adcs-adl is + for all patients?
Disease modifying?
At 57 wk it was real close and trending up
At 60 wk mmse should avg -2.8 if they have ad
Think the co is for sale?
Check the bod
not selling this pipeline
first s1 drugs to get 2+ year exploration
fisher will bring 3-71 to the top
would have sold last year for $21 but said no way
Had some of this @ 4.16 p/s
Was hoping for a pop to sell
fear the drop was initial leak or study finishing early due to noncompletes
on sidelines until data
$cur hold
That's dec 2015 poster btw
Awaiting some fda guidance im afraid
Follow the market down all day and ph dump
A no news fri and scared market spells bottom
Expect same pc as dec
have dry powder for more
set for late day dump @ 5.48
Outside of toms box
He is still due $2m in options july 5?
Has to be a milestone
plus patent not enough
News will tell
Accera ac-1204 failed in march
funny posts about preferred not passing then whini g about transparency lol
yes blind is price to pay when retail wont act like big kids
$biib ms assay was touted by $avxl don't expect to hear anything unless deal comes
given ceos style that very pr may indicate a nearly done deal
but biib does lots of these just dont pr them
how much guidance has missling missed?
Got 5.62
Saved $64 hahaha
Love the thrill!o
Anybody hear of the ceo here turning down an emp offer from immunocore last year?
The vp corp dev @ $1.6 m/ yr++
Trying to confirm
$avxl long
Lucky its nsdq
had 1k 5.70
Was able to pull it
broader mkt comes knocking!
Ouchie ouch!
Take 200 more @ 5.70
Nuff for me
In light of the timeline of a mou patent in the indication?
Co has stated inent to partner p3
Waiting on fda to start trials?
A fully funded rett trial?
Have to spend some $ eventually
Silence is deafening
Missed on the .75s got 700 @ 5.78
Hoping patent seals a deal and 15mo not withheld because bad
fingers crossed
$avxl long
Yes can't get them for that anymore
had to avg up before 7.5 exp itm
$$$avxl$$$
Broker alert on 13f filings
$avxl long @ 6
Yes maybe if saliva did not destroy it as a poison and it had a half life longer than 20 seconds
whatever
$ntrp short @ 6.50
Are mmse <5 ineligible for all trials?
I bet so couldn't find any
considered terminal and too combative?
I bet getting even 9 doses was a struggle for all involved
early detection and biomarker based pm treatment is the way
$ntrp short @ 7.25
What you talking about?
This is $ntrp board no?
B1 iv @ 20ug x 7 for 12 weeks failed
Maybe if they tried it at 5ug x 15 for 36 weeks with 3 x 5 washout adaptive with 52 week extension they would have gotten signal
Dont even go there
If we were talking about a synthetic analogue you would be correct
but b1 in its present form will not mesh
need a low dose chronic formulation
bioavailable synth analogue with decent half life
Oh come on you think there is some magic data still to come?
They couldnt even release the sep data it was so bad
Doesnt take 5 mo to extrapolate
these were late stage and it did not perform the miracle
p.05 is the bar sorry
Looking for news in am
$avxl long @ 5.72
I share simones thesis
no not a scientist but anybody on this board who has researched things can appreciate his 10 years doing so
his comments on pkc were specific to pkca not pkce
he has pointed to possible synergy between compounds as part of a pm approach that is most realistic
market forces will kill $ntrp not bad science
there is no such thing
still short @ 8
10-k from 2013 back has a table
Greek patent has 20 year term
i was talking about the pr timing of the patent not its scope so back off please