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Well said
Yes max
I have been averaging down..
The plan now is to average up!
I think this is going to be a true Blessing for many
Moreau stepped up
Rip out the heart reversal of fortune
Haha..
I know you spent some time on it and I appreciate that..
And I appreciate your posts hence why I don’t ignore you..
I am a hard win for you science types because so many of you refuse to accept he fact that our current system is beyond repair..
It 12thcentury crap
Your funny
Yea the seizure relief is fantastix
Have they increased the numbe tof posts you can make in one day?
I fell like I blew through 15 a long time ago..
Whatever
The hell you can’t
You can
Just like you can compare one patients reaction to another’s.
You can do whatever the hell you’want
but take I to account the differences..
The rbsq test didn’t change
The age and sex didn’t change
Neurens drug had a whopping 5 punt improvement and got fda appproval.
We showed a 12.9 improvement
The hell you can’t compare them
You have to dislodge logic from
Your brain NOT to compare them
A drug that almost tripled the efficacy
Of only medication. Currently available.?
Without negative side effects
Come to n
How about
We effing crushed it!
13 point improvement
Seizures stopped
No diarrhea
the Conteol group(8pt) had a better point
Improvement than Neuren’s fda $125,000 treatmwnt(5ts)
Sorry everyone
I bought more today
So if I am right this is a screaming buy
So almost any stat using averages of many inputs is going to be a mean or an average number..
So the rbsq improvement for Neuren of 5.1 reduction has to be mean or average result..
So we are comparing apples to apples..
The placebo score of anavex is over 8 point improvement..
Am I the only one sensing a terrible injustice or sabotage of our placebo numbers?
Why wouldn’t they just save $125,000 per Neuren treatment and give them a placebo?
I know one of you medical brainiacs gonna make me look dumb as a box of rocks..
Please do so ..
What is the difference between
12.9 rbsq ls mean reduction
Vs 5 point rbsq reduction for Neuren?
The placebo group in anavex outperformed the approved Neuren drug?
How the hell did Neuren get approval for a drug response that is below our placebo group?
eeting with the U.S. FDA planned for the first quarter 2022
- Conference call and webcast to be held today at 4:30 p.m. Eastern Time
SAN DIEGO--(BUSINESS WIRE)-- Acadia Pharmaceuticals Inc. (Nasdaq: ACAD) today announced positive top-line
results from the pivotal, Phase 3 LavenderTM study evaluating the efficacy and safety of trofinetide in 187 girls and young women aged 5-20 years with Rett syndrome. The 12-week placebo-controlled study demonstrated a statistically significant improvement over placebo for both co-primary endpoints. On the Rett Syndrome Behaviour Questionnaire (RSBQ), change from baseline to week 12 was -5.1 vs. -1.7 (p=0.0175; effect size=0.37). The Clinical Global Impression–Improvement (CGI-I) score at week 12 was 3.5 vs. 3.8 (p=0.0030; effect size=0.47).
What am I missing?
Diaheea 5 point improvement
Vs no diarrhea and 13 point improvement?
What the hell am I missing?
Xena
Is la mean score just another way of saying the average score drop?
So when we compare the 5 point drop of rbsq for Neuren vs our rs mean score rbsq drop of 12.. we using same stat?
5 point drop in 12 weeks vs ………..
Mayo
Neuren drug with diarrhea side effect
was approved with 5 point reduction. In rbsq.
What is the rbsq reduction after 12 weeks with no bad side effects of anavex?
I may be
I put a call in to anavex to get the plain rsbq number improvement after 12 weeks
Neuren number is 5 point reduction
Will advise when recienve
Great points the placebo dropouts I’d greatly outnumbering dosed patients..
Would have skewed these numbers ..
And wouldn’t those patient not seeing any change be the first to drop out?
They would be placebo as dosed patients saw almost immediate benefit..
The zero responders would have brought down the placebo response and create clinical significance.
What a crock of doodoo all around
Ami conflating the numbers incorrectly?
Did anavex have twice the effical response than Neuren?
Helps me
I know so many of you are so much more
Science smarter than me..
ANAVEX®2-73-treated patients demonstrated a rapid onset of action with improvements at 4 weeks after treatment with a RSBQ total score LS Mean (SE) -10.32 (2.086) points in the drug-treated group compared to a LS Mean (SE) -5.67 (2.413) points in placebo-treated patients.
Don’t explain to me the current idiocy of clinical idiocy..
But for the idiocy special..
I present a drug that improved / reduced
Pain and suffering by 10 points in 4 weeks..
Yet .. fails.. where a drug that has terrible side effects.. and only improved score
By 5 points now succesfully charges taxpayers $125,000 per treatment?
meeting with the U.S. FDA planned for the first quarter 2022
- Conference call and webcast to be held today at 4:30 p.m. Eastern Time
SAN DIEGO--(BUSINESS WIRE)-- Acadia Pharmaceuticals Inc. (Nasdaq: ACAD) today announced positive top-line
results from the pivotal, Phase 3 LavenderTM study evaluating the efficacy and safety of trofinetide in 187 girls and young women aged 5-20 years with Rett syndrome. The 12-week placebo-controlled study demonstrated a statistically significant improvement over placebo for both co-primary endpoints. On the Rett Syndrome Behaviour Questionnaire (RSBQ), change from baseline to week 12 was -5.1 vs. -1.7 (p=0.0175; effect size=0.37). The Clinical Global Impression–Improvement (CGI-I) score at week 12 was 3.5 vs. 3.8 (p=0.0030; effect size=0.47). The RSBQ is a caregiver assessment of the core symptoms of Rett syndrome and the CGI-I is a global physician assessment of worsening or improving of Rett syndrome.
Additionally, trofinetide demonstrated a statistically significant
They are considering it for Alzheimer’s
Perhaps you forgot
This entire sentence makes no sense
The placebo response is non existent whenever it occurs..
We are talking children parents caregivers
They are all compromised
Go to the chemical data
Gaba Glutmate
This is going to be a battle
You are not even close
This in the end will be viewed as success..
Theee are chemical markers to backing up dosed group..
Is there anything more evil than laughing at human suffering?
Gutless
I fear sabotage
What was the rbsq drop in the dosed
What was the ta q drop in the dosed group?
So what I am trying to get at
Is
Did the placebo group just destroy
Rett Stndrome most efficacy hope?
And if so
Don’t blame them
It’s a dreadful disease
Work around this tragedy with
Other data. Blarcamesine didn’t fail
Some one else has..
use the Gaba and Glutamate like in adult study..
5 pt drop
Vs
1.7 dropplacebo in rsbq
Neuren
What was Neuren dosed response benefit vs anavex?
What we’re Neuren’s drug effect in dosed group for children?
What was neuron response?
Poor suffering kids
This should be given to suffering children
No side effects
12 point improvement
Reduction in seizures
It’s a small group
This is an adenine way to treat human beings!
Why is anyone on placebos when you can test their blood?
This sis mid evil blood letting at its best