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In my opinion this one is a game changer if the results continue as they have.......and I don’t have any reason to believe they shouldn’t!
CART-T is mentioned!! Check it out!
https://www.foxnews.com/opinion/newt-gingrich-incredible-medical-breakthroughs-coming-to-cure-diseases-and-save-lives
Marker Therapeutics Congratulates Helen E. Heslop, MD, DSc (Hon), on Receiving the ASBMT Lifetime Achievement Award
Houston, TX – February 21, 2019 – Marker Therapeutics, Inc. (NASDAQ:MRKR), a clinical-stage immuno-oncology company specializing in the development of next-generation T cell-based immunotherapies for the treatment of hematological malignancies and solid tumor indications, today announced that Dr. Helen E. Heslop, Company co-founder and a founding member of Marker’s Scientific Advisory Board, has been recognized with the ASBMT Lifetime Achievement Award at the Transplantation & Cellular Therapy Meetings of ASBMT and CIBMTR 2019.
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Check out Phantoms post on 2/18/19 @ 11:35
Marker Therapeutics to Present at the CAR-TCR Summit Europe
Houston, TX – February 20, 2019 – Marker Therapeutics, Inc. (Nasdaq:MRKR), a clinical-stage immuno-oncology company specializing in the development of next-generation T cell-based immunotherapies for the treatment of hematological malignancies and solid tumor indications, today announced that its President and Chief Executive Officer, Peter L. Hoang, and Chief Development Officer, Dr. Juan F. Vera, will be presenting at the CAR-TCR Summit Europe, which is being held in London, UK from February 25-27.
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You got that right!!! Moving on up! Geaux Marker!!!
Houston, TX – February 7, 2019 – Marker Therapeutics, Inc. (Nasdaq:MRKR), a clinical-stage immuno-oncology company specializing in the development of next-generation T cell-based immunotherapies for the treatment of hematological malignancies and solid tumor indications, today announced the appointment of Mythili Koneru, M.D., Ph.D. as Senior Vice President, Clinical Development. In this role, she will be responsible for clinical development strategy, clinical study design, and medical oversight of the Company’s therapeutic product candidates. Dr. Koneru joins Marker Therapeutics from Eli Lilly and Company, where she served most recently as Associate Vice President of Immuno-Oncology.
“We are pleased to welcome an executive with Mythili’s extensive experience and expertise in the immunotherapy and cell therapy field,” said Peter L. Hoang, President and Chief Executive Officer. “Her impressive background in translational medicine and immuno-oncology, her proven leadership in clinical trial design and drug development, and her extensive patient care experience, will be invaluable in advancing our pipeline of next-generation T cell therapy candidates. We look forward to her many contributions to our future success.”
In her previous role as Associate Vice President of Immuno-Oncology at Eli Lilly and Company, Dr. Koneru designed early-stage clinical trials for hematologic and solid tumor malignancies and was instrumental in developing clinical trial protocols, serving as medical lead for trial conduct. She has also served as Senior Medical Director of Early Phase Clinical Development at Eli Lilly before she was promoted to her most recent position. Prior to Eli Lilly, Dr. Koneru was an Oncology Fellow in the laboratory of Dr. Renier Brentjens at Memorial Sloan-Kettering Cancer Center, where she developed adoptive T cell therapies in both leukemia and solid tumor malignancies in early phase clinical trials.
Dr. Koneru earned a B.A. in Cellular and Molecular Biology from the University of Chicago, a Ph.D. in Biomedical Research: Tumor Immunology from New York University, and an M.D. from the Robert Wood Johnson Medical School.
10-4 good buddy!
What updated AML data?
Right On AntiMarv!
Thanks JCNJ! On to next year! Geaux MRKR!
I hear ya! But it would have been nice to see a Brees vs Brady SB!
As some of you know I live in New Orleans and am a huge Saints fan and have been a season ticket holder for 15 years. I’m not watching the asterisk game this year.......sorry hanscott but the wrong NFC team is representing this year!
GEAUX MARKER!!!
Oh and welcome to the Marker board!!
Great write up WD!!
Mmm.....OK.....I will do some more digging but I thought they had more than that at MSK
What was TPIV has trials at MSK.....right?
Phantom.....could this be coming out of a Marker trial?
https://www.mskcc.org/blog/msk-scientists-fine-tune-car-cells-improve-their-performance
Marker Therapeutics to Present at the Phacilitate Leaders World & World Stem Cell Summit 2019
Houston, TX – January 17, 2019 – Marker Therapeutics, Inc. (Nasdaq:MRKR), a clinical-stage immuno-oncology company specializing in the development of next-generation T cell-based immunotherapies for the treatment of hematological malignancies and solid tumor indications, today announced that its President and CEO, Peter L. Hoang, will present a corporate overview at the upcoming Phacilitate Leaders World & World Stem Cell Summit 2019 on Wednesday, January 23, 2019.
Houston, TX – January 15, 2019 – Marker Therapeutics, Inc. (Nasdaq:MRKR), a clinical-stage immuno-oncology company specializing in the development of next-generation T cell-based immunotherapies for the treatment of hematological malignancies and solid tumor indications, today reported that data from four abstracts—including three oral presentations—were accepted for presentation at the Transplantation & Cellular Therapy (TCT) Meetings of the American Society for Blood and Marrow Transplantation and the Center for International Blood and Marrow Transplant Research (ASBMT and CIBMTR). The studies summarize data achieved using multi-tumor antigen specific T cells that were developed at Baylor College of Medicine in the laboratories of Dr. Swati Naik, Dr. Ann Leen, and Dr. Premal Lulla, and exclusively licensed to Marker.
The TCT meetings of ASBMT and CIBMTR 2019 will take place in Houston, TX from February 20-24.
Not to mention several of our trials are fully funded through the Department of Defense.........
That’s Phantoms area of expertise but the recent merger did have an offering of $70 million.........
I know of no definitive dates but believe we will see interim results all throughout this year...........I’m feeling comfortable based on the results seen to date that by years end all of us longs will be in pretty good shape......IMO
Marker Therapeutics Provides Updates of its Lead Clinical Programs
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Reports clinical data updates with MultiTAA T cells in lymphoma, multiple myeloma and acute lymphoblastic leukemia
Reports completion of enrollment for TPIV200 Phase II study in ovarian cancer
Reports interim immunogenicity findings of TPIV200 Phase II study in triple negative breast cancer
Houston, TX – January 3, 2019 – Marker Therapeutics, Inc. (NASDAQ:MRKR), a clinical-stage immuno-oncology company specializing in the development of next-generation T cell-based immunotherapies for the treatment of hematological malignancies and solid tumor indications, today announced a year-end update in five clinical trials using the Company’s therapeutic products, LAPP and MAPP multi-antigen targeted T cell (MultiTAA) therapies and TPIV200, its Folate Receptor Alpha (FRa) peptide cancer vaccine product candidate.
“We are pleased to provide an update on our progress in advancing clinical trials using our therapeutic platform,” stated Peter L. Hoang, President & CEO of Marker Therapeutics. “With our MultiTAA cell therapies, we continue to build on the size and depth of our patient dataset. These updates now bring our total reported number of patients to 72, up from 57 in our previously reported results. I believe this represents one of the most extensive sets of clinical results in cell therapy for cancer treatment and illustrates the potential safety and clinical effects of MultiTAA T cells for patients suffering from a number of terrible cancers.”
“In our vaccine program, we continue to demonstrate our commitment to excellence in our clinical execution,” Mr. Hoang continued. “Last year when I joined the company, I expressed that we would work to improve our clinical efficiency, and I believe that the completion of enrollment of our FRV-004 study in ovarian cancer over six months ahead of schedule reflects our dedication to that objective. In fact, we have now completed enrollment of our last two clinical trials significantly ahead of projections, reflecting the commitment of our management and clinical team to execute multi-center studies effectively.”
The Company reported clinical updates in three Baylor College of Medicine (BCM)-sponsored Phase I/II clinical trials using its MultiTAA T cell therapies, LAPP and MAPP:
Lymphoma
In the Phase I/II clinical trial in lymphoma, BCM has now treated 15 patients with active disease who have failed an average of four lines of prior therapy. Of these patients, five patients experienced transient disease stabilization followed by disease progression. Four patients have ongoing stable disease of between 9 to 24+ months following infusion of the MultiTAA-specific T cells, while the remaining six have all had complete and durable responses (4 months to 60+ months), as assessed by PET imaging.
No relapses observed to date for any patient entering a complete response (CR).
Patients with active disease who have ongoing complete responses after infusion of MultiTAA cells are now between 1 and 5 years in CR (ongoing).
Several patients with stable disease show potential for durable disease stabilization, with two patients observed to have stable disease for over 9 months and 24 months, respectively.
Responses in all six patients who entered a CR were associated with an expansion of infused T cells as well as the induction of antigen spreading.
None of the treated patients developed cytokine release syndrome, neurotoxicity or any other infusion-related adverse events.
BCM has also treated 17 patients who had developed a CR following their last treatment (adjuvant therapy) for lymphoma, and all but two of these patients remain in remission (3-42 months post-infusion). Monitoring has continued on all patients previously reported, and none of these patients have yet relapsed with disease. Average duration of remission for patients with a continuing complete response (CCR) is over 26 months (ongoing), versus 16 months (ongoing) as of the last patient update.
Multiple Myeloma
Marker Therapeutics also provided an update to the BCM-sponsored Phase I/II clinical trial in multiple myeloma. Results were presented at an oral presentation at the American Society of Hematology (ASH) 2018 Annual Meeting.
Ten patients with active disease were treated, including:
One patient with a CR durable for approximately 29 months before relapse, was subsequently given a second treatment infusion of MultiTAA T cells, resulting in stable disease for 3 months (ongoing) after the second treatment.
Two patients achieved partial responses (PR) of between 14 and 22 months (ongoing) as of last follow-up.
All seven remaining patients experienced stabilization of disease following infusion of MultiTAA cells initially. Three patients developed transient disease stabilization of between 3-7 months with subsequent progression, and four patients have ongoing stable disease.
Eight patients were treated in remission, with a median follow up of 21 months. Only one patient has relapsed to date.
Correlative studies show significant expansion of MultiTAA T cells, as well as significant evidence of epitope spreading with expansion of endogenous T cells specific for tumor-associated antigens that were not targeted by the MultiTAA product.
MultiTAA therapy appears to be safe and well-tolerated, with no incidence of cytokine release syndrome, neurotoxicity or any other serious adverse events related to the therapy.
Acute Lymphoblastic Leukemia
Marker Therapeutics also reported initial results from the BCM-sponsored Phase I clinical trial in acute lymphoblastic leukemia (ALL). In this study, patients were treated with MultiTAA T cells as a maintenance therapy for patients in CR post-allogeneic stem cell transplant. Leukemic relapse remains the major cause of treatment failure in hematopoietic stem cell transplant (HSCT) recipients.
10 patients have been enrolled and treated in this clinical trial, with eight patients evaluable for response. To date, all but one remains in CR, with patients ranging from 1 to 22 months in CCR (ongoing). Because of the highly refractory nature of these patients, the length of CCRs and the low rate of relapse amongst these patients, the Company believes that these early results are promising and may represent meaningful clinical benefit.
Marker Therapeutics also reported key updates from clinical studies of TPIV200, its Folate Receptor Alpha (FRa) peptide cancer vaccine product candidate.
Ovarian Cancer
Marker Therapeutics reported that it had completed enrollment in its Phase II study in ovarian cancer (Study FRV-004), using TPIV200 as a maintenance therapy for patients in their first remission after surgery and platinum-based chemotherapy. Marker has enrolled, randomized, and treated 120 patients at 17 clinical sites. The study completed enrollment six months faster than anticipated. The Company expects to reach its planned interim analysis trigger of 50 patients who have progressed by the end of the second quarter of 2019, with interim data reported by year end.
Enrollment of this study was completed over six months ahead of schedule, reflecting ongoing management initiatives to improve and enhance clinical operations efficiency.
Marker had previously projected the initiation of its interim analysis to begin in Q4 2018, triggered by the 50th patient to progress following treatment. Despite faster than expected enrollment of patients in this study, as of the end of December fewer than 50 patients had progressive disease. As a result, Marker now expects to reach its planned interim analysis trigger by end of the second quarter of 2019, with interim data reported by year end.
Triple Negative Breast Cancer
Marker Therapeutics also reported initial findings from its interim analysis of its dose-finding study (Study FRV-002) in patients with triple negative breast cancer, using TPIV200 as a maintenance therapy for patients in remission following first-line therapy. The four-arm study included low and high dose TPIV200 with or without cyclophosphamide.
Of 27 patients evaluated to date for immunogenicity, 26 showed significant immune response to the vaccine treatment. Of 80 patients treated at 11 clinical sites, 11 have shown disease progression to date following treatment with TPIV200.
“These additional clinical results strongly augment our existing, previously disclosed patient dataset. In patients who were treated for active disease in lymphoma, we continue to see long-lived, ongoing complete responses that are now durable beyond five years and have yet to observe a patient who achieves a CR subsequently relapse,” said Dr. Richard Kenney, Acting Chief Medical Officer of Marker Therapeutics. “Notably, in the adjuvant lymphoma patients we have also not seen any additional relapses, with several patients now beyond four years in their continuing complete response. While the median progression-free survival has not yet been reached in any of these trials, observationally it appears that the time to progression for patients receiving MultiTAA T cell therapy may compare favorably with results reported in CD19 and BCMA-targeted CAR-T studies in lymphoma and multiple myeloma, without inducing the toxicities normally associated with gene-modified adoptive cell therapies.”
“Given the highly refractory nature of the patients with acute lymphoblastic leukemia treated, we believe the preliminary results appear to be very promising, with only one patient having relapsed to date,” continued Dr. Kenney. “These early results may indicate that MultiTAA therapy may be able to drive clinical benefit for these patients without the need for donor-lymphocyte infusions (DLIs), and the associated risk of graft versus host disease (GvHD). Finally, our clinical sites have been very supportive of our Phase II vaccine studies in ovarian and breast cancer, and their rapid enrollment is a credit to our Principal Investigators and clinical investigative sites, as well as our clinical operations team. We are pleased with the progress in building our clinical development infrastructure and believe we can leverage that experience to drive our upcoming MultiTAA T cell studies efficiently.”
About Marker Therapeutics, Inc.
Marker Therapeutics, Inc. is a clinical-stage immuno-oncology company specializing in the development of next-generation T cell-based immunotherapies for the treatment of hematological malignancies and solid tumor indications. Marker’s cell therapy technology is based on the selective expansion of non-engineered, tumor-specific T cells that recognize tumor associated antigens (i.e. tumor targets) and kill tumor cells expressing those targets. Once infused into patients, this population of T cells attacks multiple tumor targets and acts to activate the patient’s immune system to produce broad spectrum anti-tumor activity. Because Marker does not genetically engineer its T cells, when compared to current engineered CAR-T and TCR-based approaches, its products (i) are significantly less expensive and easier to manufacture, (ii) appear to be markedly less toxic, and (iii) are associated with meaningful clinical benefit. As a result, Marker believes its portfolio of T cell therapies has a compelling therapeutic product profile, as compared to current gene-modified CAR-T and TCR-based therapies.
Marker is also advancing a number of innovative peptide- and gene-based immuno-therapeutics for the treatment of cancer and metastatic disease, including our Folate Receptor Alpha program (TPIV200) for breast and ovarian cancers and our HER2/neu+ peptide antigen program (TPIV100/110) in Phase II clinical trials. In parallel, we are developing a proprietary DNA expression technology named PolyStart™ to improve the ability of the cellular immune system to recognize and destroy diseased cells.
Let’s put MRKR aside for the next couple of weeks and concentrate on the season of Christmas.....enjoy your time with family and friends! Wife and I are heading to San Diego Friday evening for a week to visit family and our first granddaughter! Life is good!
To all my Marker buddies.....Merry Christmas and a real Happy New Year!!
Great hearing from you Blu.......hoping all is well with you and the family! Us longs are here and patiently waiting!
Marv......I got it from Twocan.........it was great! All systems go and news soon!
Thx Twocan!
I have yet to find this presentation on the MARKER web site......can someone send this dummy the link please.?
I didn’t get a chance to listen in........I’m assuming it will be archived and available soon?
Happy Thanksgiving everyone!!
Smart move!
Agree!! It is extremely well done!
Well said.......and I am being virtuous!
All good Dakota!! $$$$MRKR$$$$
All good......I’ve turned off the MRKR watch....now full on in football mode!! Big weekend for us that live in Louisiana......LSU vs BAMA and Saints vs Rams!! It’s basically a coonass party weekend and I wish all of you a great one!!!
Phantom Lord rocks! He brings our board up to another level! I’ve been on many of these message boards but by far this has been the best! I do wish we would hear again from RKMatters!
We look forward to your pontification! Carry on good man!
$$$$MRKR$$$$