In the Agenda each of the 4 places Kaufmann is to speak it says.

Walter Kaufmann Chief Scientific Officer, Adjunct Professor, Anavex Life Sciences Corp./Dept. Human Genetics, Emory Univ. School of Medicine
Dr. Walter Kaufmann is currently the Chief Scientific Officer for Anavex Life Sciences Corp. and an Adjunct Professor of Human Genetics at Emory University.

This link perhaps takes you direct to his Bio plus the 4 subjects he is to speak.

https://fragilex.org/get-involved/international-fragile-x-conference/?fbclid=IwY2xjawD6DuVleHRuA2FlbQIxMAABHdKMdvOSnwNJ6jrzVDhbpFqjaVtMimN8VZ3F9CwS-QPGok42fkn6T8L6cQ_aem_VcHVLQguorudyp1kRf7m_A#agenda

John k9uwa

We are nearly the same Mike. Except I sold ALL 1/2 post hours Feb3 other half Pre-hours Feb 4th '21. $17-$19 range. Then later had to buy back in. Average now is around $4.25 pps. No I don't think either of us are going to the Cuckoo Nest anytime soon. Yes all of us wish it happened yesterday. I do think it will happen one of these days. Looking forward to end of July. Also want to see August 15th tute totals. Some of them do file ahead by a few days.

Looks like volume picked up late today. We ended up for the day.

John k9uwa

Yes investor you have it correct.
John k9uwa

Yes, and he said they would have the OLE along with the new Pediatric trial.
John k9uwa

My question is What if the OLE for BOTH pediatric and adults shows considerable continued improvement? They only failed the Pediatric because one Placebo showed some considerable improvement.
John k9uwa

DFRAI and PowerWalker interesting Anavex the ONLY company mentioned in that many page article.

John k9uwa

Agree on the actual ownership. For us we are 80% residential Real Estate. And I was raised in that biz. Parents had a couple rentals. We have 14. 2 to live in and a dozen rentals. Two down there the rest are here. The amounts in the market I deal with. Then the Wife had some she wanted a Mgr to handle. She picked Raymond James. I said OK. So far last 2 years I am well ahead of what he has made. Now to hope that Anavex gets the EMA filed and approved.

John k9uwa

"I'd rather they were busy on MAA, NDA" 100% agree Steady. Responded to your PM last evening. All is well.
73
John k9uwa

I about the same Tom. First buy was only 100 shares low 12's now down to an average price in the low 5's. Something around 7K shares. That is more than some of the Tutes show.

I TOTALLY Agree with Talon and Xena re: that Blackock Video that Xena posted. If you haven't watched it for sure you should. Me as primarily a landlord can attest to All those "realtors" "Investors" wanting to buy up residential housing. See Xena's post. https://investorshub.advfn.com/boards/read_msg.aspx?message_id=174709997

John k9uwa

Leo Click this link and read the list.
https://whalewisdom.com/stock/avxl

you can sort the other than top owners to bottom by clicking on the top of a column.
John k9uwa

I had already voted.

John k9uwa

All sorts of info like avg pps of the insty's See Whale Wisdom.
https://whalewisdom.com/stock/avxl or any other stock you want to look at the ownership of shares by the Insty's. You can sort up or down on Any column you wish to view. I resorted the column for Average Cost PPS. Scary it is. The highest pps of all the Insty's

CIBC WORLD MARKET INC. shares 14,812 Avg PPS $19.67 OUCH

John k9uwa

"tutes end up with more than 39.2%" Consider what happened to us during the first quarter of '24. RETT flopped sort of a flop. Price goes down. Mid March hit by AF and his merry band of shorters. And right on que LawSuits. Price goes down. But the Tutes numbers were up from something around 25% to 39%. Price continues to go down during 2nd qtr. We won't know Tute percentage until August 15th. I bet will be up from 39%. That's another rule that should be changed. I say give the Tutes 7 days after a qtr to get their 13F/D/G filed. These TUTES are lowering their AVERAGE PRICE PER SHARE. StateStreet avg 8.68 pps Vanguard 6.85 Geode 7.93 BankofAmerica 7.39 Schwab 13.90.

The FDA's rewrite of the ALZ rules almost look like Anavex wrote parts of it for them.

Tom, I thought for a while today my STINK BID would get filled. Didn't quite happen. We are UP On a Friday better yet with a short week on a Friday. What's not to like? Yes all of us wish the EMA was already filed and done yesterday. It will happen when it happens.
John k9uwa

This last sentence looks like an invitation to ANAVEX to file NDA pronto. The MAB they approved today is anything but safe.

"FDA Roundup: July 2, 2024
. Today’s approval is evidence of the FDA’s commitment to helping more safe and effective drugs to treat Alzheimer’s disease become available."

As to the RETT trials. The RETT caregivers parents etc are a very tight community. They all have their own media sources to get together. My daughter hasn't had a seizure in well over a month. My daughter climbed the stairs to the 2nd floor bedroom that is a FIRST EVER. My Daughter gets dizzy spell after her daily dose. My daughter has no dizzy spells and continues to have seizures the same as before getting into this trial. She must be on Placebo. Or a parent sees something that just might be an improvement and they broadcast that to all the others. In short order that trial was the same as an open label trial.

Someplace and I don't remember which trial it was in... Anavex said if they gave the pill / dose at bedtime the patient didn't have dizzy spells and actually slept better.

to Plex your question re: "Steady" he is one of our moderators. His first post to AVXL on ihub was 07/27/2016 04:47:19 PM. He replied to something Frol had commented about. Perhaps he like some of the rest of us migrated here from other boards... Yahoo etc.

John k9uwa

Hadn't read Kevin's comment before I posted last post. Both of us have like minds.

John k9uwa

"No surprise: FDA approves donanemab" Now the patients have a choice of which Brain Bleed Med they want to try. NOT. Read someplace that in Calif it was required to get TWO DOC's to prescribe a MAB. Your 100% correct The Bar is set VERY LOW!!

John k9uwa

Thanks Guzzi I bought some ANVS this morning shortly after the open. Sold it for +105%. Should have bought more.
Oh Well made for a nice day's gain.
John k9uwa

Institutional ownership. Anavex 38%, LLY 84%, BIIB 93%, SAVA 24% less shortly due to, GE 77%, WELL 96%, AXSM 83% + 17% insiders retail near zero.

John k9uwa

Thanks Tom if we again get to $3.80 or below I'll buy more shares.

John k9uwa

"1:00 PM EDT first big buy of Day" On the volume chart on the right on the Ihub page why is that trade a different colored vertical line?

John k9uwa

"clearance of waste from the brain" This makes me remember comments on some in trials with 2-73 that the patients got better sleep. Perhaps
that assists the disposal system for the nightly flush?

John k9uwa

"AVXL owners B/C CNS Bio-diseases" Look at the list that 2-73 and the updated drug 3-71 cover. And they keep adding to the list.

John k9uwa

"MM's are screwing over some sellers badly!" makes me wonder what the deal was with the 4.5M share sale at $4.07 pps. As Market On Close a week or so ago?? Inquiring minds would love an answer. naked Short Sale? by MM's?

John k9uwa

Hi Tred Yes and No. One can have a "Ham Radio Station" for a few hundred bucks. Or for considerably more bucks one can have a competitive "contest station." I built this station back in 1989 as a competitive "contesting station" Back then sometimes I operated the station as a "Single Operator" or as a "multi opreator" in long haul DX contests. Today usually my station is used by a younger Ham Radio friend of mine. In these contests I get the notoriety as "Station Owner" and Mike my "Hired Gun" operator gets his share of wins in the long haul contests. As to me operating my Ham Radio Station? 8 months or so of the year I operate it "Remotely" Yes an internet connection between ME wherever I might be with broadband internet and the station. For me the ancient analog type a real project to learn to setup and operate my station "remotely". So yes today I run the ham station with a laptop computer from wherever I might be... usually far south during the winter.

Back to Anavex. I do think we are approaching the "Finish Line" for approval of 2-73 and probably one of these days 3-71perhaps is better than 2-73.

John k9uwa

"You served in Korea?" Yes 1966-early 1968. I lived in Seoul S Korea. My ham radio callsign while I was there HL9KW. The "Kilowatt Watt" station from Seoul S Korea. Primary MOS was Saxophone player in an Army Band. secondary MOS if the you know who jumped the DMZ was Semi-Truck driver because yes I knew how to drive anything with rubber tires. I was really pissed off when only two weeks or so back home discharged from Uncle's Army the Pueblo incident and the attempt on the S Korean Prez happened. Wishing I had still been there. Many times while I was there I was relieved of duty to the band to run Phone Patches "telephone by ham radio" calls for our troops back to the US. Explanation .. Ham Radio contact from Korea back to USA and telephone from whoever we made good solid contacts with in the US back to friends relatives of the GI. I probably can't say today what was in the Trailer assigned to me to pull if U know who jumped the DMZ. Yet today I do like some types of Kimchi. But Adrian Cronauer many times back then listened to him on AFKN and yet today enjoy YouTube replays. "Good Morning "you know what comes next" We have a group of us Mil Musicians and an annual "Reunion" and I usually attend that function.
John k9uwa

You’re a Ham? Thank you for your service. Yes I am. Welcome to my backyard Ham Radio Antenna system.

please stop the "2015" every time you post?

Powerwalker I promise never to mention that year again. I am anything but a negative poster. I do think we are finally in the Home Stretch.
The Finish Line is within sight! 🏁 I don't hide behind a moniker. Put me into your favorite search engine.

John k9uwa

Alzheimer's Patients ADLs: The same with my Mother. She was allowed to stay by herself in her own home for the first 4 years or so after we knew she had Alzheimer's. I did have an experienced caretaker there at least 8 hours a day with her. Plus meals, A Nurse a couple times per week. After that my wife and I moved her into our home. And kept the caretaker and nurse as well. Her last couple years with us... sometimes I was ME... sometimes I was "My Dad" who had passed away some 15 years prior. And sometimes she would complain to my wife THAT THING YOUR MARRIED TO HE HAS TO GO. Yet some days or parts of days she was near normal as to memory as to who is who. It is a truly terrible disease. So yes no question about it ADL's for early patients make no sense at all.

Now you know why I am here. I searched all the early stage drugs back in 2015 in trial mode and picked Anavex to be the winner.
John k9uwa

"I’m not too excited for $AVXL being say an $8 stock again" Me either. As Leo and I discussed. More like end of Hurricane Season. Probably most here do not understand that comment. A bit more into the future. Watch Aug 15th when we the dwindling retail will finally see the TUTE totals for 2nd Qtr. Currently 39% as of end of first qtr. Should be increased by end of 2nd Qtr. If we hit $8 pps I will be happy but won't be selling any shares.
John k9uwa

"Presentation is only for 12minute" there are TWO presenters. BOTH end their 12 minutes with. "Stop by our poster and ask your questions."
together with our two presentations and manning the poster we should do quite well. Yes, keep the mic away from CM during both presentations.
CM can be present at the Poster. Let the Doc's our current hires answer the Questions at the poster area.
Have been here since 2015. Not likely to leave anytime soon.
John k9uwa

Check this LINK more than one presentation from Anavex.
https://alz.confex.com/alz/2024/meetingapp.cgi/Search/0?sort=Relevance&size=10&page=1&searchterm=ANavex

Plus I am sure they will have a Poster and someone there to man the poster to answer questions.
John k9uwa

"HOLD ON TIGHT" See This FLAG 🏁 That is the Checkered Flag. Finish Line is within sight !!

To Tred and others re: Pfizer ! All I can say is the wife's Heart Specialist said: "I am seeing lots of younger people with Heart Issues"

To Plex yes all of us wish 2-73 was approved yesterday. But we have to wait and watch. Keep in mind We went through most of 2017-2019 and finally we started
back up. Share price was down a $1.50 / $1.41 ... all that long drop I was loading the boat. Cashed out Feb3 and early Feb 4, 2021... boat is well loaded
again. If we went to zero I would still be ahead from all the previous trading. So yes patience one has to have.

Talon I also would vote MERCK for partner.

Thanks Xena posted the MOC orders and a few more. Hope it continues tomorrow. Somebody bought.

Wondering Tom if we will hold $4.00? lets hope so.

John k9uwa

"The facility must meet Good manufacturing practice" I would expect Anavex to pick a Mfg Co in Ireland. 847K shares trades with 50 minutes to go in normal trading hours.
John k9uwa

Pre--Market Last Price 3.94
Bid 3.66 100 shares Ask 3.95 25000 shares Volume 808

That 25,000 shares for sale was up at close afterhours on Monday.
looks like we opened up at $3.82 and around 20K shares volume on the open.
John k9uwa

Yes I see it! Patience Grasshopper
John k9uwa

"is 9 years of patience enough to qualify" Almost is my guess. Need to go for 10 years to get a new drug finally to market.

John k9uwa

"paid for nonsense ad hominem attacks" Maybe they pay some small flat price and then ADD ON a BONUS couple bucks per Emoji. Wonder if they get a RAISE if they make it to moderator?

John k9uwa

Hola LEO Yes, your system works for you. Me it was have position. price drops buy some trade shares.. continue to do so until we got a peak and sell the trade shares. Once I tried to go back through all the records and count just how many times I did that same thing. After getting through 4 or 5 years worth I gave up trying to count the peak sale times. I think your right End of Hurricane Season.

John k9uwa

pre-market price is showing at $3.70 Yes but only because the last sale trade of yesterday was someone who sold A SHARE yes it might have
been a 1 share sale for $3.70. Below is what currently shows as the Last sale plus Bid and Ask that are still there for tomorrow morning. Doesn't mean that is where we will start. New Bids will be placed well ahead of the open tomorrow.

Last price: 3.70 down -0.1800 down (-4.64%)
Bid 3.61 x by 200 shares Ask 3.95 x by 25000 shares Volume 930.58K

If you want to see how these very small bids take place go back a page of two in messages. Xena post a bunch of them a day ago. 1 share, 7 shares, 3 shares, 1 share ... Algo's buys and sells.

Borrowed my line I see.
Have been here since 2015 not likely to leave anytime soon !
John k9uwa

Hi Tom I agree. We will be stuck for some time to come. Today's ASM firmed up a few things. No Exact dates of course. It was interesting how the volume picked up near the end of today. Also looks like a 200K BUY MOC. I think the Tutes are still buying. We won't know the answer to that until 15th of August... crazy that they get 45 days after the end of each quarter before they have to file their 13 F/D/G forms. I think they should have to file monthly and do it on the 15th of each month. Two Cents More on my stink bid for today and I would have had a few more shares. I put the bid in at $3.61. should have put 3.63 and most likely the bid would have been filled. Yes I have enough shares. But $3.63 would have slightly lowered my average cost per share.
Working on building great grandkids College funding. Pretty sure back in 2015 I picked the right horse for this race.
John k9uwa