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LOL. Your imagination is getting the best of you.
Would make everyone happier here.
But then you wouldn't get your Rikkerbot Likes.
After you, FUDman.
Congratulations... you made #13 on my ignore list!
Logistic regression method produces similar results; it doesn't discount the use of Odds Ratio equation for approximation purposes. If it were far different results, then it wouldn't be an acceptable method.
It all depends on the placebo # (which 15-20% is a reasonable estimate), then the treated # is 3x that (for super responders).
Your 70 is interestingly close to George's 76. So, anything in that range would be outstanding.
Good to know that my estimated EOTs produce a more conservative result.
From where did 12x get 269?
12x gave a figure of 269 EOT dosed participants, 30mg and 50 mg combined.
I like it... FOS = Factual, Objective Statements
Perhaps you missed this, Kevi. You might want to get yourself one of those "conspiracy pipes". It's real stuff...
“Biotech Company Says Citadel, Other Big Traders Manipulated Its Stock Price,” The Wall Street Journal
A biotechnology company accused Citadel Securities LLC, Susquehanna International Group LLP and other Wall Street firms of driving down its stock price through a series of illicit trades.
In a lawsuit filed Thursday in Manhattan federal court, Northwest Biotherapeutics Inc. alleged the market makers had repeatedly engaged in “spoofing,” where traders place orders with an intent to fool other investors about a stock’s demand and manipulate the price.
...also sued are Canaccord Genuity Inc. G1 Execution Services LLC, GTS Securities LLC, Instinet LLC, Lime Trading Corp. and Virtu Americas LLC.
Thirty brokerage firms, including some of the biggest and most trusted names on Wall Street, agreed yesterday to pay about $900 million to end a civil suit contending they schemed with one another for years to fix prices on the Nasdaq stock market.
Lawyers for the plaintiffs in the class-action lawsuit, which represented tens of thousands of investors, called it the biggest settlement ever of a price-fixing lawsuit.
The settlement, also one of the largest in the history of the United States financial markets, is distinctive because most investor complaints about Wall Street cheating have historically focused on theft and fraud, not collusion among competing brokers to fix prices of stocks.
I'm not saying "denial" of approval, as a result of FDA politics, but a possible delay or "hoop jumping". I wouldn't be surprised if the primary reason Anavex announced the identification of a biomarker is to let the FDA know they have that base covered, too, in case the FDA was considering throwing such a curve ball.
Typical FUD denial
Rationale has been provided previously. Any of the following are legitimate...
- AD data taking much longer to analyze; therefore, with the timing being close, might as well wait for Rett to secure the voucher.
- With Rett approval it'll be much easier to gain approval for AD with the same safe and effective approved drug.
- Politics! With BP's recent "political" AD MAB approvals, pushing blarcamesine too soon would likely be met with political "resistance". Don't minimize the effect of politics and BP $$$ influence. Let the MABs demonstrate failure, first, then come with a safe and effective solution. Only a FUDster would discount this very real situation.
Nope... that would be your implied 25% skepticism... not mine.
I'm just pointing out the inconsistencies in your FUD narratives.
If you wanted to have consistency in your FUD, you should've suggested that yourself. Mr. 25%.
"Legitimate skepticism"... LOL FUDman.
But remember, you only give a 25% chance for AD success, so it would seem an obvious decision, right?
Just for the prospect of a RPD Voucher worth perhaps $100M vs. the value of a working AD drug with minimal side effects.
One has to understand the politics and BP $$$ influence at play. Timing is everything.
Going for Rett approval, first, is a smart play... plus includes the $100M voucher.
Think FDA politics... in the midst of MAB approvals. Enough said.
Most companies want to move quickly after a successful pivotal P3 trial, in which they could've had an NDA filed by June. Apparently, Missling is pursuing a different strategy... and it makes sense.
Believe me... when AF is involved, it's not just "small time operators". It's bigger than that... think Citadel, et al...
Someone on Stocktwits discovered the last 200,000 shares available for shorting against were bought up early yesterday before the decline. A sign of desperation I think. I think our "shorts" are kind of small time operators
Nope... I wanted you to let everyone know that you knew, before anyone else, that Anavex was delaying AD for Rett.
Did anyone here know 9 months ago that Anavex would delay AD to wait on Rett?
It depends on when the AD NDA is filed and accepted. Approval can be expected 6-9 months later, independent of when the confirmatory trial (OLE) completes.
I think your reiterative "Doubtfulness" comes with your remuneration... along with the associated Fear and Uncertainty.
Such nonsense...
This is rather surprising...
Long-term use of certain acid reflux drugs linked to higher risk of dementia
https://www.sciencedaily.com/releases/2023/08/230809164727.htm
A typical nonsensical response from an outed FUDster.
I'm sure you're close to breaking the scales.
Well, we've got you nailed... and several others. Where did your biochecker friend go?
I expected to see him back bashing Missling now that AF issued his hit piece.
Not mine, but sorry you weren't watching your fishing pole.
I'm here to call out FUDsters (cabal soldiers) like yourself.
Thankfully, I'm not a paid FUDster / cabal soldier like you.
I'll take my $2 gains and remaining dry powder to the next level. Sorry, you missed out.
Collusive HFs don't need any help to drive the SP down (or up). AF just provides the cover to point to.
Sorry that you didn't act of AF's hit piece. It was a dead giveaway.
When one fishes, it's important to watch one's fishing pole.
Well, "scare" may be the wrong word, but it certainly motivates traders to sell when they see his hit pieces, because they know what's coming and who's behind it. I sold a good chunk when I saw it, because I know it's going down, whether I sell or not. So, why not take advantage of the manipulation and make some $. It's why we're here. (I bought half back at 9)
I don't see why an AF article should have any effect whatsoever. How does that work?
For someone who is illiterate in TA, your condescending drivel is nonsense.
This is incorrect...
What we are seeing now from the FDA is they want a placebo controlled P3/4 started while the AA NDA is being reviewed.