I can find no folly in your questions/arguments, other than to add a #6:

6. "Things just keep getting pushed and funding is getting less and less." Perhaps the Master constructed a trap door during wall construction, before leading investors, held at arms length, into a painted corner?

I suspect the presentation will be made Dr B and/or Jane Harness.

"What’s up with Galera Pharmaceuticals getting BTD on “GC 4419” for treatment on OM in February 2018? Doesn’t that help us , the idea OM needs an expedited remedy?"

Q1: Galera recruiting in ph 3(335 patients). Start date Oct 2018, estimated primary completion date Oct 2020, estimated primary completion 2024.

https://clinicaltrials.gov/ct2/show/NCT03689712?term=galera&rank=7

Q2: You would think that would help ipix. Not everyone operates with the same efficiency. It does take some people a little longer to get things done.

idk

Good work. I agree.

Just one more thing, I hereby dub you Lieutenant(meant to be a compliment).

PP,

In response to your statement "My reading of the situation is that analysis is not done, and probably was not supposed to be done by CRO."



I disagree based on my own experience(Project Manager, construction). We paid everyone within 30 days, with the exception of 5% retainage(nobody's perfect, and spelled it out in each contract(boilerplate(We were held to the same retainage by the owner's)). Retainage would be paid upon project acceptance by the project Owner(public or private). An exception was afforded to reliable(deemed by us) smaller contractors, truck drivers or specialty contractors, who provided crucial services but lacked the ability for quick cash access by banks because of small volume.

So, to twist it a bit, my guess is ipix is the "small(specialty) contractor, or truck driver, who needs cash today in order "open the doors tomorrow". My belief is the cro has long known the results, but will not hand them over till paid.

ipix is between a rock and a hard place in my opinion.

idk

p.s I'm not in Too Infinity's camp, but understand the unanswered questions

"In general I found the this 10K(Q?) sobering and straightforward. While having no control of the sp, IPIX when able is prepared to further tap Aspire as they did in this quarter prior to the sp dipping below .25from 10q:As of September 30, 2018, the available balance under the Purchase Agreement is approximately $22.3 million. However, as of date of this report, the conditions for sales under the Purchase Agreement are not satisfied and no sales may occur thereunder. In particular, the Purchase Agreement provides that the Company and Aspire Capital will not affect any sales under the Purchase Agreement when the closing sales price of the Company’s common stock is less than $0.25 per share. Recently, the Company’s common stock has traded below $0.25 per share, and there is substantial uncertainty regarding the Company’s continued ability to sell shares under the Purchase Agreement in order to meet the Company's projected working capital requirements for the next 12 months from the date of the issuance of the financial statements (or available to be issued). I also assume that the MFA(The Museum of Fine Arts is a friendly place;) is friendly and the 7M available will be tapped wen necessary. From the 10q: After the date of the financial statements, on October 5, 2018, the Company entered into a securities purchase agreement with one multi-family office for the sale of an aggregate of 2,000 shares of the Company’s newly-created Series B 5% convertible preferred stock for aggregate gross proceeds of approximately $2.0 million. Under the securities purchase agreement, the Company issued to the investors warrants to purchase up to an additional 8,000 shares of preferred stock. As the Company cannot be certain the remaining warrants will be exercised, there can be no assurance those funds will be available when needed.

"It's not a time constraint that's the problem. I found the pages in less than a minute. I gave you the Bookmark, remember?"

I do.

Please prove the following to my retort: "I must of missed it, ty. Could you be so kind to sight the pages, or reference them, where that info was revealed?"

My above response to daubers post"In response to daubersup post #248112:
"In the K it said we owed approx 4 million to CRO now it says 3 million. So we paid 1 million? Plus we paid 1 million to B manufacturer. That is my guess."

Appreiciate his guess, and your time spent responding.

"In the K it said we owed approx 4 million to CRO now it says 3 million. So we paid 1 million? Plus we paid 1 million to B manufacturer. That is my guess."

What's a (your) guess worth?

In response to daubersup post #248112:
"In the K it said we owed approx 4 million to CRO now it says 3 million. So we paid 1 million? Plus we paid 1 million to B manufacturer. That is my guess."

I must of missed it, ty. Could you be so kind to sight the pages, or reference them, where that info was revealed?

Some have more time than others... I expect LR to come to the rescue:).

"Not bad, P data partial payment made, partnership discussions still ongoing, manufacturing almost complete for B and K still alive... Enough positives to keep the dreams alive..."

Neutral at best, imo. I think it was a post by PetemanTx earlier, who advised not to (paraphrasing)expect anything major from this 10q.

From the filing, bottom of page 18: On November 2, 2018, the Company notified the holders of the warrants of the Company’s election to compel the exercise of $250,000 of warrants, which exercise is scheduled to occur on or about November 8, 2018. In addition, subject to the satisfaction of certain circumstances, the Company may call for cancellation any or all of the warrants following 90 days after their issuance, for a payment in cash equal to 8% of the aggregate exercise price of the warrants being called. The warrants subject to any such call notice will be cancelled 30 days following the Company’s payment of the call fee, provided that the warrant holders have not exercised the warrants prior to cancellation.

The Company intends to use the net proceeds from the offering for general corporate purposes, including research and development.

Also from the filing, page 21, under prurisol:The Company has completed a randomized, double-blind, parallel-group, placebo-controlled Phase 2b trial of Prurisol for approximately 189 subjects with moderate to severe plaque psoriasis. The treatment group arms are Prurisol 300mg, Placebo, Prurisol 400mg (Ratio 3:3:1) with a treatment duration of 12 weeks. We currently await statistical analysis of the results pending payment by the Company of amounts due to the research organization resulting in part from cost overruns. A partial payment was made recently after the Company secured additional financing, with additional payments planned. Further clinical development of the Prurisol program will be determined once full study data are unblinded and available for analysis.

Expenditures on Prurisol were approximately $0.1 million and $1.8 million during the quarter ended September 30, 2018 and 2017, respectively. We expect expenditures on Prurisol to continue in future reporting periods, as we complete analysis of the study. We have entered into multiple non-disclosure agreements with pharmaceutical companies that enable us to continue ongoing discussions regarding potential partnering should the trial results support such a relationship.

$0.1 million, or $100,000. Would be nice to know, as an investor, what the balance is. From page 6, cash balance as of 9/30/18 was $306,000. Bear in mind they continue to require ~ 2M/qtr($2,000,000/4=$500,000/month).

We'll see.

"The shorts are getting ready to be scorched! Next week I'm betting on a partnership. JMHO"

Hope you are right. Good luck on Sunday vs. Tennessee.

"Possibly if Leo and Art hitchhike and stay at a hostel."

I think they would starve with their thumbs out(hitch hiking).

Better chance if they steal a bicycle built for two, pack a couple backpacks, and either hope to find card board boxes along the way, or pack a tent.

I suggest the team be AB/JH vs AB/LE.

"All trials have been successful -"

Dot,

Don't forget to tap your heels as you say that(and don't forget your stink bid dog).

"The spring is tightening. Anticipation"

More like the spring was overstretched- suspension shot.

LR,

Thanks for that unaudited 10q. Crap is right.

Gotta like those baby back ribs(i.e-piggyback shares).

Source?

Still in MA?

Regarding Winthrop, I would most often take the bus from Suffolk Downs out of East Boston past Revere Beach and through Winthrop to DI. Three ways to get out there- Suffolk Downs buses, small ferry out of Rowes Wharf, larger ferries out Marina Bay in Quincy- not one of the thousands of construction people(admistrators, staff, or trades) were allowed to drive out. After the first bus ride you knew why.

Snowy Owls are unforgettable to witness, beautiful. Saw a few, over a few years, during my years working on Deer Island(Boston/Winthrop, MA) two decades ago during the colder months when they would head south from the Artic. Wasn't aware I was being "spotted" till I spotted those Snowy Owls.

Makes one appreciate nature(me at least).

DaubersUP,

"One day closer to Dday".

Boy, I hope not. Though we won that battle, I'm glad I didn't participate in that battle ((could not have(too young for WW2, Korea, and Vietnam) uncles, cousins, nephews have, and do)), type 1 diabetes took out any consideration of my involvement in early 80's while in high school, ineligible , but would, if circumstances allowed, like many of my relatives have, and do, without question.

I hope we are not closer to Dday, but to non-violent, educated,
success.

¨Any idea if co is public?¨

Yes, the name of the company is Shionogi & Co Ltd(otc ticker SGIOF~$63/sh out of Japan(also has an office in NJ)).

¨So tell us ,if it is that valuable, why doesn't Leo write a friggin check ???HHHHMMM¨

I reckon the ink in their pens has dried. Bic pens are not as affordable as they once were and I suspect the remaining ones in the their stationary closet, likely purchased at The Dollar Store more than a decade ago, are dried out. I think Beverly Bank has recently re-instituted ¨pens on the chain¨ vs ¨pens in a cup¨ due to the Houdini effect(disappearing act) of their pens. Might also explain the unanswered phones as all vital employees have been called to the parking lot to search for ¨non-cared for pens¨?

Oh, the humanity.

IDK

bradfordbros,

You state:¨As you know I don't see it as being Aspire but either way I get the feeling the seller knows the buyer.¨

Interesting post(response). What I have put in bold type, I tend to agree with your argument, and will take it a step further. I believe there are sellers and buyers who have established a relationship,and know each other, quite well, and coordinate together.

Find the nest:), Maura Healey.

George,

You seem to know more than the typical retail investor.

Break your posts down, piece by piece, if willing, so your posts can be further reviewed. You seem to declare a great knowledge about the company´s potential, via ¨ wild opinionation¨, in my mind, not known, afforded, or extracted, by most.

Whose your source?

Speak for yourself.

¨They're pounding it hard tonight, stock closing green have something to do with it. hmmm¨

Are you for real? Are you insinuating ipix is at, or near, all time highs, and content with the sp?

I suspect you´ve done quite well over the past 3 years with the sp trend(but you would never admit it).

You state:´You really think he’s reviewing menon’s history in a 10k? You think there’s other more important stuff in the 10k that he needs to make sure is correct? Cut and paste on Menon’s history. It happens.¨

Q1:´You really think he’s reviewing menon’s history in a 10k?¨
A1: Perhaps not LE at the time, but the whoever the ceo was is responsible to disseminate accurate information. Do you disagree? Is it up to share shareholders to attempt to verify public information(from a company which finds the phone to heavy?).

Q2:You think there’s other more important stuff in the 10k that he needs to make sure is correct?¨
A2: I suggest the sec all information provised in a company´s filings are important. You, apparently, do not.

snayeman,

¨P should be first priority for Leo, not k! P results might actually get SP out of the toilet¨

I follow your analogy between sp and the potty(toilet), but would suggest the sp is downstream of the toilet, it´s(sp) in the cesspool. Hopefully, sees the ¨gem(Pee, ha-ha)"when he pops the septic tank, before he pumps out the entire tank.

KarinCA,

You state¨Someone at the company prepping a filing to the SEC mistakenly copied an incorrect bio into the 10-K in 2009.¨

I guess that scenario is possible. How many employees did they have in 2009? Best I can tell 3, LE, KM, and George Evans. Based upon how the filing was written, I´m guessing it was not composed by KM.

Who knows?

As discussed with LE recently, I´m astonished that the voice mail((978) 921-4125)) is still answered by Anita Menon Beacon(sp?), who has not worked there for a while. ¨Your call is important to us¨- really? If they can not incorporate a change to their voice mail system, what else can´t...

Yes, she did. More than once over 5 years. Biopsies are no big deal. I´ve had some. Are you suggesting they are more dangerous than cancer? If not, are they considered more life threatening than certain forms(any form of? If so, why?) of cancer?

In response to: ¨With all respect. When your cousin was ill with ovarian cancer, would she have have allowed a biopsy of her tumor, another painful invasive thing on top of so many others, to yield data for a trial of an unproven drug?

Sorry for your loss.¨

Thanks for the condolence and analysis(appreciate your consideration, both of the reading of my post, and your response).

KarinCA,

In response to :.. ¨I believe they had difficulty finding test subjects in a timely fashion due to the need of a tumor biopsy in the Kevetrin ph2a ovarian cancer trial.¨



Why was it more difficult to perform the K biopsy required by ctix/ipix trial design than any other OC biopsy by any other company ?

My cousin died of OC 6 years ago, during K´s incumbency, which is, unfortunately, how I discovered this gem of a company.

I believed much of what I read from both the company, and even this board back then, for the most part, but I must say, my beliefs have shifted, on more than one front, for right or wrong.

IDK, GLTY, and All of us.

SS,

It was a whopping two person trial being conducted at two sites(Texas, then Lebanon, NH was added- though I think the trial was ended b4 the latter site enrolled anyone), not the minuscule number(1) you incorrectly proclaim. I believe it was a tough winter that year and the hopeful northerly trial subjects could not get to the trial site as there was a severe shortage of snowshoes.

So take your negative attitude elsewhere, won´t you? This baby is about to take(or, perhaps fall off) off, soon.

The Dane,

¨Look at those silly Americans. In 1963 said they would go to the moon and here it’s been five years and they haven’t done it yet.

1969!¨

I suspect you are referencing this (

¨Leo needs to stop milking Longs and celebrating his holidays and get his ass back to work. I’m tired of his mediocre performance and running the company to the ground!¨

LE has not achieved anywhere near a level of mediocrity. That´s too high a standard for him.

Interesting, thanks for posting. Boston based Proteostasis Therapeutics(pti) has a much higher caliber brainntrust than ipix.
PTI does not bother(rightfully so) to include their bean counter(CFO) among its management team.

Compare their bod to ipix bod. Also, their scientific advisers don´t appear to be ¨band-wagon Soniss´¨

http://www.proteostasis.com/company/management-team/

LR,

Appreciate you´re reply.

My point was, they are currently short of funds. I suspect they paid the cro for past services provided when invoiced. My questions are:

1. Can the contract be renegotiated?(I understand we minions are not privy to the agreement, but many agreements are fluid).

2.To what extent is the exchange of information allowed? Collusion is one thing, but if one party(ipix)is on skid row, and the other CRO proclaims ¨no tiki, no washi¨(you don´t get laundered cloths without the ticket provided at drop off), is there any exchange among parties allowed by the rules(standards)?

The fda is the final decider, based upon the results churned by the allowable exchange of information between the other two legs(ipix/cro) of the stool.

I declare, I do not claim to know the details of what, if anything, can be exchanged, which is why I suggested PP pipe in. He/she seems to have experience in this venue.

IRDK

¨Not only is that an insane amount of blatant common sense, it gives me significant confidence to buy many more shares with the realization of what we massive potential we truly have here with this company.¨

Have fun, you´re soon to be the majority shareholder with that thinking.

"a fool and his money are soon parted"

https://en.wikipedia.org/wiki/John_Bridges_(bishop)

No. It´s business.

#1, I believe(but don´t know for sure) sponsors and cro´s are allowed to exchange findings among themselves TOO SOME DEGREE(PlentyP, please interject as it sounds as though you have personally worked in this area).

#2, There are multiple parties involved in the sequence of drug approval. The most important parties being (a) the sponsor, (b) the fda, and (c) the cro. There are no financial agreements between the sponsor and fda(other than possible fees). The sponsor and cro have a negotiated contract which can be discussed and amended.

The above is my hunch, not sure how the play book reads(rules). Conflict of interest may rule out my argument as well as explain the current sp.

gl

Echo20,

You are clearly tone deaf if you did not understand my post.

Simple question, which I expect you will not refrain from answering with a solid justification of your argument:

¨Why not pay the CRO with shares much like they did with Ascroft and Sullivan?¨

Hint, if the CRO knows P is ¨money in the bank¨, ¨a winner¨, they would be all over such a deal like white on rice.

¨....but suppose the crow it’s a tool for big Pharma such as embryo....¨

Could you clarify what you´re trying to convey? I apologize, but I can´t follow your thought.

thx

"The conversion price for the Preferred Stock shall equal to the lesser of (i) $0.31625, subject to adjustment herein (the “Set Conversion Price”), and (ii) 85% of the lowest VWAP of the Common Stock on a Trading Day during the ten (10) Trading Days prior to and ending on, and including, the Conversion Date"

I guess there can be little question where those zip code transactions derive from, at least from one important source.