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Excellent research, holy. Good point that ASA is not good for all takers. I do hope that CYGX starts looking into an anti-sense anti-inflammatory. There certainly is a need and a huge market.
Something's brewing with this volume...?PR after the close today?
Holy, the standard NSAIDS have been used by millions if not billions of people, and aspirin in particular has been proven to reduce the risk of heart attack and stroke. When the NSAID is attached to a sodium molecule, the sodium can cause a problem, but as a class, the standard (Cox I & II inhibiting)NSAIDS are safe from a cardio standpoint.
OT...Chucker, don't forget catheters have their advantages too. If you can't void laying flat on your back after surgery, you're going to have to stand up, which isn't a pleasant task soon after a TKR. If you still can't do it, the nurse will put a catheter in you with you wide awake and watching. Just hope she's good looking and her nails are not to long. If it's a guy, and he seems to be enjoying his work a little too much, then you're really in trouble!
Go back to post #28, click on thalio's name, and start reading his posts, earliest to latest. You will learn all you want to know.
He posted on Multicell for a while, but has disappeared from that board too.
Bend is a little too cold and isolated. Shouldn't have too much trouble working in Eugene since I'm an RN. The best Ortho group in the entire state is in Eugene. I like Corvalis, but it's more conservative, and I like the liberality of Eugene. We were there for 5 days 2 weeks ago, and we bought a lab puppy in Coberg and drove home to San diego with her on our laps (no accidents, either!). The dog was $175 up there, and in SD she would have been $600 or more.
I'm also looking, and we have decided on Eugene, Oregon. Mild climate, trace of snow in winter, but lots of rain, 46-49"/year, mostly from Oct to March. State has a 5% income tax, but no sales tax, and property tax rates are similar to CA's.The entire S-W is in the midst of a prolonged drought, and all the pine trees are dying. Florence, Oregon, out on the coast, is also nice, but not much culturally except movies.
It was just rated in one survey as the #1 retirement spot.
Eugene is one hour inland, and we plan to get away for a month or so every winter.
Chucker, don't let them put a catheter in yur pecker and you won't get a UTI. We used to never put them in automatically, but it was a pain trying to get the older ones to pee, so now we use them on everyone. You getting the MIS technique, or does your doc do it the old fashioned way?
That should work for people with arthritis in just one joint, but for those with generalized OA or RA, a systemic drug is needed.
Hogger et al, the anti-inflammatory field is huge, and now even "huger" with the negative aspects of the Cox II's. Topical creams are of limited use however, because of their local nature and their inability to get into multiple joints at therapeutic levels. An injectible would be very useful, and CYGX should be able to do it if they have injectible delivery of their anti-sepsis compounds. But the El Dorado would be a pill. This would be very difficult, since our stomach's would tend to digest the ssDNA.
But many many patients would be willing to make a weekly or monthly trip to their doctors office for an injection that relieved arthritis pain, and prevented the deformities associated with inflammatory types of arthritis.
I happen to think Merck and the FDA jumped the gun by taking Vioxx off the market so quickly. The cardiac risk in the Brittish study went from about .75% to 1.5%, and this risk can be mitigated by taking a baby aspirin daily and by simply taking high risk cardiac patients off the drug! Vioxx and the other Cox II's were helping millions of people lead comfortable lives without as much GI upset as with conventional NSAID's. Now there are scads of lawsuits being launched by #$%&*^$$ lawyers and Merck is toast. Kinda like the asbestos industry. No wonder our meds cost so much.
Back to medical for a minute...did everyone hear the news apparently out this AM (which I heard on NPR), that there are now serious questions being raised about the safety of Bextra, one of only 2 remaining Cox II inhibiting anti-inflammatories? If it falls like Vioxx did, that leaves only Celebrex, and that may fall too.
Which means there is a wide open field for an anti-inflammatory that does not have serious side-effects. If CYGX has one, that can work systemically, not just topically, it would equal or better the potential of any sepsis or HSV treatment. Hope it's not on their back burner.
Great effort Hogger. Thanks from all of us. Do you really think LW would have made such a statement? Could it have been recorded?
...so? We're all waiting with bated breath. What did David say?
Thanks. Is the Waldroff deal the thing that's turned into a lawsuit now?
Hogger, who are you referring to in paragraph 4 of this post? I've only followed this co. since 07/03. Also, who is Waldroff? TIA.
First, go back to posts of a year or more ago, and you'll learn a lot more about PP. They are registered in the Bahamas. Second, I lived and worked in India for 6 years. The country is loaded with highly trained and underpaid or unemployed research doctors who would jump at the chance to lead a research project for very little pay. There would be almost no capital requirements for setting up a herpes study over there. China was an add-on option so it is highly likely that even less, and probably nothing, was started or spent there. If you've been around this board longer than your alias implies, what are you trying to hide?
Woody, no one who's been here more than a minute thinks that PP and CYGX are one and the same. PP is an off-shore limited partnership. As for your previous post, your feeble attempt to put a negative spin on arnold's and cgyxup's post is laughable. The money spent in India by PP is likely minimal, and in China probably zero.
I tend to agree with your take on this. But isn't it legal to manufacture drugs in this country that are not FDA approved that are intended for use abroad?
IMO, the 1/2 bil$ PP is asking for is their projected return from the India and China market over say the next 10 years. I suspect they have not been given the product to begin testing by CYGX, for some unknown reason. Hoping this issue can be resolved out of court. Could be a big dilutional hit. A suit hanging over CYGX's head is a bad stench that will cause major pharma's to stand back for a while.
Lawsuits are bad with or without a company response. If it has actually been filed, it seems confirmation could be found somewhere. I have almost as many shares as were traded today, so selling could not be done quickly. Doesn't a publically traded company have to inform shareholders if they are subjects of a lawsuit? Nothing from company to date. Something's very fishy.
How many sold today? How many held?
The relatively low volume and small drop in SP suggests the market is not giving a lot of credence to what we're discussing. We sure need some word from the company.
Your link seems to go nowhere pertinent. Do you have any corroboration? Anyone have any personal contacts who could comment on this?
I agree everything looks good. We had another patient with MRSA today, and the VRSA strain out there is even worse, so the work is very important and urgent.
I think their approach is mainly through RNAi, which multiple companies are or have been into, and probably not patentable.
We'll have to have a Texas hold-em night at Skooby's bash.
Any suggestions on stakes if CYGX is at $100?
Or a gal with a couple of 44's!
OT... How do aces loose to "quenns"?
Suky, I'm out when it stabilizes above $10, and they get NASD listed. FWIW, I'm leaving San Diego too, but that may be even sooner.
We need to get some decent publicity out of this PR to generate some interest. Someone needs to break this in the national press. Unfortunately the major financial publications will not touch a story coming out of an OTC.BB company.
Thanks for the reference, Arnold. Looks like they blew the shares.
Not familiar with this event. Did the company ever own up to it? Did they get their (our) shares back?
john
Arnold, I have been following this company for 1 1/2 yrs. What bad deal in Europe are you referring to? I'm not aware of any. Can you reference some real information, or are you just passing on internet gossip? As to the deal with PP, they obviously did trust the partnership when the deal was made. S**t happens in the business world too. They made the deal when they were really hurting for $.
All lawsuits have to be noted in the 10-K. If it come up since then, it should have been PR'ed. Don't have time to look now, can you?
One of the directors is a former Qualcomm exec. who I met at work. We are keeping in touch with their progress. I think right now they might still be taking PP's.
I wouldn't touch GTEL with a 10 foot pole either. Crystal Voice (not public yet) and many others are going to eat their lunch big time.
What's his old alias?