is...(ListenLearnLead)
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
$BLEG Branded Legacy, Inc.'s Subsidiary Elev8 Hemp Acquires USDA Organic Certification
https://tinyurl.com/yuru83jh
$BLEG Completes Acquisition of Spikes CBDx
https://tinyurl.com/4sw5wuuv
Brandon Spikes, founder of Spikes CBDx, LLC, has been an advocate of CBD for athletes for quite some time. Spikes believes that post workout recovery, with Spikes CBDx products, can lower inflammation, aid in making your body stronger, and help recover from injuries naturally. The CBD line also targets individuals who are looking for pain relief, better sleep, faster recovery and lowering inflammation. Spikes CBDx provides tinctures, lotions, moisturizer and cryo-gel roll-ons. To view all of the Spikes CBDx products please visit: SpikesCBDX.com
$BLEG Branded Legacy, Inc.'s Subsidiary Elev8 Hemp Acquires USDA Organic Certification
https://tinyurl.com/yuru83jh
$BLEG Completes Acquisition of Spikes CBDx
https://tinyurl.com/4sw5wuuv
Brandon Spikes, founder of Spikes CBDx, LLC, has been an advocate of CBD for athletes for quite some time. Spikes believes that post workout recovery, with Spikes CBDx products, can lower inflammation, aid in making your body stronger, and help recover from injuries naturally. The CBD line also targets individuals who are looking for pain relief, better sleep, faster recovery and lowering inflammation. Spikes CBDx provides tinctures, lotions, moisturizer and cryo-gel roll-ons. To view all of the Spikes CBDx products please visit: SpikesCBDX.com
$BLEG Acquisition Done
LOI - Branded Legacy, Inc. Signs LOI To Acquire First Patent
Press Release | 5/26/2022
https://tinyurl.com/2p998nn7
LOI - Branded Legacy, Inc. Signs Letter of Intent to Acquire Kamino Propagation & Research, LLC
Press Release | 04/06/2022
https://tinyurl.com/2s3km6zj
LOI -Branded Legacy, Inc. Signs Letter Of Intent To Acquire All In Extracts, LLC
Press Release | 03/17/2022
https://tinyurl.com/yc2yxn4f
$BLEG Acquisition Done
LOI - Branded Legacy, Inc. Signs LOI To Acquire First Patent
Press Release | 5/26/2022
https://tinyurl.com/2p998nn7
LOI - Branded Legacy, Inc. Signs Letter of Intent to Acquire Kamino Propagation & Research, LLC
Press Release | 04/06/2022
https://tinyurl.com/2s3km6zj
LOI -Branded Legacy, Inc. Signs Letter Of Intent To Acquire All In Extracts, LLC
Press Release | 03/17/2022
https://tinyurl.com/yc2yxn4f
Branded Legacy, Inc. Eliminates Over 430 Thousand In Debt In 2022
August 12 2022 - 09:15AM
$BLEG
Orlando, FL -- August 12, 2022 -- InvestorsHub NewsWire -- Branded Legacy, Inc. (OTCPK: BLEG), a holding company focused on the commercial development of cannabinoid-infused products from CBD topicals and tinctures to edibles is pleased to announce it negotiated the removal of four hundred and thirty-six thousand one hundred and nineteen ($436,119) in debt from its balance sheet in 2022. This past week, the Company reduced liabilities by one hundred and twelve thousand eight hundred and thirty-nine ($112,839).
Branded Legacy, Inc. has previously announced the removal of debt as well as the cancelation of common stock. The Company plans to continue to reduce its issued an outstanding shares of common stock as well as reducing its liabilities. This removal of one hundred and twelve thousand eight hundred and thirty-nine ($112,839) in liabilities helps both the Company and its shareholders.
Jermain Strong, CEO of Branded Legacy, Inc., concluded, “We are excited about the progress we have made this week. We really believe we are positioning Branded Legacy this year for some significant growth. The share structure is looking more advantageous for new investors and the elimination of debts will reduce the time to which it becomes cash flow positive. All of which will add value to our shareholders.”
$BLEG Huge I/O Reduction Company has significantly reduced its issued and outstanding and will continue to do so. More news to come.$BLEG@brandonspikes55
Twitter Post
🔗 https://t.co/ZGGLaSq9Ua
🔗 https://t.co/sV5do5Qun7#cbdedibles #OTC #cbdhealth #trending #Pressrelease #StockMarket #CBD #acquisition #delta8
$BLEG Huge I/O Reduction Company has significantly reduced its issued and outstanding and will continue to do so. More news to come.$BLEG@brandonspikes55
Twitter Post
🔗 https://t.co/ZGGLaSq9Ua
🔗 https://t.co/sV5do5Qun7#cbdedibles #OTC #cbdhealth #trending #Pressrelease #StockMarket #CBD #acquisition #delta8
This is huge for company. Volume looking better.
Yesterday 102 million shares canceled
$BLEG
Branded Legacy, Inc. Announces Cancelation of 102 Million Common Shareshttps://t.co/QqwYlrilyY @elev8hemp @SpikesCBDX @PepJ52 @brandonspikes55 $BLEG #OTC #OTCMarkets #StockMarket #BLEG #CBD #Cannabis #Hemp #McapMediaWire #PressRelease
— Branded Legacy, Inc. $BLEG (@BrandedLegacy) August 9, 2022
Branded Legacy, Inc. Cancels Another 60 Million Common Shares$BLEGhttps://t.co/jWQxqe6vPQ @SpikesCBDX @elev8hemp @brandonspikes55@PepJ52 #OTC #OTCMarkets #StockMarket #BLEG #McapMediaWire #PressRelease #CBD #Cannabis #Hemp pic.twitter.com/cTBY3IfiGa
— Branded Legacy, Inc. $BLEG (@BrandedLegacy) August 10, 2022
Yesterday 102 million shares canceled
$BLEG
Branded Legacy, Inc. Announces Cancelation of 102 Million Common Shareshttps://t.co/QqwYlrilyY @elev8hemp @SpikesCBDX @PepJ52 @brandonspikes55 $BLEG #OTC #OTCMarkets #StockMarket #BLEG #CBD #Cannabis #Hemp #McapMediaWire #PressRelease
— Branded Legacy, Inc. $BLEG (@BrandedLegacy) August 9, 2022
Branded Legacy, Inc. Cancels Another 60 Million Common Shares$BLEGhttps://t.co/jWQxqe6vPQ @SpikesCBDX @elev8hemp @brandonspikes55@PepJ52 #OTC #OTCMarkets #StockMarket #BLEG #McapMediaWire #PressRelease #CBD #Cannabis #Hemp pic.twitter.com/cTBY3IfiGa
— Branded Legacy, Inc. $BLEG (@BrandedLegacy) August 10, 2022
Yesterday 102 million shares canceled
Branded Legacy, Inc. Announces Cancelation of 102 Million Common Shareshttps://t.co/QqwYlrilyY @elev8hemp @SpikesCBDX @PepJ52 @brandonspikes55 $BLEG #OTC #OTCMarkets #StockMarket #BLEG #CBD #Cannabis #Hemp #McapMediaWire #PressRelease
— Branded Legacy, Inc. $BLEG (@BrandedLegacy) August 9, 2022
Branded Legacy, Inc. Cancels Another 60 Million Common Shares$BLEGhttps://t.co/jWQxqe6vPQ @SpikesCBDX @elev8hemp @brandonspikes55@PepJ52 #OTC #OTCMarkets #StockMarket #BLEG #McapMediaWire #PressRelease #CBD #Cannabis #Hemp pic.twitter.com/cTBY3IfiGa
— Branded Legacy, Inc. $BLEG (@BrandedLegacy) August 10, 2022
Branded Legacy, Inc. Cancels Another 60 Million Common Shares
$BLEG
https://t.co/jWQxqe6vPQ
I'm not disappointed at all. Lol what they are doing. It's looking way better.
I agree
2 days good volume. Good week so far.
Heck yeah. Share buyback??? Could be really good for all.
Nice. Looking good.
Good volume today. Company is moving in right direction for sure.
I have tried emailing the company but the emails get sent back as if it doesn't exist anymore.
Well it looks like they are posting to get in compliance. We shall see.
Lol I get your frustrations but this is just untrue lol.
I think the yield sign is holding up trading. Looks like they are fixing from the sound of their Twitter posts.
$BLEG - Finalizing some details with Kamino Propagation & Research, LLC
Twitter
https://tinyurl.com/ye2mnzan
$BLEG - Finalizing some details with Kamino Propagation & Research, LLC
Twitter
https://tinyurl.com/ye2mnzan
$BLEG - Finalizing some details with Kamino Propagation & Research, LLC
Twitter
https://tinyurl.com/ye2mnzan
$BLEG - Finalizing some details with Kamino Propagation & Research, LLC
Twitter
https://tinyurl.com/ye2mnzan
$BLEG Finalized Acquisition $BLEG @BrandedLegacy @SpikesCBDX @elev8hemp Branded Legacy, Inc. Finalizes Acquisition https://t.co/gBluxfP9oU #OTC #OTCMarkets #StockMarket #BLEG #BrandedLegacy #SpikesCBD #CBD #Hemp #Cannabis #McapMediaWire #PressRelease pic.twitter.com/EPk9Wts477
Branded Legacy, Inc. finalized agreement with Thomas “Pepper” Johnson to acquire his patent on a sports training assembly called The Quickness.
"We have been working on this agreement for just over a week now. I can truly tell that the individuals at Branded Legacy are going to be great to work alongside,” stated Pepper Johnson.
$BLEG<------------- New Acquisition DONE!
$BLEG
@PepJ52
@brandonspikes55
@SpikesCBDX
@elev8hemp
Branded Legacy, Inc. Finalizes Acquisition
CLICK HERE >>>> https://bit.ly/3m3tWvz #OTC
#OTCMarkets #StockMarket #BLEG #BrandedLegacy #SpikesCBD #CBD #Hemp #Cannabis #McapMediaWire #PressRelease
Outstanding Shares - 438,982,816 5/6/2022
Restricted - 389,084,929 5/6/2022
Unrestricted - 49,897,887 5/6/2022
Held at DTC - 32,812,13 5/6/2022
Float - 17,085,748 5/6/2022
$BLEG Finalized Acquisition $BLEG @BrandedLegacy @SpikesCBDX @elev8hemp Branded Legacy, Inc. Finalizes Acquisition https://t.co/gBluxfP9oU #OTC #OTCMarkets #StockMarket #BLEG #BrandedLegacy #SpikesCBD #CBD #Hemp #Cannabis #McapMediaWire #PressRelease pic.twitter.com/EPk9Wts477
Branded Legacy, Inc. finalized agreement with Thomas “Pepper” Johnson to acquire his patent on a sports training assembly called The Quickness.
"We have been working on this agreement for just over a week now. I can truly tell that the individuals at Branded Legacy are going to be great to work alongside,” stated Pepper Johnson.
$BLEG<------------- New Acquisition DONE!
$BLEG
@PepJ52
@brandonspikes55
@SpikesCBDX
@elev8hemp
Branded Legacy, Inc. Finalizes Acquisition
CLICK HERE >>>> https://bit.ly/3m3tWvz #OTC
#OTCMarkets #StockMarket #BLEG #BrandedLegacy #SpikesCBD #CBD #Hemp #Cannabis #McapMediaWire #PressRelease
Outstanding Shares - 438,982,816 5/6/2022
Restricted - 389,084,929 5/6/2022
Unrestricted - 49,897,887 5/6/2022
Held at DTC - 32,812,13 5/6/2022
Float - 17,085,748 5/6/2022
Branded Legacy, Inc. Signs Letter of Intent to Purchase Assets Of Kamino Propagation & Research, LLC
$BLEG
PR
https://finance.yahoo.com/news/branded-legacy-inc-signs-letter-130000033.html
Quote
https://finance.yahoo.com/quote/BLEG?p=BLEG&.tsrc=fin-srch
Branded Legacy, Inc. Signs Letter of Intent to Purchase Assets Of Kamino Propagation & Research, LLC
$BLEG
PR
https://finance.yahoo.com/news/branded-legacy-inc-signs-letter-130000033.html
Quote
https://finance.yahoo.com/quote/BLEG?p=BLEG&.tsrc=fin-srch
$BLEG Acquires Astound NMN from Rimrock Gold Corp. $RMRK
Read Full PR
https://tinyurl.com/5dx4c44z
$BLEG Acquires Astound NMN from Rimrock Gold Corp. $RMRK
Read Full PR
https://tinyurl.com/5dx4c44z
$BLEG Acquires NMN Company from $RMRK
Astound NMN is an established brand of NMN supplements. These supplements are designed to increase cellular functionality by optimizing the energy cycle and metabolic function. Its signature NMN formulation has the power to reduce age-related effects, increased energy and cognitive function. In addition, it has the ability to improved digestion, metabolism and cardiac function, immune system support, anti-inflammatory abilities, blood sugar regulation, and much more.
Read Full PR
https://tinyurl.com/5dx4c44z
$BLEG Acquires NMN Company from $RMRK
Astound NMN is an established brand of NMN supplements. These supplements are designed to increase cellular functionality by optimizing the energy cycle and metabolic function. Its signature NMN formulation has the power to reduce age-related effects, increased energy and cognitive function. In addition, it has the ability to improved digestion, metabolism and cardiac function, immune system support, anti-inflammatory abilities, blood sugar regulation, and much more.
Read Full PR
https://tinyurl.com/5dx4c44z
$BLEG --> The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule
In June of 2018, the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time added aging.1 The classification of aging as a disease paves the way for new research into novel therapeutics to delay or reverse age-related illnesses such as cancer, cardiovascular and metabolic disease, and neurodegeneration.2,3 Nutrient sensing systems have been an intense focus of investigation, including mTOR (the mammalian target of rapamycin) for regulating protein synthesis and cell growth; AMPK (activated protein kinase) for sensing low energy states; and sirtuins, a family of seven proteins critical to DNA expression and aging, which can only function in conjunction with NAD+ (nicotinamide adenine dinucleotide), a coenzyme present in all living cells.4
Across the kingdom of life, an increase in intracellular levels of NAD+ triggers shifts that enhance survival, including boosting energy production and upregulating cellular repair.5 In fact, the slow, ineluctable process of aging has been described as a “cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects in susceptible organs and tissues.”6 Aging is marked by epigenetic shifts, genomic instability, altered nutrient sensing ability, telomere attrition, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and dysregulated intercellular communication.7,8
By middle age, our NAD+ levels have plummeted to half that of our youth.9 Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan.10,11 NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside(NR) and nicotinamide mononucleotide (NMN).12,13 A conceptual framework called NAD World, formulated over the last decade by developmental biologist Shin-ichiro Imai, MD, PhD, of Washington University School of Medicine, posits NMN as a critical, systemic signaling molecule that maintains biological robustness of the communication network supporting NAD+.6
Taken orally, NMN is rapidly absorbed and converted to NAD+.14 In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+.15 Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.16
$BLEG --> The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule
In June of 2018, the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time added aging.1 The classification of aging as a disease paves the way for new research into novel therapeutics to delay or reverse age-related illnesses such as cancer, cardiovascular and metabolic disease, and neurodegeneration.2,3 Nutrient sensing systems have been an intense focus of investigation, including mTOR (the mammalian target of rapamycin) for regulating protein synthesis and cell growth; AMPK (activated protein kinase) for sensing low energy states; and sirtuins, a family of seven proteins critical to DNA expression and aging, which can only function in conjunction with NAD+ (nicotinamide adenine dinucleotide), a coenzyme present in all living cells.4
Across the kingdom of life, an increase in intracellular levels of NAD+ triggers shifts that enhance survival, including boosting energy production and upregulating cellular repair.5 In fact, the slow, ineluctable process of aging has been described as a “cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects in susceptible organs and tissues.”6 Aging is marked by epigenetic shifts, genomic instability, altered nutrient sensing ability, telomere attrition, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and dysregulated intercellular communication.7,8
By middle age, our NAD+ levels have plummeted to half that of our youth.9 Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan.10,11 NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside(NR) and nicotinamide mononucleotide (NMN).12,13 A conceptual framework called NAD World, formulated over the last decade by developmental biologist Shin-ichiro Imai, MD, PhD, of Washington University School of Medicine, posits NMN as a critical, systemic signaling molecule that maintains biological robustness of the communication network supporting NAD+.6
Taken orally, NMN is rapidly absorbed and converted to NAD+.14 In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+.15 Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.16
$BLEG --> The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule
In June of 2018, the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time added aging.1 The classification of aging as a disease paves the way for new research into novel therapeutics to delay or reverse age-related illnesses such as cancer, cardiovascular and metabolic disease, and neurodegeneration.2,3 Nutrient sensing systems have been an intense focus of investigation, including mTOR (the mammalian target of rapamycin) for regulating protein synthesis and cell growth; AMPK (activated protein kinase) for sensing low energy states; and sirtuins, a family of seven proteins critical to DNA expression and aging, which can only function in conjunction with NAD+ (nicotinamide adenine dinucleotide), a coenzyme present in all living cells.4
Across the kingdom of life, an increase in intracellular levels of NAD+ triggers shifts that enhance survival, including boosting energy production and upregulating cellular repair.5 In fact, the slow, ineluctable process of aging has been described as a “cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects in susceptible organs and tissues.”6 Aging is marked by epigenetic shifts, genomic instability, altered nutrient sensing ability, telomere attrition, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and dysregulated intercellular communication.7,8
By middle age, our NAD+ levels have plummeted to half that of our youth.9 Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan.10,11 NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside(NR) and nicotinamide mononucleotide (NMN).12,13 A conceptual framework called NAD World, formulated over the last decade by developmental biologist Shin-ichiro Imai, MD, PhD, of Washington University School of Medicine, posits NMN as a critical, systemic signaling molecule that maintains biological robustness of the communication network supporting NAD+.6
Taken orally, NMN is rapidly absorbed and converted to NAD+.14 In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+.15 Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.16
$BLEG --> The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule
In June of 2018, the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time added aging.1 The classification of aging as a disease paves the way for new research into novel therapeutics to delay or reverse age-related illnesses such as cancer, cardiovascular and metabolic disease, and neurodegeneration.2,3 Nutrient sensing systems have been an intense focus of investigation, including mTOR (the mammalian target of rapamycin) for regulating protein synthesis and cell growth; AMPK (activated protein kinase) for sensing low energy states; and sirtuins, a family of seven proteins critical to DNA expression and aging, which can only function in conjunction with NAD+ (nicotinamide adenine dinucleotide), a coenzyme present in all living cells.4
Across the kingdom of life, an increase in intracellular levels of NAD+ triggers shifts that enhance survival, including boosting energy production and upregulating cellular repair.5 In fact, the slow, ineluctable process of aging has been described as a “cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects in susceptible organs and tissues.”6 Aging is marked by epigenetic shifts, genomic instability, altered nutrient sensing ability, telomere attrition, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and dysregulated intercellular communication.7,8
By middle age, our NAD+ levels have plummeted to half that of our youth.9 Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan.10,11 NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside(NR) and nicotinamide mononucleotide (NMN).12,13 A conceptual framework called NAD World, formulated over the last decade by developmental biologist Shin-ichiro Imai, MD, PhD, of Washington University School of Medicine, posits NMN as a critical, systemic signaling molecule that maintains biological robustness of the communication network supporting NAD+.6
Taken orally, NMN is rapidly absorbed and converted to NAD+.14 In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+.15 Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.16
$BLEG --> The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule
In June of 2018, the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time added aging.1 The classification of aging as a disease paves the way for new research into novel therapeutics to delay or reverse age-related illnesses such as cancer, cardiovascular and metabolic disease, and neurodegeneration.2,3 Nutrient sensing systems have been an intense focus of investigation, including mTOR (the mammalian target of rapamycin) for regulating protein synthesis and cell growth; AMPK (activated protein kinase) for sensing low energy states; and sirtuins, a family of seven proteins critical to DNA expression and aging, which can only function in conjunction with NAD+ (nicotinamide adenine dinucleotide), a coenzyme present in all living cells.4
Across the kingdom of life, an increase in intracellular levels of NAD+ triggers shifts that enhance survival, including boosting energy production and upregulating cellular repair.5 In fact, the slow, ineluctable process of aging has been described as a “cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects in susceptible organs and tissues.”6 Aging is marked by epigenetic shifts, genomic instability, altered nutrient sensing ability, telomere attrition, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and dysregulated intercellular communication.7,8
By middle age, our NAD+ levels have plummeted to half that of our youth.9 Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan.10,11 NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside(NR) and nicotinamide mononucleotide (NMN).12,13 A conceptual framework called NAD World, formulated over the last decade by developmental biologist Shin-ichiro Imai, MD, PhD, of Washington University School of Medicine, posits NMN as a critical, systemic signaling molecule that maintains biological robustness of the communication network supporting NAD+.6
Taken orally, NMN is rapidly absorbed and converted to NAD+.14 In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+.15 Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.16
Working Relationship $BLEG & $RMRK
More deals to come. Spear heading the industry together.
I think this could be huge for all.
GLTA
$BLEG & $RMRK Volume
Decent volume from this transaction.
Well done on both parties. Lets see where this goes from here.