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Grabbed a starter here!! Believe a reversal is coming soon. MBD
Huge pop coming!! No shares available! Float/OS ALREADY gone!! Anyone selling there shares right now our retarded!! BPTH run coming over the next few days imo!
I'm expecting more news AH/PM sometime this week! MBD
Yes my friend, 25k MBD
Thanks my friend!!! I will definitely dd this!!! MBD
Yes my friend, I can see PM! Please send me the details! Would love to check it out. Can't respond, but what I will do on Friday, I believe they call it Happy Hour and allow all posters to communicate after hours.
I sent an email to ihub and asked why I had not been grandfathered in like yourself!
Their answer to me was I missed it by four people! Can you believe that they're cut off was 8000 members. And the four that made it in before me haven't posted since 2002 can u believe that. Lolol
Hey I never do this but you and I are cut from the same cloth!
What I will do is send you my private email during happy hour on Friday, that is if I don't forget, for further communication my Old School friend! Kinda sucks GETTING old!!! Tools don't work the same, nor the mind!!! Lol
TENX 20+ Million shares traded day coming soon!! I can't wait to see it!!! MBD
Love makingbiigdough on a quiet board! MEANS that NO IHUBBER DT's/Swingers are here to sell for pennies and stop the positive money flow!! MBD
The way this is trading Walker, my gut is telling me some sort of huge news drops next week. Tuesday/Wed! Hasn't been anymore insider buying/form 4's filed. Just a gut feeling that's all! We all have a gut, just what mine is saying. Lol
Have a blessed memorial day weekend my friend, be safe! By the way I added a few more today. COULDN'T resist! MBD
YES these prices are a steal! I paid over $3.00 for some of mine!
Some people paid a HELLUVA lot more!! somebody said he paid 12 bucks I believe I'm sure people paid a lot more than that as well!!
Hope all of those people get their money back and then some. MBD
Lol...4hrs MEANS Long!! Lolol
You are so right! 15k your good! I've been in TENX from probably a year and a half!! Was killing me!! Had allot of loot tied up here!! Didn't really have a choice but to load the boat in the low.40s-50's! ALWAYS knew it was going to come back.
Missed allot of other big money plays, but oh well plan on EASILY making it all back and then SUM!! TENX is a real winner NOW!! Everything is lining up perfectly imvho! Glad you are in My friend
BEEN A LONG ROAD, but time for it to run and do I mean run hard and HIGH!!! Lots of insiders buying over the last 3-4 days!! A doctor dropped over 470,000k into TENX couple days ago. Don't know if you saw that filing?
BLESSINGS my friend! No-brainer here!! I will look at your posting history and see what else I can join you in real soon!
Like from the good ole days, I don't talk about or pump other stocks and other plays on a board that isnt that STOCKS board. Just me, even though it's pretty much just me here! Lololol MBD
Yes my OG FRIEND!! I remember you from way back when there were real Investors in the market who used to help each other out!
Knew how to hold and everyone madebiiigdough Oh how I miss those days!! Call me crazy but we could have a PARABOLIC MOVE like BPTH to the $70.00's!
Of course I won't be holding all of my shares that long! I'll start looking to take some profits around $9-$12 levels. A little at a time! I am holding well over 200k+ shares. So I have the leisure of taking my time, selling and holding for DIFFERENT levels to be reached.
You are still in the game so that says a lot about you! Patience pays big time!!! Good luck my friend!
GREAT PHASE II News on the way, as well as Fast track APPROVAL!! Wouldn't doubt a few more surprises as well!
God Bless you and your family with great HEALTH during these troubling times, as well as in all your investments MBD
Yes Walker, I truly believe it's TENX time. Good time to Grab yourself a few if you don't have any imo. Been a LONGTIME waiting!! MBD
Nice and slow. MBD
AMZN also looking to get into the THERAPEUTICS INDUSTRY from what I hear!!
Eyeing TENX!! TENX up BIG in PM up .20 $1.18/$1.80!! LMAO!! Why not, rumored to buy everything else that ISN'T nailed down! MBD
Just the beginning!!!! MBD
So manipulated!! I just Continue to buy and wait for that day when MM's FINALLY let it go! MBD
Made 7 figures+ with AKTX, in which I held for over a year! I Love TENX even more!!
TENX will prove to be well worth the LONG SACRIFICE!!! Expecting even more gains with TENX!!! MBD
Love it more than ever, Continually buying, have brought my average down tremendously.
TENX is so close to that big move upward!! Could come at anytime! Patience pays off huge rewards here in TENX! MBD
$6-8+ With News Imo! MBD
TENX, I have that feeling that something is about to drop!! I'm not going to split hairs over a few cents!
Going to knock out these .58's! Don't want any regrets or woulda, coulda, shoulda moments when news comes out and we move BIG TIME!! MBD
TENX!! The part I really like!!! TENX has never talked directly to the point of maximizing shareholder value!! Get ready for some blockbuster news imvho!!! YES IT'S ME GRABBING EVERY SHARE I CAN GET MY GREEDY LIL HANDS ON @.57/BELOW!!!
BLACKROCK AND MANY OTHER TUTES WANT SHARES, WHY WOULDN'T I!!! By the way he CEO OF BR was on Fox news the other day talking about how their fund has been seeking out under priced bios! Especially those that have the potential to help with the Coronavirus pandemic!! MBD
Additionally, our Board of Directors continues to review strategic alternatives focused on maximizing stockholder value. "
Rogerthat!! Lol...Going to be a VERY FUN RIDE BROTHER!!! MBD
TENX like I've been saying! Sooner than later, I truly believe we see some type of partnership DEAL soon!!! Tick tock!!!!
Next week at the very latest is the last time shares will be available at these levels. Honestly, i think it could be eow!! MBD
Print Release
March 12, 2020
Tenax Therapeutics Completes Enrollment in Phase 2 Pulmonary Hypertension Trial
Tenax Therapeutics, Inc. (NASDAQ: TENX) announces enrollment completed in Phase 2 levosimendan HELP study
HELP study exceeds target enrollment with 37 patients
84% initial open-label lead-in response rate to qualify for randomization
Pulmonary capillary wedge pressure (PCWP) was reduced, on average, by 7.5 mmHg during exercise following the initial levosimendan infusion
No serious drug-related adverse events have been reported to date
Top-line data expected in second quarter 2020
Contacts
Westwicke, an ICR Company
Stephanie Carrington, 646-277-1282
Stephanie.carrington@icrinc.com
Tenax Therapeutics, Inc. (Nasdaq: TENX), a specialty pharmaceutical company focused on identifying, developing and commercializing products that address cardiovascular and pulmonary diseases with high unmet medical need, today announced that it has completed enrollment of their Phase 2 clinical trial of levosimendan.
The multi-center, double-blind, placebo-controlled Phase 2 trial is designed to evaluate levosimendan in patients with pulmonary hypertension and heart failure with preserved ejection fraction (PH-HFpEF). The study is also known as the HELP Trial ( Hemodynamic Evaluation of Levosimendan in Patients with PH-HFpEF). The primary endpoint is the change from baseline Pulmonary capillary wedge pressure (PCWP) with bicycle exercise (25Watts) at week 6 following five weekly infusions of levosimendan post randomization. There is an 80% power to detect a ≥ 4.8 mmHg reduction in PCWP from baseline. The Company expects to report top-line data in the second quarter 2020.
“We are delighted that enrollment has been completed in this Phase 2 trial and anticipate top line data to be reported during the second quarter 2020 following the completion of dosing and data analysis,” stated Anthony DiTonno, CEO of Tenax Therapeutics. “Pulmonary hypertension due to left heart disease represents a significant unmet medical need given the lack of effective therapies for over an estimated two million patients in the US. Levosimendan with its triple mechanism of action has the potential to represent a breakthrough treatment option for these patients.”
Initial Response
The trial has a predefined response criterion that patients must meet following a 24-hour open-label infusion of levosimendan before they can be randomized to the 6-week double-blind phase of the trial. The criterion for randomization is a reduction in PCWP during supine exercise of 4mmHg following the open-label infusion when compared with each patient’s baseline exercise PCWP. 37 of 44 patients who received the open-label lead in infusion, approximately 84%, achieved this predefined responder criterion.
Invasive exercise hemodynamic measurements from the first 30 evaluable patients showed statistically significant improvements during the open-label lead-in phase when compared to baseline, including an average reduction in pulmonary capillary wedge pressure (PCWP) of 7.5 mmHg , an average reduction in pulmonary arterial pressure (mPAP) of 5.1 mmHg, an average reduction in right atrial pressure (RAP) of 5.0 mmHg, and an average increase in cardiac output (CO) of 0.6 liters/min. All of these open-label lead-in phase hemodynamic improvements achieved statistical significance (p≤0.01, paired t-Test)
Adverse Events
There have been no drug-related serious adverse events, and only 1 patient has withdrawn from the study prior to completing the 6-week double-blind phase of the trial . All of the patients who have completed the 6-week double-blind phase of the trial have elected to enroll in the open-label extension study.MBD
All we have to do is be a Lil more patient!! Sit back have your favorite drink and get ready for the fireworks!! Lol..MBD
TENX is so under the radar!! I have madebiiigdough in most of the biotechs! TENX is pretty much the only that has not run yet.
When the News comes, at it will ALL the money from all over will run over here to our Lil hidden gem TENX! LOL
I BELIEVE IT WILL BE THE BIGGEST RUNNER OUT OF ALL OF THEM ALL MY FRIEND!!
NOT A MATTER OF IF MY BROTHER!!!! WHEN I TRULY BELIEVE!!!! Grab all you can get your hands on if possible! JMO.... That's what I've been doing. MBD
HERE YOU GO MY FRIEND! THANK GOD I COULD COPY NEWS ARTICLE!! MBD
In response to the pneumonia epidemic of new coronavirus infection, the National Health and Medical Commission issued the "Pneumonitis Diagnosis and Treatment Program for New Coronavirus Infection (Trial Version 4)", which provides clear guidance for clinical diagnosis and treatment. The article points out that the clinical manifestations of patients with viral infection are mainly fever, fatigue, dry cough, and severe cases progress rapidly to acute respiratory distress syndrome, septic shock, difficult to correct metabolic acidosis and coagulopathy.
In the above clinical manifestations, septic shock is one of the more serious cases. In patients with pneumonitis infected by the new coronavirus, sepsis may occur when antibiotics are not optimally controlled. The incidence of sepsis is about 1.5% and the mortality rate is 10%, of which about 4% develop septic shock. Sepsis-related myocardial depression is called septic cardiomyopathy, and the mortality rate is as high as 50 to 70% when septic shock occurs.
In the "New Coronavirus Infected Pneumonia Diagnosis and Treatment Scheme (Trial Version 4)", for the treatment of severe and critical cases, the need for circulatory support was clearly stated, that is,
Levosimendan as a calcium sensitizer can increase cardiac output without significant changes in heart rate and myocardial oxygen consumption. In addition to improving hemodynamics, it can also improve tissue microcirculation in patients with sepsis . More importantly, Levosimendan is a long-acting heart-strengthening medicine. The injection of a single dose of Levosimendan can maintain its effect for 7-10 days.
In clinical use, a levosimendan combined with 250ml of 5% glucose solution is recommended for intravenous infusion using an infusion pump. A direct maintenance dose of 0.1 µg / kg / min is recommended for 24 hours of infusion. If the patient's blood pressure is very low, the recommended dose starts from 0.05 µg / kg / min, and after about 3 hours, the dose is adjusted to 0.1 µg / kg / min according to the patient's condition.
[Common name] Levosimendan injection
[Ingredients] Levosimendan, absolute ethanol, polyethylene glycol 400, citric acid.
[Indications] Short-term treatment of acute decompensated heart failure (ADHF).
[Dosage]
The initial loading dose is 6-12 µg / kg, the administration time is not shorter than 10 min, and then the continuous infusion is 0.1 µg / kg / min. Adjust the infusion rate between 0.05 and 0.2 µg / kg / min according to the patient's tolerance and response. The administration time for patients with acute decompensated heart failure is usually 24 hours. Monitor the ECG, blood pressure, and heart rate.
[Adverse reactions]
The most common adverse reactions were headache and hypotension. For other adverse reactions, please refer to the instructions.
[Taboo]
1. Mechanical obstructive disease that significantly affects ventricular filling or / and ejection function;
2. Severe liver and kidney (creatinine clearance
3. Patients with severe hypotension and tachycardia;
4. Patients with a history of torsional ventricular tachycardia;
5. Patients who are allergic to levosimendan or any other excipient.
[Precautions]
1. For patients with low basal blood pressure and patients at risk for hypotension, a more conservative dose is recommended;
2. Severe hypovolemia should be corrected before medication, if the blood pressure or heart rate changes excessively, the infusion rate should be reduced or the drug should be discontinued;
3. The hemodynamic effect of this product lasts for 7 ~ 10 days. After the infusion, the blood pressure should be monitored non-invasively until the blood pressure starts to rise;
4. Use with caution in patients with mild to moderate renal impairment and patients with mild to moderate liver impairment;
5. The abnormal blood potassium concentration should be corrected before medication, and the blood potassium concentration should be monitored during treatment.
Please refer to the instructions for other precautions.
For medical professionals only
Last thing I will say is GET AS MANY AS YOU CAN AT THESE RIDICULOUS LEVELS!!
TUTES AREN'T HERE TO MAKE $19 PROFIT!! THEY ARE BUYING IN FOR MILLIONS JUST LIKE I HAVE!!
Good luck my friend! One day soon we will be thanking God AND smiling all the way to the bank$$$MBD
Look at my post 8019!! The link is there, You have to click on English! MBD
I made A KILLING ON BPTH when it ran to $72.19 I believe?
Of course didn't hold until that level, but made HUUGE GAINS MY FRIEND!
Call me CRAAZY but I think TENX could do the same thing! Let me see if I can find that article. MBD
Lol...I have it at that price because I like those bank account figures!! On a SERIOUS NOTE, I just put that in GTC so my shares CAN'T be borrowed by brokerage house to sell on the market!!
Hello my friend! This has been one helluva journey!! YES I am still here!!! Lol
Have NOT sold one single share!! Holding a HELLUVA LOT OF SHARES THAT I have on lockdown!! Price $72.50!! LOL
As far as data....what do I know!! I truly believe it is going to be earth shattering!!! Levosimendan is a one of a kind drug that is going to revolutionize the critical care market!!!
Data should hit imo between the 8th-12 of April!
ALL I KNOW IS IT IS COMING SOONER RATHER THAN LATER!! LOL.. Everyday is a day closer my friend!!
These little small time pennystock day traders are cracking me up!! Someone posted they flipped for $19 profit!! LMAO!!!
IR used to talk to me ALL THE TIME!!! HAVE BEEN EERILY QUIET THE LAST FEW MONTHS!!
ALL I will say imo is, IT'S COMING!! AND WHEN THE NEWS STARTS FLOWING IMO. IT'S NOT GOING TO STOP!!!
FLOOD GATES GOING TO OPEN UP AND ALOT OF REAL MONEY IS GOING TO BE MADE!!!!
If you have read my posts here LEVOSIMENDAN IS ALREADY BEING USED TO FIGHT THE CV in China and other places around the world!!! NO NEWS HAS BEEN RELEASED PUBLICLY BY COMPANY YET!!
I emailed Stephanie in regards to this, no reply my friend!! I'll tell you this. As long as I have been buying, holding and accumulating, NOT SELLING FOR LESS THAN A 7+ FIGURE PROFIT!!! Do the math my friend, and for that to happen, I don't need to double digits!!! God Bless you my friend and welcome back!
Please stay save during THESE sad and crazy times!! Keep everyone in your prayers, and ESPECIALLY OUR FIRST RESPONDDERS!!! They have a crazy and scary job to do right now!!
I have many doctors, nurses and other first responder friends who I worry about!! God please keep them ALL safe!!!! MBD
TENX any day now! MBD
TENX... Dilution should be done at any moment now imo! Back to $1 plus level. Then bring on that GREAT DATA NEWS AND COVID 19 NEWS with a PARTNERSHIP!!!! MBD
TENX! When the next News release drops, the roof is going to blow off of this!! Mark my words!!!!
Look how far those legs are spread apart! MM's know what's coming! ALWAYS know before shareholders do!!!!!
It will probably be in relationship to COVID 19 imo!! Can't wait for TENX 20-30 million+ days of shares trading!!! MBD
When TENX finally pops! OMG it's going to really explode!! NEVER seen a stock held down like this!!!
News of offering closing should be forthcoming. Then I think we see some great News shortly thereafter. Followed up by Excellent data News!!! JMO...added more@.50!
..MBD
makingbiigdough Wednesday, 03/18/20 05:41:01 PM
Re: None 0
Post #
8019
of 8019
TENX is helping CV PATIENTS ALL OVER THE WORLD!!! What's it going to take for us to get some CV NEWS HERE!!!! GEEEZZZ!!! Management NEEDS to really get their heads out of the sand!!!
LEVOSIMENDAN has helped, and is continually helping China as well as other countries all over the world, recover from the CV battles!! Why NOT TELL THE WORLD!!???MBD
Click on link for the News article!!
https://k.sina.cn/article_6009754278_1663592a600100nu3y.html?from=health
makingbiigdough Wednesday, 03/18/20 05:41:01 PM
Re: None 0
Post #
8019
of 8019
TENX is helping CV PATIENTS ALL OVER THE WORLD!!! What's it going to take for us to get some CV NEWS HERE!!!! GEEEZZZ!!! Management NEEDS to really get their heads out of the sand!!!
LEVOSIMENDAN has helped, and is continually helping China as well as other countries all over the world, recover from the CV battles!! Why NOT TELL THE WORLD!!???MBD
Click on link for the News article!!
https://k.sina.cn/article_6009754278_1663592a600100nu3y.html?from=health
TENX is helping CV PATIENTS ALL OVER THE WORLD!!! What's it going to take for us to get some CV NEWS HERE!!!! GEEEZZZ!!! Management NEEDS to really get their heads out of the sand!!!
LEVOSIMENDAN has helped, and is continually helping China as well as other countries all over the world, recover from the CV battles!! Why NOT TELL THE WORLD!!???MBD
Click on link for the News article!!
https://k.sina.cn/article_6009754278_1663592a600100nu3y.html?from=health