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Cbeck out
https://www.fda.gov/newsevents/Newsroom/pressanouncements/ucm565148.htm
retts als ftd Huntington's the list of orphan inds for $avxl the goes on and on
What orph inds do they have already
just rett?
My phone suks
taking part in the boatload of fireworks show
happy 4th to free people everywhere stay safe!
How were they supposed to show a signal with a few doses in late stage cases?
Its an iv treatment for agitated patients
not going to work
the 40ug dose was toxic!
Of course they are bound to present at conference on terms of duty
the results did not come at conference that is the important point
$ntrp covered @ 6.40 long @ 7
Sigma receptor modulators: a patent review
Interesting read and noted papers of interest in biblio
from my digging i believe pre-084 developed by su and Maurice not pursued because it is phencylidine derived and property of nih
pcp and all derivatives are schedule 1
Su was working on pcp receptors not sigmas in addiction but is now doing sr2 studies
maurice took the formula to vamvakides for scaffolding on sigmaceptorplatform
along came 2-73
M's science corp cutamesine sa4503 is of interest
p2 in stroke completed website lists als and occular disorders but appears to be dead in the water
Esteve deep into sr1 antagonists in neuropathic pain and as potentiation of opiods
This moa could be big part of solving opioid epidemic and $avxl has antagonists in pipeline a1519 i believe
Is everybody so ready to have this drug the first approved disease modifying therapy for the costliest health threat in the world?
I need more risk shares for that reward!
Drexel u patent supporting $avxl moa
9388126
And wo2016064711 is nat stage in ca 2964520
Bot 741 5.52
11541 for me!
avxl long @ 5.70
Dr George Perry rezearcher id a-8611-2009
Just recently started reading his papers
he commented on avxl ctad results but was misquoted on bryo results
but he knew bryo increased peroxynitrite
i think his theories on oxidative stress will meet anavex ros mediation through ca++ regulation in the realm of hormesis
pmc3742177
Yes! Thank you for expounding on the post and highlighting the correlation between the articles
Anavex is alone in the public sector using this approach to neurodegenerative diseases
reading of the ca2+ issues in all those diseases as compared to the indications avxl is exploring is intriguing
perhaps biogens ms interest is as big as some think
Yes hope to see anavex research in future a&d articles
link to perry video please
$avxl stays in Russell vol to follow!
Try this
http://www.alzheimersanddementia.com/article/S1552-5260(16)33127-2/fulltext
Calcium hypothesis
Not so easy
On a phone
on an island
On the beach
with big fat fingers
Anyway now read this recently
Www.alzheimersanddementia.com/article/s1552-5260(16)33127-2/fulltext#cebib0010
Hope the link works
wind is blowing
The anavex thesis
pmc3122891
Happy reading
$avxl has mou patent for 2-73 & don granted
you only hold off on payment for one reason
bot 1240 for 11452 long @ 5.62
My bet is on $bayn
Agree dont ruin a good bear thesis
Same answer as to other?s
risk vs reward
if he succeeds in achieving 1st dmt in ad the comp package is peanuts
$>50,000,000,000 market biggest in all of medicine
50 other drug candidates have been sacrificed or sold and $avxl is going forward to p3 with a $500k/q burn rate
Few first time ceos do this
I had hoped for fireworks at adpd after waiting for wihwb some firm confirmation
I know no such thing in biotech
Decided to buy before aaic but nervous
Most trial readouts fit lb critera anyway right?
Ill watch the board for detectives to report lol
Everybody else is already there
sol rvt sunv bryo don even thc-ad
i hate this game that $avxl plays
and i thought they always had late break submissions and im wrong?
Planning on selling trade share gains on runup but maybe just chuck it all
Should get blitzkrieg pkpd 1.5 yr readout p2b/3 design 3-71 anything!
The works
instead waiting for abstract s that have titles changed and are late
Avg mmse of the variability study was 12
Avg mmse of 2-73 p2a was 21
Point to f1ash and ofp
next zone in play is 6 super responders improving over 1.5 years
upper support at all reportable no change
lower target zone 4-6 declining 1.7 pts
This bord has had a mean average of 200 posts per day for the last 2 years
watch someone reply how drastically incorrect my calculations are without getting the point of the comment
$avxl slow and steady and lots of lolly lolly lol
So based on all this ambiguously positive therapeutic data you guys dont think it is safe enough to move to a p2b/3 efficacy exploration?
Better buy as much $axon as you can hold before aaic then!
$avxl long
Au connection?
1-41 preclin paper authored by christopoulos avlani and sexton from monash u
macfarlane is from monash
Yes just networking
the wizard and his supermodel girlfriend
$avxl bio int member 205978
Not listed as exhibitor
Only partnering
ceo and director of business development are listed as attendees
Broker gave me 600 short how nice!
$axon short @ 23.50
Down thru data
Cover 12.20
Bot 212 on the ta stair step @ 5.52
100212 for me
either 15-18 wk data is conclusive and all else is gravy or co fights to stay afloat through $ draining failures into sub penny land
Hope the rise into data pattern holds and can sell trade shares high
cover with july puts 4:25
Hope patients are sleeping well
$avxl long @ 5.68
Out $gtxi on data
added $avxl @ 5.72
9800 long
Preaching to the choir doc but
hallelujah! !!
Look 2 posts later something about tryptophan
sleep cycles nsaids and 2-73
It will all come together
google tryptophan and ad
Sepracor had the relevant patent wo2001012630
Sunovion aquired
Uspto 6762177 hinders 3-71 until 2020
The deep sleep pattern will be important
pubmed/25273321 and 24755275 and 21531141
2-73 is succesor to PRE-084
3-71 is spirocyclic ligand 10x as powerful
ncb1104-1054.html
We may get clinical evidence first
precisely!
Make the mistake of so many saying anavex is effective because it fixes things at the start of the disease process
that is a presumptive assumption
think that is frrols point and i agree
The restoration of cellular homeostasis and dna ascribed protein folding through ca2+ mediated process is theory
nothing factual has been presented
that is p3
Ir just gives boilerplate
Side effects dont happen until the clinic
it became 1-41 then 2-73
Pre-084 had affinity to d2 and 5ht and is pcp derivitive
maurice took the formula to vamvakides to create endogenous ligand for s1 with affinity to m1 at the transmembrionic site on the sigmaceptor platform
Why have they not prd the plus patent?
Or paid the fees to get grant pub?
Even if it covered methods completely abandoned any co would still pr per reg fd
Green flag imo
Agree and by the same token since the top researchers do not fully understand the biology how could you expect an expert to refute the science?
Just having a compound like this in human testing is incredible enough
it might have a profound effect on the advancement of science on sr1 ligands but to expect it is a magic pill is foolish
odds of approval are 1:1000 regardless of what anyone says
odds of making $$$ on the ride are considerably better
Aaic poster lists as delirium grade 3: not related
ctad slide lists as ae: delirium; grade 2
Is that the confusion? It is for me
Might answer some ?s
sa article 3687706
Interview with t maurice
What happened to pre-084?
Could have had an extra 87 at 5.95 but thought pr might hit
Fell right into that 30¢ zone
follow ta rules not hunches!
$avxl
The 52wk charts in that pub appear to reflect the same late upturn as 2-73 showed
completely placebo effect?
Nasids flufenamic and mefenamic acid have possible ad efficacy
Nature.com/articles/ncomms12504
Read from fig 4
A link to 2-73 moa?
Will 70wk data be new ground?
$kura long@ 8.28