Rec finished accum & now holding CTIX. I come here daily, listen more than I talk, and am grateful beyond measure for everyone's contributions.
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Roches failed Ph3: yeah, BP’s endemic culture of responding to a lackluster clinical trajectory is analogous to guys who refuse to ask for directions even when they, their bitching wife, the guard rail, and every other car around them can see that they are catastrophically lost. Rather than taking the next exit, saving $100mm, and acquiring a new, more promising compound, they just put the pedal to the metal. In the interest of common sense, maybe C-level execs should be scouted from the warehouse floor.
“B is not a vaccine... Therapeutics will have a place”
Yes, but the general public is, on average, a Kardashian, and that mass-produced demographic of mouth-breathers want a vaccine...so *in my best Chris Farley impression* “FOR THE LOVE OF GOD, just start calling B a Vaccine!”
Fungus: Huge unmet need. Huge. Very few compounds available not just for Candida Aurus, but for Mucormycosis, which is often a death sentence for burn patients, or other immunocompromised case. Combat with systemic Voriconazole and Amphotericin b, which ravage liver and kidney.
Fauci smacks of Don Fanucci, the neighborhood boss who burdens shopkeeper, Signore Abbandando with his fat, useless nephew, Remdes- erm- Sandiago... but Fanucci, in doing so, bit off more than he could chew. I hope in the end, the power players who smugly thwarted the work of those who stepped up in earnest to vanquish this virus ultimately find themselves gasping their last in helpless, hopeless isolation.
I got a 50% on a calculus test once. I didn’t get $70 million dollars, I got summer school.
I knew it. The only way GILD was going make Remdesivir a self-fulfilling prophesy was to mix a third-party’s efficacious drug (Brilacidin) into the bolus. So now, there’ll be $5000 worth of inert ingredient plus some Brilacidin to make it work. Whatever it takes to bring a scam together..
“We have no IRS no SEC and soon no police. A wonderful world!!” Too true. I just supplied a copy of both sets of asset statements my former employer had me prepare in 2017.. the original true one, and the fraudulent one hiding nearly $300k from federal estate taxes. I even prepared a third statement to compare line for line in case they were bereft of calculator. Sent it to the whistleblower unit in Ogden UT, and the fraud unit in Fresno, CA last November. Rat bastards reneged on my commission on a fat contract, in case anyone wonders about my motive. IRS just sent me a letter: “We will not be investigating this matter. Decision final.” I swear, you can’t even spoon feed government.
“All Covid-19 Vaccines will fail” We pretty much know this. Question is, will even a fraction of Operation Warp Speed/Barda funds be directed elsewhere?
Oh, I don’t disagree!
“Make sure you set all of your shares to a day sell for $20.00 per share. Do not give others the ability to use your shares to short.”
I’m not convinced that’ll stop shortens from borrowing my shares.. I may be old school, but I believe the only way to do that is to literally be in possession of your share certificates. I actually requested this of Cellceutix via an email back in late 2015, and I ended up receiving a telephone call from Leo Ehrlich, asking me to withdraw my certificate request just before he launched into a diatribe against Rosen et al. In his opinion, there simply wasn’t any benefit to holding the certificates. I gave him the benefit of the doubt, and obviously continue to do so, but the incident still sits funny with me.
The lack of expression of ACE-2 in platelets does not explain the clotting issue. Ace-2 is expressed in the endothelial cells of the blood vessels, which now includes them as fellow targets. The disease injures vessel structures, and therein lies the catalyst for thrombocytopenia and thrombosis. I’ve got a good link here somewhere-
https://medicalxpress.com/news/2020-07-complications-covid-von-willebrand-factor.html
Agree with all, except grant. Don’t see grant coming, or at least not one that reflects the neighborhood comps. I’d love to have egg on my face, but whatever. That said I’m dumping all my Ino cash into IPIX on today’s news. Not thrilled in the least with the putz rate at which things are developing, but they are still moving in the right direction. Peer will move this to stupid heights.
Thank you Karen and Farrell re: interesting information on Brilacidin from the ABSSSI trial, which dosed via IV.
This was the data I was looking for. My CTIX folder on my 12 year old desktop closely resembles the shoebox I bring my CPA every tax season. I was indeed confusing the speedy PK of Kevetrin with the slower breakdown of Brilacidin. Please delete my post from earlier today if it lends to misinformation. Thank you for taking the time to ferret out the pertinent news releases.
Yes it’s about the science. The osmotic flow of money from the stupid to the clever. I’m sure there’s been some very heated exchanges over the unexpected incongruity between Gilead’s Remdesivir and Wuhan Virology’s SARS-CoV2. Things weren’t supposed to get this complicated, and we, being just another fly in the ointment, are being held at bay by Hahn and Fauci and the like so some very lucrative orders for an insipidly expensive drug that barely works can be filled.
Brilacidin levels clear the body in very short order if I remember correctly, though I’m having fits finding a citation, and cannot recall if that dynamic was topical, G.I. or systemic use. This was viewed/spun as a pharmacokinetic asset. Maintaining levels as prophylaxis shouldn’t be necessary, given how selectively SARS CoV-2 presents seriously. Most medical personnel would theoretically mount a correct natural response in the event of a PPE or hygiene failure. Those who do not mount a proportionate response would be treated accordingly, and should rethink their occupational exposure going forward. I’m familiar with the Brilacidin isn’t conducive to pathogen resistance talk, but I’m far from convinced of that. As Dr. Ian Malcolm so succinctly reminded us, “life finds a way”. I default to the judicious and targeted use of any antibiotic.
What’s the plan of continuity if our illustrious one-man-biotech comes down with Kung Flu?
More importantly, IPIX Brilacidin could be an excellent vehicle for the personal enrichment of the politically connected. Better even, than the thinner, less graft-worthy stocks of our competitors. A simple SP spread eliminates the need for complicated kickback schemes and corruption entanglement risks. You’d think Fauci would be on this like a hobo on a hamburger
“Our government is currently spending trillions right now trying to keep the economy afloat. A treatment that saves lives, and allows the world to safely open up, would be worth more than microsoft and amazon combined.”
The logic stands, yes, if there is no reasonable alternative therapy upon the horizon.. but there is. Publicized alternatives. Ours being one. In a sense, the governments federal and state have adopted a tunnel vision, which like an animal in heat, relentlessly tracks but one object: Remdesivir. The very name plays almost trance-like in my mind as I say it, because it’s become a buzzword among the painfully- non-biotechnically savvy political class. The target is and should always have been the swift and effective control of a pandemic. Instead, it has become “make thus drug successful, cost what it may, spin what you must.” They’ve practically reverse engineered the pandemic to suit Remdesivir, and potentially plowed aside salvation to that end. That said, I’ll retire to my dinner table, fully remorseful for my emotion-fueled rant, because, as you so aptly pointed out, there is logic contained in the emergency use designation, both humanitarian and economic. I’m still pissed though.
Pence/DeSantis “34,000 vials of Remdesivir being shipped to Florida”
Nice to see a such a formidable, state-sponsored order placed for a drug that is not approved for use in any indication. Am I still a tin hat wearer for pillorying this inexplicable and consistent lack of hurtles for Gilead Sciences?
Precisely. Who on the Barda board would just hand $400 million to a one-man OTC LLC with a virtual office, operating out of a briefcase in the back seat of his car in Boca? No one. I wouldn’t. The only way IPIX gets a mondo grant, in my opinion, is if BARDA structures it with BP partnership conditions, or subsidizes an outright private buyout of the intellectual property. I’m counting on peer review, not grant. Upon that, we see buyout.
Depends on the grant sum. Moderna received $483million or a vaccine many argue is a shot in the dark. Unlike our friends in the vax biz, we already have a safety profile on Antiviral/Antimicrobial/Antifungal and non-steroidal Anti-inflammatory Brilacidin thanks to multiple human clinical trials. A grant approaching anything close to the Moderna would mathematically add 80 cents to the existing share price, just doing cursory math in my head, but more importantly, it would instill a huge level of confidence in the compound, and speculation is what drives SP to stupid levels, quickly, just like our run-up to nearly $5 several years ago. Since that rally, we’ve diluted heavily, which would ordinarily preclude a repeat of that success, but for the acquisition of Brilacidin PMX30063 and the sudden good fortune brought us courtesy of Wuhan Virus, Inc. I’m tempering my expectations to $5, but there are far better analysts on this board who will fall well to either side of this. Anything is possible in this insane environment, including windfall or total loss of investment.
Unloaded 80% of my IN Oh at 30.08, watchin’ and waitin’ on weak hands to hand me one more bonus boatload before grant/peer day.
Excellent compilation. But sadly, FDA Commissioner Dr. Stephen Hahn was just on GMA, stating (paraphrasing) “but the other thing that’s different from earlier in the year, is therapeutics- antiviral Remdesivir and Convalescent Plasma”.
https://abcnews.go.com/GMA/News/video/fda-commissioner-speaks-record-high-cases-71572150
NIH's Covid-19 "Treatment Guideline Panel" is pretty heavy on GILD. Out of 53 individuals named in Appendix A, Table 2 of NIH's COVID-19 Treatment Guidelines Panel, Financial Disclosure for companies related to Covid-19 Treatment or Diagnostics, 13 panelists disclosed a financial interest in a Covid-19 Treatment or Diagnostic company. Out of those 13 panelists, 8 are vested with Gilead Sciences. No other pharmaceutical company even comes close in popularity. If anyone wondered why Remdesivir continues to be held skyward with such pageantry, despite its penchant for attracting blow flies in clinicals, this might make you question the objectivity.
https://www.covid19treatmentguidelines.nih.gov/panel-financial-disclosure/
This material needs to be grafted into Brilacidin / PMX 30063’s Wikipedia entry if it hasn’t been already. Anyone here a Wiki contributor?
My lovely Dr wife wrote White House yesterday asking if [their head was so far up Fauci’s ass that] they’ve missed recent developments regarding this viable anti-Covid compound that has emerged from the US RBL testing with 97% effectiveness against Covid in living human lung cells. Hey, at least we got an auto-reply, which is a lot more than any other gov’t agency does anymore.
Very powerful interests at work to keep this pandemic in place, at least through this election cycle. I can’t imagine there’s going to be any grease on the skids for a simple, cheap therapeutic that threatens it all.
Dexamethasone.. it’s downright embarrassing the drugs they keep championing. I disregarded the content after the opening line, “the leader of the W.H.O. clarified that...”
Sitting in the ICU burn unit of Shands at University of Florida since 5/23/20, watching over a 17 year old member of our family with 40% third and fourth degree burns covering everything from head to waist has presented multiple moments that SCREAMED for Brilacidin. Burn victims experience a cytokine storm, primarily of iL1 and iL6. Cortisol and inflammation are off the charts. Kidneys shut down and/or become damaged. Then infection sets in. Opportunistic lung, blood, and then the mother of all infections: FUNGAL stemming from the fertile ground of necrotic tissue that can run as deep as bone. This boy is fighting skin and skin structure infection. He’s fighting self-destructive Inflammation. He’s fighting Fungal infection from Candida, Fusarium, Aspergillus, and Mucor and the current standard of treatment is Amphotericin-B, which is highly toxic to the kidneys, even as the kidneys are already failing under the burden of fluid loss and decreased cardiac efficiency. The patient is often on dialysis before Amphotericin-B is administered. Fungal infection by itself in the case of Mucor, imposes a 50-100% patient mortality. For older patients, it is a death sentence. Brilacidin’s MOA hits on every one of these battle fronts. Every single one, according to the data we have. A drug Specifically designed for Skin and Skin Structure Infections, Anti-inflammatory, Anti-Bacterial, Anti-Fungal, Anti-Viral, and surely more tolerable than the current standard of care for fungal infection. The moment this drug breaches the levy, wherever that breach occurs, I expect a cascade of demand for it in every field of medicine.
Extraordinary article. Rare is the writer who understands there lies a yawning chasm between vaccine and therapeutic.
“Inflated ‘vaccine elephants’ dancing around” understated point of the month. The nauseating ignorance in reporting on the Covid effort has made me roll my eyes more than my teenage daughter. It’s not a vaccine that will address this, but a THERAPEUTIC.
The RBL is the DMV of labs. There’s a culture in government that is willfully obstinate, swollen with entitlement and will double down on those characteristics whenever pressure or deadlines are imposed. I doubt they’ve even ordered the culture plates yet
The highest concentration in these tests was 100ug/ml, which delivered 85% inhibition, which addresses nothing toward (1) what is MTD, and would the dose dependent curve continue beyond this datapoint? nor (2) time dependency and frequency of dosing: would continued dosing continue the inhibition curve?
Also, these tests are in vitro. There is no cytokine or chemokine activity. No macrophage response occurring in a test tube. Brilacidin is the lone fighter in the in-vitro ring. An in-vivo test, however, could be an entirely different dynamic, in which I’m betting Brilacidin would enjoy a symbiotic relationship with a governed host immune response.
Judging from every other govt office, the RBL’s are probably closed in observance of Covid-19. I’m sure there’s a logical explanation- carbon monoxide leak in the building could account for this also.
I don’t know, but if the Chinese didn’t already have the blueprint to synthesize Brilacidin, they surely do now.
Excellent find! First one that’s ever delved into the construction of our molecule!
Phase 2 or phase 3, all archaic contrivances of the FDA which has zero relevance in whatever room they walk into. This agency is a throbbing embarrassment of civil servant, Peter principle incompetence. The first pandemic in 102 years, and on Day-1, it outstripped their comprehension and capabilities like a Roadrunner Coyote cartoon. The president is watching Covid creep across his Oval Office carpet right about now. Hopefully he’ll get pissed enough to appoint a provisional agency of objective-driven competents to effect data-based results in real time, and relegate the FDA to amusing itself unraveling a roll of toilet paper.
Now, don’t get snippy and jump to conclusions. Vaccinations should be used judiciously, just as antibiotics. Should we just treat whole populations across the board with antibiotics prophylactically? We know how that panned out, which is a chief reason we’re all now invested in Brilacidin. Remember, you are altering the immune system in an accelerated fashion without long term studies as to the unintended consequences, therefore there must be a risk-benefit analysis. Is the disease of sufficient virulence to justify the estimated risk? With polio, yes. With varicella, no. Some adjuvants, like metals, accumulate in tissues, which is why the relentless pushing of flu shots is cringeworthy. I can hardly be classified as an anti-science or anti-vax when I have over a quarter million invested just in these sectors, but thirty years in Ag science, a field in which you can’t cheat nature (for long) has humbled me with objectivity and skepticism (30 years of using “safe and effective” chemicals like RoundUp”) have come back to bite me in the ass, such that I recognize that there are elements of this science that are, in fact, not settled science. I question things.. and I especially question anything which draws fierce objection to being questioned.
Seems a colossal wasted effort to vaccinate wholesale populations, whom, according to WHO (I know, I know..) up to 80% of those exposed do not present or do so mildly. “The (early April) WHO report found that “80% of infections are mild or asymptomatic, 15% are severe infections and 5% are critical infections”. Though we don’t know what proportion of that 80% were purely asymptomatic, or exactly how the cases were counted, it again points to a large majority of cases who are not going into hospital and being tested.” The natural exposure for that 80% was already the best vaccination they could hope to receive. I still see interventional therapy for that decisive minority of severe to critical potential cases as the brass ring- both logistically and economically.