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"tutes end up with more than 39.2%" Consider what happened to us during the first quarter of '24. RETT flopped sort of a flop. Price goes down. Mid March hit by AF and his merry band of shorters. And right on que LawSuits. Price goes down. But the Tutes numbers were up from something around 25% to 39%. Price continues to go down during 2nd qtr. We won't know Tute percentage until August 15th. I bet will be up from 39%. That's another rule that should be changed. I say give the Tutes 7 days after a qtr to get their 13F/D/G filed. These TUTES are lowering their AVERAGE PRICE PER SHARE. StateStreet avg 8.68 pps Vanguard 6.85 Geode 7.93 BankofAmerica 7.39 Schwab 13.90.
The FDA's rewrite of the ALZ rules almost look like Anavex wrote parts of it for them.
Tom, I thought for a while today my STINK BID would get filled. Didn't quite happen. We are UP On a Friday better yet with a short week on a Friday. What's not to like? Yes all of us wish the EMA was already filed and done yesterday. It will happen when it happens.
John k9uwa
This last sentence looks like an invitation to ANAVEX to file NDA pronto. The MAB they approved today is anything but safe.
"FDA Roundup: July 2, 2024
. Today’s approval is evidence of the FDA’s commitment to helping more safe and effective drugs to treat Alzheimer’s disease become available."
As to the RETT trials. The RETT caregivers parents etc are a very tight community. They all have their own media sources to get together. My daughter hasn't had a seizure in well over a month. My daughter climbed the stairs to the 2nd floor bedroom that is a FIRST EVER. My Daughter gets dizzy spell after her daily dose. My daughter has no dizzy spells and continues to have seizures the same as before getting into this trial. She must be on Placebo. Or a parent sees something that just might be an improvement and they broadcast that to all the others. In short order that trial was the same as an open label trial.
Someplace and I don't remember which trial it was in... Anavex said if they gave the pill / dose at bedtime the patient didn't have dizzy spells and actually slept better.
to Plex your question re: "Steady" he is one of our moderators. His first post to AVXL on ihub was 07/27/2016 04:47:19 PM. He replied to something Frol had commented about. Perhaps he like some of the rest of us migrated here from other boards... Yahoo etc.
John k9uwa
Hadn't read Kevin's comment before I posted last post. Both of us have like minds.
John k9uwa
"No surprise: FDA approves donanemab" Now the patients have a choice of which Brain Bleed Med they want to try. NOT. Read someplace that in Calif it was required to get TWO DOC's to prescribe a MAB. Your 100% correct The Bar is set VERY LOW!!
John k9uwa
Thanks Guzzi I bought some ANVS this morning shortly after the open. Sold it for +105%. Should have bought more.
Oh Well made for a nice day's gain.
John k9uwa
Institutional ownership. Anavex 38%, LLY 84%, BIIB 93%, SAVA 24% less shortly due to, GE 77%, WELL 96%, AXSM 83% + 17% insiders retail near zero.
John k9uwa
Thanks Tom if we again get to $3.80 or below I'll buy more shares.
John k9uwa
"1:00 PM EDT first big buy of Day" On the volume chart on the right on the Ihub page why is that trade a different colored vertical line?
John k9uwa
"clearance of waste from the brain" This makes me remember comments on some in trials with 2-73 that the patients got better sleep. Perhaps
that assists the disposal system for the nightly flush?
John k9uwa
"AVXL owners B/C CNS Bio-diseases" Look at the list that 2-73 and the updated drug 3-71 cover. And they keep adding to the list.
John k9uwa
"MM's are screwing over some sellers badly!" makes me wonder what the deal was with the 4.5M share sale at $4.07 pps. As Market On Close a week or so ago?? Inquiring minds would love an answer. naked Short Sale? by MM's?
John k9uwa
Hi Tred Yes and No. One can have a "Ham Radio Station" for a few hundred bucks. Or for considerably more bucks one can have a competitive "contest station." I built this station back in 1989 as a competitive "contesting station" Back then sometimes I operated the station as a "Single Operator" or as a "multi opreator" in long haul DX contests. Today usually my station is used by a younger Ham Radio friend of mine. In these contests I get the notoriety as "Station Owner" and Mike my "Hired Gun" operator gets his share of wins in the long haul contests. As to me operating my Ham Radio Station? 8 months or so of the year I operate it "Remotely" Yes an internet connection between ME wherever I might be with broadband internet and the station. For me the ancient analog type a real project to learn to setup and operate my station "remotely". So yes today I run the ham station with a laptop computer from wherever I might be... usually far south during the winter.
Back to Anavex. I do think we are approaching the "Finish Line" for approval of 2-73 and probably one of these days 3-71perhaps is better than 2-73.
John k9uwa
"You served in Korea?" Yes 1966-early 1968. I lived in Seoul S Korea. My ham radio callsign while I was there HL9KW. The "Kilowatt Watt" station from Seoul S Korea. Primary MOS was Saxophone player in an Army Band. secondary MOS if the you know who jumped the DMZ was Semi-Truck driver because yes I knew how to drive anything with rubber tires. I was really pissed off when only two weeks or so back home discharged from Uncle's Army the Pueblo incident and the attempt on the S Korean Prez happened. Wishing I had still been there. Many times while I was there I was relieved of duty to the band to run Phone Patches "telephone by ham radio" calls for our troops back to the US. Explanation .. Ham Radio contact from Korea back to USA and telephone from whoever we made good solid contacts with in the US back to friends relatives of the GI. I probably can't say today what was in the Trailer assigned to me to pull if U know who jumped the DMZ. Yet today I do like some types of Kimchi. But Adrian Cronauer many times back then listened to him on AFKN and yet today enjoy YouTube replays. "Good Morning "you know what comes next" We have a group of us Mil Musicians and an annual "Reunion" and I usually attend that function.
John k9uwa
You’re a Ham? Thank you for your service. Yes I am. Welcome to my backyard Ham Radio Antenna system.
please stop the "2015" every time you post?
Powerwalker I promise never to mention that year again. I am anything but a negative poster. I do think we are finally in the Home Stretch.
The Finish Line is within sight! 🏁 I don't hide behind a moniker. Put me into your favorite search engine.
John k9uwa
Alzheimer's Patients ADLs: The same with my Mother. She was allowed to stay by herself in her own home for the first 4 years or so after we knew she had Alzheimer's. I did have an experienced caretaker there at least 8 hours a day with her. Plus meals, A Nurse a couple times per week. After that my wife and I moved her into our home. And kept the caretaker and nurse as well. Her last couple years with us... sometimes I was ME... sometimes I was "My Dad" who had passed away some 15 years prior. And sometimes she would complain to my wife THAT THING YOUR MARRIED TO HE HAS TO GO. Yet some days or parts of days she was near normal as to memory as to who is who. It is a truly terrible disease. So yes no question about it ADL's for early patients make no sense at all.
Now you know why I am here. I searched all the early stage drugs back in 2015 in trial mode and picked Anavex to be the winner.
John k9uwa
"I’m not too excited for $AVXL being say an $8 stock again" Me either. As Leo and I discussed. More like end of Hurricane Season. Probably most here do not understand that comment. A bit more into the future. Watch Aug 15th when we the dwindling retail will finally see the TUTE totals for 2nd Qtr. Currently 39% as of end of first qtr. Should be increased by end of 2nd Qtr. If we hit $8 pps I will be happy but won't be selling any shares.
John k9uwa
"Presentation is only for 12minute" there are TWO presenters. BOTH end their 12 minutes with. "Stop by our poster and ask your questions."
together with our two presentations and manning the poster we should do quite well. Yes, keep the mic away from CM during both presentations.
CM can be present at the Poster. Let the Doc's our current hires answer the Questions at the poster area.
Have been here since 2015. Not likely to leave anytime soon.
John k9uwa
Check this LINK more than one presentation from Anavex.
https://alz.confex.com/alz/2024/meetingapp.cgi/Search/0?sort=Relevance&size=10&page=1&searchterm=ANavex
Plus I am sure they will have a Poster and someone there to man the poster to answer questions.
John k9uwa
"HOLD ON TIGHT" See This FLAG 🏁 That is the Checkered Flag. Finish Line is within sight !!
To Tred and others re: Pfizer ! All I can say is the wife's Heart Specialist said: "I am seeing lots of younger people with Heart Issues"
To Plex yes all of us wish 2-73 was approved yesterday. But we have to wait and watch. Keep in mind We went through most of 2017-2019 and finally we started
back up. Share price was down a $1.50 / $1.41 ... all that long drop I was loading the boat. Cashed out Feb3 and early Feb 4, 2021... boat is well loaded
again. If we went to zero I would still be ahead from all the previous trading. So yes patience one has to have.
Talon I also would vote MERCK for partner.
Thanks Xena posted the MOC orders and a few more. Hope it continues tomorrow. Somebody bought.
Wondering Tom if we will hold $4.00? lets hope so.
John k9uwa
"The facility must meet Good manufacturing practice" I would expect Anavex to pick a Mfg Co in Ireland. 847K shares trades with 50 minutes to go in normal trading hours.
John k9uwa
Pre--Market Last Price 3.94
Bid 3.66 100 shares Ask 3.95 25000 shares Volume 808
That 25,000 shares for sale was up at close afterhours on Monday.
looks like we opened up at $3.82 and around 20K shares volume on the open.
John k9uwa
Yes I see it! Patience Grasshopper
John k9uwa
"is 9 years of patience enough to qualify" Almost is my guess. Need to go for 10 years to get a new drug finally to market.
John k9uwa
"paid for nonsense ad hominem attacks" Maybe they pay some small flat price and then ADD ON a BONUS couple bucks per Emoji. Wonder if they get a RAISE if they make it to moderator?
John k9uwa
Hola LEO Yes, your system works for you. Me it was have position. price drops buy some trade shares.. continue to do so until we got a peak and sell the trade shares. Once I tried to go back through all the records and count just how many times I did that same thing. After getting through 4 or 5 years worth I gave up trying to count the peak sale times. I think your right End of Hurricane Season.
John k9uwa
pre-market price is showing at $3.70 Yes but only because the last sale trade of yesterday was someone who sold A SHARE yes it might have
been a 1 share sale for $3.70. Below is what currently shows as the Last sale plus Bid and Ask that are still there for tomorrow morning. Doesn't mean that is where we will start. New Bids will be placed well ahead of the open tomorrow.
Last price: 3.70 down -0.1800 down (-4.64%)
Bid 3.61 x by 200 shares Ask 3.95 x by 25000 shares Volume 930.58K
If you want to see how these very small bids take place go back a page of two in messages. Xena post a bunch of them a day ago. 1 share, 7 shares, 3 shares, 1 share ... Algo's buys and sells.
Borrowed my line I see.
Have been here since 2015 not likely to leave anytime soon !
John k9uwa
Hi Tom I agree. We will be stuck for some time to come. Today's ASM firmed up a few things. No Exact dates of course. It was interesting how the volume picked up near the end of today. Also looks like a 200K BUY MOC. I think the Tutes are still buying. We won't know the answer to that until 15th of August... crazy that they get 45 days after the end of each quarter before they have to file their 13 F/D/G forms. I think they should have to file monthly and do it on the 15th of each month. Two Cents More on my stink bid for today and I would have had a few more shares. I put the bid in at $3.61. should have put 3.63 and most likely the bid would have been filled. Yes I have enough shares. But $3.63 would have slightly lowered my average cost per share.
Working on building great grandkids College funding. Pretty sure back in 2015 I picked the right horse for this race.
John k9uwa
"I predict the market will be flat tomorrow" Almost all of us agree on that statement. All except TotallJones he thinks we will go down tomorrow.
John k9uwa
Yo Total me thinks your in for a real surprise tomorrow.
John k9uwa
Interesting very small bids. As Of 11:30 so market only open 2 hours.
Last price $3.66 down -0.0700 (-1.88%)
Bid 3.68 x by 900 shares
Ask 3.69 x by 1800 shares
Volume 140.75 K
Volume at 140K is very low for two hours after normal open time. Most Likely there is a BUG in our ASM
meeting this morning. As soon as they find out what happened in the meeting then perhaps we will either see upward or downward
shares trading hands?
John k9uwa
re: Ern and other super responders. A couple years ago I spent a couple days looking for followup information on the super responders. The only one I did find something on was the lady who wrote books. She did write a new book and had it published 3 years after that Television Interview took place.
John k9uwa
abew4me Your 2 questions are all that we really need answered. You hit it 100% for what is IMPORTANT.
Your 2 questions were:
"1) Did you apply for Accelerated Approval with the EMA?
2) If the answer is "yes" to the above question, then ask them ...what was the approximate date that they applied for Accelerated Approval?"
Thanks
John k9uwa
Thanks TRED Popcorn in hand for the last 1/3 of the movie!
Thinking back about our FDA How many of those advisors QUIT "took a WALK" when FDA approved first MAB. Black Box warning and the uptake has been very slow as most Doc's won't prescribe MAB. Comparing FDA to EMA, EMA wants Anavex to submit for full approval. Back someplace in our trial it was found that some had a dizziness and by taking the dry pill just before bedtime no dizziness issues and they slept better. Tutes increasing their shares. Now we have a Director buying shares. He now has a total of 5,000 shares. I own considerably more than he has. But at least he is a director buying shares. Anavex has posted info for mods to our FDA for their updated methods of dealing with ALZ. Sometime ago I read the FDA's proposed but not yet final.
We have several new members of BOD / Employee's who have great credentials.
Tom so far my "latest Stink Bids" haven't been executed.
We have one member who said YES he will attend the Shareholders Mtg tomorrow. Maybe they will actually give us some real news tomorrow?
LEO that is really funny about DR Horton. Sometime I'll tell you my experience with them.
John k9uwa
"It shows regulators are pressing hard to approve AD treatments. Oral Blarcamesine is effective, overall much safer than mabs." Add the fact that in parts of EU they do not have the required testing facilities that must be used with the MAB's.
John k9uwa
As a followup to my last post. That post shows the increase of Institutions who own Anavex Stock. This post take a look at some major Pharma companies and who owns their stock.
Start with Biogen 93% , Merck 78%, LLY 84%, JNJ 72%, PFE 68%, ABBV 73%, AMGN 81% And the same names Vanguard, Blackrock, State Street, Geode are in the top 10 owning those companies stocks. One of these days they will all own large percentage of Anavex.
John k9uwa
Lets ADD to what Red said: First comment a few of us posters to Ihub who complain about our CEO won't mean Beans when it comes to voting our shares. Next part. Institutional ownership increased from around 30% to 39.24% DURING the first quarter of 2024 Jan1 through March 30. During that time our price dropped $6 to $4. Also in Mid March the Ambulance Chasing Lawyers and Adam Fartstain came after us with their hope of a lawsuit. These same law firms and Adam did exactly the same thing to us several years ago.
Those institutions 200 of them kept on buying. State Street Corp owns 7,299,007 shares. They bought OVER 50% of those shares during the first Qtr of 2024. Their AVERAGE PRICE is $8.68 per share.
Blackrock Inc owns 6,645,538 And yes during 1st qtr they sold off 25,000 shares a mere pittance compared to thee 6.6M they own Their average PPS is $7.32.
Vanguard Group INC owns 4,414,682 and they bought 54,034 during the first qtr of 2024 Average Price is $6.85
GEODE CAPITAL MANAGEMENT, LLC owns 1,712,727 during 1st qtr they bought 47,363 shares Their average for all shares $7.93
BANK OF AMERICA CORP owns 851,128 shares During the 1st qtr 2024 they bought 646,190 yes 3/4ths of what they own bought last qtr avg price $7.39
Now something interesting about all 4 of these companies. State Street, Vanguard, Geode and BAC have OWNED ANAVEX shares since Q4 2015 Blackrock first bought Anavex Q2 2016. Those five own 24.4% of Anavex. The other 190 institutions own 15% of Anavex.
I also have owned Anavex since 2015. And yes us RETAIL still own or did own as of 30 March 2024 60% of Anavex. There is a good chance that end of 2nd Qtr the Tutes will own considerably larger percentage of Anavex. They are not looking for a couple dollars per share payday. Many of them have price averages in the 12 to 15 bucks per share range. None of them are here to gain a couple dollars per share. They know where Anavex is going and they will stay there until they get a drug or drugs approved. So who is buying these days? Smart Shorts buying out of their short position. Smart Institutes buying in and those already here buying more shares.
Those institutions have a lot more ability to find out about a company than the whole collective bunch of us on I-hub and ST.
The Source of the above numbers is Whalewisdom https://whalewisdom.com/stock/avxl If those Institutions wanted Missling gone then he would be gone.
Another interesting tute. CITIGROUP INC First into AVXL Q2 2016 they have 571,645 shares. They bought 468,957 of those shares 1Q of 2024 That is nearly a 500% increase in the shares they hold.
The majority of these 200 institutions are sure that Anavex will bring a drug to market. Otherwise most would not be here. They are increasing their ownership in Anavex. Sorry they don't have to file their 13F/D/G's until 45 days after the end of the Qtr. Some will file early by mid July you will see a few of them reporting.
I'll take the silent word of these Tutes over the bunch of Fudsters on Ihub ST etc. For those who think Missling could care less what the price is of Anavex Stock.. think about this. He owns 1,250,210 shares. At $4 thats 5M. If the price goes to $40 as predicted by a couple analysts then his shares are worth 50 Million. As to WHEN this will happen? Don't ask me... I say it will be in Due Time. Many of us want it yesterday... we have friends relatives and would like to see it happen for ALL the patients of CNS diseases.
John k9uwa
Pe-Market this morning 9:28AM
Last price: 3.8203 up +0.0703 up (+1.87%)
Bid price by size 3.82 x by 24400 shares
Ask price 4.00 x by 300 shares
Volume 620
Looks like the buyer for 24400 shares got their shares. 9:33AM
Last price: 3.79 x 100 shares, K up +0.0400 up (+1.07%)
Bid price 3.72 x by 1100 shares J
Ask price by 3.80 x by 300 shares Q
Volume 37.28K
9:35AM only 2K more shares bought and price dropped to $3.72
volume 39K shares
at $3.73 I bought a few more shares
John k9uwa
"FDA gave Lilly unanimous approval" My Brothers friend who's wife was in the Biogen test. She is past her 18 months with some slowing. Now she is going downhill rapidly.
John k9uwa
Hi Xena
direct from my broker as if I was about to place an afterhours bid. I thought about it.
17:50 Afterhours...
Last Price x Size / Exch
Last price: 3.7384 up +0.0384 up (+1.04%)
Bid price by size 3.68 x by 1100 shares Ask price by size 3.74 x by 200 shares
Volume 2.00M
No phone call to me from Anavex. I already voted. Voted NO on a couple items.
John k9uwa