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Kiwi, EPA
Omega 3 Index Test
5/27/16
EPA = 7.2
AA = 6.7
Cheers, Hypo
Kiwi,
Started V in May 2014 but no prior tests.
May 2015 = 1.35
May 2016 = 1.08
Cheers, Hypo
Invest,
An interesting link below of those countries who have universal healthcare. Having worked in 18 of those on the list and many more I have had some experience with their systems. That small experience was always favorable.
Since your comments have raised my interest I'm going to contact some of my friends in Europe and Asia for their healthcare experience.
https://truecostblog.com/2009/08/09/countries-with-universal-healthcare-by-date/
On a separate note, I suggested that a friend in Germany have his wife try to have her doctor to prescribe Vascepa for preT2D and colon issues. The doctor had no knowledge of V nor was there an outlet found.
Cheers,
Hypo
Dude: Excellent Input
You are another confirming case for EPA.
Cheers, Hypo
Dry Eye Syndrome, a 2015 presentation
My Opthalmologist handed me an article last week that contained this reference. I have been urging him to test Vascepa on his more severe patients w/o success. But when he read an article in a CME publication from UFL that referenced a presentation by Dr. Donnenfeld the attitude changed. He knows Dr. Donnenfeld personally thus Dr. Donnenfeld carries a little more weight. In addition, his wife has very severe Dry Eye problems so there was a personal reason for a test close to home.
Cheers,
Hypo
____________________________________________________________________
http://ophthalmologytimes.modernmedicine.com/ophthalmologytimes/news/re-esterfied-omega-3-fatty-acids-effective-dry-eye?page=0,0
__________________________________________________________________
San Diego—Oral consumption of re-esterfied omega-3 fatty acids (1680 mg EPA and 560 mg DHA) once daily for 12 weeks is “an effective treatment for dry eye disease,” said Eric D. Donnenfeld, MD.
"Oral omega-3 supplementation is one of the foundations for the management of meibomian gland dysfunction and dry eye symptoms," said Dr. Donnenfeld, Ophthalmic Consultants of Long Island, New York.
More in this issue: Femto safety not guaranteed by adequate suction
Dry eye is the leading cause of meibomian gland dysfunction, and oral nutrition is considered a primary therapy, he said.
Dr. Donnenfeld presented data from a study that assessed the effect of oral re-esterified omega-3 fatty acids on tear osmolarity, MMP-9, ocular surface disease Index (OSDI), tear break-up time (TBUT), Schirmer's score, corneal staining, and omega index.
“Looking at osmolarity has become the lynchpin for dry eye,” he said.
By week 6, there were already statistically significant differences between the treated eyes and the placebo group, and by week 12 even more so in all study parameters, Dr. Donnenfeld said.
With MMP-9, “there was a large trend change from baseline in the omega-3 treated group,” he said.
TBUT changes were statistically significant by week 12, he said, and OSDI symptoms were reduced by 17 points in the omega-3 group versus 5 in the placebo group by week 12.
pril 19, 2015 By Michelle Dalton
The omega index measures omega levels in the plasma. At baseline all patients were in the 4s, but by week 12, those in the omega-3 group had improved to 7.19. The goal is to have a level around 8, he said.
“That’s when the magic happens, when you really start getting the benefit of omega-3s,” he said.
In case you missed it: Treating dry eye with intense pulsed light
Specifically, mean tear osmolarity improved from 326.0 mOsm/L at baseline to 317.7 mOsm/L at week 12 in the placebo group and from 326.2 mOsm/L to 306.9 mOsm/L in the omega-3 group (and this was statistically significant beginning at week 6, Dr. Donnenfeld said).
Likewise, the OSDI improved from 27.1 to 22.0 in the placebo group from baseline to week 12, and from 31.4 to 15.5 in the omega-3 group from baseline to week 12, reaching statistical significance by week 12. TBUT improved from 4.61 to 5.81 seconds in the placebo group and from 4.78 to 8.25 seconds in the omega-3 group.
Dr. Donnenfeld added there is a difference between triglycerides that have been re-esterfied and ethyl esterides. This study did not evaluate the difference between the types of omega-3 fatty acids, but used one company’s re-esterized triglycerides.
Four companies currently sell re-esterized triglycerides, but not all patients can afford the name brand. During the question-and-answer session, Dr. Donnenfeld suggested physicians recommend 2 to 3 times the recommended dose for the non-name-brand versions.
"The advantage of using a re-esterified triglyceride omega-3 fatty acid is that the omega-3 maintains its natural triglyceride structure which can be easily metabolized and absorbed,” Dr. Donnenfeld said. “Greater bioavailability translates into greater physiological value.”
Although specific data were not presented, Dr. Donnenfeld said fluorescein-staining scores were also improved.
Also, “internists think there may be bleeding differences in groups that are using supplementation, but I have not found that,” he said.
Raf, Nov 2013 and 4 gms
Raf
Started Nov 2013 and 4 grams
JL: EPA/AA ratio
When I read your post I thought it would be interesting to post my EPA/AA results for 2 tests.
Test 1: May, 2014 Units are hard to read, I interpret as Micrograms/liter
EPA 272
AA 202
Ratio 1.36
Test 2: May 2016 Units given as range results vs referenced ranges
EPA+DHA index - 8.7 Classed as high
O6/O3 Ratio - 2.1 Classed as low
EPA/Arachidonic Acid Ratio - 1.1 Classed as high
Arachidonic acid - 6.7 Classed as In Range
EPA - 7.2 - Classed as high
DHA - 1.6 - Classed as In Range
From these data is appears my ratio has declined over the ensuing 2 year period.
Perhaps this data will be useful to others on this board.
Cheers, Hypo
BC. I think that Amyris Inc could develop an algae, if not already developed elsewhere, that would perform well for producing EPA. They certainly have the skill set to suit the need.
Cheers
JL, What is the Positive source which causes a negative electron charge at the surface of the vessel wall? I have a very specific reason for the question.
I know this is off V subject material so you may answer to hypochlor@yahoo.com if that is preferred.
Cheers
JL....
What a marvelous timely discussion!!
Cheers
Jl,CouldBe,Dancing
Thank you for the input. My wife went under an ophthalmologist's care as of Friday so we shall see how that progresses.
Blepharitis Inflamation - Help Anyone
My wife has developed this malady and is having tough time getting it under control. Since it is based on eyelid inflammation it seems plausible this problem would be treatable with Vascepa as is the case with DES.
Outstanding post. But are the shorts paying attention?
Whally
I second your motion. I have to believe there are many others who share our opinion.
Cheers
JL, An excellent question given it's potential.
Cheers,
Hypo
BC and all, AA/EPA Ratio, Plasma
I used Quest Diagnostics.
Test Code: 17864
CPT Codes(s): 82491, 84999
Cheers,
Hypo
BC – AA/EPA ratio info
I had this test done in May, 2014 shown below. I am taking 20 mg simvastatin and 4 gm Vascepa. Data review over time also shows a 30% drop or so in TG’s after some time on V. Background:
A) During my May, 2013 lipid check with Dr. Mark R. Goldstein, a lipid specialist formerly with Cleveland Clinic, Vascepa was discussed. We agreed to add Vascepa to my lipid control regimen (2gm early morning and 2gm in the evening at dinner) and reduce the Zocor dose by halving the 40mg tabs to 20mg. I also discontinued the daily baby aspirin.
B) Lipid data range for 2 tests post Vascepa, test 1 at 6 weeks from start, test 2 was 5 months from start and the last is current.
a. Test 1
i. HDL – 59
ii. LDL – 102
iii. Total Cholesterol - 173
iv. Trig’s – 60
b. Test 2
i. HDL – 59
ii. LDL – 97
iii. Total Cholesterol - 165
iv. Trig’s – 43
c. Test 3 – May, 2015
i. HDL – 56
ii. LDL – 100
iii. Total Cholesterol - 164
iv. Trig’s – 42
• EPA tested at 272 micromol/L
• AA tested at 202 micromol/L
• Sorry but I have no AA/EPA reference before the addition of V to the regimen.
Cheers
Thanks
JL, A Question
Do you have a sense of the test and approval time for the EPA that PHOTONZ would supply?
Cheers,
Hypo
CJR, Joint Pain
CJR, I have been on V since mid-May 2013. I am 75, play tennis 2-3 times per week and experience no joint pain. That was not always true. When I was maxed out on Simvastatin there was some joint pain and muscle cramping. I now have none of those issues having been able to reduce my Sim to 20 mg dosage while on V with no change in Lipid profile. I posted that data back in the June time frame.
Cheers, Hypo
Bio & JL,
I do not recall any specific anti-inflammatory data that would be applicable for their label. Have I missed it?
JL, Dramatic unexpected personal results have been my experience as well!!
JL, Statin reduction
I can say this, when I started on Vascepa in May 2013 I was taking 40mg Simvastatin. When I began the Vascepa regimen my doctor and I agreed to reduce the statin to 20mg. The result was that my cholesterol numbers remained within a range of 165-175 so the prospect of synergistic behavior seems realistic. Cheers
ZMAN, Thanks for that.
JL, thanks for your comments. Golf, well...
I will follow your suggestions but I'm a little confused since well masticated food is nearly as finely divided as that in a smoothie. Seems to me the sugars in either case would be extremely similar in digestion rate. There is protein powder in the pantry, just have not started using it as yet. Butter is no problem.
Golf, I live on a Pete Dye Protégé course. More than a few have quit this complex because they felt defeated. My handicap is 19 on tees with a 119 slope at 5100 yards, at 75 that's ok. Everything here is shot placement and course management. Its easy to lose a few here between the water and the Palmettos
Cheers
Hypo's diet
My diet is generally as follows.
Breakfast is a smoothie of Oatmeal, yogurt and fruit, generally blueberries and a couple of slices of toast with margarine. A lot of coffee 4-5 cups. I do not use protein powder at the moment but am researching this addition.
Lunch is generally a sandwich of multigrain bread, tune or salmon mixed with yogurt, onion etc. with a cup or 2 of green tea.
Dinner is will be red meat 1-3 timss per week, 4/5 oz. portion and fish, seafood or chicken the other nights. All are with salad or steamed vegetables. We also add curry to many of these dishes, lunch and dinner. The key facet here is small portions brought to the table.....no seconds. The beverage is a glass of wine or a beer, if no alcohol then English Breakfast tea.
Virtually no dairy but for the yogurt while seldom more than 1 egg per week. Red meat is restricted, almost no beef or pork but a little lamb, an Aussie wife's influence.
I think key facet is that I get a lot of exercise, doubles tennis 3 times per week, 2-3 hour stints,and a minimum of 4 rounds of golf per week...cart golf that is. Walking is restricted to going to your ball when your cart mate is looking in the bushes!!
I hope this helps.
Cheers
I had my EPA-AA ratio checked with my last blood work in May.
Data:
EPA = 272
AA = 202
Chol Ratio; 3.1
Chol total: 173
HDL: 56
LDL: 106
Non HDL: 117
Trigs: 55
Meds daily for the past year:
20 mg Simvastatin
4 gm Vascepa
I have no AA/EPA ratio history as this was the first test. The cholesterol figures are nominal for the last 5 years.
I trust this is what you are looking for.
Cheers
JL,
I see no reason to elaborate further than you have outlined on the site. One page is all that is necessary. Then contacting a few in their association to expand the word.
http://www.aao.org/member/related/state_directory.cfm
JL,
It seems we should be contacting the association.
http://www.aao.org/member/related/state_directory.cfm
A presentation, mailing or finding a few in these associations who grasp new technology at the start.
JL, Do you have 3 bullet points that you would present to a site designer? That would be the start of an initial site design outline.
Interesting!! My very competent eye doc has the same closed mind for his response was similar. Guess we have to find those with more interest in the problem.
I am surprised there are no ophthalmologists on this forum able to assist in beginning the initial move forward.
Done! Thanks. Don't know why I couldn't get on before.
nofanofthis
Have you recommendation links?
Have you recommendation links?
I suspect diet is the difference on the HDL numbers. Thanks for the suggestions on the Rosacea issue.
Cheers
My 5 mo. V experience
History:
a) 74 years of age
b) Active, tennis or golf 6-7 days a week
c) Family history of high cholesterol; father had triple bypass, cholesterol > 400 mg/dl
d) I was cholesterol tested after my father’s triple BP in the mid-70’s: I had 350 mg/dl total, began jogging
e) Began statin treatment 1989, Mevacor, to Lipitor, to Zocor, dose rate from 40 to 80 mg on these. High dose Lipitor and Zocor gave muscle cramping problems.
f) Lipid data range for the last 4 years on 40 mg Zocor
a. HDL – 53-64
b. LDL – 82-101
c. Total Cholesterol – 146-174
d. Trig’s – 42-85
Present:
A) During my May, 2013 lipid check with Dr. Mark R. Goldstein, a lipid specialist formerly with Cleveland Clinic, Vascepa was discussed. We agreed to add Vascepa to my lipid control regimen (2gm early morning and 2gm in the evening at dinner) and reduce the Zocor dose by halving the 40mg tabs to 20mg. I also discontinued the daily baby aspirin.
B) Present Lipid data range for 2 tests post Vascepa, test 1 at 6 weeks from start and test 2 was 5 months from start.
a. Test 1
i. HDL – 59
ii. LDL – 102
iii. Total Cholesterol - 173
iv. Trig’s – 60
b. Test 2
i. HDL – 59
ii. LDL – 97
iii. Total Cholesterol - 165
iv. Trig’s - 43
C) Physiological changes
a) Dry eye; My left eye had sufficient irritation to cause me to use “No More Tears” use 2-3 times per day; changes began within 2 months after starting Vascepa. That problem is, for the moment, history.
b) Rosacea; I have been fighting Rosacea on my nose for over 3 years. My dermatologist gave me Sodium Sulfacetamide (SS) to treat the small “blisters” that occur topically. This does not rid you of the affliction. After Vascepa use for about 3 months the incidence of blistering began to abate. That condition seems to have stabilized where I have rare minor topical treatment requirements.
c) Muscles and low back; Sore muscles and back stiffness have been standard morning fare for several years. The low back problem is a disk that will eventually require attention. These aches and pains are not gone but I would estimate an 80 to 90% soreness reduction.
The above data points to the value of Vascepa for me.
Cheers,
Hypo
Prescription growth...
Applying a linear regression projection to prescription growth using the data March through June as seen on SA from "Quoth the Raven" suggests a target by year end of between 8,000 and 10,000 prescriptions per week. The data population is sufficient to have a reasonable confidence level.
Atlas,
I'm assuming the chart is an Excel sheet. If so, would you put in a linear regression average and extend it to the end of the year. That would be a reasonable extrapolation of the Script growth rate without accounting for any acceleration over that time.