Tell frrol to produce the evidence that ORs were endpoint measurements.
Or better yet... why don't you provide it?

Then please provide the evidence you claim exists.
I believe you're wrong about this. Nothing I've read or heard supports your claim.

My point is that frrol makes false inferences... just like his buddy, Investor, does routinely.
Just because ADL mean score wasn't provided, doesn't suggest it doesn't exit and isn't significant.
Endpoints were met, as the company continues to reiterate. It's only the FUDsters who deny.

There is no evidence that ORs were used as endpoint measurements.
They were included to highlight the strong responders.

Those wanting to see a list of paid FUDsters who reside on this board, just look at the 'Like' list on this baseless post...
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=172839022
It's not the complete list, however.

Your post is full of misinformation and opinion. For one, you have no evidence to prove your statement...

Ignore the FUD nonsense about "changing endpoints". Endpoints haven't changed.
The ORs were supplementary information identifying the strong responders who functionally improved. There is no need to re-present them again.

The Sept 14 PR not only drills down further into the ADAS-Cog and CDR-SB data, but also reveals key biomarkers that will be instrumental in gaining AA... with current OLE (~450 patients) serving as the confirmatory trial.

These surrogate biomarkers provide objective and irrefutable improvement measurements compared to the somewhat subjective questionnaires.

And what about the lack of cupholders? LOL

Don't count on it. The collusive AF Cabal prides itself on smearing any and all truths and ramping up the FUD narrative with more lies in providing cover for coordinated short attacks. I've seen it happen to other biotechs with excellent peer-review articles. It's how these criminals work.

LOL... you've been flagged, a long time ago.

It was also determined that bedtime dosing was a solution for most patients. And, over time, the AEs would diminish.

Why would one reference an obvious paid-for hit piece in SA with made-up untruths? Be an investor!

Simple... because the hired FUD has to be called out.

The gains were over identified IMPROVEMENT thresholds, not just baseline.

Excellent article on an AD website... should gain some significant attention.

FUD analysis only show up in paid-for hit pieces on SA. An obvious sign of corruption.

Glad you're finally coming around and seeing the light of reality.
Does that mean your handlers have hit their low SP target price and it'll begin to rise now?

This, however, remains a false statement...

This...

You're really talking nonsense. I wish you'd cut the crap.

The SA article is nothing but a made-up paid hit piece from one of Fraudstein's underlings.
It's full of untruths.

Pure BS FUD as usual from you.
ORs were never endpoint measurements; they were strictly supplemental to highlight the super responders.

So stop with the bullcrap.

You may be right and I had the term slightly skewed. Although the meaning is the same.

There most likely are patients scoring very high on 50mg. It's just not broken out yet.

Missling has stated that 30mg produced as good of results as 50mg for most patients, especially the WT genetics. It's why the data remains pooled... and is great news! Though, we should see subgroup results in the peer-reviewed journal.

Lots of FUDsters (cabal soldiers) jumping in on that hit piece article with nonsense FUD comments.
It is truly laughable the amount of effort being applied to attack a company that's about to offer the next SOC in Rett and AD.
The HF cabal hire a ton of flunkies to carry out its mission.

Yeah, that seems to be the common collusive HF script, supported by their FUDsters... knock it down as long as you can... until NDAs and approvals.

In this case, as in most, the FUD shoe fits. It's why you showed up today.

Did you think your FUD here would get less flack than your FUD on NWBO?
You took quite a beating over there.

Would a doctor believe that only certain parts of the brain could be sustained by beneficial S1R activity, but not other parts? It would seem to me that the brain would be uniformly affected.

"Changing endpoints" is lying FUD!

I believe Hoskuld's remark about Cog over ADL has to do with its less subjective, more reliable, measurement... either one remembers something or they don't.

ADL is much more subjective and can vary daily. It is also more influenced by placebo effect. Therefore, in a short 48-wk trial with mild-moderate patients there's likely significant "noise" around baseline and below. For that reason, the Odds Ratios were introduced to highlight those who significantly improved, over placebo, if the mean score difference might not have been as robust. There's also the ceiling effect associated with ADL measurements.

It wasn't for you, Wolf; I have respect for you.

Hey FUDster, the endpoints haven't changed one bit! The latest PR is a further drill-down on the original endpoints... as well as the identification of key biomarkers. Missling alluded to these biomarkers earlier in the year... now presented.

FYI, the ORs weren't endpoint measurements... they were supplemental.

The likely outcome of these results is that AA will be granted based on the biomarkers and endpoints, together, with the current OLE becoming the confirmatory trial.

You left out the word "hit". LOL

You don't know that "super responders" was a term used years ago by Missling to describe some of the patients' improvement on blarcamesine?

The Odds Ratios gave us an indication by how many over placebo... >3x (Cog) and >4x (ADL).
I think the FDA is also surprised by those numbers.

Don't you worry about the Rett results.

Dream on...
Or be an investor!

Indeed they do. Easier money for a doc to be a highly paid expert FUDster, than actually practicing medicine. Perhaps his retirement plan.

All of today's FUD postings this morning was nothing more than to provide cover for a planned takedown.

You do know that these FUDsters are all paid to be here working for a collusive HF organization... right?
It's no secrete.

FYI... Anavex will be granted approval in both Rett and AD next year. The ongoing OLE will serve as the confirmatory trial (as Missling mentioned) in the AA pathway. Mark it!

It's too funny to see you jumping in here all of a sudden with some sort of instant "expertise" on the subject. LOL
IGNORE!

REPEAT: They have not dropped the Odds Ratios! Only a FUDster would make that ridiculous claim.
The ORs are still valid in highlighting the Super Responders!
Your tripe is getting rather old.

LOL... still measuring himself by his parents' approval. Too funny!