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I'd beg to differ with you. He didn't take his eye off the prize, just found a faster way to claim that prize. Say he did the Alz trial first. He would be at the mercy of continuous relentless shorts and attacks by take your guess. By starting Rett and/or Parkinsons before Alz p2/3, he is loading up for a nice one two three punch if data comes back positive.
Imagine announcement of Rett, then Parkinsons some time later. Then Alz would follow. By the time the news wears off that 3 trials are running, time for p2 results for Rett and/or Parkinson. Then if those trials are positive, off to p3 all the while the alz p2/3 steadily closes in on 6 months.
So again, eye off the prize? I dont' think so. Just adding up those smaller bears to get that one big bear that he really wants.
All IMO. By the way, what was the results of the voting?
Lol, most people that bought 2-3 years ago isn't negative. Try again. That's a FACT. And they most definitely are VERY comfortable with the position they have
Anyone look at the filings lately? A lot of put and calls placed by one co.
https://fintel.io/so/us/avxl
Lol Tom, looks like an art piece from my 1st grader. How you interpret that is amazing.
No!! You won't get me to sell my shares. Try all one wants to influence our board, but I'll take our CEO, the Anavex board, and their plans over an anonymous poster trying to make loud noise.
Everyone is entitled to an opinion, mine just happens to not agree with yours.
Note:
I am a true long and will continue to hold as long as it takes.
Do you have proof that its NOT? As of the PR, it stated it wasn't for that, but who knows about the future. Speculation is great isn't it.
I always have a question go unanswered
BP cares nothing more than to screw over small bio over a new approach to a disease that looks promising. Just because the CEO is preparing his company for such a threat isn't a bad thing. Im sure he knows how it works and how to combat against such an act, being that he has the prior experience at a previous job.
So yes, better to have a poison pill in place before the data release and trials start, rather than later when its too late and you're left packing your office up because you've been replaced.
If only you thought of a poison pill BEFORE......
I'm willing to lose the shares I have by waiting and seeing how this game is played.
Exactly. So end of story about another trial in another era. Only thing to do is hold if you believe in the science and sell if you don't. Only a p2/3 with 300 patients with a placebo and.......yada yada yada like the one being designed will prove if it is better than SOC.
Can we please keep the topic AVXL, not other failed trials almost a decade old.
It isn't a subset that has continued the P2a trial for A-273. The ENTIRE group wanted to continue taking the drug.
that sounds NOTHING familiar like what was in bold
subset of a few dozen patients with early-stage, mild Alzheimer’s, who had taken Flurizan for an extended period of 24 months, showed significant improvement. Largely on that basis the Phase III study went forward.
Another ANTI-AMYLOID fail. Whats the point? Trying to connect the dots and say 99% of trials fail, so Anavex will fail?
Translation= Reducing Amyloid plaques WILL NOT benefit an Alzheimers patient over time.
How in the hell did Ph3 fail? HAVING THE WRONG TARGET
Report as in livestream? Hopefully we all go into the meeting with an open mind and no expectations.
So bottom line would be Rett and MJFF has better qualified professionals than OP, who always seems to make one assume that Anavex has NOTHING better than SOC for Alzheimer's.
Like those that did DD would sell just because someone on a message board is thinking what's best for us shareholders.
I'm sure a sell off WONT happen, let alone hit any part of the 2's.
Glad to see you back doing your thing. Good things must be right around the corner.
No wonder the Dr. wants a shareholder rights plan. He needs retail to hold so no one threat can own majority stake.
I'd bet a lot of shares would be sold as we started hiking up the mountain, giving just that scenario a chance.
Truthfully, I'm not selling because I have my core in my 401 and have a good 25 years before retirement.
All the conspiracies being made up is truly hiarious , especially coming from those few "longs".
Just remember, any other CEO in charge and BP would have already got what they wanted.
Impatience isn't what got Buffett his Billions.
If there's new data, they would have to PR it in the morning or before its revealed I believe.
Yup, some even plan to wait a decade or two. What's worse, spending thousands in getting the word out or BILLIONS on a trial that ends with ub knowing you have no chance of the drug besting placebo?
Lol 4.6x for the NEW soc?
I'm locked, loaded, and patiently await the Dr. to lay his hand down.
Anavex has the potential to do something NO other BP has done, and they've been trying for 10-15 years. Billions and billions of dollars spent with nothing more than 5 weeks of pushing off the inevitable. Along with a bunch of side effects.
Trying to discuss anything besides the science as a negative shows where one stands. Missling said no issues with patent, I believe his word. Investing, not trading, in a company requires a level of trust from the company and shareholders.
Nothing besides negative news will make ME doubt my investment.
No news on data this week? That's fine. When it's ready it's ready. The plan is in effect and for some reason shareholder rights is now important for us.
Good luck Longs and Believers.
That doesn't sound like a true long. 10:1?
Any BP that misses out on a partnership with AVXL will miss out on a potential drug of the century.
Not pumping, just open ones eyes and realize how many people would be taking medicine for multiple reasons.
Bottom line?
BP needs us more than we need then. Blink? And Missling would gladly phone Asia and see if anyone is interested in a partnership. All IMO.
Comic relief . Thanks for the laughs this A.M.
If they get approval for one, chances are pretty good for more
Better than BIIB chance of an Alzheimer's p3 success.
There is a debate because:
1. There is no scientific angle to attack against.
2. Desperate times calls for desperate measures.
3. I've noticed double standards against Anavex for a while now.
This is wrong for them to do while other BP does the same thing.
Oh my, TAXES now.... Lol, lets go after those 5 gallon water bottles that they refill every week next.
Good to see you still hanging around JBG. Good luck to you with your trades.
Back that up with the data please. Links. This was discussed before as most of his compensation is in the form of stock options at different levels and prices.
I hope to see Missling follow through with his vision. Hate to see some BP schmuck get all the credit for the last few months of work on a-273.
I think its the understanding of the difference between 5% and .05%
5% is .05 of all shares. I believe its what eagle was trying to say.
Whats the chances of having .049 AND having a load of call options to increase their % even more?
I could see the pps increase above their strike just to exercise their calls.
That's what I took it as. Shareholders could exercise their right, right being 1 share of the pre-required day, to purchase a share at a set price the board approved.
Maybe because they want to be sure to get it designed right. If one wants quick trials, I hear NTRP should be ones huckleberry.
This will be one smooth running BP if they are given a chance to mature. Top notch CEO and a board that does what's best in the interest of its shareholders.
Its actually from the latest pr.
I believe that Missling is preparing the company to defend against one though. Maybe there was an offer and he turned it down knowing Anavex is worth a lot more. So as a precaution, this is in play as well as the Shareholder rights plan.
Imagine this scenario:
Biogen tested our drug and found it to work better than their own MS drug. On top of that, Biogen knows that their Alzheimer candidate is inferior to our drug. So why would they license MS, leaving the other cash cow available for someone else?
Then theres Axon and their ceo and hedge fund crooks. They seem to have the resources to launch a take-over knowing how much spent now would return to them later in multiples.
Lakeshore, I believe the date was feb 17
I got mine for Fidelity and Robinhood. Voted already, but will mail in my vote anyway.
Whats the point?
People don't survive Alzheimer's disease. So imagine how much people pass away before even reaching 85 to meet that statistic.
Taken from the same Alzheimer Association is this:
• Every 66 seconds, someone in the United States
develops Alzheimer’s.
• By mid-century, someone in the United States will
develop the disease every 33 seconds.
https://www.alz.org/documents_custom/2016-facts-and-figures.pdf
page #22
A confirmation that we may be on to something with our pipeline.
First, read THIS, which was published 3 days ago:
"Abnormal levels of calcium in the mitochondria, the cell’s powerhouse, may lead to neuronal death in Alzheimer’s disease and dementia, according to researchers at Temple University’s Center for Translational Medicine"
A topic at ADPD, "CALCIUM STORES IN ANIMAL MODELS OF AD" which will be discussed by Weizmann Institute, which is where Dr. Fisher works and where we got A-371 from. HERE
"Extensive research in the past two decades has focused on amyloid plaques in Alzheimer’s disease (AD) patients, suggesting that their removal will stop/slow the disease process. Despite increasing past and present evidence, these studies neglected to address the possible involvement of calcium handling machineries in the initial causes of functional and structural deterioration in neurons, associated with AD"
A-273 also relates to the below pr if one just read the entire pr vs what is quoted below.
Then, in a pr from Anavex just about 3 years ago is this:
"The scientific findings indicate that too much calcium signaling in neurons may be involved in causing Alzheimer’s disease (AD). These calcium alterations can be modulated directly through the inositol triphosphate (IP3) receptor, representing a potential new therapeutic approach to treating AD. The findings indirectly confirm the therapeutic opportunity in Alzheimer’s disease for ANAVEX PLUS, an agonist of the sigma-1 receptor (S1R), because the S1R acts as a calcium signaling modulator via IP3." which can be viewed in its entire pr HERE.
TIC TOC TIC TOC goes the clock
Only a matter of time before we go BOOM
To be fair, I didn't say he wasn't part of the trial anymore. I just saw on his LinkedIn and shared with everyone something I found.
Others take information like that and turns it into "fake news"
Hahaha
Lol the confusion attempt is real. In a couple weeks, we will hear from the horses mouth. In the meantime, I'll tuck away my shares and wait for news vs making it up.
Would Macfarlane leaving Alfred Health have anything to do with the start date of p2/3? According to it, he left in June 2016.
Taken from his linkedin: HERE
Director/Associate Professor, Aged Psychiatry
Company NameCaulfield Hospital (Alfred Health)
Dates Employed2008 – Jun 2016 Employment Duration8 yrs 6 mos
As the longest-serving Director of Aged Psychiatry in this position since the creation of the Department in 1994, I ran a 40-EFT aged psychiatry service in south-east Melbourne, comprising a 15-bed acute inpatient unit, a community case management service and a liaison psychiatry service to some 300 aged care, rehabilitation and acquired brain injury beds.
My time was split between administration, teaching, working as the acute inpatient consultant on the ward, and running a clinical trials/research unit that deals primarily with industry-sponsored trials of potential disease-modifying agents for Alzheimer's disease.
I think I read that each share would have an option to exercise their right to buy a share at a said price.
Think someone could break down all the rights this would give so the common person could understand what the shareholder rights would actually do for us?
Yes, which could be the reason Missling is on the conference tour trying to get the name out.
In this crooked game where BP livelihoods could vanish, anything is possible because we are a threat to them. To think they aren't circling us from above like vultures is foolish. We already survived one playbook thrown at us and here we still stand.
A 1:4 to get on the Nasdaq yes. A 1:32 would look a bit suspicious no?