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It's clear to most investors that the Cog & ADL ORs were presented in the first PR and CTAD to highlight the strong responders, along with stat. sig. Cog & CDR mean scores. It was the purpose of the presentation to demonstrate patient IMPROVEMENT in the trial, differentiating it from all other past AD P3 trials. That was clearly accomplished. Since the ORs were pre-specified in the SAP that data alone was sufficient to proclaim the trial a success in meeting endpoints.
What the Sept 14 PR accomplished was not only to detail how ADAS-Cog and CDR-SB calculations alone (each with p< .025) make for an acceptable FDA trial result, but also identified 2 key biomarkers that will facilitate an AA pathway option. Whether ADCS-ADL had a p < .05 is now immaterial.
It's only the common FUDsters who keep trying to make an issue of ADL as they disregard all of the significant data that will lead to FDA approval, with the OLE likely becoming the confirmatory trial.
You and raja are quite the FUD couple...
... won't happen until sometime Anavex might release solid and complete data
LOL! That's perfect!
Loading up where the criminal cartel is buying is smart buying. Bring it, FUDster!
Just to call you out is satisfaction... because you're not blatantly obvious as most, but you are.
Yep, there's sooo much FUD being posted daily that it's a full-time job calling it out.
It's hard to be bothered about the truth, right?
You're the one selling crap, FUDster... by suggesting we haven't seen REAL NEWS yet. Complete BS!
One has to be a cabal soldier to know the answers to your questions.
All that investors can do is wait it out and buy more.
Why not buy where the WS criminals plan to buy?
Cabal soldiers, including AF, can take stellar irrefutable Rett data and spin a false narrative as cover for a short attack.
We've seen it with every positive PR for the past several years. So don't give us your crap about REAL NEWS, FUDster.
Not a chance of any frivolous suit. This is 100% collusive manipulation.
A common tactic by the criminal cartel prior to NDAs and approvals... to scare out retail and gather up cheap shares for themselves.
FUDsters here try to turn all real news into fake news. Don't ya'll?
Take advantage of the collusive manipulation. I'm loading up here. Great opportunity to buy at depressed levels a company that'll deliver the next SoC for Rett and AD.
Got more cheapies sub $7! How about you?
Don't forget the pompous idiot camp, that which you sit alone.
Your BS narratives are DOA. Pathetic FUD.
It's pretty easy to see who the paid cabal soldiers are here, who try to hide their collusive SP manipulation with nonsense narratives... plain FUD!
Stop with the FUD nonsense. We all know this is organized manipulation prior to NDAs and approvals.
It happens all the time to targeted biotechs.
Only FUDsters have a problem with it.
LOL! Not fooling anyone. We all know the reason why you're here... it's a remuneration thing, a FUD job. The only thing you share are twisted narratives based on invalid inferences.
You're the biggest joke of the board... and have been exposed as a FUD fraudster and cabal soldier.
Your credibility is zero, because of your ill intent.
We understand, your childish retorts are difficult to control.
It seems rather clear that Anavex is positioning 2-73 with the FDA that it, both, meets endpoints (as explained in the 9/14 PR) and has associated measurable surrogate endpoints to support an AA pathway.
AND has a confirmatory trial underway... OLE.
Checkmate!
I call him a FUDbot
Tell frrol to produce the evidence that ORs were endpoint measurements.
Or better yet... why don't you provide it?
Then please provide the evidence you claim exists.
I believe you're wrong about this. Nothing I've read or heard supports your claim.
My point is that frrol makes false inferences... just like his buddy, Investor, does routinely.
Just because ADL mean score wasn't provided, doesn't suggest it doesn't exit and isn't significant.
Endpoints were met, as the company continues to reiterate. It's only the FUDsters who deny.
There is no evidence that ORs were used as endpoint measurements.
They were included to highlight the strong responders.
Those wanting to see a list of paid FUDsters who reside on this board, just look at the 'Like' list on this baseless post...
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=172839022
It's not the complete list, however.
Your post is full of misinformation and opinion. For one, you have no evidence to prove your statement...
Method A was not by mean changes for the 3 endpoints. The ADCS-ADL endpoint was by odds risk
Ignore the FUD nonsense about "changing endpoints". Endpoints haven't changed.
The ORs were supplementary information identifying the strong responders who functionally improved. There is no need to re-present them again.
The Sept 14 PR not only drills down further into the ADAS-Cog and CDR-SB data, but also reveals key biomarkers that will be instrumental in gaining AA... with current OLE (~450 patients) serving as the confirmatory trial.
These surrogate biomarkers provide objective and irrefutable improvement measurements compared to the somewhat subjective questionnaires.
And what about the lack of cupholders? LOL
Don't count on it. The collusive AF Cabal prides itself on smearing any and all truths and ramping up the FUD narrative with more lies in providing cover for coordinated short attacks. I've seen it happen to other biotechs with excellent peer-review articles. It's how these criminals work.
LOL... you've been flagged, a long time ago.
It was also determined that bedtime dosing was a solution for most patients. And, over time, the AEs would diminish.
Why would one reference an obvious paid-for hit piece in SA with made-up untruths? Be an investor!
Simple... because the hired FUD has to be called out.
The gains were over identified IMPROVEMENT thresholds, not just baseline.
Excellent article on an AD website... should gain some significant attention.
FUD analysis only show up in paid-for hit pieces on SA. An obvious sign of corruption.
Glad you're finally coming around and seeing the light of reality.
Does that mean your handlers have hit their low SP target price and it'll begin to rise now?
This, however, remains a false statement...
...the endpoints are not met as required.
This...
On the other hand it could be they are just beating the sh%#^t out of retail because they know their chance to accumulate cheap shares is coming to an end.
You're really talking nonsense. I wish you'd cut the crap.