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Because I can read I know what work he has done for most of his career. Pretending DeGrado is the big difference maker now is just silly. People cling to such nonsense because the stock is worthless and has a tough row to hoe in the coming trial.
How speculative is it, to realize there is NO peer reviewed paper for B v C, and NO grant? It is plain facts. DeGrado knows grants and papers and he does not know trials.
Maybe we can move on from DeGrado and focus on the trial- whenever we get more details.
I get it- shareholders are nervous and are trying to find reasons for hope. It ain't DeGrado, I know that much.
DeGrado- gimme a break already. Great career, but his skill set is not the x factor all here pretend it is. He is not a clinical trials specialist. He is not an epidemiologist.
How helpful was he when he coulda helped? With papers and grants? You know, the stuff he does all the time.
Did IP get a grant to look at other viruses? NO.
Did IP get more grants to investigate IP and B? Umm, NO.
Did IP produce a peer reviewed paper of B v C research? Sigh No. They have not even managed to do that. They submitterd prepub, and that was all/
He is a guy who knows the ins and outs of grants forward and backward- his entire career is running labs and getting grants and publishing papers.
So for the things that he knows how to do he has not been helpful so far as one can see.
And now his skill set is NOT what IP needs.
Good grief. He joined IP because there is some chance B will benefit patients with COVID 19, but he has no idea if the upcoming trial will work or not. We have not been given trial details yet, as well.Your ability to sleep will depend on trial success and DeGrado designs synthetic molecules and does not run trials, and has NO CLUE if B v C will succeed.
He has the same hopes we all do and that is surely why he joined
Umm, could you remind the board how Degrado and Brilacidin did with prior company? Polymedix? Despite many extremely promising studies for antibacterial use, it failed. It is entirely possible that IP will meet the same fate this spring
It will be a miracle if it is a good enough corona drug
Amusing, really, to think that DeG and B are all you need to know when they already went down the drain with much better data....
Sticky, and see you in 60 days
Dude- we all bought at much higher prices, if we followed the stock over time. Of course it may be worth 100x current value. It may also be worth nothing in 3 months. I have savings to buy a million shares now, since my tuition days just ended? Would that be wise?
How about wait for the trial data? Now that makes sense. Like I said, buying now silly, based on hope and not reason.
What we know:
1) the Bakovic paper re B v C has not been published in any peer review journal so far. So much for peer review, touted by the company, touted by so many here. What happened, folks? Oct 30 date( very late per Leo hype) but nothing since on the publishing front. So it was sort of a scientific, what, exactly? Good enough for a trial, not good enough for publication. Sigh.
Other data from Bakovic is NOT B, it is LL-37 for VEEV. Hey wasn't it B that was supposed to be so great for all those other viruses, per IP PRs???? Scandalous and pathetic misleading speculation by our company and our CEO, IP and Leo. Which leads us to....
2) No grant despite the hype. None. Maybe B has a role for other corona viruses, maybe not. So much grant hype, over and over, and NOTHING ever came of it. A joke played on the shareholders, who have yet to figure it out, apparently.
3)Trial did not start yet, although Leo promised q4 and said trial discussions began 9 months ago in April 2020. Any day now.
Oh yeah, the planned trial is likely to focus on those with widespread disease already, while the drug's main benefit has been reported to be stop of viral spreading.....best wishes, B, you might help, but it'll be a miracle if the human trial recapitulates the lab data. But you all know that, right?
4)People are dying by the thousands, daily, just in the US, despite standard care, and solutions are desperately needed. It is NOT AT ALL CLEAR that B is a solution despite what you may read here. Sticky this for now and and we will meet back here in 60 days and assess the COVID therapeutic world. Cross your fingers and hope that B can play a role and see you in mid March
ha! totally right of you to call me out on that. Nonetheless, I may be right- who has the guts to go all in now? I for one have a lot of money to put in now, but why?
I will wait for the trial results. That is the only rational course. Crazy to buy now, crazy.
good grief. Total speculation no basis in reality.
Of course it might work- quoting percentages is irresponsible and nonsensical
I am sure you are telling all your family members to sell their houses to invest in IP, just as you have, given your level of confidence.
How has that worked out so far?
Fine, one supposes, if you bought all your shares under 10 cents ....LOL.
sure if it shows real benefit.
For those who pretend that is more likely than not,much more likely success than failure- that is a dangerous game. The current share price tells you how much the broader market agrees with that assessment
too funny. Share price less than 30 cents- generally- until trial results. Maybe not even more than 25 cents....
fair enough- how about trial start in a week and enrollment over 7-10 days? Should that be so difficult?
Sure go ahead and give up on March 15.
I think it is eminently doable if Leo is telling the truth.
Do you doubt the word of IP?
OK then: other than getting the trial data, pray tell what will change the share price?
A grant? no news forever about this.
UC? Forget it. Cannot walk and chew gum.
Details of trial? Means little. the results mean everything. Everyone said the big blast off would be Sept or Oct or Nov or Dec. LOL
No blast unless trial success. Will be lucky to stay above 20 cents until that time-
trial results are a straw man? Leo said 29 day trial starts this month. March 15 is realistic. Others here- trusted regulars-predicted mid trial interim data available RIGHT NOW. Did that bother you????
March 15 is reasonable. What date do you prefer?
You know, for data?
March 15. nothing to see here- other than trial protocol-until March 15, or so, if Leo is even getting it right , and trial starts this month. One month trial and then we get results.
But only if positive. If negative IP and Leo will delay and delay and delay telling us shareholders....
ah, the slip twixt lab and actual human patient-
the problem of course : no one knows if the trial will succeed, or fail. That is the only additional news that means anything at all. Totally up in the air.
3 in 1, 3 in 1- occ maybe a hindrance rather than a help? Yes, the antibacterial component is mostly what I am thinking of. The average COVID pt does NOT get antibiotics now, unless odd chest x ray or CT or positive sputum or very elevated procalcitonin. Otherwise they are treated with an antiviral and an anti-inflammatory drug- not antibiotics. Do some go on to develop a bacterial component to their illness? Of course just like anybody very ill, staying a long time in a hospital, on a vent etc etc.
BUT- killing off the gut flora with an antibiotic may have consequences, for one thing. The average clinician wants to think that they can direct his/her therapy and not just shotgun it. Providing quite broad antibiotic coverage is one of the things that B does as part of the package of effects. But how much that 1 part of 3 in 1 will help is not certain at all at this point.
It will be one of the fascinating things to look at in the trial
just start the trial already, please. For our part: prayer that there is success, and that disease not too widespread already for failure. How about trial details, please?
B v C Q1 start? B v UC ever? Time passes.
walk and chew gum much? 3/5/2020 B vs UC trial planned. Really? Really? Bring it on Leo
total nonsense obv. Other therapies have a huge impact of course. They have huge impact ALREADY. Already standard of care is to give dexamethasone- IF B trial were done earlier then maybe its antiinflamm effect woulda made a difference and then the dex trials would have to prove additional benefit and B would already be standard
Seriously?
Other therapies and their trials and their timing - are critical
So true, so true. Let's have no news until there are many other good therapeutic options for COVID and herd immunity from vaccines. Then some news, but maybe not even then- maybe wait even more.
We had SARS and MERS now COVID.
So maybe now news for several years, would really be ideal.
LOL
best case? B succeeds in the trial and works for other viruses as well. Nonetheless: Critical time lost as competition for treatment heats up and hospitals have been full of those needing treatment for many months already. B would already be standard of treatment had this been done 3 months ago.
You know, when everyone here said it would happen....
worst case? B has some benefit for patients in stopping disease spread, and it succeeds in a trial designed to show this benefit. Unfortunately, the company trial was for patients who already had widespread disease, and the trial fails, and there is no money for another. B for UC oral trial also has no funding. The company folds. The successful trial is run by the company that picks up Brilacidin for nothing just as did IP before.
9 months of discussions and plans for a human trial...and B is not in the game yet, nationwide 4000 deaths yesterday, Mass. hospitals full of corona patients.
9 months of talking and planning and NO START of trial. Almost like it's all talk - all talk and no action
Eyes open, OK. can you recall predicting data to analyze in a week or two ? Hmmm.
upcoming one year anniversaries:
Feb 18- IP announces use of B v c
April 6-IP announces discussions of human trial of B for c
Vaccines already out in millions of doses and B.
Let me see- oh yeah no human trial started. So much for all that interest and discussion.
Welcome to the non warp world of IP and B as the world struggles to confront the corona virus. Hospitals full and still filling, folks....
Q4?? So rear view mirror. Will B v C start Q1, even?
Get in the game Leo. So much chatter about the trial and interest and institutions and everybody talking at you and here we are.
Slow- oh so slow squandered summer- and here we are.
What if you have a great drug and no money? And you cannot find a partner with clout?
It looks just like this and we still do not know if B helps people with C- one year anniversaries coming up soon for B interest and research.
But here we are. B OM , forgotten. B UC- really? IP talked about it not so long ago and not a word anymore. Can IP walk and chew gum? Of course not.
I would simply wait for the trial, just as we all do now. In the meantime he has plenty of patients to see and plenty to read. Lab data=interesting. Human trial data( we have none of B for C)=compelling
Just one opinion- I do not know Dr Sax at all. I would not suggest he read lab data about B now HOWEVER once trial is done, and if it is positive I will be glad to write to him. But then he will already have seen the data and will draw his own conclusions.
If B for C is for real- excellent efficacy - then B will be synthetic molecule of the year and DeGrado Man of the year for 2021. But we are not there yet. And may well never be.
We may soon be back to a focus on UC. What about the UC trial Leo?
Have I jumped up and down about being right? Sept and Oct and Nov and now December have all come and gone and there is no trial. No blastoff. It was suggested that I was about to be extremely embarrassed as the trials would start in q4, paid by others. How did that turn out?
My "usual mantra" about length of time was spot on.
Of course, none of that matters, other than getting B into a trial it has the best hope for success in, and getting the results ASAP.
That I am sure we agree on.
and why not? Every shift I work I see many COVID-19 patients. If I and my hospital are struggling with resources imagine California and how bad it is there. How many COVID patients are you seeing daily? How many scared faces are you dealing with?
I spent the last 90 minutes of my shift yesterday trying to find an ICU bed for a patient with a non COVID-19 problem. There were no unit beds available. Finally my own ICU took the patient after saying there was no way to fit him in before. I tried almost all the hospitals in Boston and Worcester- certainly all the big ones. NO unit beds. That is the strain of COVID, one small example.
What about all those patients? They are all nervous and many are desperate.
It is going to get worse before it gets better. Leo has talked trials forever now, and institutional interest and contacts, and where are we?
Where is B for C? What if B had been tried before Remdesivir and before steroids? B could be standard of care and all the other drugs could get in line, and see if they could add to B's benefit.
That is not how it played out and still we wait for the critical moment for IP and B. Let's hope the trial succeeds, and that if it does not, that there is money for a different sort of trial, ED or outpatient based for those with less severe disease.
Yes I know the sounds a bit melodramatic and self-focused, but it speaks to what is happening in every hospital and ED now
Last April 27 PR talking about rapid advancement into human trials of B for C- company already at work on this. Is that warp speed, or what?
Yes, it's non warp
every 33 seconds a corona virus death recently...Leo has talked about a trial for many months and all the institutional interest etc etc. Maybe start the trial already....so much squandered momentum for IP.
his response I would guess would match ours- unsure, few adverse effects, good half half life, given to many patients already, a plus, just not to those with COVID : let the trials begin!
Thanks for posting the Sax piece. He writes a lot of interesting stuff.
interesting that you post this since today Paul Sax an ID guy at the Brigham wrote about COVID and ivermectin. He is a well respected ID specialist with a long track record of writing about topics of interest for all physicians. He is not sure what to think but notes the short list of current easily prescribed output options for COVID treatment- ZERO!
What if B actually works? OK so it is not easily given, but if it works they will find a way to get it to patients.
Please IP get a move on. And please have a reasonable trial population, if that is attainable.
no answer. Of course he is too busy to write, I would bet. Desperately trying to nail down the inpatient trial. In several countries even? We all sit and wait for B to get in the game -
is that what I said? No interest? I said that no trials for COVID have been done in my hospital so far as I know. I wrote to Leo to suggest an ED based trial, since so many people come in who get IV's placed and who could get B or placebo easily. But much easier to monitor patients in a hospital setting
I think hospitals would be glad to participate since so little out there to help. From a patient standpoint, I would be glad to sign up if I had COVID just to move the science forward, if I were the one who was sick. So little else to try as an option.