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Hilarious
Underlying mechanisms involved in the icosapent ethyl reduction of cardiovascular events still cannot be attributed to an anti-atherosclerotic effect
Agree but if NIssen is so certain he should pay for it
Then why pussy foot around they should repeat REDUCE IT with corn oil ....
I have a strong sense that AMRN is on a slow steady rise - I am sensing a lot of resilience - feels like this Dog wants to run - nothing scientific - just a Gestalt activated by all the potential that continues to accumulate ...
THis is not good its a direct competitor for Vascepa .... I am concerned the Canadian play is simply for ulterior motives? or to have the entire pipeline ? Thoughts
If you are going to leave assets move them into an irrevocable trust in SOuth Dakota
WOw AMRN's IR needs to take a lesson ....
Yes AMRN finally has a marketing team ...... unicorns are crying in the daisies but getting hugged by sheroes ...
Wow HIKMA actually tries to suggest that atrial fibrillation has the same physiologic basis as CAD....
the only reference in Hikma’s label to CV issues
warns against administering icosapent ethyl to CV patients because it can cause “[h]eart rhythm
problems” and hospitalizations for “people who have heart (cardiovascular) disease or diabetes
with a risk factor for heart (cardiovascular) disease.”
Thanks Raf
Sleven .. cant access ...
I am cautious of PREPARE IT and have gone on record I am not expecting success (hope I am wrong) . Having said that if + YES i do believe they will appropriately use the news to their and ours advantage !
I find this fascinating ... I continue to stumble upon story after story now that is touting AMRN ...
https://www.marketscreener.com/quote/stock/AMARIN-CORPORATION-PLC-1658813/news/Amarin-LATEST-CLINICAL-RESEARCH-EVALUATING-VASCEPA-VAZKEPA-IN-PATIENTS-WITH-RESIDUAL-CARDIOVASCULA-36183837/
what happened?? Somehow they have managed to get a marketing team going that actually understands the real world - MY guess is they hired this out or brought in someone that knwos more than just unicorns and daisies ...
OK so either I am totally confused or this grad student needs a new career.
The operating thesis for REDUCE IT is --- high trig induce CAD
Concerns arose because in REDUCE IT the placebo group which received mineral oil had higher event than the group receiving Vascepa - causing a theory to emanate that the mineral oil induced the events.
However this grad student indicates mineral oil reduced trigs - based on the above thesis the control group receives cardioprotection from the mineral oil - meaning vascepa worked even better than the date revealed !!
1.) Theory high trigs induce CAD
2.) Study pits purportedly neutral mineral oil against Vascepa - STudy is successful revealing VAscepa reduced coronary events significantly better than mineral oil
3.) Theory arises that maybe mineral oil induced events and that Vascepa therefore really did not reduce them.
4.) Study shows mineral oil actually increases trigs
5.) Based on #1 mineral oil group should have had a reduction not increase in events
6.) HOwever Vascepa showed even a more significant reduction in events than mineral oil - meaning that Vascepa is actually working better that the data revealed !!!!
Capt Beer make a pretty picture so Dr. Nissen can understand
0.3 is only $16 - I Still think if US market restored should be what market previously valued - $26 - why accept 40% less ?
Very true - and in this case for some investors the time value of money is somewhat destructive to a long term investment even if resurrection occurs ....
YEs unfortunately my naivete is being replaced by a healthy level of skepticism - perhaps Apes will provide a level playing field for us humans ... what I find disconcerting and I guess why I have always been a long player - intuition , knowledge and understanding regarding events in the short run may be countered by these activities - however, in the long run I do believe true value eventually surfaces
Nice Article on Stock Titan about upcoming meeting
https://www.stocktitan.net/news/AMRN/latest-clinical-research-evaluating-vascepa-r-vazkepa-icosapent-qzsi4csjt2ja.html
and yahoo has an article !!!
https://www.yahoo.com/now/latest-clinical-research-evaluating-vascepa-110000569.html
THis is exactly what they should be doing rather than tweeting about sheroes unicorns and daisies
Once again I find the situation odd and difficult to explain. WE have one of the worlds largest pharmaceutical firms lending credence to the value of the medication by entering into a promotional agreement. I would think that these actions would allay fears and validate the potential resulting in small surge in stock price .....
Now we know why the stock surged last week- someone leaked PFIZER'S interest in Canada - SEC should be all over this
Yea Pfizer smells blockbuster - RESURRECTING LIPITOR - made them more money than any other drug
did I MENTION VASTOR ... LOL
What happens in that situation ? MUst the pharmacy dispense V if they dont have gV ?
Once again all this can be eclipsed by simply stating ...I am buying at $y.xx and I am selling at $y.xx - pretty simple - no one has to agree with why you think that way - all that matters - is the end result
Solid advice TKE
ANother marketing strategy for Vascepa
I previously posted my concerns over how Vascepa gets put into the line up for cardiovascular disease - theer a a huge number of drags currently available
Beta Blockers
Statins
Aspirin
Ace INhibitors
Nitro
Xarelto
SGLT's
GLP's
etce etc
OK now you have to get the Doc to think of Vascepa - this is obvious but for some reason it just hit me . ANswer is -
Doc with all of those meds you are going to have to worry about a ton of interactions - look you can add Vascepa onto anything and there are NO worries.
THis type of information is golden - Docs can only remember so much and when you have a med that has no worries you will reach for it ....
SOme of the new migraine meds are like that patient comes in they are on three meds still no benefit - no juggling required just add the fourth
Matter of fact there's the commercial -
doc is juggling 8 bowling pins with different classes of meds
next picture they are all over the place - and one hits the doc in the head ( implication patient event malpractice ?)
then the statement -
Why JUggle ?
Vascepa goes with any and all cardiac meds providing a further 25% reduction in cardiac events ....
If the US market is restored the stock market previously valued the stock at $26. Therefore IF US market is restored a BO under that price imho devalues the stock
Zman ... I sure hope i can sing " who let the Apes out " soon ...lol
I agree Duke - this does not make sense to me other than perhaps a trigger for crossing EMA of 200 days - but why did it cross ? The other scenarios should be gradual - recognition of news should be a bell shaped curve over x amount of time - we just saw a spike.
This is like the "Americas best doctors list" you pay them $100 and you become a best doctor ...hilarious - i guess the question is -
if they lead in education how can Lovaza rx be expanding at the same rate or better when the market for them is 1/10th the size ?
The answer is MDs are clueless and think all Omega 3's are the same ---> meaning the educators have dismally failed
Pdude / MOderators - the article should be pinned to the site for future reference as its the best biochem summary
Just wondering if there is anyway to research major brokers recommendations - did a major broker recommend AMRN to their clients and this is the cause of the surge ?
I find it hard to believe that AMRN price struggles to move on primary findings but has a 14% move on a secondary action of a remotely related drug where very few would have the knowledge PDude has to connect the dots .
I find it eerily to be a flip ADCOM situation - in our favor - wonder if something could have leaked on PREPARE IT ?
Thanks KIWI
hope people are not buying in hope of Prepare IT because if it fails stock will then tank again ...
Does anyone know why we are going up today ? Is it technical buying triggered by threshold activation? Is someone accumulating ? If so why ?
My gestalt is that it will not be successful again not based on any complex analysis of its biochemistry - just odds - most of these things are failures - look at how many have already failed - thats all I am saying - but I do hope I am wrong
Exactly .... this is part of the complexity discrimination process that runs in docs brains - to be useful it has to be totally novel specific and complex - this is why Lovaza was never marketed as fish oil - there was never any mention of that - docs thought it was a 'novel complex pharmaceutical product'
If AMRN wants to be successful marketing they need to understand how docs think - thus far they have totally blown it by letting themselves be pigeonholed as "fish oil"
I agree RMB and you bring up a good question if the study was favorable stock should soar then come back down as reality sets in - but then slowly rise again as its true value CAD becomes recognized. My guess would be to sell into that good news wait a month or so and come back in on dips - the question of course will be to define "dip" This would be a wonderful "problem" to face ...lol
I certainly dont have the depth of biochemistry analysis that PDUDE has done however have gone on record that I dont think PREPARE IT will be successful. I do hope I am wrong. I base this on the fact that for over 35 years I have watched compound after compound in the lab and petri dish show great promise and be a "breakthough" and then fall flat on their face when actually used in a clinical study. I did not think REDUCE IT was going to be a success either.
Having said that my skepticism has kept me from investing with hope which is dangerous - I originally bought at $1.xx and sold at $3.xx and now hopped back in at $4.xx and most recently $3.xx - none of these buys were based on any belief that PREPARE IT will be positive.
MY patient had a bottle of vascepa thrown at him ..... fortunately he only had SUPER FISH OIl injuries .... I will let myself out ....
Agree thats where my bet is ...