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Went to CTAD found oral presentation not poster(s) on10th.
Saw something about Dec8 availability of data..
Can that be confirmed?
thanks cbd..
i had to recheck that mono therapy data and
when I did ..BAM...... MMSE line going UP at 6 months..And that is an average of 7? since 24 is low end of normal.
Are you kidding me?
the good Dr could not have given us better news than dual therapy was a bust..
COULD NOT HAVE GIVEN US BETTER NEWS!
C
I thought everyone had committed to memory the unbelievable results of the Mono Therapy group?
If any of you have not , I strongly urge you to go review this data!
At 6 months his group was separated in at least 2 charts for Adcs and MMSE ..
The assumption I make is simple logic;
IF we are moving forward than we must have a positive result!
Good logic?
IF dual therapy has been ruled out as having better effect(fact by good Dr statement) Fact
THAN the good effect we must be talking about is the result of MoNo-Therapy whose EFFeCTS were separately displayed in 6 month poster.
The market doesn't realize what I just said,, it's time to accumulate,
You are all welcome!
So than if everything in my post is factual that would mean this post is
Well,, misguided?
MMSE on 7 patients of mono-therapy from 6 month chart :
Start 22 end almost 25.. 24 is a low normal score for MMSE. Facts
ADCS-ADL 6 Month poster :
Start 70. End 70 Fact.
Some higher some lower as these are averages : fact
These were my main points Xena
Which of these are not factual?
What I am pointing out is that many of
Us saw the monotherapy data as the results for which we had hoped for..
Go back and look at the MMSE score going UP! 24 the score same as healthy score! The good Dr in his own way has told us that the positives of Monotherapy have continued.
It is only 7 patients but we know that the average, average of all monotherapy patients was no deterioration at 6 months! So some must have done a little better ! That is unbelievable at 6 months of mild to moderate Alzheimers..
We have the drug!
Prepare the drums..
We are going to launch a Humanitarian Apoeal to President Trump and FDA..
Not to overwhelm Anavex but to petitition our leaders to help them!
With positive ham-d results already announced and the announcement of mono therapy success should be confirmed dec 8-10 with data at CTAD
Frill you have had some exceptional insights and your questions have led me to yet another presumptive conclusion. Since the good Dr has revealed to us that the combination therapy (20 of 27 cohort) has shown no differential or increase in benefit to mono therapy and we know that mono therapy has been great enough on 7 people to validate a Phase 3 trial which will cost tens of millions dollars..
Than my friends is it not a reasonable assumption that the 9 and 12 month results for that cohort of mono therapy must demonstrate as good as or better than current SOC?
And with minimal negative side effects and positive HAM-D
At 6 months
The number is down to 27 participants.. if more "n" drop out they will share "why" just like they did with 5 who dropped out..
Remember. This is not a blinded study..they have immediate access to all data except maybe pharnacokinetic..many patients are close to two years..
I again repeat. The company have three other promising drugs, they would not destroy lol credibility for A2-73.. if the data were less than exciting they would just move on..
Not hold oral presentation at CTAD..
They have TOLD US the mono therapy
Data is the deal..( No dual benefit).
Honestly. It is simple logic.
Accumulate
Thank you dRx ..that is correct..
You can't get return without risk.
It's like Groundhog Day all over again, no one ain't seen nothin! What short Cabal?
Jimmy
This Co and the opportunity will go from " fears of dilution, lack of efficacy, mismanagement, too many directions, too many drugs in pipeline, not communicative enough, too slow to sell out to a bigger company, yada, yada, yada,,,
To
It's too expensive to buy now..
What a riot
Could this be a conjunctive therapy with A2-73?
http://medicalxpress.com/news/2016-11-antibiotic-cell-brain-areas-alzheimer.html
From Limited research, Injection/or IV..no oral avail.
MD would have to go through risks/rewards. Side Effects appear
negative and diverse. Also, I would assume: risks of loss of effectiveness as Anti-Biotic if over used.
Is in Generic Form..so appears relatively inexpensive..assume that means has proven relatively safe..
"Ceftriaxone seems to increase excitatory amino acid transporter-2 pump expression and activity in the central nervous system, so has a potential to reduce glutamatergic toxicity.[3"
Point to posting this story, is so many of these maladies are pointing towards an epidemic of diabetes. The inflammatory cells may be a wave reflex to agitations due to lack of insulin to calm the systems.
Homeostasis is a great goal, but my guess is without proper Diabetic care, it continues to attack everytime your body processes food, or stressful events.
I would think teaming up A2-73 with a Diabetes Treatment should be a serious consideration..
Announcing Victory through Failure.
I have requested other posters fully extrapolate the implications of
Mono-Therapy vs. Dual.
1. IMO: Our Trial will now be using Donezipil Patients as Placebo Group..No dual Therapy Group..
a. we currently beat Aricept if only by lack of negative Gastrointestinal reactions to A2-73 vs Donexipil(Aricept) and side Benefits related to HAM-D test- vs Anxiety, Insomnia et al...
2. Using Donezipil as baseline allows A2-73 to REALLY give Patients a CHOICE..and as a stand alone would become very successful just from those who do not wish to experience Side Effects of Donezipil.
3. LOGIC, since we know there is evidenced Efficacy in Phase 2a over and above Aricept by itself, and since we now know, that there appears to be no benefit to Dual Therapy, the very simple conclusion is ..
MonoTherapy of A2-73 in multiple Alzheimer's tests shows greater efficacy than Aricept/Donexipil. Good enough to command Ariana, Cogstate and Neuronetrix, MJFF, Rett Syndrom Assoc., and yes, Biogen, to continue to want to partner with Anavex.
I still do not believe the market has taken into account the full positives fo the good Dr's negative commentary..
Side Note: Why would stopping PAIN without using destructive Opioids increase the value of Anavex? Non-Opioid Pain relief is such a small market anyway..What 5-10 Billion a year? could use to help Heroin Addicts..really Anavex should just sell off this drug for $2 to avoid losing any more market value..You gotta love this stock..Accumulate!
Anavex hires Ariana, next Interview:
No Benefits to Dual Therapy! Logically you would think this a negative!
When we put them together we receive no greater benefit..
NO GREATER BENEFIT over ????????? the drugs used separately?
NO GREATER BENEFIT over..say it with me each drug as Mono-Therapy!
That makes sense...
Since we KNOW that our A2-73 has shown Efficacy so far with Dual Therapy, and that efficacy, not including HAM-D Positives, appears to at least equal Donezipil mono therapy, than is the good Dr. trying to
cough out that A2-73 in Mono Therapy is BETTER than Dual Therapy and MonoTherapy with Donexpipil?
The good Dr can not say ..Mono Therapy with A2-73 is better than Dual Therapy, or better than DZP. Because A2-73 Phase 2a is about SAFETY and A2-73 showing Efficacy, not measuring it.
So the good Dr could not say, we appear to have the new SOC, and it appears to work better without DZP, but really,
Is that NOT what the good Dr. JUST DID?
Ariana is going to help us clarify what we have and what we don't. We don't have a drug that plays better with Donezipil Type Drugs(Memantine, etc..).
What we have is a drug that plays really well with the Sigma 1 Ligand, a Homeostasis Chaperone located in EVERY MAJOR ORGAN throughout the body..
Heart, Mind, Eyes, Diabetes, CNS, Depression, etc..
Ladies and gentleman..Biogen is one lucky Company..
It will not take Biogen long to figure this out..
Not long at all..
The good Dr. in the interview said something along the lines,
"There does not seem to be ANY BENEFIT to DUAL THERAPY".."Taken independently of any current therapy"
here is the logic that needs to be followed (IMO) regarding this statement: Right before the good Dr says no difference in benefit between dual/mono he states the compound has shown the ability to repair cell balance, cognitive function, better cell functionality of body" "whats bad for heart is also bad for the brain"
And the OPPOSITE is probably true for A2-73! What is GOOD for the Brain is Good for the HEART!
Back to Logic
A: We KNOW that there is Benefit to OUR Treatment: So OBVIOUSLY, the good Dr is NOT saying there is no benefit, just that there is no additional benefit to adding Donezipil or any other current SOC.(all use same modality)
B: Since we KNOW A, than the good Dr.'s Statement LOGICALLY means that
the Benefits derived in MONOTHERAPY are NOT ENHANCED by DUAL THERAPY!
So we may logically assume as of this statement:
Anavex studies will be moving forward as primarily MonoTherapy!
and that the Benefits observed are same as MONO THERAPY!
I think it's GREAT NEWS..Save big $$ for Governments AND
lose the side effects of DZP..NICE!
It would be nice if George or Dado would comment here regarding Monotherapy benefits..My guess is that there are some negatives..but what are the LONG TERM positives? The Market is not recognizing the LONG TERM POSITIVES! We will REPLACE DZP altogether!
so..for 6 months my expectations would have been OK, a little too high, except for the changing of ADCS-ADL start point form PRE-Clinical to PRE-12 WEEKS! A start point of 64 vs 70 IS DRAMATIC in 5 WEEKS! so, one number is wrong or both numbers are wrong..By using the Lower Number of 64 for Base Point on ADCS-ADL I am being LENIENT and GIVING A2-73 it's best opportunity to perform! A higher start would show a greater decline!
So starting at 64 and hypothesizing-estimating a twice as effective rate as DZP, or really even the same rate as DZP at 8 Points over 1 year -
56 Pts on ADCS-ADL or higher..That is NOT being overly positive..
If we can not hold that number after 1 year, and
the MONO-THERAPY LINE does not show effecacy in the MMSE(above 20?) I think
Ariana better hunt hard..but if our numbers can't slow regression better than this..we should review, Parkinsons, Early Alzheimers, Insomnia..
MY POINT is THe DOCTORS and FDA and Caulfield Hospital and COGSTATE and NEURONETRIX and AVXL BOARD and..ALREADY KNOW THE NUMBERS and WE ARE MOVING AHEAD with an ALzheimers Phase 2/3..
SO ..one would guess that the numbers we shall see Dec 10th should be better than these..Unless you have a better Data Reference to Oner Year Mild To Moderate Alzheimers Patients on Donezipil?
Also, man we are a DOG BEAT Board! Expectation TOO HIGH..
when do you think Adam F. will hit us with his best shot?
WAN..HIT THEM WITH OUR BEST SHOT! We got the DRUG!
A tale of two pathways
Dec 9th we hear one..a well trodden pathway, strewn with
the recent rotting corpses of recent travelers and then on Dec. 10th
we hear of another path, a new path.
the old path is run by a hedge fund guy, who optioned his family millions, and whose medical background was scant..but BIG BUCKS were easily convinced out of Billions for at least the Old Path was well worn! they would not be the first FOOLS!
On Dec 9th we will learn what the term "Conversion Algorithm of ADCS-ADL"
means..my personal guess is as many of you would suspect, that the positive results of the old way may only be measured in delusional measurements of downward directions through their "integrated velocity". In other words, the results need an algorythm "converted"- Not to be that guy, but isn't that what an alogrythm is? If you need to convert an Algorithm hasn't it lost it's value?
The rest of the announcement for the old path reads similarly less than exciting, "An oral presentation "An Assessment of Dependence Level Progression Using a Conversion Algorithm of ADCS-ADL to Dependence Scale and Data From a Double Blind Placebo Controlled Trial of Intepirdine (RVT-101)" will be made at 12:15 p.m. PST
yeah the "Dependence Level Progression" does not sound like an overtly positive outlier of "good things to come". Didn't see any mention of presentation partnerships to Wonker over the good news either..
Remember this was a tale of TWO pathways, the other NEW pathway is revealed on Dec 10th. With respected Scientific Partners: COgstate and Neuronetrix Anavex's good Dr.Missling will present;
8.45 a.m OC59 - 9-Months and 12-Months Safety and Exploratory Efficacy Data of ANAVEX 2-73 in a Phase 2a Study
in Mild-to-Moderate Alzheimer’s Disease Patients
Stephen Macfarlane, MD1, Marco Cecchi, PhD2, Paul Maruff, PhD3 , Kristina M Kapiak4, Christopher U Missling, PhD4
(1) Caulfield Hospital, Melbourne, Australia, (2) Neuronetrix, Louisville, KY, USA, (3) Cogstate Ltd.,
Safety and Exploratory Efficacy..hm..no Reverse Polarity Extrapolation Algorithms? nope.
But for our next phase, so the new trail holds no surprises, We will just be bringing in Ariana to Snipe out the most obvious paths for a succesful Phase 2/3 Strata..
Even Ariana could not have found a "Convergent Algorithm for Dependence Level Progression".
Or wait, maybe the Artificial Intelligence that is Ariana
COULD have found it, if her mission were reversed.
Don't think the good Dr will go down that path..ever
Meander..
Are they or aren't they?
This is the question!
It seems we have two chants, both of which have basis
in Anavex Statements. Are the Patients on MTD or are they
still at minimal tolerated dosage?
It is a fair question as we seem to have a CTAD at 6 month quote saying
NO on the poster. and other quotes saying that the Patients have
been adjusted to their most tolerated dosage.
So which is it?
It is an adaptive study whose main goal is safety. I imagine that both
statements are true keeping in mind the above main goal of the study.
The dosage was changed for some but not to a level for EFFICACY but to a level of Toleration. There is a difference, right?
So in an adaptive trial, the dosages have been adapted to improve Efficacy, but not risk Safety Event. This makes complete sense. Until you know what optimum dosage is, don't risk safety! I think a better question is Have some Patients on Dual Therapy (20 out of 27) moved to Mono Therapy? This would be somewhat useful Data to have if there was a positive response, but again, what if there is a negative response? Do we know enough yet about Mono Therapy to advise other Patients to that route? And are there Safety risks?
My OPINION: DZP is a minimally effective treatment and has never been shown to do anything but delay more serious Alzheimers symptons As a patient on both, it would seem a Reasonable Risk not only to discard DZP, but up my dosage on A2-73 over time to 50Mg a day. IF I were in the study and I could make my own diagnosis and set my treatment based on what is so far proven, this would be my decision.
Don't you think other rational caregivers and family members came to this same conclusion? a good question to IR would be, Have any Patients, Caregivers and Family Members requested a change from Dual Therapy to Mono-Therapy since the 6 month Data has become available?
And have these Patients been allowed to begin Mono-Therapy?
What do you think? It's an Open Adaptive Trial? You can't really make someone take DZP? Can you? I guess you could threaten to throw them out of the Study and withdraw A2-73..but WOW..that seems HARSH..
Do you think MORE PATIENTS HAVE GONE MONO since 6 month Data Release?
So again, I don't mean to beat a dead horse, but everyone here at least realizes that this is a Mild To Moderate Alzheimer's Study that is
OPEN..Started enrolling Patients in Dec of 2014. The Dr's and Partners have Data on Patients well beyond 1 year. Guess at least 1/2 they have for 18 Months. Around Half the Participants are Apoe4 Positive.
Just think about all the Data that has been revealed since 2014? In every area of Alzheimers..Diagnosis-Testing(Taurx, etc) and then throw in Ariana, an artificial intelligence source that may assign and interpret billions of data byte.That is aware of the most recent Data from the WORLD and PAST DATA from Blinded Placebo Groups(Our Blind Placebo Group) We are not coming into Dec 10 with questions, we are coming into Dec 10 with answers.
Those answers are going to be what the Phase 3 is going to confirm.
Those of you worried about bad data, must come to understand something so simple..as this THEY ALREADY KNOW THE DATA..It is not a CLOSED, PLACEBO BLINDED STUDY..
THEY would NOT be moving forward with ANYTHING other than A3-71 IF THE DATA WAS BAD..I KNOW people are smart..but honestly I think the CABAL has scared most big $$$ away..for now..but isn't that when you can cash in the bigbucks? Let's see whose right and whose wrong..I like our hand. Do you? There do seem to be too many Aces in the deck..I think Ray Nauer is not Dudley Doright but Snydley Whiplashh in disguise and a card cheat at that! Throw him OUT of the Club!
It's a back room game of high stakes poker and your bank is deeply overmatched at the table. Anyone of the other 5 Players could buy you 100 times over, yet here you sit! but it gets better, because the Dealer just dealt you a Royal Straight Flush!
You look down at your little stack, as it's been a LONG NIGHT and you realize, even if you go all in, that ain't gonna do it..So you sneeze or spill a drink and leave the table for a second. The Wealthiest guy at the Club, a nice guy, but ..not that nice, left the game earlier because the cards were not going his way and he had lost a lot of money, a lot. He was not happy. You nonchalantly approach him, about trying to make some of his money back and he laughs. That is until you inform him you have a winning hand and you are willing to share the pot..than he stops laughing, but he wants to SEE your hand. It's a poker game and well..you cann't be too obvious, because then who is going to call your bet?
He won't take your word for it, but he offers to bankroll you all the way, if you have the hand you say you do..You go back to the table, and the other players see your little pot, and they want you OUT..So they start bidding up the POT, until the bet is well beyond your Table Stack.
Now you are not playing Table Stakes, but there are some gentlemanly rules about adding Funds at the Game.
The Bet comes around to you and it's pretty high,, but you have just enough to call the bets..and you KNOW the ALL IN BET is coming..but you can not be the one to make it..
SO you slide your chips in..and the ALL -IN gets called by the player next to you..and EVERYONE CALLS because they all want a piece of that POT, so the POT is now a Lifetime's worth of wealth for almost anyone.
The bet now comes to you, you look down to make sure YOUR HAND hasn't CHANGED! Yep Royal FLush..Still Beautiful!
With your cards flatly on the Table you look around, indignant, they know you can't call the bet, but quietly in walks your money man. They all know he had a rough night, but not that rough that he would bankroll you? That would cost all of them a LOT OF MONEY, but there he is..why?
You Look Over, and you tell everyone the rules of the game, that you are allowed to raise money to match a bet that is on the table and raise an equal amount if able to prove funds. You explain that you have the winning hand and that you are able to match their bet, thanks to Mr. B Iogen, and you RAISE THEM back the same amount of the Pot..AFTER YOUR BET IS PLaced in the middle.
The Pot has now become STAGGERING in it's size, and each of the other players must now risk Lifestyle Capital to match you and Mr. B. Iogen's bet. They had seen their least favorite Club Member enter the room, but they never thought, he would turn on them like this! They all know your money man would not have entered the room and put up cash if YOU DIDN'T have a winning hand..but the POT is so LARGE and the other players have so MUCH to LOSE...The few moments go by slowly as each Player at the Table Folds his Cards until there is only one Player left besides you. He is the wealthiest Club Member and has had a good night. When he went all in, he was not trying to buy the POT, he had 4 Aces!
He considered, that it could be a bluff..He considered what a tremendous bluff it would be..That if he folded 4 Aces he would always feel himself a FOOL..And Mr. B Iogen had even been a friend once!
Ray Nauer kept tapping his cards..4 ACES he thought..I would be the laughing stock..not just to lose but to lose to you!
You really didn't care whether Mr. Ray Nauer put in his chips or not. You are not big fan of his, as he is a lot less intelligent than he thinks he is..probably about an 100 on the ole IQ if you had to guess..But he came from deep wealth, and he was in the Club..
But the Pot isn't why you are sitting at the table at all..You don't care about the money..yOu have a plan to help Millions of People who are sick and dying..and that POT..Right THERE..is going to allow you to do just that..and if Ray Nauer calls you..well you will just do it that much faster!
And then after what seems like an eternity, Ray firmly TAPS down his last ACE, gives a wicked bad look to Mr. B. Iogen, and as he slides his cards FACE UP into the pot, he looks at you square in the eye, POUNDS the TABLE hard and screams..I CALL!
Now you know you can not lose, but Mr. B Iogen has not actually seen your cards(he has a pretty good idea that you are telling the truth but he has NOT SEEN your cards).
Slowly Mr. B. Iogen walks over to the table and flips your cards for all to see..TEN OF HEARTS(the Hamilton), JACK OF HEARTS(Ariana & FDA) the QUEEN OF HEARTS (Caulfield Hospital Phase 2/3) the KING OF HEARTS (MJFF Phase 2/3 for Parkinsons) and finally your last card as it flips..it's red and it's an Ace (December 10 CTAD) and it's all HEART!
It is nice to see Mr. B Iogen in the room.
I am limited to one post a day, so..
The Ancedotal Tea Leaves all SCREAM GOOD DATA!
Well are we? Update:
Powerwalker and Amateur17: excellent conversation! Noone even mentioned Delusional Dilutionals or Pretentia Patentia ..
So is the data good enough to extend the continuance of Anavex Beyond Dec 10 or are we just shutting the doors and going home? hmm..
Why did the patients and caregivers ask for a two year extension almost 1 year ago? And why did the Australian Government APPROVE it? hmm..
And now Anavex actually has the completed data for a year and a half of probably close to half the participants....so we may be looking at 52 week data but Anavex has been looking at 52 week data for almost one year..right?..hmm..
So we are having an honest discussion about whether or not the data is good enough to continue our multiple IND's and even our Alzheimer Studies? hmm..
Anavex since knowing 52 week data and 70 week data for a lot of Trial Pariticipants has hired ARIANA..Engaged Biogen(Paying for A2-73 Testing) ia an MS Trial..Has received and announced positive interim "In Viva" Data from Michael J Fox Foundation's Lund University(which granted cost of trial!)..
If you read the Tea Leaves ..Both Rett Syndrome Association and Caulfield Hospital have announced NEW CONTINUATION TRIALS for A2-73..Neither Organization known to be deceptive or "hyper" when relaying information to a desperate patient population. And if you are able to read english..the last News announcement from Anavex regarding Parkinsons SAYS they are PLANNING A PARKINSONS PHASE 2!
Now it is reasonable to wonder WHERE the good Dr is going to get his funding for 3 Phase 2/3 Studies in 2017..but the good Dr has said he doesn't need anymore money..oow..that could mean he already has money $9,000,000 necessary to accomplish what he needs, but more likely means he has the money he needs $75,000,000 ($25 Million per Trial) lined up through Grants(MJFF & Rett Syndrome & Governments) & In-Licensing. I think it would have been irresponsible of the good Dr to say this and then go all Dilutional..But the Delusionals have a good scare point and until we see the news. But what is worse case here..worst case? We have tens of millions of more dollars for 2-3 Phase 3 Trials? We are trying to save people's lives for goodness sakes..Any dilution comes with Liquidity which in less than 1 year could turn the corner to be worth BILLIONS..it's a better gamble than VEGAS by 100 times and we are trying to help people!.And you can write it off your taxes if we don't.
I would like to say this to the scaremongers and negative nancys...that don't really mean it..you are just flat out long Anavex Stock and really deeply disappointed that we are at our 52 week low.
2 years ago, when first accumulating Anavex Stock, and did quite well, the only reason the stock went up is Patients were getting better. They were as was proved out in 5 week Data and even subsequent releases for 17 Week..
31 Week Data proved more elusive..some of the Data was unbelievable, the Mono-Therapy! It really was/is what many of us expected and hoped for everyone. Bu then you had the ADCS-ADL Data which had changed it's begin point from 64 to 70? Why? I don't know but..it should NOT have changed in my opinion, but I am not a Dr. If you leave teh Adcs-ADL start score at 64 than 6 month Data for Everyone is really quite postive! really..it shows people have gotten better and stayed better for 6 months..But other data does show a trend for Dual Therapy Patients of regress..The Leadership of Anavex promises that the Pooled data is positive but since it is pooled Data, it is difficult to "see" the data that THEY KNOW..I take them at their word..They have done everything they can to make A2-73 FAIL..They don't want to spend any money on a FAILED PHASE 3 for A2-73, as they have A3-71 in the WINGS..if A2-73 isn't strong enough to get the job done in a phase 3..ANAVEX wants to know that NOW!
But if you use your logic instead of the emotion of a low priced stock..you see that ..if people were not getting better, and teh data was bad,,ALL THESE THINGS WOULD NOT HAVE OCCURRED..
Not the extension, not MJFF, Not Rett Syndrome, Not Caulfield Hospital, Not Biogen, Not, Ariana, not the Major Science Conference with COgstate and Neuronetrix.
People are getting better, but they had mild to moderate Alzheimers for goodness sakes. It is a terrible terrible disease and many of these participants are in their 70's or older..
Again..this is an OPEN TRIAL ..ALL DATA ..including many from over One and a half years is immediately available..I never thought people would actively root against Anavex and attack them..Never..Who could be so cruel? Yet here you witnessed teh attorney, the investment short letters, teh pundits..all going out of their way not just to attack the science but to attack the integrity of le leadership. they are still here. still short a stock trying to save lives. still betting on death over hope and then lying about it!
the gamble/the risk/reward basically has not changed from when I first acquired Anavex and fell in love with the science and management. I think the science has proved 100 times better for we are SAFE, EASY TO TAKE, and HELP GENERAL CNS HEALTH! but for those of you only committed to Curative or SOC for Trillion Dollar vested in research and still uncured diseases .from ALL the Ancedotal evidence, which ALL POINTS TO YES! (except the price of our stock), as one of my heroes would say:
Are we making people better? Well are we?
- Ariana is bringing Medicine into 21st Century by using Artificial Intelligence not only to scour Ongoing Trial Data for
meaningful direct & Corollary Success, but
then to use EXISTING TRIAL Data to compare and aid the search!
Like wow man..the good Dr read my mind and maybe my posts about NOT NEEDING A BLIND PLACEBO!..Sounds like some archaic Torture..
YOu will be Blinded and Fed a Placebo for One Year Until you DIE!
We can do better, Anavex can do better, and guess what,,they are trying!
- YOU have to re-read that Ariana announcement..
they announce Phase 2 for Parkinsons..Do you think THAT news is priced into stock? BAM!
The Shorts had everything working their way..
Delusional dilutional Gag Gap Fill Dip to $.10 on it's own Stock Board!
I think there are more Short Sellers posting on this Board than longs..
The Stock at it's 52 Week Low, certainly with Christmas end of year Tax Loss 30 Day Selling right around the corner! Oh it would be a stock full of Long's Equity in their Ashen Socks this year!
Shorts are NOT GOING TO COVER because the stock is low..They believe it's worthless! As A2-73 is a scam and will soon utterly fail in 1 Year Phase 2 Data! And Shorts have momentum!
So what happened a couple of days ago? Volume wasn't tremendous..but the first day of buying usually isn't tremendous Volume, it's just someone notices the Right Buying, slightly panicked, larger blocks than normal..paying up(not worrying about Market Maker Cabal dropping the stock $.30 5 seconds after they bought..It's little things..kind a like a fire..
you smell smoke..panic! The shorts and market makers panicked yesterday. they will try to find out the WHO and WHY of yesterday's enthusiasm..We will be watching very early on, what they found out..
Maybe it was a long or a short with an itchy finger..
With three phase 2/3 Clinicals and Biogen and Ariana in the mix and
Dec 10 right around the corner..makes sense..
Shorts would not pour gasoline on a little fire though,,the shorts would come back with some water and try to extinguish and excitement..UNLESS..
UNLESS..the smoke isn't from an itchy finger..it's from a greedy grab..then the Shorty McShort Shorts may pour a little gasoline on th e blaze..cause really brothers, who wants to be short Anavex the day IT HAPPENS!
The Shorts are nervous down here..because even though they want YOU to believe all the negative manuer they shovel your way..They know in their hearts..all their lies about Anavex are just that..lies..and someday soon..someday very soon...Shorts have a lot more to lose at this point than longs..a lot more
having said all that..the good Dr said he didn't need more cash any time soon..so go figure..
looks like yesterday was an itchy finger..
like I said ..Short Cabal owns this ..
was hoping yesterday represented a major new player..
just same old thugs..
i agree with you..so Biogen has head start..
where in-licensing of ALL Anavex compounds and IND's could cash out
sooner rather than later might be territorial ..
Far East..where other companies could in-license distribution for a territory..
Others with greater expertise in this market could walk through difficutly of Different IND's...you would think Biogen would make a play for whole kit and kiboodle..
for investors....
i don't know if this moment will be forever written in Stock market lore..but wow..
if this is not an entry point I don't know what is.
for long term investors..
this may be a pretty good entry point for a two year investment in a company trying to help save lives and stop painful diseases..
ok so..
lets keep this one simple as simple does..
re-read Anavex and Ariana Announcement..
it includes wording indicating a planned Phase 2 for Parkinsons..
Shorts don't cover bottoms on low volume days..they never try to show their buying much less let it create Momentum Up..SO while AVXL is at a 52 week low, with 30 day window of TAX LOSS selling in full bloom..there is no way shorts booking profits on up day..other than FEAR..
FEAR of what? Larger than normal Buy Blocks, WHO the Buyer is, willingness to BUY UP for Blocks..
Market Makers are the number one shorts..so ..
I think ..if patterns follow..the Market Makers will try to Stomp out the Momentum by showing Pre-Market Price up ..say to $3.25 or $3.30 and then walking the price down to $3.10 for opening..trying to let everyone think..$3.25 is high for day and we go down from start..
If the Market Makers do not move up the stock pre-market..
Either way..we shall see today how impatient and wealthy yesterday's buyers are..
Power walker..i dreamed of a party where an artist was painting the outline of a riverfront in beautiful pastel, while a pianist lightly cascaded a beautiful Mozart rift(which would have played better on a Harpsicord truth be told) and just as I was going in for cool glass of punch a golf ball shattered the nearby window and landed in the punch bowl.
damn the luck! as I was thirsty!
Shorts don't cover if they don't have to.. they let it ride.. something is afoot!
Well said..we have an exceptional Drug and
The good Dr has accomplished much in 3 years with limited Capital.
It's exciting
It's a small biopharm stock with hundreds of millions probably dedicated to its failure by evil , corrupted forces..
only invest what you may afford to lose in any stock..
In moderato
The other way you KNOW the data is good..
Anavex hired Ariana!
Why hire a company to help you create Phase 3 Trial of Data is bad or people getting sick?
You dont..
we have Good Safety data Dec 10..
And with all positives seen so far in so many IND
That is enough to mean a $500,000,000 market value someday.
I think we will see tens of billions.. but hey I will take fives of billions..
Understood..
But .. it is an open Clinical..Yes
Safety has continued .. and It is well past 52 weeks.. Yes.. ( not so positive about moving forward if otherwise)
Multiple Organizations have
Announced next Phase Clinicals including ; Rett Syndrome, Caulfield Hospital for Alzheimer's and Anavex has mentioned next phase for Parkinsons..
none of this happens without good data..
The problem with good data is we all wanted great data.. this is mild to moderate Alzheimer's. We need to be in PRE CNS with A2-73..stop issues before they start...
I disagree .. it's an open trial.
We have second hand confirmation /announcements of phase 2/3 in three INDs with reputable organizations..They did not mention these New Clinicals because they don't know the data.. Biogen didn't do a material agreement because they didnt know the data..
They know the data.. it's good enough to move forward for phase 2/3 in 3 indications..
Anyone asking for more is asking to be a part of he Cabal of fake expectations and Cabal sell off on fake disappointment..
we have already plummeted! there is no plummet! this is MANIPULATIOn..
We have Parkinsons, Rett Syndrome and Phase 2/3 for Alzheimers.
there is NO Fail..only people who are looking to EXPLOIT SITUATION by engaging in too high expectations..so that they may be part of SHORT CABAL MOMENTUM MANIPULATED SELL OFF are going to use terms like..
homerun, hit it out of the park..
We are looking for continued proof of SAFETY..and
glimmers of Efficacy both for Combined DZP & A2-73 and Mono-therapy..
That is it..and we already KNOW we have enough to plan PHASE 3 ..Because this is NOT A BLINDED PLACEBO Clinical Study..
THEY ALREADY HAVE THE DATA..oh my gosh ..
it's like dealing with Ground Hog Day ALL OVER AGAIN..
Everytime..
Lucy hold that football..you promise?
Unbelievable..really..
We humans are truly small small people..with short little memories and
interests that never ever wander far from self..
If retail buys into this blather..
Pmk the pharmacist?
Deluge Alzheimer Advocacy Groups with good data regarding A2-73 which
Will be released dec 10.
thanks TOB..
hey..again there i sNO GAG order..AVXL following Law in releasing OS COunt to EVERYONE AT SAME TIME..Helloooooo..
Don't call them and waste their time! Again..
so there may not be a Gag Order at all?
so we might be looking at a ..
Faux Gag Dip Gap Filler?
or a Dip Faux Gag Gap Fill?
my 15 posts are going to be out early today!
A Dip Gap Fill Faux Gag?
False Gag, real Gap Dip Fill!
Fill a real Dip Gap with a Faux OS Gag?
Dr aisle 7, he can't stop!
absolutely believe through slush funds Big Pharma funds Hedge Funds to slow down development of succesful new Pharma..absolutely! I alos think they engage Investment news letters over cocktails about upcoming competition..
the money being wagered against Anavex is NOT BECAUSE ANAVEX is bad people or bad science..
it's that it's bad economics for Big Pharma!
Biogen broke ranks..but even then was not able to lock down a, Anavex $$$ deal.(that we know of ). Why not?
because the good Dr knows that until our science is walked down the line, Shareholders will never get full value!
The good Dr doesn't want to be the Cubs trading away Lou Brock for 5 Beans..Big Pharma just trying to delay process to IMITATE SCIENCE..
The race is on..