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using simple math and reported MMSE scores from 31 Weeks and 57 Weeks, using averaging from Super Responders(IMO MOnotherapy ) and others (Dual THerapy w/Aricept) ..:
Conjecture based on Reality of Alzheiemrs being a degenerative drug:
The Patients on Dual Therapy at 52 Weeks scored 15.9 on their MMSE, this would be very close to Aricept
Score line at one year, about a 4 Point decline. At 52 Weeks the MonoTherapy Group(A2-73 Alone/Aricept Naieve)
scored 24.6( Probably more than 8 POINTS HIGHER than SOC with Aricept!).
At 57 Weeks , so just 5 weeks later, in a regressive disease, that has never shown pause after one year, much less
REVERSAL(because that is what Higher Scores mean on MMSE!) the average scores for Monotherapy went to 25.6(Up a Full Point!) and here is the UNEXPLAINED PART, the Scores for, what were the Dual Therapy Patients went UP as well
from 15.9 Average to 16.9 Average.(Lots of Assumptions , but I can back them up with Company statements and numbers) So the question becomes, how is this possible ? the Dual Therapy Group had shown a typical negative downward chart slightly better than SOC..How does the Dual Therapy Group show reversal from 52 weeks to 57 Weeks?
It is my continued belief that many if not all patients involved in this ADAPTIVE TRIAL are NOT Taking Aricept any longer.
And base on these averages, it would appear that a large number of Dual THerapy Patients STOPPED taking Aricept at 52 Weeks. So ..based on this assumption, than Mono Therapy with A2-73 is absolutely reversing symptoms..and should be made available as a Breakthrough Medicine IMMEDIATELY! The FDA and ANAVEX have this Data and More, they should share it with the World. One year into a Mild to Moderate Alzheimers Study to be able to effect reversal in close to 100% of Participants is nothing less than Miraculous!
IN 5 WEEKS? are you kidding me? If this IS TRUE than think of ALL the PATIENTS that could be IMMEDIATELY SAVED!
Anavex OWES the WOrld this information..
How many Patients have stopped taking Aricept and What have been their resultant Scores on Testing?
If the numbers I have crunched are TRUTH, than it is inhumane not to make them Public and OFFER A2-73 to EVERY Single Mild to Moderate Alzheimer Patient! We are not a cruel species! Let us not deny our suffering elderly a chance..We are better than that!
These numbers were based upon reported 7 Mono/ 6 Superresponders and N=27/ N=25 Statements by the good Dr re: no difference in Dual Therapy and abandoning of Dual Therapy Strata as target. These numbers were published at 31 Weeks and at CTAD. Assumptions made include 6 superrespnders are all MonoTherapy(7 High Scores at 31 Weeks were MonoTherapy).
And to ADD credence to my belief, a logical reason for no longer delineating Monotherapy vs Anavex Plus Aricept..IS Montherapy is far more efficacious, showing Aricept to be counter-indicated?
Is this WHY we have DELAY? The powers that be are too scared to say
STOP TAKING ARICEPT, start taking A2-73? They shouldn't be..
"n brain and retina, microglial secreted factors cause pleiotropic effects on immunoregulation and inflammation. However, microglia activation via inflammatory stimuli can lead to chronic neuroinflammation and enhanced neuronal injury. 6,7 Several pathologic conditions are exacerbated by neuroinflammation, including stroke, Alzheimer's disease, Parkinson's disease, and traumatic brain injury. 8–10 Within the eye, disease states including glaucoma, diabetic retinopathy, and age-related macular degeneration share neuroinflammation as a common pathologic component. 11–13 In addition, many studies indicate that strategies for decreasing chronic inflammation prove therapeutic. 14,15 Therefore, microglia-mediated responses to inflammatory stimuli are treatment targets for vision-threatening diseases. "
Wonder if the good Dr did an eye checkup before the trial started?
Anavex has stated. That They either havedrug supply or have ordered for Rett Syndrome Trial.
How do you know you have supply necessary unless you know number of participants and duration of trial?the only way you know duration and number of participants is if everyone has agreed ; fda, Rett syndrome, Anavex..to trial design, Rett syndrome
Will have zero problem filling Trial quickly.IMO..(tight knit group)
If everything agreed to announce and begin trial soon.
Very soon.
M
reminds me of the time I went to speak to a priest to make sure I was still sane..
thanks for the post..I agree..Go visit a Dementia Ward and rewatch this video..
The Risen! The Fog Denied! Like Flipping on a switch!
If painting a picture in Oil Paints of a beautiful Harbor or playing a piano or playing golf didn't get ya'
This guy did..forgetting to take out the trash on Thursdays!
I mean are you kidding me!
What a beautiful soul and then to come back and shout to the World..
Wow..HERO HERO HERO!
anavexnow.com
share the video! Seeing is believing!
https://www.facebook.com/TheProjectTV/videos/10154154448498441/
The P300 is Reversal for many. Soon(the good Dr already knows) IMO we will have reversal in ALL Mono Therapy Patients...
I doubt there are any Aricept patients left in trial.
I wonder how we lost 7 Trial Members? By my calculations, new wunda drug, we should not have lost any..
yeah..sure,,no one said anything to her..
25 out of 25 patients rik roll Alzheimers and she is cautious?
she must not need the medicine eh?
Put her under oath..with a 5 year perjury count in the balance and just
nicely ask if anyone said somehting to her about being more "cautious".
Alzheimers is a DEATH SENTENCE WHAT are we being CAUTIOUS ABOUT?
The fact that we are NOT SENTENCED YET?
that's not true..
there are 60 Million hsares authorized ..but not yet issued..
the board could authorize and issue these shares at will..thus destroying any takeover..
the fact is we have THE drug..No one else has it..No one has EVER had it..
No one else has EVER stopped Dementia! EVER ..EVER.
How many thousands of times has humnnkind tried? The jealousy of th emedical , scientific and pharmacologic world at the Humanitarian Accomplishment of ANAVEX is SICKENING!
Their petty hatred and envy is KEEPING PEOPLE FROM GETTING THIS DRUG!
Who changed that one Analysts mind? I retweeted her Anavex Tweet and now she walks it back? WHO GOT TO HER?
most of the other 18 -19 patients in the study that were originally dual therapy are now Monotherapy and recovering nicely. IMO-Dodo bird whisperer!
the dam will break, and maybe that analyst that changed her tune will
talk on a criminal witness stand. new leadership won't stand for this petty capitalistic hatred, letting people die! The world is changing.
Share the Project Video on Facebook and twitter..
Watch it again, it's beatuiful!
As humans we are always worried about what is next..
Take a few moments and THINK about what OUR Drug saved this
guy from ..Like a lightning Bolt from out of the blue.
saving his mind, saving him, from oblivion, the pain..
i know we can't stop worrying about $.10 but really can't we try?
kids, the fact is we have the drug..
make your plans accordingly..
most of the other 18 -19 patients in the study that were origianlly dual therapy are probably now Monotherapy and recovering nicely.
the dam will break, the word will leak,..the demand will grow..
Share the Project Video on Facebook and twitter..
Watch it again, it's beatuiful!
As humans we are always worried about what is next..
Take a few moments and THINK about what OUR Drug saved this
guy from ..Like a lightning Bolt from out of the blue.
saving his mind, saving him, from oblivion, the pain..
i know we can't stop worrying about $.10 but really can't we try?
Yes the good Dr cashed in another 3 plus million shares .. what will he need big Pharma for now? Gives Anavex $17,000,000 to start three trials, by end of 2017 ..govts and associations will be falling all over themselves for A2-73 their sick patients..throwing money at Anavex..
What is the good Dr going to do with Big Pharma? Express scripts can handle distribution.. word of mouth, internet, and news videos of recovering Alzheimer's patients will be all the marketing they will need.
No Adverse Events , No Bad Side Effects.. positive side effects.
Caution you will sleep better , be happier and have more energy , quit taking this drug immediately if you experience new found sense of humor!
THEY know 2 years OUT what is going to happen to the patients who have stopped taking Aricept..
We are not partnering .. a little birdie told me so..
Anavex is going it alone. They don't need BP, as it is obvious BP wants to control it all. Anavex is going to run the table and they have a tremendous team to make that happen.
We are not partnering with anyone except Governments..
Haybe Biogen..since they are testing for MS..
you guys..
The Super Responders were Aricept Naieve (IMO/CMA)..
They responded immediatley..It's what the Sigma 1 Ligand DOES!
The other patients responded probably just as quickly once
they STOPPED TAKING ARICEPT.(IMO/CMA)
the 300 Patients..IF they are SMART(the patients that is) WILL STOP taking ARICEPT once they get accepted in the TRIAL...
I don't think they will MAKE anyone STOP..but...
IF that is the case and most Patients are MONOTHERAPY on A2-73 ALONE,
the RESPONSE will be almost IMMEDIATE..
We should have Rett Syndrome by then anyway..ZERO ARICEPT problem..
I don't know if Anavex accessed Lincoln Park Finance deal or not.
Does anyone know for certain? Would have preferred a no strings attached Grant..but hey..I understand if it's not.
I do know that Anavex increased their cash position by approximately $10,000,000. Good, they need it for 3 Phase 2/3 Trial upcoming in 2017,
Alzheimers, Parkinsons and Rett Syndrome. My guess is before the year is over we may add two-three more:
Insomnia, a type of Epileptic indication, and/or a recovery type Indication from Injury.
Let's revisit the Lincoln Park Finance Deal one more time. just in general.
It's the best deal we could get financing wise at the time. It minimized immediate Dilution and allowed for an ADAPTIVE Business model based on what happened during the Trial. Keep in mind 99% of ALL Alzheimer's Drugs fail. Certainly Finance Companies keep that in mind! From a Company standpoint, this was the deal they wanted, flexibility, dilution as needed.
But I would like to add my two cents here to LONGS:
One it's better than a LOAN which puts undo pressure on Staff and the Budget. Trying to Pay Interest with no income is hard to do.
Two, Longs may actually AVOID DILUTION altogether! Simply buy more stock! If Anavex had to issue 10% more stock to fund it's operations for another year, add 10% to your holdings! No one gets to "BUY IN" below market because they know THE CLUB. YOU DO! No one gets cheap Warrants or access to unlimited supply for Market Making..
Why do you think the Market makers hate us? Because the good Dr. didn't join their CLUB and SELL YOU OUT..
2017 is here..and may I remind everyone..Unlike Biogne, Lilly, Axon, etc. We are NOT waiting to FAIL, as the Company Pushes through Medical Trials..We are PUSHING FOR IMMEDIATE ACCESS! Keep sharing the Videos!
Anavex should do a full physical, including a recorded interview of every patient in Australia, at beginning, and quarterly.
Also, the depth of the Beginning Physical should be expanded to include
every Organ that is known to house Sigma 1 Ligand Cells:
Heart(blood Pressure, EKG, Echocardiogram?)
Eyes(Actual Vision, ANY deficits, Macular Degeneration? regeneration?)
Digestive- Urinary
Sexual-
After reviewing the Project Interview again..
IT IS UNBELIEVABLE WHAT THIS DRUG IS DOING!
This guy was an irritable grump vegetable one year ago..
AND LOOK AT HIM! Funny, engaging, self deprecating hopeful, aware.
DO YOU REALIZE, that THEY KNOW they are ADDING STRESS to HIS SYSTEM and perhaps CAUSING INFLAMMATION..HERO! HERO! HERO!
He DID THAT INTERVIEW for US!
What a STUD!
great find, this is the Video that makes it real, human.
I visited a Mild to Moderate Dementia Ward recently.
Maybe we should put AF, JF and a few brutish posters from this Board on a Tour, because their actions are delaying the ONLY drug that works.
They are fighting for someone..but DOES THEIR DRUG DO THIS?
NO!
with Governments ready to FUND or Help Fund and Associations willing to help fund..Why give up control? The homerun is control..
If you want control..make a run at us..see who stands with the good Dr and sells for $50/share..haha..yeah..I thought so..
Lock & Load we are going into the jungle
$100? is only $4 Billion! The Market Value for Alzheimers alone is $8-$30 Billion. Add in Parkinsons, Insomnia, MS, AS, Shizophrenia, Epilepsy, Autism, Depression, Heart health, Eye Health..
What part of , A2-73 makes the Sigma 1 Ligand Dance doesn't everyone understand?
The ONLY reason Average scores for ALL Patients ROSE is becasuse..
PATIENTS STOPPED TAKING ARICEPT..
Do the math on what that means when ALL Alzheimer Patients want to switch
to Anavex re: SOC!
So if 20 people figured out, that if they stop taking Aricept while they are taking A2-73 and then THEY all got BETTER like the original 7 got better from the start that NEVER took Aricept.
How long will it take every other Patient ALL over the World to figure it out? About 1 Conversation because Aricept sucks to take and does next to nothing..The demand for Anavex will be so OFF THE CHART out of the GATE as to make YOU SICK(like taking Aricept)! That we are not through $50/pps is a testament to the idiots running Wall Street and managing your investment dollars. Take advantage of their idiocy RIGHT NOW..AnavexNOW.com
Bravo II
The market makers hate Anavex.
The good Dr could have coughed an this Cabal would have joined hands
To sink the stock. They hate him for not doing a secondary!
There is a good reason for not saying where $10 million from.. bear trap about to spring.. can't wait!
We stopped Alzheimer's. Everything else is a sideshow ..
Did somebody die?
NO. Worse! They found $10 million
And no one knows where it came from!
oh the Market Makers are PISSED..haha..they are about to get
PR'd out of business..
remember the comedian Flip Wilson?
well you youngins won't..
but i do believe the good Dr may quietly look in the mirror and give himself a smile..so predictable..really..did they think that was my final act?
The Bear Trap is Set,
and
Here Come the Judge! Here come the Judge!
kmadd,
so a lightning bolt source..I like it!
Hmm..maybe Biogen or Lilly..both have deep relationships within Anavex..
I saw the troubles MJFF had with FOX pharma..Missling would be even worse, but maybe MJFF learned( maybe MJFF took different Tact by asking for Key Docs to be part of Anavex's SAB?)
Neuron came up flat with Soldiers injuries...they are in a competitive space, but see their drug as Adjunt..Regardless of WHAT ANY OTHER DRUG DOES..FIRST you gotta create HOEMOSTASIS! So neuron, and I hope it works for Rett Syndrome, will still need Anavex to create Homeostasis..
neuron should be teaming up with Anavex in SEVERE Alzheimers..
Aussie's may just be covering all the related costs(providing Institutions and Docs at NO CHARGE..no charge for testing,,AND paying for DRUGS..) in this regard paying Anavex some money for Corp Costs would make some sense..$10,000,000? Maybe..Australia has 300,000 and growing problem..
I think in review it is a toss up from Aussie Gov't or Lightning Bolt..
EIther Way..How long till Blast Off?
raja,
don't forget Rett Syndrome funding..along with MJFF and Govt's..
but what got me..I don't think the $17 Million is dedicated to any one Trial....it sounded like those may be Anavex operational dollars..or how else could they last two years? did ANavex just get granted money for being awesome? I really don't care if they sold more stock to get it..the key is we have it!
We as longs have to pinch ourselves ..and remind ourselves..
Of all the BILLIONS spent..all teh YEARS..all the FAILURES..99%!
99%! FAIL!
WE ARE IT! This was NOT SUPPOSED TO HAPPEN..So
Pinch yourselves and hold on tight..because it's about to get a little crazy! And if you have ANY DOUBT..go look at those graphs from 6 months to
52 weeks to 57 weeks..and KNOW..MONOTHERAPY is the REASON FOR THE SEASON! Merry Christmas!
Also..just remember what the market would have done to us if Anavex had failed?
my guess is ..Australia Phase 2/3 already may be filled from respnding e-mails. And REtt Syndrome will have their patients ready to go...within weeks if not sooner..MJFF won't have any problem finding Parkinsons Trial Patients..They already have drugs for Rett Syndrome Trial..
So we see where the good Dr is going..Rett Syndrome to make drug available to market place. Australia to get world excited. You will be able to tell difference in patients..there will be a humanitarina releasing of Placebo Group in Australia...Parkinsons and Rett Syndrome Trial on ly three months.. But even those may see a Humanitarian Release of Placebo Group..
Paralell..by 4q of 2017..
$17 Million enough for 2 Years?
This would make sense as well as MJFF as how could Aussie's KNOW before everyone else that the $$$ was there to fund Phase 3 Program?
Sorry ..this should have read 2016 Grants funded in November NOT 2017.
it was a long night..
I looked for a Conference or event where this might be announced. Am still looking. It would be a Parkinsons event with Dr. Nilsson.
Hi Miss Australia! nice to see you back!
After reviewing a few sites,
I believe the amount of money that has been Granted
Anavex is actually between $9.5- $10 Million (as one must account for Cash Spent during October and November) and that these monies (IMO) were most likely granted by MJFF. The 2017 MJFF dollars were delivered in November which would align with when Anavex received funding. Also, the three new Scientific Advisory Board Members were probably part of the "deal" to get the Grant. I may not be correct on this source, but this makes the most sense.
The Michael J Fox Foundation is probably awaiting a Science Conference or Major Public Conference to announce it's Scientific findings form it's "in-vivo" study and the very generous grant.
We won't keep all the money but my oh my.. the good Dr plays a mean game of poker..
We stopped Alzheimer's!
We should be a $500 stock. Maybe higher..
at these points in time
I like to remind everyone why we are here..
It really is a very simple equation and one that
the Long Time Longs have asked themselves many times
and we always come away with same answer..
Are People getting better?
and now we know,,definitively ..that they are.
I don't know about you guys..but I don't want CoreyRenauer or AF on my side
EVER! It would be like agreeing with Hillary Clinton about something..
WHaaaat?
People are getting better..but not just on Day 5..but on
day 400! I mean..the reality is..
A2-73 on Mono is BETTER than anything we could have hoped for..EVER..
I want to be the first to say it..and I want you crazy knuckleheads to
remember me being the first to say it..but are you ready for my
latest , craziest Hypothesis?
The Hungarian Irishman American hereby postulates..
That not only is A2-73 making Alzheimers patients STOP deteriorating..
and BETTER than when they started.. are you ready for this..
A2-73 May be MAKING THEM BETTER THAN THEY HAVE BEEN for a LONG < LONG TIME! May be better than THEY EVER WERE!
I think even I gotta say..that's one toke over the line sweet ..
BAM! There I SAID.IT..I didn't say cure either!
look ..not even going to read it right..why bother..
but it is GREAT NEWS that JF still hates Anavex!
JF loved Lilly right up until it lost $8 BILLION!
JF still loves Biogen as it loses $$BILLIONS!
The best indicator an Anavex Long could EVER hope for
is Jean Fountenou HATING Anavex!
Long way to go ..boys an dgirls..a long way to go!
this would be my speculation as well ba..
they saw data first with PART C extension..
they also probably know that this is a MonoTherapy...so will
save money on Aricept! and Long Term Care..
What an investment for the people of Australia!
Nice to know some Governments not run by a Cabal of Bureaucrats and Wealthy,
If your not scared
Your at the wrong place,
When your not scared you
Sell
Biogen Down
LLY Down
AXON. Down
Anavex about to fly..the calm before the storm
Cash money
Don't kid yourself.
Human nature is difficult to gauge.
Don't you think taking care of sick elderly is a Big Business? There are many parties that profit from sick elderly.. drug companies especially..
Do you think BP analysts will be blackballed if seen cheering on Anavex? Also if Anavex does do all it purports to do how many researchers just lost their jobs?
How about charity groups? Who needs them if people are not getting sick? How many people just lost their jobs at nursing homes, charity organizations?
There is unbelievable pressure not to solve Alzheimer's, Adam Fuerstein is not alone in his bubble..
The failures of BIOGEN AND lilly mean more trials, more investment dollars... Who loses with Anavex?
...
This is spot on!
They are more concerned about making informed decision than wrong decision. "Why would you buy before they said that?"
The delay in the press conference is for Retail, it's the docs way of giving Retail a chance to buy more or buy back in if you have sold.
I don't know if any major news today,,
But the overall average on graphs going up after 50 weeks and the confirming announcements of Parkinson's and Rett Syndrome
Should be enough for even the weak of heart..
It is possible the $10 million came from dilution.. but I am guessing some if not all from Australian Government..
We will see..
If you read IHUB you knew about all three Phase 2/3 studies, because we confirmed them over a month ago, through ARIANA Announcement/ Caulfield Hospital/ and Rett Syndrome Association PR.
The company had not formally announced other than..we are planning on planning..
so it's new news to the rest of the world..just not us.
and it's major! Mulstiple Scleroiss update/timeframe? Insomnia update/timeframe? Can you imagine a non-addictive/non-psychotic drug that helps you sleep and think better?
so..here is a logical statement..for many elderly who can not sleep, it is because they have to urinate in the middle of the night..is it possible that A2-73 is also helping the Digestive Tract? Hellooo, any Sigma One Ligands down there?
What I would really like to discuss is not what the good Dr and our team of the hardest working employees in BioPharm have accomplished this past year..
The Biogen Deal, Three Phase 2/3 setups for next year, succesful destruction of Alzheimers for the FIRST TIME EVER!
What I would like to discuss is the fact that the good Dr and great Team, accomplished all this with the same amount of money that Big Pharma uses to light a campside fire at Sea Island, Ga in the heat of July!
Pay the good Dr. MORE! WOW
Or government grants
Heads will explode!
He said he wasn't worried about money.
I guess the heck not!