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VERY unlikely! Auto1 has no way of assessing PSTI's "reputation" (yeah, I know, the "market" told him!).
What we do know is that outstanding institutions and specialists and thought leaders in the field (muscle regen. for example) are willing to collaborate with PSTI, and administer PSTI's products to their patients. That speaks louder in my view.
Yeah, good for BR, but why didn't he give us a heads up BEFORE (as opposed to AFTER) the fact (LOL!!!). Doesn't he want us to benefit also?? (LOL, again).
First, my complement on the excellent metaphor (Mikeys poetic influence on "Eich" is beginning to show).
An additional thought, this particular stone turns into a lighter than air ballon, and reverses direction whimsically and in a very entertaining way. Note that we've been HOVERING in a tight range, which does imply a regular and daily change in direction. I notice that stocks do that!!!
One might add that not only do you have to REMEMBER history, but you need to be able to pick out the relevant and filter out the dross! Failure to do that will result in chasing your own tail (i.e. running around in circles, ok if you're on a race-track, counterproductive in investing)!
"In fact there's an inverse relationship between safety and efficacy requirements!"
Yes! I remember distinctly that it was a voluntary act! Now comes Auto1's "counter argument":
Ouch, that hurts! Now for the powerful rhetorical counter puch:
I just don't know how to counter that powerful assertion. Auto1 doesn't give us a single example, must be that they're just "too numerous to count". I imagine he started counting, then after hours of counting, perhaps having gotten to thousands of examples, he just got tired!
Exactly! There's an astonishing amount of research going on today. Much of it is highly specialized, so it makes sense to have journals that cater to specialists. The sum total of new papers published any given month is probably in the thousands, couldn't fit that in three journals. The paper in question was published in "Journal of Cachexia, Sarcopenia and Muscle" specializing in guess what: muscle wasting and damaging diseases or events (such as hip replacement operations). The right place to publish the effect of PLX-PAD on muscle recovery after hip surgery.
Regards, zzaatt.
Papers published in the same journal, gives a sense of why Dr.Tobias Winkler, et.al. published in the Journal of Cachexia, Sarcopenia and Muscle
Article first published online: 24 August 2018 Impact of different palliative systemic treatments on skeletal muscle mass in metastatic colorectal cancer patients Sophie A. Kurk, Petra H.M. Peeters, Bram Dorresteijn, Pim A. de Jong, Marion Jourdan, Hugo J. Kuijf, Cornelis J.A. Punt, Miriam Koopman, Anne M. May
Article first published online: 21 August 2018 Prevalence of rheumatoid cachexia in rheumatoid arthritis: a systematic review and meta-analysis Rafaela C.E. Santo Kevin Z. Fernandes Priscila S. Lora Lidiane I. Filippin Ricardo M. Xavier
Article first published online: 14 August 2018 Aging-related anorexia and its association with disability and frailty Kota Tsutsumimoto, Takehiko Doi, Hyuma Makizako, Ryo Hotta, Sho Nakakubo, Keitaro Makino, Takao Suzuki, Hiroyuki Shimada
Article first published online: 6 August 2018 Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women Jun-Il Yoo, Mi-Ji Kim, Jae-Bum Na, Yun-Hong Chun, Young-Jin Park, Yongwhi Park, Young-Sool Hah, Yong-Chan Ha, Ki Soo Park
Article first published online: 2 August 2018 Oxidative stress-induced dysregulation of excitation–contraction coupling contributes to muscle weakness Rizwan Qaisar, Shylesh Bhaskaran, Pavithra Premkumar, Rojina Ranjit, Kavithalakshmi Satara Natarajan, Bumsoo Ahn, Kaitlyn Riddle, Dennis R. Claflin, Arlan Richardson Susan V. Brooks, Holly Van Remmen
Article first published online: 31 July 2018 Screening for low muscularity in colorectal cancer patients: a valid, clinic-friendly approach that predicts mortality Elizabeth M. Cespedes Feliciano Egor Avrutin Bette J. Caan Adam Boroian Marina Mourtzakis
Article first published online: 27 July 2018 LY2495655, an antimyostatin antibody, in pancreatic cancer: a randomized, phase 2 trial Talia Golan, Ravit Geva, Donald Richards, Srinivasan Madhusudan, Boris Kin Lin, Haofei Tiffany Wang, Richard A. Walgren, Salomon M. Stemmer
You missed the point (astonishing!!) I'll repeat: There are hundreds of specialty medical journals. Doctors and researchers follow most closely journals that deal with their specialty. Not "mullet wrappers", important, serious journals. See below for a reprint of my previous post. See if you understand the point this time around.
There are hundreds of medical journals, covering every specialty, read by doctors/scientists who are working in a subspecialty of interest. It's sheer idiocy to think that the only valid journals are the three referenced by "Auto1" given the massive amount of research and interesting new data.
Cardiologists dont' need to (and can't) keep up with every new piece of research in "Clinical and Experimental Gastroenterology", or Roentgenology or "Cutaneous and Ocular Toxicology" or "American Journal of Alzheimer's Disease & Other Dementias Neurology", etc..
The article referenced was published in a journal that is followed by doctors working in a field that is concerned with and needs to follow developments related to muscle regeneration after (iatrogenic) trauma (hip surgery). Makes sense, doesn't it?
Here's a partial list of medical journals ("mullet wrappers" according to "Auto1"): (See if you can squeeze all these into three journals)
Academic Medicine Academic medicine Association of American Medical Colleges English 1926-present ACIMED Medical informatics National Center of Information on Medical Sciences in Cuba Spanish 1993–present Acta Anaesthesiologica Scandinavica Anaesthesiology, Intensive Care Scandinavian Society of Anaesthesiology and Intensive Care Medicine English 1957-present Acta Médica Portuguesa Medicine Portuguese Medical Association Portuguese 1979-present Acta Neurologica Scandinavica Neurology Wiley-Blackwell English 1925-present Acta Orthopaedica et Traumatologica Turcica Orthopedics Turkish Association of Orthopaedics and Traumatology English 1962-present Acta Oto-Laryngologica Otolaryngology Taylor and Francis Group English 1918-present Acta Paediatrica Pediatrics Wiley-Blackwell English 1921-present Acta Psychiatrica Scandinavica Psychiatry Wiley-Blackwell English 1926-present Acta Radiologica Radiology Sage Publications English 1921-present Advances in Therapy Clinical medicine Springer Science+Business Media English 1984-present African Journal of Paediatric Surgery Surgery Medknow Publications English 2004-present AIDS AIDS Lippincott Williams & Wilkins English 1987–present Alimentary Pharmacology & Therapeutics Pharmacology Wiley-Blackwell English 1987-present Alzheimer Disease and Associated Disorders Alzheimer's Lippincott Williams & Wilkins English 1987-present Alzheimer's Research & Therapy Alzheimer's BioMed Central English 2009-present American Family Physician Family medicine American Academy of Family Physicians English 1969-present American Journal of Alzheimer's Disease & Other Dementias Neurology SAGE Publications English 1986-present American Journal of Emergency Medicine Emergency medicine Elsevier English 1983-present American Journal of Gastroenterology Gastroenterology Nature Publishing Group English 1934-present American Journal of Medical Genetics Genetics Wiley-Liss English 1977-present American Journal of the Medical Sciences Medicine Lippincott Williams & Wilkins English 1820-present American Journal of Obstetrics and Gynecology Obstetrics and Gynecology Elsevier English 1920-present American Journal of Public Health Public Health American Public Health Association English 1911-present American Journal of Roentgenology Radiology American Roentgen Ray Society English 1908-present The American Journal of Surgical Pathology Surgery, Pathology Lippincott Williams & Wilkins English 1977-present American Journal of Translational Research Medicine e-Century Publishing Corporation English 2009-present American Journal of Transplantation Transplantation Wiley-Blackwell English 2001–present American Journal of Tropical Medicine and Hygiene Tropical medicine American Society of Tropical Medicine and Hygiene English 1921-present Anaesthesia Anaesthesiology Wiley-Blackwell English 1946-present Annals of Cardiac Anaesthesia Anaesthesiology Medknow Publications English 1998-present Annals of Emergency Medicine Emergency medicine Mosby English 1972-present Annals of Family Medicine Family medicine Annals of Family Medicine, Inc. English 2003-present Annals of Human Biology Population biology Taylor and Francis Group English 1974-present Annals of Human Genetics Human genetics John Wiley & Sons English 1925-present Annals of Internal Medicine Internal medicine American College of Physicians English 1927-present Annals of Medicine Internal medicine Taylor and Francis Group English 1969-present Annals of Pediatric Cardiology Pediatrics, Cardiology Medknow Publications English 2008-present The Annals of Pharmacotherapy Pharmacology SAGE Publications English 1967-present Annals of Physical and Rehabilitation Medicine Rehabilitation Elsevier English 1982-present Annals of The Royal College of Surgeons of England Surgery The Royal College of Surgeons of England English 1947-present Annals of Surgery Surgery Lippincott Williams & Wilkins English 1885-present Annual Review of Medicine Medicine Annual Reviews English 1950-present Archives of Disease in Childhood Pediatrics BMJ Group English 1926-present Archives of Osteoporosis Bone Health Springer Science+Business Media English 2006-present Arteriosclerosis, Thrombosis, and Vascular Biology Vascular biology Lippincott Williams & Wilkins English 1981-present Asian Cardiovascular and Thoracic Annals Cardiology SAGE Publications English 1998–present Aviation, Space, and Environmental Medicine Aviation medicine Aerospace Medical Association English 1930-present British Dental Journal Dentistry Nature Publishing Group English 1904-present Biological Research For Nursing Nursing SAGE Publications English 1999-present Biology of the Neonate Neonatology Karger Publications English 1959-present Biomedical Imaging and Intervention Journal Radiology University of Malaysia English 2005-present BJUI Urology Wiley-Blackwell English 1929–present Blood Hematology American Society of Hematology English 1946–present Bone Marrow Transplantation Transplantation Nature Publishing Group English 1986-present BMC Cancer Oncology BioMed Central English 2001-present BMC Medicine Medicine BioMed Central English 2003-present BMJ Medicine BMJ English 1840-present Brain Neurology Oxford University Press English 1878-present Brazilian Journal of Medical and Biological Research Medicine Associação Brasileira de Divulgação Científica English 1968-present Breast Cancer Research and Treatment Oncology Springer Netherlands English 1981-present British Columbia Medical Journal Medicine British Columbia Medical Association English 1924-present British Journal of Anaesthesia Anaesthesiology Oxford University Press English 1923-present British Journal of Cancer Oncology Nature Publishing Group English 1947-present British Journal of Dermatology Dermatology Wiley-Blackwell English 1888-present British Journal of Diabetes and Vascular Disease Diabetes SAGE Publications English 2001-present British Journal of Medical Practitioners Medicine JMN Medical Education English 2008-present British Journal of Ophthalmology Ophthalmology BMJ Publishing Group English 1917-present British Journal of Sexual Medicine Sexual Health Hayward Medical Communications English 1973-present British Journal of Surgery Surgery John Wiley & Sons English 1913-present Bulletin of the World Health Organization Global Health World Health Organization English 1947-present CA – A Cancer Journal for Clinicians Oncology Wiley-Blackwell English 1950-present Calcified Tissue International Bone Health Springer Science+Business Media English 1967-present Calicut Medical Journal Medicine Calicut Medical College English 2003-present Canadian Journal of Gastroenterology & Hepatology Gastroenterology, Hepatology Pulsus Group English 1987-present Canadian Journal of Infectious Diseases & Medical Microbiology Infectious Disease Pulsus Group English 1990-present Canadian Medical Association Journal Medicine Canadian Medical Association English, French 1911-present Canadian Respiratory Journal Respiratory Health Pulsus Group English, French 1994-present Cancer Medicine Oncology John Wiley & Sons English 2012-present Cardiology Cardiology Karger English 1937-present Cardiovascular Diabetology Cardiology BioMed Central English 2002-present Cephalalgia Headache SAGE Publications English 1981-present Chest Cardiology, Respiratory Health American College of Chest Physicians English 1935-present Child: Care, Health and Development Pediatrics Wiley-Blackwell English 1975-present Chinese Medical Journal Medicine Chinese Medical Association, Wolters Kluwer Medknow English 1887-present Chronic Illness Chronic Illness SAGE Publications English 2005-present Circulation Cardiology Lippincott Williams & Wilkins English 1950-present The Cleft Palate-Craniofacial Journal Craniofacial Medicine Allen Press English 1964-present Clinical Anatomy Medicine Wiley-Liss English 1988-present Clinical and Experimental Gastroenterology Gastroenterology Dove Medical Press English 2008-present Clinical and Translational Science Medicine Wiley-Blackwell English 2008-Present Clinical Breast Cancer Oncology Elsevier English 2000-present Clinical Case Studies Clinical medicine Sage Publications English 2002-present Clinical Chemistry Medicinal Chemistry American Association for Clinical Chemistry English 1955-present Clinical Colorectal Cancer Oncology Elsevier English 2001-present Clinical Gastroenterology and Hepatology Gastroenterology, Hepatology Elsevier English 2003-present Clinical Genitourinary Cancer Oncology Elsevier English 2002-present The Clinical Journal of Pain Pain Management Lippincott Williams & Wilkins English 1985-present Clinical Leukemia Oncology CIG Media Group English 2006-2009 Clinical Lung Cancer Oncology Elsevier English 1999-present Clinical Lymphoma, Myeloma & Leukemia Oncology Elsevier English 2000-present Clinical Medicine: Oncology Oncology Libertas Academica English 2007-present Clinical Microbiology Reviews Infectious Disease American Society for Microbiology English 1988-present Clinical Ovarian Cancer Oncology Elsevier English 2008-present Clinical Pharmacology: Advances and Applications Pharmacology Dove Medical Press English 2010-present Clinical Pharmacology & Therapeutics Pharmacology Wiley-Blackwell English 1960-present Clinical Science Medicine Portland Press English 1909-present Clinical Toxicology Toxicology Taylor and Francis Group English 1968-present Comprehensive Therapy Medicine Humana Press English 1975-2010 Contemporary Clinical Trials Research Design Elsevier English 1980-present COPD: Journal of Chronic Obstructive Pulmonary Disease Respiratory Health Informa Healthcare English 2004-present Critical Care Medicine Emergency Medicine Lippincott Williams & Wilkins English 1973-present Critical Reviews in Microbiology Infectious Disease Taylor and Francis Group English 1971-present Critical Reviews in Oncogenesis Oncology Taylor and Francis Group English 1994-present Critical Reviews in Toxicology Toxicology Taylor and Francis Group English 1971-present Current Gene Therapy Gene Therapy Bentham Science Publishers English 2001-present Current Medical Research and Opinion Medicine Taylor and Francis Group English 1972-present Current Pain and Headache Reports Headache Springer Science+Business Media English 1994-present Cutaneous and Ocular Toxicology Toxicology Taylor and Francis Group English 1982-present DARU Journal of Pharmaceutical Sciences Pharmacy BioMed Central English 1990-present Deutsche Medizinische Wochenschrift Medicine Thieme Medical Publishers German 1875-present Developmental Neurorehabilitation Neurology, Pediatrics Taylor and Francis Group English 1997-present Diabetes Diabetes American Diabetes Association English 1952-present Diabetes and Vascular Disease Research Diabetes SAGE Publications English 2004-present Diabetes Care Diabetes American Diabetes Association English 1978-present Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Diabetes Dove Medical Press English 2008-present Drug and Alcohol Dependence Addiction Elsevier English 1975-present Emergency Medicine Journal Emergency Medicine BMJ Group English 1983-present Endocrinology Endocrinology The Endocrine Society English 1917-present Epilepsy Currents Epilepsy Allen Press English 2001-present European Journal of Cancer Prevention Oncology Lippincott Williams & Wilkins English 1991-present European Journal of General Practice Family medicine Taylor & Francis English 1995-present European Journal of Medical Research Clinical research BioMed Central English 1995-present European Journal of Palliative Care Palliative Care Hayward Medical Communications English 1994-present European Journal of Physiotherapy Physical Therapy Taylor and Francis Group English 1999-present European Medical Journal Medicine European Medical Journal English 2012-present European Radiology Radiology Springer Science+Business Media English 1991-present Expert Opinion on Biological Therapy Therapeutics Taylor and Francis Group English 2001-present Expert Opinion on Drug Delivery Pharmacology Taylor and Francis Group English 2004-present Expert Opinion on Drug Discovery Pharmacology Taylor and Francis Group English 2006-present Expert Opinion on Drug Metabolism & Toxicology Pharmacology Taylor and Francis Group English 2005-present Expert Opinion on Drug Safety Pharmacology Informa English 2002-present Expert Opinion on Emerging Drugs Pharmacology Informa English 1996-present Expert Opinion on Investigational Drugs Pharmacology Informa English 1992-present Expert Opinion on Medical Diagnostics Diagnostics Informa English 2007-2013 Expert Opinion on Pharmacotherapy Pharmacology Informa English 1999-present Expert Opinion on Therapeutic Patents Patents Informa English 1991-present Expert Opinion on Therapeutic Targets Drug design Informa English 1997-present Expert Review of Clinical Pharmacology Clinical pharmacology Informa English 2008-present Family Practice (journal) Family medicine Oxford University Press English 1984-present Future Oncology Oncology Future Medicine Ltd English 2005-present Gastroenterology Gastroenterology Elsevier English 1943-present Gynecologic Oncology Oncology, Gynecology Elsevier English 1972-present Hand Surgery Surgery World Scientific English 1996-present Harefuah Medicine Israel Medical Association Hebrew 1920-present Heart Cardiology BMJ Group English 1939-present Hepatitis Monthly Hepatitis Kowsar English 2002-present Hormone Research Endocrinology Karger Publishers English 1970-present Hospital Practice Medicine Informa Healthcare English 1966-present Human Pathology Pathology Saunders English 1970-present Human Reproduction Reproductive medicine Oxford University Press English 1986-present Hypertension Cardiology American Heart Association English 1979-present Immunogenetics Immunology, Genetics Springer Science+Business Media English 1974-present Indian Journal of Anaesthesia Anaesthesiology Medknow Publications English 2002-present Indian Journal of Dermatology Dermatology Medknow Publications English 1955-present Indian Journal of Dermatology, Venereology and Leprology Dermatology Medknow Publications English 1990-present Indian Journal of Gastroenterology Gastroenterology Indian Society of Gastroenterology English 1982-present Indian Journal of Medical Microbiology Infectious Disease Medknow Publications English 1983-present Indian Journal of Medical Research Medicine Medknow Publications English 1913-present Indian Journal of Medical Sciences Medicine Medknow Publications English 1947-present Indian Journal of Ophthalmology Ophthalmology Medknow Publications English 1953-present Indian Journal of Pharmacology Pharmacology Medknow Publications English 1969-present Indian Pacing and Electrophysiology Journal Cardiology Elsevier English 2001-present International Archives of Medicine Medicine iMed.pub English 2008-present International Journal of Geriatric Psychiatry Geriatrics, Psychology John Wiley & Sons English 1986-present International Journal of Medical Sciences Medicine Ivyspring International Publisher English 2004-present International Journal of Obesity Obesity Nature Publishing Group English 1977-present International Journal of Psychoanalysis Psychology Wiley-Blackwell English 1920-present International Journal of Speech-Language Pathology Speech Pathology Informa English 1999-present International Journal of Surgery Surgery Elsevier English 2003-present Investigative Ophthalmology & Visual Science Ophthalmology Cadmus English 1976-present The Israel Journal of Psychiatry and Related Sciences Psychiatry Israel Science Publishers English 2008-present Israel Medical Association Journal Medicine Israel Medical Association English 1999-present JAMA: The Journal of the American Medical Association Medicine American Medical Association English 1883-present JAMA Dermatology Dermatology American Medical Association English 1960-present JAMA Facial Plastic Surgery Plastic Surgery American Medical Association English 1999-present JAMA Internal Medicine Internal Medicine American Medical Association English 1908-present JAMA Neurology Neurology American Medical Association English 1960-present JAMA Ophthalmology Ophthalmology American Medical Association English 1929-present JAMA Otolaryngology–Head & Neck Surgery Surgery American Medical Association English 1925-present JAMA Pediatrics Pediatrics American Medical Association English 1911-present JAMA Psychiatry Psychiatry American Medical Association English 1959-present JAMA Surgery Surgery American Medical Association English 1920-present The Johns Hopkins Medical Journal Medicine Johns Hopkins Press English 1889-1982 Journal of Acquired Immune Deficiency Syndromes HIV/AIDS Lippincott Williams & Wilkins English 1988-present Journal of the American College of Cardiology Cardiology Elsevier English 1983-present Journal of the American Geriatrics Society Geriatrics Blackwell Science English 2001-present Journal of the American Osteopathic Association Medicine American Osteopathic Association English 1901-present Journal of Ayurveda and Integrative Medicine Integrative Medicine Elsevier English 2010-present Journal of Bone and Joint Surgery Bone Health The Journal of Bone and Joint Surgery, Inc English 1889-present Journal of Cachexia, Sarcopenia and Muscle Muscle Health Wiley-Blackwell English 2010-present Journal of Cancer Oncology Ivyspring International Publisher English 2010-present Journal of Cardiovascular Translational Research Cardiology International Society for Cardiovascular Translational Research English 2008-present Journal of Clinical Endocrinology and Metabolism Endocrinology The Endocrine Society English 1941-present Journal of Clinical Investigation Medicine American Society for Clinical Investigation English 1924-present Journal of Clinical Oncology Oncology American Society of Clinical Oncology English 1983-present Journal of Clinical Psychopharmacology Psychology Lippincott Williams & Wilkins English 1981-present Journal of Clinical Sleep Medicine Sleep medicine American Academy of Sleep Medicine English 2005-present Journal of Experimental Medicine Medicine Rockefeller University Press English 1896-present Journals of Gerontology Aging Oxford University Press English 1946-present Journal of Hypertension Cardiology Lippincott Williams & Wilkins English 1982-present Journal of Immunology Immunology The American Association of Immunologists English 1915-present Journal of Infection in Developing Countries Infectious Disease Journal of Infection in Developing Countries English 2006-present Journal of Internal Medicine Medicine Wiley-Blackwell English 1863-present Journal of Investigative Dermatology Dermatology Nature Publishing Group English 1938-present Journal of Medical Biography Medical Personnel SAGE Publications English 1993-present Journal of Medical Case Reports Medicine BioMed Central English 2007-present Journal of Medical Economics Medicine, Pharmacology Taylor and Francis Group English 1998-present Journal of Medical Genetics Genetics BMJ Group English 1964-present The Journal of Medical Practice Management Health Management Greenbranch Publishing English 1984-present Journal of Medicine Medicine Karger Publishers English 1970-2004 Journal of Nervous and Mental Disease Psychiatry Lippincott Williams & Wilkins English 1874-present Journal of Occupational and Environmental Medicine Occupational Medicine Lippincott Williams & Wilkins English 1959-present Journal of Oncology Practice Oncology American Society of Clinical Oncology English 2005-present Journal of Pain Research Pain Dove Medical Press English 2008-present Journal of Pakistan Medical Association Medicine Pakistan Medical Association English 1951-present Journal of Pediatric Endocrinology and Metabolism Endocrinology Walter de Gruyter English 1985-present Journal of Pediatric Gastroenterology and Nutrition Gastroenterology Lippincott Williams & Wilkins English 1982-present Journal of Pediatric Health Care Pediatrics Elsevier English 1987-present Journal of Pediatric Orthopaedics B Pediatrics Lippincott Williams & Wilkins English 1989-present The Journal of Pediatrics Pediatrics Elsevier English 1932-present Journal of Postgraduate Medicine Medicine Medknow Publications English 1955-present Journal of the Royal College of Physicians of Edinburgh Medicine Royal College of Physicians of Edinburgh English 1971-present Journal of the Royal Society of Medicine Medicine SAGE Publications English 1809-present Journal of Studies on Alcohol and Drugs Addiction Alcohol Research Documentation English 1940-present Korean Journal of Anesthesiology Anaesthesiology Korean Society of Anesthesiologists English 1968-present Läkartidningen Medicine Swedish Medical Association Swedish 1965-present The Lancet Medicine Elsevier English 1823-present Langenbeck's Archives of Surgery Surgery Spring Science+Business Media English 1860-present Macedonian Journal of Medical Sciences Medicine Institute of Immunobiology and Human Genetics English 2008-present Mayo Clinic Proceedings Medicine Elsevier English 1926-present The Medical Journal of Australia Medicine Australasian Medical Publishing Company English 1914-present Medical Law International Medical Law, Bioethics SAGE Publications English 1993-present The Medical Letter on Drugs and Therapeutics Pharmacology The Medical letter, Inc. English 1959-present Medicine, Conflict and Survival Global Health Taylor and Francis Group English 1985-present Melanoma Research Oncology Lippincott Williams & Wilkins English 2004-present Menopause Gynecology, Aging Lippincott Williams & Wilkins English 1994-present Mens Sana Monographs Mental Health Medknow Publications English 2003-present Middle East African Journal of Ophthalmology Ophthalmology Medknow Publications English 1994-present Molecular Medicine Medicine The Feinstein Institute for Medical Research English 1994-present Mount Sinai Journal of Medicine Medicine John Wiley & Sons English 1934-2012 Movement Disorders Neurology Wiley-Liss English 1986-present Myanmar Medical Journal Medicine Myanmar Medical Association English 1953-present National Medical Journal of India Medicine All India Institute of Medical Sciences, New Delhi English 1988-present Nature Medicine Medicine Nature Publishing Group English 1995-present Nature Reviews Cancer Oncology Nature Publishing Group English 2001-present Nature Reviews Cardiology Cardiology Nature Publishing Group English 2004-present Nature Reviews Clinical Oncology Oncology Nature Publishing Group English 2004-present Nature Reviews Disease Primers Medicine Nature Publishing Group English 2015-present Nature Reviews Gastroenterology & Hepatology Gastroenterology Nature Publishing Group English 2004-present Nature Reviews Immunology Immunology Nature Publishing Group English 2001-present Nature Reviews Microbiology Infectious Disease Nature Publishing Group English 2003-present Nature Reviews Nephrology Nephrology Nature Publishing Group English 2005-present Nature Reviews Neurology Neurology Nature Publishing Group English 2005-present Nature Reviews Neuroscience Neurology Nature Publishing Group English 2000-present Nature Reviews Rheumatology Rheumatology Nature Publishing Group English 2005-present Nature Reviews Urology Urology Nature Publishing Group English 2004-present Nederlands Tijdschrift voor Geneeskunde Medicine Vereniging Nederlands Tijdschrift voor Geneeskunde Dutch 1857-present Neural Regeneration Research Neurology Publishing House of Neural Regeneration Research English 2006-present The Neurologist Neurology Lippincott Williams & Wilkins English 1997-present Neurology Neurology Lippincott Williams & Wilkins English 1951-present Neurology India Neurology Medknow Publications English 1953-present Neuropsychiatric Disease and Treatment Neuropsychiatry Dove Medical Press English 2005-present Neuropsychiatry Neuropsychiatry Pulsus Group English 2011-present The New England Journal of Medicine Medicine Massachusetts Medical Society English 1812-present The New Zealand Medical Journal Medicine New Zealand Medical Association English 1887-present Nursing Children and Young People Pediatrics, Nursing RCN Publishing English 1989-present Obstetrics and Gynecology Obstetrics, Gynecology Lippincott Williams & Wilkins English 1953-present Open Medicine Medicine Walter de Gruyter English 2006-present Orbit Ophthalmology Informa Healthcare English 1982-present Osteoporosis International Bone Health Spring Science+Business Media English 1990-present Ostomy Wound Management Wound care HMP Communications English 1980-present Paediatrics & Child Health Pediatrics Pulsus Group English 1996-present Pain Research & Management Neurology Pulsus Group English, French 1996-present Pan American Journal of Public Health Public Health Pan American Health Organization English, Portuguese, Spanish 1997-present Pathologica Pathology Società Anatomo Patologi Ospedalieri Italiani Italian, English 1908-present Pediatric Research Pediatrics Nature Publishing Group English 1967-present Pediatrics Pediatrics American Academy of Pediatrics English 1948-present Personalized Medicine Personalized Medicine Future Medicine English 2004-present The Physician and Sportsmedicine Sports Medicine Informa Healthcare English 1973-present Plastic Surgery Surgery Pulsus Group English 1993-present PLoS Medicine Medicine Public Library of Science English 2004-present PLoS Neglected Tropical Diseases Global Health Public Library of Science English 2007-present Postgraduate Medicine Medicine Informa Healthcare English 1916-present Le Practicien en Anesthésie Réanimation Anaesthesiology Elsevier Masson English 1997-present Preventive Medicine Preventative Medicine Elsevier English 1972-present Primary Dental Journal Dentistry Faculty of General Dental Practice English 1994-present Progress in Osteoporosis Bone Health International Osteoporosis Foundation English 2000-present Psychiatric Genetics Psychiatry Lippincott Williams & Wilkins English 1990-present Psychosomatic Medicine Psychology Lippincott Williams & Wilkins English 1939-present QJM: An International Journal of Medicine Medicine Oxford University Press English 1907-present Radiology Radiology Radiological Society of North America English 1923-present Rambam Maimonides Medical Journal Medicine Rambam Health Care Campus English 2010-present Rejuvenation Research Aging Mary Ann Liebert English 1998-present Research and Humanities in Medical Education Medical humanities Medical Humanities Group at the University College of Medical Sciences English 2014-present Revista Pediatría de Atención Primaria Pediatrics Exlibris Ediciones English 1999-present Scandinavian Journal of Infectious Diseases Infectious Disease Informa Healthcare English 1969-present Scandinavian Journal of Occupational Therapy Occupational Therapy Informa Healthcare English 1993-present Scandinavian Journal of Surgery Surgery SAGE Publications English 1919-present Scientia Pharmaceutica Pharmacology Österreichische Pharmazeutische Gesellschaft English, German 1930-present Seminars in Ophthalmology Ophthalmology Taylor & Francis English 1986-present Spine Orthopedics Lippincott Williams & Wilkins English 1976-present Statistics in Medicine Statistics John Wiley & Sons English 1982-present Stroke Cardiology Lippincott Williams & Wilkins English 1970-present Surgical Endoscopy Surgery Springer Science+Business Media English 1986-present TAF Preventive Medicine Bulletin Preventive Medicine Gulhane Askeri Tip Akademisi English 2001-present Tehran University Medical Journal Medicine University of Tehran English 1943-present The Journal of Neurobehavioural Sciences Neurology Üsküdar University English 2014-present Transactions of the Royal Society of Tropical Medicine and Hygiene Global Health Oxford University Press English 1908-present Trends in Molecular Medicine Medicine Elsevier English 1995-present Women's Health Issues Women's Health Elsevier English 1990-present
There are hundreds of medical journals, covering every specialty, read by doctors/scientists who are working in a subspecialty of interest. It's sheer idiocy to think that the only valid journals are the three referenced by "Auto1" given the massive amount of research and interesting new data.
Cardiologists dont' need to (and can't) keep up with every new piece of research in "Clinical and Experimental Gastroenterology", or Roentgenology or "Cutaneous and Ocular Toxicology" or "American Journal of Alzheimer's Disease & Other Dementias Neurology", etc..
The article referenced was published in a journal that is followed by doctors working in a field that needs to know about muscle regeneration after trauma (hip surgery). Makes sense, doesn't it?
Here's a partial list of medical journals ("mullet wrappers" according to "Auto1"): (See if you can squeeze all these into three journals)
Academic Medicine Academic medicine Association of American Medical Colleges English 1926-present ACIMED Medical informatics National Center of Information on Medical Sciences in Cuba Spanish 1993–present Acta Anaesthesiologica Scandinavica Anaesthesiology, Intensive Care Scandinavian Society of Anaesthesiology and Intensive Care Medicine English 1957-present Acta Médica Portuguesa Medicine Portuguese Medical Association Portuguese 1979-present Acta Neurologica Scandinavica Neurology Wiley-Blackwell English 1925-present Acta Orthopaedica et Traumatologica Turcica Orthopedics Turkish Association of Orthopaedics and Traumatology English 1962-present Acta Oto-Laryngologica Otolaryngology Taylor and Francis Group English 1918-present Acta Paediatrica Pediatrics Wiley-Blackwell English 1921-present Acta Psychiatrica Scandinavica Psychiatry Wiley-Blackwell English 1926-present Acta Radiologica Radiology Sage Publications English 1921-present Advances in Therapy Clinical medicine Springer Science+Business Media English 1984-present African Journal of Paediatric Surgery Surgery Medknow Publications English 2004-present AIDS AIDS Lippincott Williams & Wilkins English 1987–present Alimentary Pharmacology & Therapeutics Pharmacology Wiley-Blackwell English 1987-present Alzheimer Disease and Associated Disorders Alzheimer's Lippincott Williams & Wilkins English 1987-present Alzheimer's Research & Therapy Alzheimer's BioMed Central English 2009-present American Family Physician Family medicine American Academy of Family Physicians English 1969-present American Journal of Alzheimer's Disease & Other Dementias Neurology SAGE Publications English 1986-present American Journal of Emergency Medicine Emergency medicine Elsevier English 1983-present American Journal of Gastroenterology Gastroenterology Nature Publishing Group English 1934-present American Journal of Medical Genetics Genetics Wiley-Liss English 1977-present American Journal of the Medical Sciences Medicine Lippincott Williams & Wilkins English 1820-present American Journal of Obstetrics and Gynecology Obstetrics and Gynecology Elsevier English 1920-present American Journal of Public Health Public Health American Public Health Association English 1911-present American Journal of Roentgenology Radiology American Roentgen Ray Society English 1908-present The American Journal of Surgical Pathology Surgery, Pathology Lippincott Williams & Wilkins English 1977-present American Journal of Translational Research Medicine e-Century Publishing Corporation English 2009-present American Journal of Transplantation Transplantation Wiley-Blackwell English 2001–present American Journal of Tropical Medicine and Hygiene Tropical medicine American Society of Tropical Medicine and Hygiene English 1921-present Anaesthesia Anaesthesiology Wiley-Blackwell English 1946-present Annals of Cardiac Anaesthesia Anaesthesiology Medknow Publications English 1998-present Annals of Emergency Medicine Emergency medicine Mosby English 1972-present Annals of Family Medicine Family medicine Annals of Family Medicine, Inc. English 2003-present Annals of Human Biology Population biology Taylor and Francis Group English 1974-present Annals of Human Genetics Human genetics John Wiley & Sons English 1925-present Annals of Internal Medicine Internal medicine American College of Physicians English 1927-present Annals of Medicine Internal medicine Taylor and Francis Group English 1969-present Annals of Pediatric Cardiology Pediatrics, Cardiology Medknow Publications English 2008-present The Annals of Pharmacotherapy Pharmacology SAGE Publications English 1967-present Annals of Physical and Rehabilitation Medicine Rehabilitation Elsevier English 1982-present Annals of The Royal College of Surgeons of England Surgery The Royal College of Surgeons of England English 1947-present Annals of Surgery Surgery Lippincott Williams & Wilkins English 1885-present Annual Review of Medicine Medicine Annual Reviews English 1950-present Archives of Disease in Childhood Pediatrics BMJ Group English 1926-present Archives of Osteoporosis Bone Health Springer Science+Business Media English 2006-present Arteriosclerosis, Thrombosis, and Vascular Biology Vascular biology Lippincott Williams & Wilkins English 1981-present Asian Cardiovascular and Thoracic Annals Cardiology SAGE Publications English 1998–present Aviation, Space, and Environmental Medicine Aviation medicine Aerospace Medical Association English 1930-present British Dental Journal Dentistry Nature Publishing Group English 1904-present Biological Research For Nursing Nursing SAGE Publications English 1999-present Biology of the Neonate Neonatology Karger Publications English 1959-present Biomedical Imaging and Intervention Journal Radiology University of Malaysia English 2005-present BJUI Urology Wiley-Blackwell English 1929–present Blood Hematology American Society of Hematology English 1946–present Bone Marrow Transplantation Transplantation Nature Publishing Group English 1986-present BMC Cancer Oncology BioMed Central English 2001-present BMC Medicine Medicine BioMed Central English 2003-present BMJ Medicine BMJ English 1840-present Brain Neurology Oxford University Press English 1878-present Brazilian Journal of Medical and Biological Research Medicine Associação Brasileira de Divulgação Científica English 1968-present Breast Cancer Research and Treatment Oncology Springer Netherlands English 1981-present British Columbia Medical Journal Medicine British Columbia Medical Association English 1924-present British Journal of Anaesthesia Anaesthesiology Oxford University Press English 1923-present British Journal of Cancer Oncology Nature Publishing Group English 1947-present British Journal of Dermatology Dermatology Wiley-Blackwell English 1888-present British Journal of Diabetes and Vascular Disease Diabetes SAGE Publications English 2001-present British Journal of Medical Practitioners Medicine JMN Medical Education English 2008-present British Journal of Ophthalmology Ophthalmology BMJ Publishing Group English 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The "geniuses" I defer to are the physician scientists doing the actual work. The reason you can still buy PSTI at current sale prices is precisely because the "market" is too stupid to assess the most reliable information available.
No need, just look at Yahoo, they report current value (it's $1.3065, and will be until Monday 9:30 AM)
Another thing to ponder: a "mathematical model" gives results that are as good as the selected variables. Models make no specific predictions about expected P3 outcomes, at best, you could construct some formula that looks at general probabilities, based on the universe of known clinical trials, and how one stage, with specific results, is followed by the next stage. In other words, it would be very non-specific, and less predictive than the observations coming from people doing the clinical trials (i.e. the doctors in the clinic).
The only thing "decorated" in my "background" is our yearly Christmas tree, and even there I'm only an assistant!
A clinical study of a pioneering placenta-based cell therapy product, PLX-PAD, has shown that it can dramatically enhance the mobility of patients with peripheral arterial disease (PAD) in their legs, and greatly reduce, or even eliminate, their need for surgery and hospitalization.
For more comments by the doctors doing the actual work see my msg # 15072. They're very optimistic that PLX-PAD does in fact have efficacy. I just defer to the people who actually know!!!
Actually, it's a civilized conversation among well meaning posters. Responsive to decent, reasonable questions! It's what this board is supposed to be about! Something not everyone posting here is able to comprehend!
No, it's a scientific paper in a peer reviewed medical journal! It's "not a clinical trial" ??? No, it's a scientific paper in a peer reviewed medical journal! Have we settled that now?
It's not in "the basement"! It's a scientific paper in a peer reviewed medical journal!
Actually, those studies ARE happening, even as we speak!!!!
Until we get the final results of that, we try to glean information from multiple sources to try to assess the probability of success in the studies that are in fact happening now!
That's why "a scientific paper in a peer reviewed medical journal!" is a good source of information. One of many!
He made good money, but would have made orders of magnitude more if the value of his shares increased, along with ours. Maybe he had information that we don't have, and made big strategic mistakes (in retrospect), but I think he had as much incentive to do the right thing as anyone.
I think the vituperative attacks on the man are way over the top!
Thanks for that, but I defer to Spidey on technical insights and Allo on DD.
Spent a few years in college preparing to go into science (goal: research in the biomedical field), got as far as graduate school (only 1st year), but due to various circumstances switched to computer science. My specific knowledge is VERY dated, but I did retain enough to at least have a decent sense of what is plausible and reasonable in this very new field (regenerative medicine). The reality is that even the scientists (at Pluristem) do not have total knowledge... even they could be surprised by results in the clinic. We can only apply some sort of educated guess, to be confirmed or not by the results of actual clinical data.
LOL, I most definitely want to be complete! I'll say this much: there are a lot of smart people who believe in and use charting. I have never been able to convince myself that it works in a situation that is moved by binary events (approval: thumbs up or down). But, I will read your posts with interest and we'll see if you can change my mind.
(the above from Auto1). The poster's name is "skitahoe"! Your abbreviation of his alias reveals a great deal!!! Any particular reason for the gratuitous ugliness? (for non-native speakers of English: "hoe" is street slang for "whore")
The above addressed from Auto1 to skitahoe. As for me, I welcome skitahoe's insights.
It does give us some sense of the human side of the story, and of the sort of experiences patients undergo after a very scary diagnosis.
That's news to me! What do you think a successful CLI P3 will do for profit. I'm guessing (and it is an EDUCATED guess, the best we can do before the facts are available), given the huge patient population with PAD, that profits will be enormous. And yes, I'm guessing that CLI will be successful, otherwise I would not be investing in Pluristem.
Most likely so will Pluristem! It's a biotech, pre-approval. If you're going to invest at all, you have to make a guess, not a random, baseless guess, but one based on the data publicly available. Lack of certainty is the nature of biotech investing.
My best guess is that the news was more of a scientific/technical nature than the sort of thing that gets investors all excited. Maybe the company feels that official announcements of the clinical kind should be rolled out only if it excites the crowd. This paper had a lot of findings and tons of data about specific "expression profile" and "surface markers" and "signal transduction" and the sort of stuff that scientists/doctors (and Spidey) want to know, but not necessarily the general investment public.
Also, papers for publication in a journal are generally muted and properly scientific. So you cannot include claims like "this is a home-run" or anything of the that sort. Additionally, I think the result of this work was used to design future clinical trials, so future results should be better, based on what they've learned. Also, note the conflict of interest statement at the bottom of the paper. These guys (and gals) have to maintain (at least the appearance of) scientific independence, given that they're academics at various institutions.
Anyway, that's my best guess.
Con?ict of interest: Tobias Winkler, Carsten Perka, and Georg N. Duda are members of a clinical advisory board of Pluristem Ltd for future indications. Tobias Winkler, Carsten Perka, Georg N. Duda, and Philipp von Roth ?led a patent together with Pluristem Ltd. Esther Lukasiewicz Hagai, Racheli O?r, Lena Pinzur, and Eli Eyal are current or former employees of Pluristem Ltd. Tobias Winkler, Petra Reinke, and Hans-Dieter Volk received in the past consulting fees from Pluristem Ltd. but not for this project.
Yes, absolutely! It's the sort of data set that comes out drips and drabs, but until we get official P3 results, it's something you can chew on and test and retest your investment thesis.
It's also obvious that details of the MOA of this very dense (in the sense of rich, detailed) paper is part of the pioneering work done by PSTI and collaborators. The basic clinical science that comes out of this kind of work is also very good for the company in refining it's various programs and look for appropriate targets when looking to expand to other indications.
I can't honestly say that the article by itself proves that PLX-PAD for post-surgical support is a slam-dunk, but it gives us incremental information that looks good, and it's just one element of a great deal of data available for us outside.
I did like the finding about the consistency of the cells from different batches. MSC based regen. medicine is very new, the FDA needs a lot of proof that the approved drug work reliably and the results are reproducible. The fact that Pluristem can "expand" the cells, under conditions that guaranty uniformity is incredible (and essential). My favorite metaphor is that the cells go thru the appropriate finishing school and come out well behaved, well meaning, and ready to do the job they were groomed for.
1. Any clinical work that shows safety enhances chances of approval. In fact there's an inverse relationship between safety and efficacy requirements! A drug with less than stellar efficacy has a better chance of approval if the side-effects don't kill the patient.
2. The results indicate clear efficacy: The primary finding of our study was an improvement in muscle strength mirrored by an increase in muscle volume in the cell-therapy groups compared with the placebo group
3. Clinical results corroborated by morphological findings: Most striking was the concordance of the results gathered from the functional assessments and micro-morphological and macro-morphological studies with the immunological analyses.
4. A great deal of new information about the MOA of the cells: examples (long paper, much more info): our data reveal that the effect of transplanted PLX-PAD cells is not based on differentiation but rather on trophic and immunomodulatory support of the endogenous regeneration. This finding is consistent with recent studies on tendon healing demonstrating the decisive role of early trophic factor delivery to the site of injury.
Remarkably, alterations of immune cell subsets displaying the immediate post-operative stress were significantly reduced by PLX-PAD therapy (followed by lots of details!)
5. Batch to batch efficacy was very consistent! That knowledge is essential to convince the FDA that the cells in each vial will have the expected effect!! In other words, Pluristem has mastered the production techniques to mass-produce the cells with no variation.
(lots of data...., then): This expression profile is in line with the proposed anti-inflammatory, immunomodulatory, cell-interaction, tissue homeostasis, and angiogenesis influencing properties of PLX-PAD. Importantly, PLX-PAD cells from different preparations or even from different donors expressed an almost identical marker profile underlying the robustness of the manufacturing process (VERY, VERY important!!!!!!!)
OK, this is based on a very quick reading of a very detailed paper! Hopester thinks (to Allo): This article you wastefully posted was not significant
I don't know how hopester could have come to that conclusion (maybe his charts told him, after all, that's all that really matters, right?)
From PLX11: "Clearly, they are being careful with the EAP. Probably a wise decision. Any added risk would not be worth the short term revenue gained."
I also explained this in more detail, it must have been over your head (surprising, cause it's very simple).
Again: careful patient selection is absolutely essential, they pick a subset of patients who will most likely benefit from the given medication. This is to identify the proper target population, an essential part of the sequence of clinical trials. It's enhances the probability of approval by excluding patients whose condition would introduce artifacts (unrelated co-morbidities, or disease stage that is outside the therapeutic potential of the drug). The faster the approval, the sooner the appropriate patients get the help they need.
I wouldn't put too much faith on a conclusion based on ONE company. Not statistically significant. Besides, it's the value of the science that has something to do with the ultimate outcome. Maybe he has more to work with at Advaxis.
Pretty much tells you "all you need to know" about "Eich"'s investment strategy! LOL!
If you don't buy that nonsense, then do your own DD. You might start by determining the list of products, target indications, results so far, the quality of the collaborators and institutions involved in the ongoing clinical trials... and more.
If you accept the "Eichian" investment philosophy I can save you a minute or two: $1.33...oops, now it's $1.32..., you're all set! Good luck!
FALSE! All numbered items from 1 to 7 come from the mouth of "Eich"!
(And... Here's the antidote to "Eich"s "Truth"!)
The first paragraph is excerpted from the 10K, that's true, but as anybody who's ever read one of these documents can tell you that it's standard legalese boilerplate. In fact it's a miracle that Pluristem only "accumulated a deficit of $215,697,000" in over a decade of operation, with NO debt at all, and having accomplished miracles in terms of their science and and presence in the clinic for multiple indications, with many more in the pipeline.
REPEAT: All the following comes from the mouth of "Eichking"! Lets go thru and respond to each. This is a worthwhile exercise since this sort of "analysis" is a constant theme (you'll see it repeated EVERY day!)
1) The DoD hasn't even started trials, and may not EVER. PSTI is "interested" in further discussions on this with them. LOL
A totally deceptive claim! This a reference to R18 and the DoD has been gathering data for years. Given the nature of ARS, the only way to test is with non-human subjects (nobody will volunteer to receive a fatal dose of radiation). The DoD is getting the kind of data that will be sufficient for "approval" in the form of a procurement and acquisition for stockpiling. Could happen anytime (maybe tomorrow AM, or a few months, we'll see).
2) If their products were so miraculous, ONE patient would have come forward with their life saving story
Misleading! We have had numerous reports from doctors working with PAD patients: all very positive and with strong commitment to pursue the objective of mitigating the debilitating effects of the disease. The most knowledgeable people are "coming forward"! Patient testimonials come later!
3) If their products were so miraculous, the PPS would not be $1.33 PATHETIC
More of the "market" is talking nonsense!
4) They will dilute again, soon, taking this under $1, never to return again until the next RS, bank on it
NO, NO, NO, Don't "bank on it"! It's a totally unfounded opinion! Very pessimistic! You need to be rationally optimistic to do ANY investing, and look at the success Pluristem has had in getting funds with minimal dilution (of course, there will be SOME dilution, no cause for panic, or even distress, it's normal!!!! )
5) More than half of the 10-K was dedicated to how they pay the leeches in management.
Standard anti management rhetoric. They take a much bigger risk than the posters here, and deserve proper compensation. Having seen these type of folks close up, I know the kind of intelligence and dedication and hard work required to guide a company like Pluristem to success. Totally in line with other late stage biotechs.
The quote "Eich" gives us: "they don't know when they will be profitable....."IF EVER" LMAO." is particularly deceptive, given that it's standard in EVERY safe harbor section of EVERY 10K and similar corporate documents (without the "LMAO", the version of the document that I read does NOT have that, perhaps "Eich" has access to the original)
6) The fact so much of the 10K is dedicated to employee compensation and so little dedicated to the actual science speaks volumes.
Just a rehash of point 5! I don't think it speaks "volumes", I don't think it even squeaks a scintilla!
7) This was nothing but a rehash of what they have already said, which is nothing but spin.
It's actually a legally required document, it's MOSTLY legalese, and boilerplate (as expected, it's NORMAL!). They do talk about the science in the 10-K and a multitude of other sources, no shortage of science information. You just have to look.
Quote: Need I go on? Not really! These points have been made MANY, MANY times before!
Quote: DEAD MONEY is an understatement. Not by the normal definition of "understatement". I would characterize it as a FALSE statement.