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Really I didn’t mean to scare the shorts
This post is for PDD .. no way out HIGH DOSE AD Leg of 170 patients followed..
Well actually TGD did say to specifically review high dosage of PDD.. but what does he know?
But..
Having said that..
let’s und Ray and our Biology
We help reset cellular homeostasis..
There might be other drugs approved within 5 years that target hyper diseased CNS areas.. ANVS to be specific..
Also
If other drugs are SAFE.. there should be almost ZERO reason why combining them with a S1r agonist would make them unsafe! So look at a BIo Vie or a Cassava for a mighty fine combo..
They may however just save the low hanging fruit from different directions.
Annovis is truly a powerful bio active.
There are other companies working
But for right now get us access to Blarcamesine..
The DZP combo failed..
The high dosage is only hope..
I don’t know how much dizzy hurts
But give me some hurt
Well it kind of does .. doesn’t it..
Sorry just it be clear this is from High Dose PDD trial data.. thought it said that on there .. ooops
You really think TGD didn’t know this when he emphasized the high dosage group and look to the PDD trial?
Duh.. what else can TGD tell the longs?
SIGMAR1 mRNA expression significantly increased in ANAVEX®2-73-treated patients vs placebo (p=0.035) over the course of treatment and was significantly associated with improvements of MDS-UPDRS scores and cognitive efficacy endpoints CDR system.
Drum roll please.
Shhh….
Should probably release this during market hours so they have to stop trading!
MDS-UPDRS[1] Total score improved significantly by -14.51 (p=0.034) for patients treated with ANAVEX®2-73 high oral once-daily dose compared to placebo. The improvement is clinically relevant corresponding to a relative improvement of 18.9% over 14 weeks.
The answer to everyone’s question is
already public news..
How did the high dosage leg perform?
Anyone may find it..
This will be a victory lap conference for news released by end of this quarter
Our stock price doesn’t mean we are failing
Our stock price reflects the corruption of capitalism and America
I know it is
Nice
They created to fund raise
Hope it raises millions
Thx falconer..
And a3-71 five years down the road..
All the pessimism is unwarranted..
Unwarranted
The high dosage kills it..
It’s a home run for hope
Book it!
High Dose makes you Dizzy as hell
And saves your life..
Give me some Dizzzy before I go to bed !
Looks like average does stoke over a year for early AD is around 4.5 on Adas cog..
So a patient would expect to go from
45 to 50 on adas scale..
Co mingled data of 30 & 50 Mg treated
slows drop to 45 to47.5..
That’s great significant ..
But what this isn’t telling you is
We don’t need to co mingle our high dose for approval..
The high dose over 35mg data is
170 patients some drop outs..
Didn’t understand how important and good DIZZY was..tragic really!….
Now they just give high dosage to patients at night!
Sleep well? You betcha! See better too no doubt!
The high dosage benefit is going to be jaw dropping..
Soft fud
Begging to slaughter 50,000 seniors a month for anther 3 years .. what heartless brutality.. the arrogance of intelligence..
What else does anyone need to know?
What AF says?
Get me access TGD
So I think this is going to be pretty close to my estimates for success!
High dosage zero decline and improvement over 80% so90% of
160 is 154 still at baseline or better on higher dosage…
154 perhaps all doing better now afte 1 plus years in OLE.. will have to see PDD OLE data to confirm long term bennies continue down the road..
This is insane! Get us this drug!
Never mind
I see the Adas cog decline basically cut in half with Blarcamesine ..-4 placebo
-2 Blarcamesine ..
Bet higher dose even stronger..
• Among patients, who improved with ANAVEX®2-73 treatment, Mean ADAS-Cog score improvement -4.03 points
Is anavex saying dosed patients went from
60 to 56
Whereas placebo went from 60 to 65 over a year?
• Among patients, who improved with ANAVEX®2-73 treatment, Mean ADAS-Cog score improvement -4.03 points
So someone help me here
Is anavex saying that Adas cog for
High dosage: actually improved 4 points from baseline?
So .. the Ada’s cog score
Would go from a 55 to a 60
For a placebo ad patient over 12 months..
This would be a decrease in ability..
So based on what anavex has told us..
Where is this score for our Dosed patients?
The test administrator adds up points for the errors in each task of the ADAS-Cog for a total score ranging from 0 to 70. The greater the dysfunction, the greater the score. A score of 70 represents the most severe impairment and 0 represents the least impairment.??
in AD - Literature
Meta-analysis Of Placebo Group Decline1
•from cassava presentation..
Cognitive decline was reported in a published, meta-analysis of 20,000 patients with mild-to- moderate AD in randomized, controlled trials1.
5.5 point average decline over 12 months on ADAS- Cog among study subjects who were administered placebo in randomized, controlled trials.
Cognitive decline was reported in two P3 studies of Biogen’s aducanumab in patients
with early AD2:
5.2 point average decline over 18 months on ADAS- Cog among study subjects who were administered placebo in randomized, controlled trial
A safe drug that saves a high percentage
Of high dosage patients from deveolpi g dementia.. a death sentence disease..
But.. we can’t have access?
Because evil is arrogance
Institutions would love to catch longs out 30 days for tax loss.. ouch
Murder most foul
To delay access
Expand please
Jimbo
Peace be with you
TGD would not lie to you
Me either
Review Resveratol clinical research and ViNIA ‘s effect
Agreed
These are the same “investors’
“ that drove up Biogen three times by &30,000,000,000 each time?
Yeah.. they are brain child’s
Anavex should let a third party bio stat co report the PDD OLE data..
They should pay with every blood Penny they made from investorS!
This is stealing!
They don’t create crap then steal from investors who funded great life saving research!
They are pariahs and cowards of the worst order!
If no one has to account for shares
what is the point of the market?
If they may sell shares that never existed
than how May anyone win?
They are destroying Capitalism
Through naked short selling,
lying cabals, and corrupted/ineffective Govt oversight.
People won’t just leave Capital Markets
they will never return.
Anavex is much more than one company trying to save lives..
We shall see
Yeah
I thought they had the data..
This was me..
We met endpoints primary and secondary
We are actively going for approval..
Remember when people said we missed endpoint?
Like in your post?
You do the same thing you accuse others of doing.
The company said they met primary and secondary endpoints..
The theee fingers pointing back at you are yours from pointing at others..
TGD does have data from PDD Ole
I don’t know why we are not supporting longs with this info. ?
It is frustrating that our PR is so weak.
Oh well.. the player with more chips is winning..we need to see the cards ..