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Shub
Understood and understand.
Death is death, whether by stopping of a beating heart or the dissimulation of a human mind..
Extraordinary consequences call and demand exceptional action .
AnavexNOW
Let the pressure begin,,,
Mild to moderate AD lives matter!
We are and will be historically epic !
Ruby
I've been here before
It is the CLUB threatening the good Dr
By demeaning Anavex's efforts and trying to pressure him into selling us out by doing massive secondary only with CLUB members.
The good Dr may eventually take the CLuBS money BUT it will be on OUR terms.. not theirs!
God Bless the good Dr and all the staff at Anavex and all the Patients in the trial! I hope they are all as lively and spunky as our project TV host!
We are at ground zero of a miracle drug and I am loving it !
Basparks. I don't 100% disagree with you or your analysis of changing data points. What I won't do is suspend my common sense ( which needs suspension every now and then)
But my common sense says
That the good Dr said Combination Therapy was no longer a targeted Strata and then to prove that out there is no Comob Therapy Data at 9 or 12 months. Why not?
Because many of the patients have changed their Medicine and. O longer take Aricept! You can't graph what you don't have.. they stopped after 6 months.. that was how long it took super 6 to really start glowing..
I think that is why they did the 5 week review .. the light is turning on in all the patients now on Monotherapy!
It's the home run we prayed for!
Merry Christmas!
So some else please plot the math and find the average MMSE of the 19 SOC responders from 52 weeks to 57 weeks. All I did was add up graph points of the super 6 at 52 and 57 weeks then averaged throes numbers.
Then used total MMSE average at 52 and 57 weeks, then subtracted out the average of the 6 super responders to fined the average of the 19.
I found a one point increase in MMSE from 52 to 57 weeks for the 19 average SOC responders.
What does this means? I think it means Patients are mostly Monotherapy now and doing well.
Anyone care to show their math?
Pristine
Impeccable.
The country club wants clean sheets for the 2nd seating!
Sounds like a 5 star dinner!
How about playing th piano again?
Painting pictures again?
Just give me the drug!
Is everyone insisting for a placebo for an incurable disease when we have a drug that may be showing. 100% response at stopping and reversing the deadly disease. Because the patients are old? And whether they live or die doesn't matter that much?
What is wrong with us!
We have a treatment that works and we act like we lost!
We won! let's get A2-73 in the marketplace helping people.
Not true..
We need our participants to get better with their testing...
We know the Placebo gets worse..
If you have 25 people that have incurable cancer do you really give them a placebo?
In pre trial all 25 cancer patients showed remission, but for our next phase we are going to take 300 incurable cancer patients and let 100 of them die so we can all feel better about the 200 that survived.
We don't need a placebo for a safe drug that works, we need ACCESS!
Look. I like Piotr s work.
Our agreements are more than 90%
Than our disagreements.
I used simple math averageing to
From 41, 52, & &57 weeks, mono, dual, and super 6.
The numbers plotted at 52 & 57 by only 6 patients could not have been responsible for overall average of 25 going up that much at 57 week reading. And my averaging proved that.. the 19 patients averages an MMSE score of 15.9 at 52 weeks and went up to around 17 at 57 weeks..this accounts for overall increase in MMSE.. my theory continues to be tha Monotherapy is destroying Alzheimer's symptoms only as a Monotherapy Agent.. and that MORE patients than 6 or 7 have stopped dosing Aricept and are getting better..
I don't think it is a year, but more like 6 months for super effects.. 17 on MMSE still needs to go up..a lot!
But I think that is what's happening and if it is .. we should get immediate ACCESS!
So Anavex IR responded to my question as to what 57 week test was:
"This is a close-out, end of PART B visit."
I asked for greater clarification but based on my question of why 57 week test and 52 week..
the assumption would be an additional data capture point as close out of Phase 2a .
Again re-enforcing my hypothesis
That many if not all patients are on Monotherapy and are doing better after 1 year..
BAM
I disagree with part of your conclusion but agree with other parts,,
The company basically does say
That trial participants have changed their medication by dropping the Anavex Monotherapy designation..
There obviously is a reason Dual Therapy is no longer quantified and IMO it is because so many patients are no longer on Aricept.
But I agree that the change to Monotherapy has happened over a longer period of time .. I would argue probably at 6 months .. many patients stopped taking Aricept..as IS and WAS their RIGHT! They didn't sign up to be Placebo Group they signed up for ADAPTIVE trial.. and they adapted!
Brilliant. It just seems the astutes do not wish to adapt. I hope they get trumped!
You don't need a placebo group.
I appreciate the thoughts.
I have been wrong before.
But..logically and mathematically everything I have said on this topic still holds true
We have rising scores at the end of the Phase 2a part B, the only known reason for longitudinal stopping and reversing of Alzheimer's is A2-73,
I stand by my hypothesis that many if not all patients are now Ann's have been DZP Naieve
It was just yesterday.. nothing yet..
I did..
blu please explain last 5 week data split again?
they show MMSE at 52 and 57..
My hypothesis that the ONLY KNOWN VARIABLE - A2-73 Monotherapy -
that has EVER stopped and Reversed Alzheimers over a 6 month period/12 month period..is the ONLY reason that MMSE Scores may go up after 12 Months..
There is NO OTHER REASON that may explaing Rising MMSE scores for thi sTrial at 57 WEEKS..(IMO
With the scores that we saw at 31 weeks for the Monotherapy 7, it would be statistically improbable that ANY of the 6 Super Performers were Dualtherapy. They did not separate them by Aricept Niaeve, IMO because soon, there will be few if any Patients still in the trial taking Aricept/ Donezipil.
The averages for All Patients on the MMSE Scores went up by ONE Point from 52 weeks to 57 Weeks,(24.6 to 25.6 MMSE for Super 6 & 15.9-16-9 MMSE for Moderate 19) thus indicating (IMO) a vast majority of patients went Monotherapy for Part C extension! there is no KNOWN drug OTHER than A2-73 capable of stopping AND reversing Alzheimers at one year.
My Hypothesis is, is that Even after a year, an Aricept Patient using a Monotherapy of A2-73, may be pulled from the darkness!
The Short & Distort may look themselves in the mirror, for their wickedness has slowed this process by at least 6 months!
DO YOU KNOW HOW MANY WE COULD HAVE SAVED? Tens of Thousands..
OUTRAGEOUS!
We need immediate access to this drug Right Now!
The FB group just has different outlook on things, and since I have already spent considerable time on this I don't wish to revisit.
I request those whose number one goal is to get A2-73 ACCESSIBLE, to remain focused on that goal. Joining groups that may not share this as their number one goal will be a distraction.
So what is the definition of spamming a stock board? Calling it a scam is an incredible insult to the stocks owners and personnel .
It mean they are duplicitous in an illegal act.
But that's OK?
I don't understand why these posters are allowed to denigrate Drs and other shareholders by calling us thieves and scammers.
If those assertions were made towards those controlling rhis board it would not be allowed for long. Would it?
Falconer. Don't do it! Please..
Stay independent of the FBers..
17 million cash
Rett syndrome Phase 2/3
Alzheimer's Phase 2/3
Parkinson's Phase 2/3
All beginning Q1 2017
So yeah. Good luck with AF and being short.
Why free markets are beautiful things
Agreed
what will happen first:
Phase 2/3 Rett Syndrome Announcement?
Biogen Moving Forwrd?
MJFF Parkinsons?
Australia Phase 2/3 Alzheimers?
Update on Insomnia Testing?
Pain Killer?
Cancer Killer?
Ocular Testing?
Heart Testing?
A3-71 Update?
Epilepsy Update?
New Partner?
FDA New Deesgination?
Update of Longitudinal Data from Phase 2a PART C?
New IND ?
New Drug Candidate from out Small Molecule finder?
already have 17 million, aussies will help so will rett syndroma assoc. and MJFF.. once we have Rett Syndrome underway in Q1 of 2017..money will not be issue..we will have BTD by 3-4 Q 2017..Between Rett Syndrome and Longitudianl data from PART C...17 million more than enough for 6 months..
we don't need luck anymore..
anavex is going to devastate the CNS Pharma Market as a Monotherapy.
Homeostasis is going to solve a lot of problems and make a lot of other medication unnecessary. ACAD's would appear to be one of them.
If you don't have AD..then you don't develop Psychosis..then guess what you don't need..
Jimmy great post!
so Anavex has said emphatically that A2-73 creates Homeostasis..
And I think some may explain why OUR activation/modulation of
the Sigma 1 Ligand may be so beneficial to the body..but
maybe Biogen may show EXACT MOA..thus locking out any doubts..
New solution for Anti-Dilution:
Buy more stock!
20% more outstanding? add 20% to your holdings!
There you are now officially non-diluted..
Thank You, Thank You very much!
when everything points to a direction..it would make sense for both..
i have NEVER heard Dr Missling say NO DILUTION...never..
The Combo Patent is meaningless as the Computer Model failed to Impact Aricept's competion for the Sigma 1 Ligand..
Combination Therapy is done, what good would a Combo Patent be?
We don't know what is occurring behind the scens regarding Money..
we don't know..But the insiders aren't selling..what is your point Ziggy?
That we need more money?
The LIncoln Park deal is the fairest way to raise that money..
You want to keep your ownership non-diluted? INVEST MORE!
o special deals for teh Club, ..
tough Crowd
plex,
if you are hoping for a buyout, you shortchange the risk you have taken!
we are on a path by the end of 2017 to begin creating revenue through
the Rett Syndrome Efforts. Do not doubt A2-73! It will effect the Human Body's Sigma 1 Ligand to go to work!
Talon,
I am of the belief that Government,Medical(not Pharma) and Media Leadership are all of the same cloth, Human.
They are as intelligent as us, therefor they see same Data, which to be fair to them, always seems to be cloaked in the future. I think this is because it is an Adaptive Trial, so through Adapting we are always learning so much more. The good Dr has much of the new Data, but may only use what he knows to frame what he is sharing.
The plan as I see it, to Begin Phase 2/3 for Rett Syndrome, get it filled first Q of 2017, finished 2Q 2017, and A2-73 Available by Cross Prescription 3Q-4Q of 2017.
That is his quickest path to Access, to Revenue, & Independence.
Meanwhile, to proceed with Phase 2/3 for Alzheimers and Parkinsons. (IMO)
MJFF and Anavex have completed a deal, as part of the deal was assigning three members closely associated with MJFF to the Scientific Board of Anavex.
I don't think the good Dr is "hoping" for a lightning bolt from Government, but he does keep a lightning rod extended with multiple Government meetings, presentations and contacts. I am sure the good Dr will continue this tactic. You never know when or where Lightning may strike!
But I bear good news and it is simply this, soon, very soon, with most if not all(MY Intelligent GUESS BASED ON INCREASING MMSE Scores at 57 Weeks) remaining Phase 2a PART C patients having switched to Monotherapy by ceasing dosing of Aricept, have been responding like the 6 Super Responders.
The average respnders (N=19) of 16.9 MMSE at 57 Weeks, is data from some some time ago. As we have an open Trial, the good Dr has their continuing Data, AND I might add for many of the N=19 this Data may be 6 months along! By MY theory, That could mean some of those who have switched to Monotherapy are up through 20 on their MMSE scores and MAYBE HIGHER! PURE SPECUALTION! But the FDA and Anavex HAVE this Data..
the good Dr always has access to this Data, it must inspire Dr Missling and the Anavex Team! Their Work is changing the WORLD!
Maybe the good Dr has to play this Part, the Part of a Scientist proving a hypothesis beyond doubt.
But to give this a wrap, once the Politicians See what we see in the Patients Lives, once the Bureaucrats see the convincing Evidence of the immediate BUDGET SAVINGS, and once the Medical Community sees the ever increasing MMSE scores of switched Patients, and once the Media begins to interview the families and recovering patients on a regular basis..
There is not time frame for these happenings, as the FDA could take action tomorrow, today..We DON'T KNOW..
I would like to think, that we celebrate Christmas this year with the knowledge that for the first time in the history of Man, we have reversed Dementia in the elderly! It is a Miracle to be celebrated. I celebrated with my family and co-workers, please celebrate with your loved ones.
We may do our best to encourage Lightning Strikes, in Government, Media, Bureaucracy, Medicine but in the end, we are passengers aboard the good Ship Anavex.
Our good Captain,Dr Missling, is not racing through Iceberg infested waters, and with such precious cargo, who may blame him?
Well bourbon. The good Dr has already said this so. ??
A2-73 didn't overcome a negative respnse to Aricept..
A2-73 appears to be able to effectively reverse the symptoms of
ALzheimers even after 1 year of co-medicating with Aricept which now appears to be Contra-Indicated for use with A2-73.
millstone,
i took out the strong respnders at 52 weeks and 57 weeks..so
no..the average responders scores went up about 1 point from 15.9 to 16.9.
there is no chance the strong respnders were responsible for this move.
I crunched the numbers withdrawing the 6 super responders and their scores from the overall averages at 52 weeks and 57 weeks. The scores without these high responders are close to the same as Aricept 20MMSE down to 15.9MMSE at 52 weeks 4 points .. that is usual SOC down for Alzheimer's in MMSE. So taking out top responders (Monotherapy-i will not suspend my intelligence to think this group anything else) at 57 weeks,
This Minimal responding group of 19, which should have continued down closer to 15 MMSE at 57 weeks instead went UP to 16.9 MMSE!.. a 2 point reversal of Alzheimer's swing One Year into a mild to moderate study! It's unbelievable ! IMO The only way this happens so quickly is if many changed to Monotherapy or the few that did change skyrocketed in 5 weeks.. I think it more likely that many went Mono after 52 weeks ..of not all..
Or that could be your placebo, Aricept and anavex
If the reaction of rising MMSE scores was immediate to dropping of Aricept
I believe all participants would be Aricept free during trial.
The adaptive trial was adapted to only focus upon A2-73 . We know that as Anavex dropped "Aricept" from Strata clarification. We know that patients are allowed to stop taking Aricept and stay in the study as why else would you drop Aricept as Strata if taking it were still necessary? It's not. Most if not all trial members have stopped taking Aricept for PART C .
As they and their caregivers are rational human beings.. and this group on non responders at 52 weeks bloomed and my guess is .. is still blooming .. the beautiful part is ..
How high may they go?
Can the MMSE group that started at 20 went to 15.9 then at 57 weeks was at 16.9 .. can this group go through
20 on their MMSE ? Through 22?
May they achieve a 25.6 like other Monotherapy group? So exciting
Thank you Xena,
As always, he FDA and Anavex have this data and have had this data as it is an OPEN trial.
I don't see how they may come to any different conclusion.
Their excitement must be off the charts!
Ruby
So please understand I believe A2-73 should be made immediately available with current data.
At 5 weeks without having charts in front of me, there was a washout period and did they separate out Monotherapy at that point?
Anyway there is a placebo effect that washes out after 12 weeks so we had placebo effect and high responders affecting scores at 5 weeks.. so really you need to go to 31 weeks and average out the scores of high responders and 52 weeks and do the same. When you do this you see that the average of the other patients is really on the Sam negative slope as Aricept by itself.. now that is still ok as A2-73 has side benefits ,, but..
With super responders(full remission) we all expected everyone to be doing better..
It turns out that by Post Review of Graphs the ONLY conclusion that makes sense is that
At 52 Weeks MMSE went from 15.9 to 16.9 score, and the only way in my opinion that Alzheimers could be reversed in 19 patients at one year is the only drug that has ever reversed Alzheimer's A2-73, and since these patients were already taking A2-73 for one year, something else must have changed . Anavex has said they have not optimized dosing so that is probably not the case, the only thing that is logical is that a high number of patients stopped taking Aricept!
Which means, that there are millions of people Right Now that we may save from the ravages of Dementia/Alzheimer's if we get them A2-73!