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The patent is still pending, I believe. It's HARD to wait. LOL
Kelowna, British Columbia – November 9, 2017 – Lexaria Bioscience Corp. (OTCQB: LXRP) (CSE: LXX) (the “Company” or “Lexaria”) a drug delivery platform innovator, announces it has filed a new patent application with the US Patent and Trademark Office (“USPTO”) utilizing the Lexaria DehydraTECHTM technology for delivery of phosphodiesterase type 5 (PDE5) inhibitors – trade names of existing well-known products include ViagraTM (sildenafil) and CialisTM (tadalafil).
In its new patent application, Lexaria has named the PDE5 inhibitors from the group consisting of avanafil, lodenafil, mirodenafil, sildenafil (or analogs thereof, for example, actetildenafil, hydroxyacetildenafil, or dimethylsildenafil), tadalafil, vardenafil, udenafil, acetildenafil, and thiomethisosildenafil. In addition, under the new patent application each of these named molecules may be combined with a cannabinoid such as cannabidiol (“CBD”), where the cannabinoid delivered in concert may provide complementary vasodilatory activity beneficial together with the PDE5 inhibitor.
A common complaint of existing PDE5 delivery is the slow-acting nature of the substances. Building on existing successful research with cannabinoid delivery, Lexaria believes its patented DehyraTECHTM technology will allow for faster acting treatments in many cases utilizing lower dosage quantities.
As is true with Lexaria’s other patents and patent applications, the new PDE5 patent application is for the improved and more rapid delivery of the named molecules and is meant to be complimentary to existing or newly planned consumer products with a view to attracting prospective licensees or partners interested in utilizing Lexaria’s technology in next generation commercial products.
Lexaria’s patented DehydraTECH™ technology is focused on improved delivery methodologies of many commonly used API substances. As such, it provides an additional layer of effectiveness that is designed to harmonize with the intellectual property of third parties. Both patented and generic API substances can utilize Lexaria’s patented technology. Lexaria’s long term strategy is to partner with the world’s leading firms as they deliver best-of-class products to their existing large consumer groups.
Old News Here's the pertinent news release that has probably piqued the interest of all these renowned neuroscientists.
Kelowna, British Columbia – June 29, 2018 – Lexaria Bioscience Corp. (OTCQX: LXRP) (CSE: LXX) (the “Company” or “Lexaria”) a drug delivery platform innovator, announces it has filed an important new patent application with the United States Patent and Trademark Office (“USPTO”) for innovation in treatment options related to central nervous system disease or disorders including viral infection, cancer, neurodegenerative disorders, ADHD, anxiety, depression, OCD, schizophrenia, Alzheimer’s, Huntington’s, Parkinson’s, neuropathic pain and more.
In recent laboratory testing, Lexaria’s breakthrough discovery evidenced greatly enhanced drug delivery to brain tissue. Nicotine in-vivo (animal) studies showed that up to 560% more nicotine was delivered to brain tissue utilizing DehydraTECHTM than concentration-matched controls lacking DehydraTECHTM enhancements. The study provided evidence of surprising effectiveness in crossing the blood-brain barrier (“BBB”) which the Company is investigating more extensively, leading to Lexaria’s patent application titled: “Enhancement of Delivery of Lipophilic Active Agents Across the Blood-Brain Barrier and Methods for Treating Central Nervous System Disorders.”
It is well documented that nicotine – while addictive – does not cause cancer. It is the tar and other chemicals formed when cigarettes are combusted that cause cancer. Thus, an efficient delivery mechanism of minute quantities of nicotine that does not require combustion could lead to greatly reduced death and disease through the avoidance of smoking, while also potentially aiding reduced chemical dependence on nicotine until such time as addictive-avoidance behaviours can be empowered.
Lexaria’s surprising discovery of the DehydraTECHTM apparent effectiveness in crossing the BBB also opens the door to possibilities of delivering other therapeutic drugs in the treatment of intractable diseases.
The BBB, while providing effective protection to the brain against circulating toxins, also creates major difficulties in the pharmacological treatment of brain diseases. Most charged molecules, and most molecules over 700 Daltons in size, are unable to pass through the barrier, and smaller molecules may be conjugated in the liver. These factors create major difficulties in the pharmacological treatment of diseases of the brain and central nervous system (“CNS”), such as Alzheimer’s disease, Parkinson’s disease, bacterial and viral infections and cancer.
Many therapeutic agents for the treatment of diseases and disorders of the brain and CNS are sufficiently hydrophilic to preclude direct transport across the BBB. Furthermore, these drugs and agents are susceptible to degradation in the blood and peripheral tissues that increase the dose necessary to achieve a therapeutically effective serum concentration. However, as described above, although lipophilicity is generally associated with molecules that are easily able to cross the blood-brain barrier, lipophilicity is not the leading characteristic for molecules that transverse the blood-brain barrier. Seelig and colleagues studied the association of different factors with the ability of molecules to diffuse across the blood-brain barrier, including lipophilicity, Gibbs Adsorption Isotherm, a Co CMC Plot, and the surface area of the drug to water and air (Seelig et al. (1994) Proc. Nat. Acad. Sci. (USA) 91:68-72). Their results showed that barrier permittivity is based on a complex interaction between relative size and the surface activity of the molecule, in which the surface activity includes the molecular properties of both hydrophobic and charged residues (Seelig et al. (1994) Proc. Nat. Acad. Sci. (USA) 91:68-72).
Prior methods for delivering drugs across the BBB involve three general categories: (1) liposome-based methods, where the therapeutic agent is encapsulated within the carrier; (2) synthetic polymer-based methods, where particles are created using synthetic polymers to achieve precisely-defined size characteristics; and (3) direct conjugation of a carrier to a drug, where the therapeutic agent is covalently bound to a carrier such as insulin. Liposomes are attractive for transporting drugs across the BBB because of their large carrying capacity. However, liposomes are generally too large to effectively cross the BBB, are inherently unstable, and their constituent lipids are gradually lost by absorption by lipid-binding proteins in the plasma. Synthetic polymers have run into difficulties having the drug carried across the cell only to be trapped in an endothelial cell or a lysosome, instead of the desired result of being ejected into the brain parenchyma.
Direct conjugation of pharmacological agents with the substances that can be transported across the BBB, such as insulin, has also been attempted. Insulin and insulin-like growth factors are known to cross the blood brain barrier by specialized facilitated diffusion systems. (Reinhardt et al. (1994) Endocrinology 135(5): 1753-1761). Specific transporters also exist for glucose and for large amino acids such as tryptophan. However, the specificity of the insulin transporter has proved to be too high to allow pharmacological agents covalently linked to insulin to cross into the brain. Similar results have been obtained with glucose and amino acid conjugates, whose uptake has been observed to obey the same general principles as other low-molecular weight substances, with only uncharged molecules below 700 Da achieving significant access to the brain.
Lexaria’s application requests patent protection for the delivery of cannabinoids, terpenes and terpenoids, non-steroidal anti-inflammatory drugs (i.e., NSAIDs), vitamins, nicotine, phosphodiesterase type 5 (PDE5) inhibitors, estrogen, progestin, testosterone, scopolamine and more, utilizing Lexaria’s already-patented DehydraTECHTM methodology combined with any of a wide variety of emulsifiers, starches, oils, flavorings and foods.
With approximately 50 patents now granted or pending worldwide, the Company’s policy has evolved to continue to issue news releases on material patent filings and issuances, but not on every patent-related development.
Dr. Ed Ergenzinger was also Director of Intellectual Property and Legal Affairs, Duke Human Vaccine Institute, at Duke University. This is where Dr. Matthew Fraser is associate professor and director of basic science research in the department of surgery, division of urology.
So all 4 of these experts who have been appointed to Lexaria's advisory board have been recruited from institutions where Dr. Ergenzinger has worked.
He obviously knows them personally and has shown them the results of Lexaria's research and they're intrigued and want to be involved.
I haven't bought any shares for a long time, but I'm buying more today!
Well, maybe 1906 is the private company that has licensed DehydraTech for beverages? I believe they were only licensed for edibles before.
That's great, growing revenue for Lexaria. Also shows that 1906's product is well liked and that DehydraTech works.
Dr. Ed Edergenzinger is an adjunct professor of law at Wake Forest University
https://www.linkedin.com/in/edergenzinger
Also, the National Research Council of Canada, our research partner, has extensive experience in investigating methods of crossing the blood-brain barrier.
Interesting that every one of them has a strong background in neuroscience and of course Chief Legal Officer and Senior Vice President of Innovation
Dr. Ergenzinger also has a strong background in that field and also vaccines. In order to be an effective drug to treat neurological disorders, the drug would have to be able to cross the blood-brain barrier, that has been the challenge to date.
I had a dream last night. Lexaria in conjunction with NRCC had applied for patents to cover the oral use of vaccines and insulin with nano-emulsified DehydraTech. Imagine no more needles! This is possible if there is a successful crossing of the blood-brain barrier.
Muchos Bunka bucks coming soon!
Like you say, "In Bunka We Trust" LOL
Someone should print up some Bunka bucks with the motto and his face.
I don't think Lexaria wants to reveal the terms of the deal as it would adversely effect their negotiating ability in regards to deals with other companies.
Hopefully, it's a larger private company that's just about to go public.
NEWS
Lexaria Bioscience Announces Beverage License Agreement with California-Based Cannabis Company
(via TheNewswire)
Kelowna, British Columbia / TheNewswire / April 24, 2019 - Lexaria Bioscience Corp. (OTCQX: LXRP) (CSE: LXX) (the "Company" or "Lexaria"), a drug delivery platform innovator, announces that it has entered a definitive 5-year agreement, via its subsidiary Lexaria CanPharm ULC, to provide Lexaria's patented DehydraTECHTM technology to a private California-based cannabis company for its utilization in certain cannabis-based beverages to be produced and sold in the states of California and Nevada.
Financial terms of the agreement are not being disclosed. The DehydraTECH-enabled beverages are protected under Lexaria's many existing US-g ranted patents and may include any combination of ready-to-drink beverages such as non-alcoholic beers, wines and spirits; cold or hot coffee or teas, sports drinks and much more.
Lexaria has developed methods of combining nano-emulsion technology with its proprietary DehydraTECH processes to create beverages with market-leading aesthetic and performance characteristics. Lexaria is currently experiencing unprecedented demand in several North American markets for use of its technology for beverage applications.
About Lexaria
Lexaria Bioscience Corp. has developed and out-licenses its disruptive delivery technology that promotes healthier ingestion methods, lower overall dosing and higher effectiveness of lipophilic active molecules. Lexaria has multiple patents pending in over 4 0 countries around the world and has patents granted in the USA and in Australia for utilization of its DehydraTECH(TM) delivery technology. Lexaria's technology provides increases in intestinal absorption rates; more rapid delivery to the bloodstream; and important taste-masking benefits, for orally administered bioactive molecules including cannabinoids, vitamins, non-steroidal anti-inflammatory drugs (NSAIDs),nicotine and other molecules.
www.lexariabioscience.com
I think it's clear NHS's tech doesn't work orally. There must still be harm to the stomach and liver with the use of their nanotechnology. It's like they have the comparable product to Nicorette gum, spray and patches but please don't swallow! People would much rather pop a pill.
On the bright side, it is only for transdermal, intranasal and intraoral applications, not oral.
Beaten to the Punch?
Nanosphere gets notice of allowance for NSAID patent
2019-04-24 10:00 ET - News Release
Mr. Robert Sutton reports
NANOSPHERE HEALTH SCIENCES HAS RECEIVED NOTICE OF ALLOWANCE FOR A PATENT FOR ITS BREAKTHROUGH NANOPARTICLE ENCAPSULATIONS OF NSAIDS
Nanosphere Health Sciences Inc. has received formal notice of allowance from the Canadian Intellectual Property Office (CIPO) for application No. 2,970,91, covering "The Method of Treating Inflammatory Disorders and Global Inflammation with Phospholipid Nanoparticle Encapsulations of NSAIDs." NSAIDs being non-steroidal anti-inflammatory drugs, which include ibuprofen, aspirin, and naproxen among others.
This patent allowance adds to NanoSphere's already robust IP portfolio. In 2018 NanoSphere received a master patent covering NanoSphere's core technology, the NanoSphere Delivery System(TM). This groundbreaking delivery platform encapsulates a broad range of bioactive compounds in a protective membrane, transporting them rapidly and effectively into the bloodstream and cells for the most rapid and effective results.
"Nano-encapsulating NSAIDs in a stable nanoparticle structure allows for a more rapid onset of symptom relief, longer lasting activity, greater therapeutic activity from a smaller dose and potential reduction of dangerous side effects,' said Chief Science Officer Richard Clark Kaufman. "The current class of NSAID drugs are very effective, but they can also create an increased risk of gastrointestinal bleeding or ulcers, heart attacks, kidney disease, and liver failure," said Kaufman. "Our research has been aimed at delivering these medicines both systemically and locally to target sites without passing through the gastrointestinal tract. By doing so we can create more effective treatments, with fewer adverse effects and enable long-term, safer use of NSAIDs." "The granting of the patent further establishes NanoSphere as an advanced biotech company and secures our position as the leader in advanced nanoparticle delivery," said Robert Sutton, CEO of NanoSphere Health Sciences. "Through our research and development, we aim to be the de facto mode for NSAID delivery worldwide, which according to Allied Market Research, the market is in excess of $100 billion, with an annual growth rate of 5.9%." With the issuance of this patent, NanoSphere will now have long-term market exclusivity over this delivery platform for NSAIDs with patent infringement prohibited. The company will now officially launch commercial development of a platform of pharmaceutical applications for the treatment of pain and inflammation. This patent allows for nanoparticle encapsulation of NSAIDs for transdermal, intranasal and intraoral applications, providing superior advantages over traditional pain management therapies. "This patent confirms NanoSphere's commitment to creating a portfolio of non-opioid analgesics that can be delivered by a variety of methods. Administration of NSAIDs through oral or intravenous routes is not always convenient or even possible. Utilizing its patented delivery system, NanoSphere will make available a safe and precise alternative for NSAID delivery," said Senior Director of NanoSphere's NSAID program, David Theil, M.D.
About NanoSphereHealth Science, Inc.
NanoSphere Health Sciences Inc., is a biotechnology firm specializing in the creation of the NanoSphere Delivery System(TM), a revolutionary platform using nanotechnology for the biodelivery of supplements, nutraceuticals and over-the-counter medications for the cannabis, pharmaceutical and animal health industries, and beyond. For more information on NanoSphere, please visit http://www.nanospherehealth.com.
About Evolve Formulas
Evolve Formulas, product line developed by NanoSphere Health Sciences, is the provider of the world's first and only scientifically proven nanoparticle delivery system in cannabis. Evolve's pioneering product, Transdermal NanoSerum(TM), is a fast-acting, ultra-strength transdermal formula infused with nano-encapsulated cannabis and cannabis extracts.
© 2019 Canjex Publishing Ltd. All rights reserved.
Stockman you're eating the chicken and the eggs. LOL
But I can't see a LP buying Lexaria Hemp (CBD) and not Lexaria Canpharm (THC), they would want both.
Maybe the reason that ChgrD+ hasn't launched yet is that LXRP is in negotiations to sell Lexaria Hemp outright to a LP like Cronos?
Hope they keep a recurring percentage.
Above average volume in the great white north again today with 261,700 traded. Looks like most of the selling is coming outta Canuckland!
Because everyone is waiting for some important news, like a partnership with a major LP or a pharma company or another launch of ChrgD+(lol). So today's news is sort of a letdown and doesn't really mean much to the average investor, instead of taking options for remuneration they're going to get higher pay to avoid some tax, big deal!
Tuesday morning, 10 a.m. Eastern
— Business of Cannabis (@BofC_Global) April 8, 2019
Join #BofCLive for a check in with @terryd1 of @HillStreetBevCo pic.twitter.com/cGLuFbmBZR
Hit or hit-up? LOL
Well, it's almost 5 months to the day since Lexaria announced the launch of ChrgD+ and still nothing!
How's that for executing your business plan?
Whatever could be holding this up, a shortage of CBD oil?
Volume was above average on LXX.ca at 198,700. Stockcharts only shows 166,498 which is only from the main exchange. A nice reversal candle has formed none the less.
Older Info but explains how LXRP will be entering the edibles market in Canada
Nuka Enterprises (1906 Chocolates)
For those newbies to Lexaria, monetization of the company will likely be increasing with the expansion of 1906 chocolates into Canada through their link through Lexaria to Cannfections Chocolates. 1906 also has plans to sell to states other than just Colorado:
Under the new ten year semi-exclusive agreement, Nuka Enterprises will leverage DehydraTECH™ in its U.S.-based products with a focus on recreational states like Colorado, Nevada, California, New Jersey, and Massachusetts. The company also has acquired an option to expand its products and brand to Canada, including through the use of Lexaria’s existing chocolate and confections contract manufacturer licensee, Cannfections Group Inc.
Here's a link to the article:
https://www.otcmarkets.com/stock/lxrp/news/Lexaria-Solidifies-Presence-in-Edibles-Market-with-New-Agreement----CFN-Media?id=191328
Courtesy of Yowza123 on Stockhouse
That's my biggest problem with this company, they don't like to give updates. They have a real communication problem and I've just about had enough. Why should I stay invested in a company that can't be bothered to keep investors informed?
Makes no sense. They claim to have a 28,000 sg. ft. facility in Vegas + the facility in Louisiana but when they expand they're only going to have 30,000 sg. ft. all together. Wow, a 2,000 sg. ft. expansion.
Shaark Fin Soup coming up!!
Lexaria Bioscience Begins Largest Cannabinoid R&D Program in its History
2019-03-20 12:51 ET - News Release
KELOWNA, BC / ACCESSWIRE / March 20, 2019 / Lexaria Bioscience Corp. (OTCQX: LXRP) (CSE: LXX) (the "Company" or "Lexaria"), a drug delivery platform innovator, announces that work has commenced on its largest-ever cannabinoid research program, which will also test Lexaria-designed nanotech enhancements. This new program is comprised of 11 separate animal studies, each of which is comparable in scope to individual animal studies conducted by the Company during 2018.
Lexaria began its 2019 in vivo study design six months ago and laboratory test articles have all been produced and exceed all required quality control thresholds. The project has now advanced to the implementation stage. This 2019 R&D project is the largest undertaken in the Company's history and will test for a variety of potential performance enhancing variations of the DehydraTECHTM delivery technology which has already evidenced industry-leading performance.
The Company expects this research to lead to even greater improvements in DehydraTECH performance in next-generation formulations currently under development. Because the current research may also lead to additional patent filings, the Company is not able to provide more detailed design information at this time. Lexaria expects to gain insight into mechanisms by which DehydraTECH-enabled CBD has so often outperformed generic CBD in various trials.
Beginning in early 2018, Lexaria has also evaluated various Company-created nano emulsions to be used in combination with the DehydraTECH delivery system. The 2019 R&D program will for the first time ever evaluate DehydraTECH in combination with these nanotech emulsion formulas. Lexaria has produced countless varieties of beverage formulations enhanced with a combination of DehydraTECH together with nanotech enhancement and believes it has produced beverage formulations that offer industry-leading performance characteristics.
Although there are countless varieties of nanotech available due to the age and maturity of that technology, no other company in the world can offer a combination of nanotech with DehydraTECH nor the increased performance characteristics of both.
Lexaria also announces that, effective March 15, 2019, it has terminated the definitive license agreement entered into between Lexaria CanPharm ULC and NeutiSci International Inc. that was originally announced on February 26, 2018.
Finally, Lexaria announces a change in policy whereby it will no longer uniquely announce each small option or warrant exercise that involve less than 1% of the Company's outstanding shares. Larger warrant and option exercises or a series of small exercises that cumulatively exceed 1% of shares outstanding, will still be announced.
About Lexaria
Lexaria Bioscience Corp. has developed and out-licenses its disruptive delivery technology that promotes healthier ingestion methods, lower overall dosing and higher effectiveness of lipophilic active molecules. Lexaria has multiple patents pending in over 40 countries around the world and has patents granted in the USA and in Australia for utilization of its DehydraTECHTM delivery technology. Lexaria's technology provides increases in intestinal absorption rates; more rapid delivery to the bloodstream; and important taste-masking benefits, for orally administered bioactive molecules including cannabinoids, vitamins, non-steroidal anti-inflammatory drugs (NSAIDs),nicotine and other molecules.
www.lexariabioscience.com
For regular updates, connect with Lexaria on Twitter https://twitter.com/lexariacorp
and on Facebook https://www.facebook.com/lexariabioscience/
FOR FURTHER INFORMATION PLEASE CONTACT:
Lexaria Bioscience Corp.
Alex Blanchard, Communications Manager
(250)765-6424 Ext 202
Or
NetworkNewsWire (NNW)
www.NetworkNewsWire.com
For anyone new to the board Lexaria also has this deal.
https://www.lexariabioscience.com/news/lexaria-enters-licensing-agreement-canadian-cannabis-chocolate-manufacturer/
Kelowna, British Columbia – January 25, 2018 – Lexaria Bioscience Corp. (OTCQX: LXRP) (CSE: LXX) (the “Company” or “Lexaria”) a drug delivery platform innovator, announces it has entered a definitive technology licensing agreement (the “Agreement”) with Cannfections Group Inc. whereby Lexaria is providing its patented DehydraTECHTM technology to empower next-generation performance in cannabis infused chocolates and candies to be developed and sold in Canada and internationally.
Cannfections Group Inc. is an infused chocolate and gummies contract manufacturer that has been newly established by one of Canada’s leading chocolate companies with over eighty-five years of experience in producing high quality chocolate and confectionary products that meet the industry’s strictest quality requirements, as a pending entrant into the Licensed Producer program for cannabis infused products. The founders of Cannfections currently manufacture chocolate retail products for several leading international and domestic chocolate brands.
Under the terms of the Agreement, Lexaria can offer other licensee partners the option of utilizing Cannfection’s formulation and manufacturing expertise to produce cannabis infused, DehydraTECH™-powered chocolates and gummies where approved. This Agreement is expected to lead to new product entries for Canadian cannabis edibles, and exportation to the increasing number of other international markets where permitted around the world. The term of the agreement is seven years.
“By licensing our technology to Cannfections, Lexaria can now offer its commercial clients the expertise of one of Canada’s oldest and most established chocolatiers utilizing next-generation DehydraTECHTM technology,” said Chief Executive Officer Chris Bunka. “This is a long term strategic relationship meant to offer technology, value and expertise to Licensed Producers wanting to offer the highest quality chocolate edibles available in Canada once permitted under Health Canada regulations.”
Lexaria’s patented DehydraTECH™ technology is focused on improved delivery methodologies of many commonly used active pharmaceutical ingredient (“API”) substances. As such, it provides an additional layer of effectiveness that is designed to harmonize with the intellectual property of third parties. Both patented and generic API substances can utilize Lexaria’s patented technology. Lexaria’s long term strategy is to partner with the world’s leading firms as they deliver best-of-class products to their existing large consumer groups.
I suspect Hill Street was negotiating a joint venture with Cronos when along came Altria and made an offer for the majority of Cronos and everything was put on the back burner until the new BOD could meet and vote on the deal. Just my .03 cents worth!
https://www.ctvnews.ca/business/edibles-legalization-fraught-with-hurdles-lack-of-clarity-companies-say-1.4339669
Hill Street Beverages plans to build their facility in conjunction with a LP. (Cronos?)
Vaporize?