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Therapeutic Solutions International Reports Unexpected Findings of Synergy between QuadraMune™ and Diabetes Drug Metformin in Animal Models of COVID-19 Lung Damage
PR Newswire PR Newswire•July 22, 2020
New Data Suggests Nutraceutical Product May Amplify Known Beneficial Effects of AMPK Activation in Pulmonary Inflammation
OCEANSIDE, Calif., July 22, 2020 /PRNewswire/ -- Therapeutics Solution International, Inc., (OTC Markets: TSOI), announced today filing of a patent showing potent synergy between QuadraMune™ and the antidiabetic drug metformin in treating COVID-19 associated lung damage models.
It was discovered that the ability of QuadraMune™ to protect the lungs from inflammation that resembles coronavirus-induced pathology is markedly amplified by concurrent administration of metformin.
At a mechanistic level, it was shown that metformin increased the ability of QuadraMune™ to:
a) increase the number of "healing macrophages" ("M2" macrophages);
b) augment production of anti-inflammatory and regenerative proteins; and
c) suppress production of pathological inflammatory proteins.
"We are currently preparing to conduct a 500-person study evaluating protection from COVID-19 in individuals at high risk of infection, which is listed on the NIH website1," said Dr. James Veltmeyer, Chief Medical Officer of the Company. "In light of the current findings, we are extremely interested in evaluating outcomes in patients already taking metformin, which is one of the commonly used drugs in elderly populations."
Metformin has previously been shown to possess numerous therapeutic benefits in addition to its activities on diabetes. Beneficial effects of metformin include stimulation of immune responses2, suppression of cancer3, reduction of nicotine withdrawal side effects4, and inhibition inflammation5.
"It is naïve to believe that therapeutics that we develop will be used in isolation," said Timothy Dixon, President and CEO of the Company. "We are grateful for our scientific advisors who have guided us to perform 'out of the box' experiments in terms of combining QuadraMune™ with clinically relevant companion medications. We are continuing our journey to develop QuadraMune™ as a science-based nutraceutical, as well as to understand mechanistically its modes of action in order to continually work to improve potential for efficacy."
About Therapeutic Solutions International, Inc.
Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. The Company's corporate website is www.therapeuticsolutionsint.com, REDACTED
1 https://clinicaltrials.gov/ct2/show/NCT04421391
2 Eikawa et al. Immune-mediated antitumor effect by type 2 diabetes drug, metformin. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1809-14. https://www.pnas.org/content/112/6/1809.long
3 Malinowski et al. Metformin's Modulatory Effects on miRNAs Function in Cancer Stem Cells-A Systematic Review. Cells . 2020 Jun 4;9(6):1401 https://www.mdpi.com/2073-4409/9/6/1401
4 Brynildsen et al. Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal. Proc Natl Acad Sci U S A . 2018 Apr 17;115(16):4282-4287 https://www.pnas.org/content/115/16/4282.long
5 Gou et al. High fat-induced inflammation in vascular endothelium can be improved by Abelmoschus esculentus and metformin via increasing the expressions of miR-146a and miR-155. Nutr Metab (Lond). 2020 May 13;17:35. https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-020-00459-7
Therapeutic Solutions International, Inc.
ir@tsoimail.com
a couple more 6 digit trades
back to back 6 digit trades for the same share count...hmmmm
really feeling good about this run
6 digit trades...here we go
wtf 1.5 at 93 and then back to 75?
lol, looks like they were sleeping
huge spread
looks like they want copper like now
looking super thin
A very pretty picture in deed
lol, it is called consolidation
Yeeeehawww...more milestone shares. Big week coming!
Gee, why would they want stock instead of cash. Hmmmm
Thanks for sharing
you will fight them with a PR as well.
I disagree on the insiders/management
lol, orchestrated p & d...that is not the company doing that. It is other large investors or VC types. too funny
Hmmm, I thought charts meant nothing in OTC land? Waffle
I believe the company has to pay ihub to distribute the news releases
lol, no one would read that they do not want any pregnancies as they would effect the hormones and other aspects of the body that may cause a different outcome or be construed as causing the outcome itself. PFFFT
Why on earth would that matter?
his website says MD
yes, I think there is a link that is TOS
Blood clotting is a major issue regardless of covid
HUGE NEWS!!!!! Therapeutic Solutions International Reports QuadraMune™ Inhibits Inflammation Induced Blood Clotting: Possible Implication for Ongoing Covid-19 Prevention Clinical Trial?
PR Newswire PR Newswire•July 13, 2020
OCEANSIDE, Calif., July 13, 2020 /PRNewswire/ -- Therapeutics Solution International, Inc., (OTC Markets: TSOI), reported today new data showing that the ingredients of QuadraMune™ suppress expression of an inflammation stimulated molecule which is known to induce coagulation of blood. Inhibition of this coagulation-promoting molecule, called Tissue Factor, was synergistic with all four ingredients of QuadraMune™ when combined. Tissue Factor is known to be associated with COVID-19 disease1,2, and is the culprit for clotting associated conditions such as deep vein thrombosis and atherothrombosis3.
"Myself and my colleagues are puzzled by the abnormal blood clots that are found throughout the body of COVID-19 patients. We are seeing strokes in patients in their 30s, and abnormal blood coagulation pathology that normally is restricted to patients with hematological abnormalities. It is shocking that some autopsy studies report these blood clots to be found in almost every major organ of the body4" said Dr. James Veltmeyer, Chief Medical Officer of the Company and co-inventor of the filed patent disclosing the new data. "The finding that components in QuadraMune can inhibit inflammation induced expression of the coagulation molecule Tissue Factor, has profound implications for our ongoing research program. We previously listed at ClinicalTrials.gov a registered Covid-19 prevention trial5 and we are in discussions whether trial modification is necessary based on these exciting new data."
The data, which is basis for a new patent filing, demonstrate that pterostilbene, thymoquinone, sulforaphane, and epigallocatechin gallate (EGCG) suppress TNF-alpha induced expression of the molecule tissue factor. Tissue factor is one of the key molecules which causes blood clots. Importantly, the Company previously reported that QuadraMune™ inhibits production of inflammatory molecules from the blood of healthy volunteers while stimulating natural killer cells6. The inflammatory molecules which QuadraMune™ has been shown to suppress, are associated with poor prognosis in patients with COVID-197.
"Our mantra is to diligently, systematically, and very precisely, follow the science" said Timothy Dixon, President and CEO of the Company. "We have a world-class scientific advisory board who has been guiding us in the development of these two global approaches to COVID-19: our QuadraMune™ nutraceutical approach, which is commercially available today, and our StemVacs™ cell therapy approach, which will require FDA clearance. By working in these two different worlds we are obtaining valuable cross-fertilization and, in our opinion, making progress at a "Warp Speed."
About Therapeutic Solutions International, Inc.
Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. The Company's corporate website is www.therapeuticsolutionsint.com , REDACTED
1DiNicolantonio et al. Thrombotic Complications of COVID-19 May Reflect an Upregulation of Endothelial Tissue Factor Expression That Is Contingent on Activation of Endosomal NADPH Oxidase. Open Heart 2020, Jun;7(1).
2Bautista-Vargas et al. Potential Role for Tissue Factor in the Pathogenesis of Hypercoagulability Associated With in COVID-19. J Thromb Thrombolysis . 2020 Jun 9;1-5
3Saha et al. Tissue Factor and Atherothrombosis. Curr Pharm Des . 2015;21(9):1152-7
4https://www.the-scientist.com/news-opinion/autopsies-indicate-blood-clots-are-lethal-in-covid-19-67727
5https://clinicaltrials.gov/ct2/show/NCT04421391
6https://www.biospace.com/article/releases/san-diego-top-doctor-collaborates-with-therapeutic-solutions-international-to-report-quadramune-immune-boosting-data-in-clinical-trial/
7De Valle et al. An Inflammatory Cytokine Signature Helps Predict COVID-19 Severity and Death. medRxiv. 2020 May 30;2020.05.28.20115758.
Therapeutic Solutions International, Inc.
ir@tsoimail.com
So what was his PHD in?
Seems to be right on target...MIT wow!
a direct statement from the FDA email you received?
I am not a big fan of pump advertising. It typically is a large shareholder trying to build up the price to sell into. All it does is make the company look bad
covering baby
wow 1.15M share cover just happened
For those that missed the PR yesterday
Therapeutic Solutions International Submits Publication on StemVacs™ Preclinical Data Supporting COVID-19 Indication
PR Newswire PR Newswire•July 7, 2020
Company Advances its Clinical Stage Cancer Immunotherapy Candidate into Battle with Coronavirus
OCEANSIDE, Calif., July 7, 2020 /PRNewswire/ -- Therapeutic Solutions International, Inc., (OTC Markets: TSOI), announced submission of a publication providing preclinical data which supports repositioning of its Cancer Immunotherapy StemVacs™ as a candidate for treatment of COVID-19. StemVacs™ is based on activating universal donor immune system cells called dendritic cells in a manner so that upon injection they reprogram the body's "Natural Killer" cells.
Natural killer cells are the most potent cell type in the body in terms of killing viruses. Unfortunately, natural killer cells also produce chemicals called cytokines which at high concentrations can be lethal. The current data suggests that StemVacs™ can activate natural killer cells while at the same time suppressing lung inflammation. This dual mechanism of action makes StemVacs™ a promising candidate for treatment of coronavirus.
"The activation of natural killer cells caused by StemVacs™ was so significant that we were able to obverse inhibition of tumor growth. The data submitted today strongly suggest the possibility of using our immunotherapy in COVID-19, but also supports the original disease indication of StemVacs™ which is oncology" said Dr. James Veltmeyer, first author on the publication and Chief Medical Officer of the Company. "Many immunotherapies possess the potential side effect of what is called cytokine storm. Interestingly, our immunotherapy actually seems to suppress pathological inflammation."
The authors of the paper discussed the concept of a potential "tolerogenic loop" in which the dendritic cells are activating natural killer cells but also stimulating generation of T regulatory cells which act to protect the lung from excess inflammation.
"Given that StemVacs™ already has an IND number with the FDA, the studies that we need to undertake to initiate our COVID-19 repositioning need only to support potential efficacy. We believe that the data we are submitting for publication strongly supports efficacy" said Timothy Dixon, President and CEO of the Company. "We are in the process of collecting data from patients treated with StemVacs for cancer and once these data are properly presented, we hope to file an IND amendment to request the FDA to allow us to initiate clinical trials in coronavirus."
About Therapeutic Solutions International, Inc.
Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. The Company's corporate website is www.therapeuticsolutionsint.com REDACTED and our prepublication may be read at https://therapeuticsolutionsint.com/CV/JTRM-D-20-01274.pdf.
Therapeutic Solutions International, Inc.
ir@tsoimail.com
so does someone else based on the volume and the chart
Money Mountain still in play
Continue with the promo and I see a strong price
OCEANSIDE, Calif., July 7, 2020 /PRNewswire/ -- Therapeutic Solutions International, Inc., (OTC Markets: TSOI), announced submission of a publication providing preclinical data which supports repositioning of its Cancer Immunotherapy StemVacs™ as a candidate for treatment of COVID-19. StemVacs™ is based on activating universal donor immune system cells called dendritic cells in a manner so that upon injection they reprogram the body's "Natural Killer" cells.
Natural killer cells are the most potent cell type in the body in terms of killing viruses. Unfortunately, natural killer cells also produce chemicals called cytokines which at high concentrations can be lethal. The current data suggests that StemVacs™ can activate natural killer cells while at the same time suppressing lung inflammation. This dual mechanism of action makes StemVacs™ a promising candidate for treatment of coronavirus.
"The activation of natural killer cells caused by StemVacs™ was so significant that we were able to obverse inhibition of tumor growth. The data submitted today strongly suggest the possibility of using our immunotherapy in COVID-19, but also supports the original disease indication of StemVacs™ which is oncology" said Dr. James Veltmeyer, first author on the publication and Chief Medical Officer of the Company. "Many immunotherapies possess the potential side effect of what is called cytokine storm. Interestingly, our immunotherapy actually seems to suppress pathological inflammation."
The authors of the paper discussed the concept of a potential "tolerogenic loop" in which the dendritic cells are activating natural killer cells but also stimulating generation of T regulatory cells which act to protect the lung from excess inflammation.
"Given that StemVacs™ already has an IND number with the FDA, the studies that we need to undertake to initiate our COVID-19 repositioning need only to support potential efficacy. We believe that the data we are submitting for publication strongly supports efficacy" said Timothy Dixon, President and CEO of the Company. "We are in the process of collecting data from patients treated with StemVacs for cancer and once these data are properly presented, we hope to file an IND amendment to request the FDA to allow us to initiate clinical trials in coronavirus."
About Therapeutic Solutions International, Inc.
Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. The Company's corporate website is www.therapeuticsolutionsint.com , redacted and our prepublication may be read at https://therapeuticsolutionsint.com/CV/JTRM-D-20-01274.pdf.
Therapeutic Solutions International, Inc.
Company Advances its Clinical Stage Cancer Immunotherapy Candidate into Battle with Coronavirus