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And I like to point out Brilacidin only required one dose where dapto required seven. The single dose variable could price B very competitively.
Any interest or bargaining would be completely internal. Secrecy is very important. A deal would be huge hopefully it happens.
So Basilea is buying/licensing antibiotic assets. B has proven to be a robust antibiotic. Leo's been real quiet. hmmm
Nice to see a deal. I expect mud to be thrown at it though.
Good post. If there's smoke there's fire.
Leo's been quiet for sometime now. Definitely need an update on the Basilea discovery. Thanks for posting PJ. You too frenchbroad!
I'm definitely staying in to see what transpires. After this long of a news blackout a good update will be like water in the desert.
That's my hope. Things are getting real.
Now we have a Super bug winning against Daptomycin.
https://www.yahoo.com/news/deadly-mrsa-superbug-develops-bulletproof-142935281.html
Is Fox Chase tied to Fort Detrick, Maryland? They test for some nasty stuff there.
Thanks for posting. Good to keep seeing B in the news.
Hard to look away huh. Leo's been real quiet what's the next green light going to be.
"The molecules identified here, are having novel scaffolds and first time reported to have antimalarial activity." I see Brilacidin is one of the compounds. Good to see more testing.
No drug is like spring water. Dapto side effect can kill you but it got approved.
I'm looking for funding a phase3 OM as the space is wide open. I don't see another absssi anytime soon Dapto is off patent and cheaper for insurance to approve now. We'll see.
Brilacidin has been used in multiple successful tests. Stop the rhetoric.
Those short attacks were used to kill the company and wipe share holders out. Cancer is not your friend.
Polymedix failed as a company due to it's prime drug candidate failing nothing to do with Brilacidin. The ABSSSI trial was re-ran very successfully by IPIX against Dapto with B given in a single dose compared to 7 day dapto IV. Btw I see Furenstein called B a oral drug which it's not.
It's the whatever sticks rule. Have a blessed Easter.
I'm seeing green AH.
Yahoo- 12.00 +0.02 (+0.17%)
After hours: 07:12PM EDT
I have no answer as to why this update.
Oral drug dosage form comprising various release profiles
Abstract
The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
Inventors: Li; Xiaoling (Dublin, CA)
Applicant:
Name City State Country Type
Triastek, Inc.
Nanjing
N/A
CN
Assignee: Triastek, Inc. (Nanjing, CN)
Family ID: 57440194
Appl. No.: 16/402,028
Filed: May 2, 2019
Prior Publication Data
Oct 24, 2019
Document Identifier Publication Date
US 20190321299 A1
United States Patent 11,278,499 Li
March 22, 2022
The guys bought and paid for.
April fools share swap.
Good to see Thanks. Looking forward to our next update.
Safety study so nothing to get too excited about. A Phase2 efficacy is where the rubber meets the road. But I agree it's a nice run up.
Include Walmart in your portfolio. Always have a cushion:)
The tensile strength is amazing. Many try but she wont shear. Funding news will be huge.
Broke 4 cents fast. Let's keep it up.
I wish I had the answers. We need to get in on APP money.
We may fall under this: Accelerating Antiviral Development
https://ncats.nih.gov/antivirals#:~:text=NCATS%20will%20play%20a%20pivotal%20role%20in%20the,to%20address%20other%20virus%20families%20with%20pandemic%20potential.
Positive observations were seen in the compassionate use study where some very sick patients had been given a longer dosing duration.
"Analysis of the compassionate use of Brilacidin in the U.S. in critically-ill COVID-19 patients who had exhausted all other therapeutic options also is planned. Changes to biomarkers and positive clinical changes were observed, with some compassionate use patients administered Brilacidin more frequently and over a longer duration than patients in the Phase 2 Brilacidin COVID-19 trial".
Also "Collaborative work with NIH and other researchers on Brilacidin’s broad-spectrum antiviral properties is ongoing and generating promising data, with future updates planned".
“These results, along with observations on the compassionate use of Brilacidin in COVID-19 related to dosing, as well as data being generated from ongoing scientific collaborations, are informing paths forward for our Brilacidin antiviral program.
Looking for some possible grant money to come out of APP. We'll see.
Unlike your bleach Brilacidin was well tolerated. “Based on analyses of our Phase 2 trial results, Brilacidin showed promising treatment effects in NEWS2 clinical improvement scores and among patients with the most elevated biomarker levels,” said Leo Ehrlich, Chief Executive Officer at Innovation Pharmaceuticals. “These results, along with observations on the compassionate use of Brilacidin in COVID-19 related to dosing, as well as data being generated from ongoing scientific collaborations, are informing paths forward for our Brilacidin antiviral program.
Promising is what we need. Most covid treatments showed no promise.
Lots of parasites. NIH says Brilacidin kills covid-19 plus seen promising results in many other nasty viruses.
Not long ago ivermectin was a banned word.
Like it. Go volume.
Allegedly hmm.
Easy answer is Cellceutix was planning a phase 3 for absssi in 2015 and Pliant was started in 2015. So likely that is why absssi phase 3 is in DeGrado's BIO. Cheap shots at the Dr is uncalled for.
William "Bill" DeGrado scientific co-founder of Pliant therapeutics. Nice to see.
https://pliantrx.com/team/bill-degrado-ph-d/
Nice buys.