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Beartrap,
IMO, the way they handled the two things is to make sure the results authentic and rule out the doubt about any potential conflict of interest.
Take a look what happened around the same time the combo trial was started. NIH gave funding to AMRI which had two of its employees listed as inventors of the new poly-iclc patent, to CRL which used to manufacture DCVax-L for the p3 trial, to Rutgers State University for genetic analysis, and to The Emmes company for statistical analysis and clinical trial management. Are these funding related to the combo trial? There is a possibility, isn't it? There is no coincidence in biotech.
newman,
So sorry to hear about your friend's son. It must be devastating for the family. I hope he will recover soon.
I read something about DC vaccine in anti-fungal field.That's why I mentioned about the potential value of DCVax-L in fighting fungus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401965/
I was once pondering about the possibility that LP would use DCVax-L to fight AIDS. Never in a million years would it occur to me that LP already did some trials by RevImmune using CYT107. My impression is that LP is going to build an empire and make NWBO "the next Amgen".
BTW, software design on numerical analysis is my job. I am a completely lay person on medicine and I feel fortunate that NWBO longs haven't laughed at me.
Eagle8,
I really appreciate your insightful posts.
Great moment is coming. I can almost hear the drumbeat.
Great post, KIPK
Has the human immune system been evolving over millions of years? Who knows our immune system better than the commander of human immune system, the dendritic cells?
I strongly suggest every NWBO longs should download the data Dr.Liau uploaded. There are over thirty thousand genes. All those overexpressed ones have significant changes after the administration of DCVax-L plus poly-iclc.
Now I think I know why all the BPs are hiring people with expertise on computational biology like crazy.
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE237562
As for BO, I really don't think there will be one. The reason is simple. Merck cannot afford it. We can use Prometheus as an illustration. Merck paid half of the market cap of two rare diseases. The market cap for solid tumors could be $300b. Can Merck pay $150b? I haven't included infectious diseases, autoimmune diseases, antifungal field and I haven't included the possibilities on all the mammals. Oh, I haven't included the value of newly found peptides from the DCVax-L platform which can be used for neo-peptide vaccine.
There must be a reason that UCLA is ambitious to build a bio Silicon Valley!
https://s21.q4cdn.com/488056881/files/doc_presentations/2023/04/Splash-Investor-Event-Slides-FINAL-1.pdf
beartrap,
No need to spend time on this. All in all NWBO has the sole ownership of most patents related to DCVax-L. The current combo trial is using the technology licensed from NWBO.
There is something we should be curious about.
See this analysis on the tissue samples from the p3 trial which was done by NCI scientists and Dr. Liau with no NWBO employees involved. Ask yourself why Dr.Bosch was not among the coauthors.
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE249282
Then take a look at the combo trial. The same question: why NWBO is not among the collaborators?
https://clinicaltrials.gov/study/NCT04201873
Both have NCI involved, both are related to DCVax-L and yet NWBO didn't show up in both.
https://clinicaltrials.gov/study/NCT02834013
beartrap,
No need to spend time on this. All in all NWBO has the sole ownership of most patents related to DCVax-L. The current combo trial is using the technology licensed from NWBO.
See this analysis on the tissue samples from the p3 trial which was done by NCI scientists and Dr. Liau with no NWBO employees involved. Ask yourself why Dr.Bosch was not among the coauthors.
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE249282
Then take a look at the combo trial. The same question: why NWBO is not among the collaborators?
https://clinicaltrials.gov/study/NCT04201873
Both have NCI involved, both are related to DCVax-L and yet NWBO didn't show up in both. Why is that?
Note that NCI knows very well about DCVax-L since it has been funding Dr.Liau over the past many years. Here is a clinical trial initiated in January 2017 and run by NCI. It has 94 types of rare cancers. Guess what? GBM was not included.
https://clinicaltrials.gov/study/NCT02834013
They all are going to buy you beer when sp goes to the moon which can happen soon.
I forgot you could be the one that made up this BS.
Are you still bragging about your 20 years of pharmaceutical experience?
You cannot get your BS straight. There is only one unique know-how on this planet that dendritic cell can be well trained and educated so that they can recognize cancer cells and attack them. NWBO is the sole ownership of this know-how. The different names are just different symbols for the same thing.
Your record of the past many years clearly indicates that you like trivializing everything about NWBO. If developing DC vaccine were so easy, Lisa Butterfield would have been successful in her attempt to develop DC vaccine. The same would happen to Nina Bhardwaj and I. Melero.
Horse,
They can exhaust all their BS. That's why they have to grab this specific BS as their last resort. I consider they really feel the pain now.
Are you still telling the story that ATL-DC is not DCVax-L?
Who invented this BS? You or Fraudstein?
If ATL-DC were not DCVax-L, ATL-DC alone would have gone through safety and dose escalation trial first before it can be combined with another drug which must have gone through the similar trial too. You knew this simple fact when you first spread this BS, didn't you?
You have no credibility at all. No NWBO longs would believe what you said.
BTW, enlighten me what the original thought looks like. You must have picked up something origibal from one of the most prestigious colleges in the country. Be altruistic and share with us just for once.
I am certain now you can never be a big donor to your college then.
Have you bought your 50k shares back? Load 1m if you can. Then you can be a big donor to the college you graduated from.
Everyone knows what is your goal. Use your BS to knock down the sp even further so that you can play your little game.
You call those people voting Yes are blind. I think you are dumb. If you think all the cure stuff about DCVax-L is nonsense, how could you not be dumb?
Made the call and voted 'For' for all items.
Thanks again.
Oh, bro, huge compliments which I really don't think I deserve. Many thanks, though. I feel grateful toward all the NWBO longs. It is their faith, patience, and support that NWBO can survive and is about to thrive. Those NWBO longs are the real heroes!
One thing for sure, all of us longs will be rewarded enormously.
Really appreciate it.
Does anyone know how to vote on computershare?
Thanks
Great post!
Thanks, Chiugray
Marty,
When did you build up the position? Your average is 48c. Why are you still whining? You may seriously consider loading more.
Can you point me the website?
Thanks
Thanks for the reply.
I found it was really interesting. All the targets in the collaboration trials between Merck and Moderna fall into the category of 'hot tumor'. I suspect they don't have confidence in giving 'cold tumor' a shot.
But Merck is one of the collaborators in a clinical trial on the toughest target which is using the technology licensed by NWBO. Sorry Moderna. Sooner or later, Merck will cut you loose just what happened to Seagen after spending $1.6b.
clinicaltrials.gov/study/NCT03897881
https://classic.clinicaltrials.gov/ct2/show/NCT05933577
https://clinicaltrials.gov/study/NCT06077760
https://classic.clinicaltrials.gov/ct2/show/NCT06295809
https://clinicaltrials.gov/study/NCT06305767
https://clinicaltrials.gov/study/NCT06307431
Both Keytruda and Opdivo hit patent cliffs in 2028. Time is running out for Merck and BMS.
https://www.proclinical.com/blogs/2024-2/top-10-drugs-with-patents-due-to-expire-in-the-next-5-years
I think you know how NWBO is related to what BPs are doing now. This is one of the reasons you are full of desperation.
Ever since NWBO submitted the filing package, your agitation level has been on the rise dramatically. How deeply are you trapped?
Like I used to suggest your buddy IC: Bail now or go broke later.
Slides from Merck & Co., Inc. (MRK) Investor Event last night
https://s21.q4cdn.com/488056881/files/doc_events/2024/Jun/03/asco-investor-event-slides-final.pdf
https://seekingalpha.com/article/4697398-merck-and-co-inc-mrk-investor-event-asco-2024-transcript
Are you dumb?
The last patient was enrolled in June 2021. Did you even read the outcome measures? Have these type of measures ever been chosen by any other trials? Such disruptive measures must be approved by NCI, FDA, UCLA and Merck. You cannot see this. Such a pathetic loser!
Went through all the ASCO abstracts from Merck. I cannot see anywhere something that can be called "Novel Oncology Treatment".
It will interesting to see what Merck is going to say tomorrow.
NCI might be involved too.
People who are using stopwatch to measure the approval time may ask the questions like:
1. Will MHRA notify the company that submits the drug application for approval before listing the announcement on their webpage?
2. How many weeks will MHRA give the company that submits the application before making the announcement?
3. Is it possible that NWBO has been notified the news and the company is waiting for the right moment to announce the news?
IMO, these questions are full of fun.
Doc logic,
Did you notice that Dr. Vivek Subbiah was active on linkedin and X in terms of posing new papers, FDA new guidance, latest scientific development on immunotherapy?
NWBO was listed in his disclosure on conflict of interest in nearly every paper he published since the Direct trial. But he didn't like the publication of the JAMA paper at linkedin when Dr. Bosch posted it. He didn't post the publication of the new Nature article either. In fact, I haven't seen he mentioned any publication on dendritic cell stuff. No doubt he publicly keeps distance from NWBO on purpose.
Don't forget to make yourself look like you are really living in UK unless you are suffering insomnia.
Congrats, I am so happy for you.
EX,
Did you put comments on the Nature article using my ihub account username?
That's hilarious! Thanks Zadie420.
Dude is a Zombie then. I haven't had time to rebut his long BS post yet.