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This is the ultimate reality. We all have an appointed time to go. Hope to prepare well to meet the Maker as well as one can. In our day to day life, we put this reality on the back burner and go haywire in our pursuit of happiness.
Thanks Dr Bala. I do think that he needs to gather more information. All the things we have signals on point to positive results. However due to nwbo image I think some people have just completely dropped it off their radar. I can understand his view especially if nwbo is going to take forever to release the data. I hope you all make money and retire but just hope if there’s something which works it should get to patients sooner. Prayers!!
I hope so that tld is released soon and puts this to rest for the sake of patients...
Thanks Gary for not doubting what I was saying and a measured response. I am talking about top tier institution which happens to be very well established for gbm. But his outright dismissal of dcvax perplexed me. Nwbo have destroyed their image and understandably folks are wary of this. However his assertions that neurooncology won’t accept this trial without concurrent control, this product doesn’t work etc. after pressing hard, he did agree that he needs to look at the data from these folks. He happens to know his colleagues at UCLA and hence I was shocked even more with this assertions.
I wish I was bs ing my friend. I am going through this disease with my loved one and hence became involved in this discussion. So yes I want this thing to succeed and do wonders. Hence my positive tone in previous messages. But in my discussion with “friend” I was very disheartened to hear his outlook.
Not sure how much you guys will concur with this. But I spoke to one of the top oncologist and his view was that this doesn’t work. This is crap.
After asking and highlighting some of the points usually made here, his biggest reservation was that if you have a product that works you don’t hide. He said I haven’t heard a thing in my community. He is one of the guys closely involved in asco.
He was very certain no way this is getting past fda. He was like if this works run a proper trial. He promised to look at the latest data and what not. But man this thing is written off in the community.
Looking at the detailed table of content, I doubt we will get anything substantial from the book. I say that based on how densely packed the book is. I am a little bummed out but hope I am wrong.
Absolutely and thank you for setting a great example for rest of us. However more of us need to step up. I say that based on how much inequality and injustice exists out there. I definitely advocate fairness - a flat tax rate. Just suggesting that lack of trust in institution should not be lack of action.
Yeah it’s v sad that humanity has come to a place where we have to force each other to share what we will not remotely end up using for generations. Unfortunately can’t even say it’s lack of god consciousness because we largely appear and suggest to be god fearing and loving. In such case and regardless it’s high time people really ponder over the existence and creation and search for true meaning of our being. Peace.
Lots of assumptions. Trying to understand how likely or unlikely it is. While all signs are encouraging, there’s still possibility that they end up talking about keytruda. I guess we will have to wait and watch.
Could you share more details? Appreciate it. Thx.
Hey folks - sorry if this is already answered but could it be that cns trial update just after ASM is about keytruda trial and not nwbo?
Trying to get more details on it but no avail. Would appreciate any response.
This is exactly the outlook longs should have. Hold because you want this company to succeed for glio needs a cure. I want to believe in this company. Not holding since long like others but hey go big or go home.
You can’t wake up someone who is pretending to sleep. May the TLD come out super strong...
Totally understand. Thanks for transcribing (:
Yeah makes sense. Let’s see how it unfolds. Thx for responding.
I was trying to suggest some would hope for good tld for $, some for cure, some for proving a point etc.. I’m cool with anything as long as it’s favorable. Peace!
Forgot to say thank you. This is so helpful. Not sure how you got this but would appreciate if you could share the recording.
Yes unfortunately I know that. What I am referring to is much more than just SOC, everyday they don’t explore more along dcvax they are doing something else with side effects.
As an analyst, this is what I would have imagined her saying. This is what throwing away the baby with bath water really means (although I would like to believe it’s more than just reference to single arm studies and she also has positive tld)
Fwiw I agree with the reasoning and not being a purist for sake of it. I can afford to be purist when I am ab testing idiots to get more likes or sell more toilet papers, not when it’s a matter of life and death.
Please pray she has good tld whatever your motivations maybe.
Fwiw I believe no matter what the plan is or was and when&where things appear, if there’s an effective drug it will propel forward. Fda, clinicians, patients would take anything over ugly side effect bearing treatment.
Btw do you know if it is a hard requirement for them to go and update clinicaltrial website?
I have been reading short reasons and comments. Not sure if they are genuine anymore. If you are unsure, I’d say wait and then come back to check the ground truth. Unless of course you got time to kill then continue.
And let’s stop with study design nonsense. I don’t think “investors” here know anything especially when I see people repeating the same thing after reasonably explaining it over and over. I want to say y’all are smarter but being intentionally obtuse. But for the last time, based on indications, most likely it would be a partial + external synthetic control.
Happy to know that fda already opined on synthetic control how tos. Now just need the data to come out. But yeah I feel strongly about this. I don’t think any fda or medical overlords can dismiss this on technical grounds if there’s a substantial benefit demonstrated. Keep in mind there was no mgmt or idh factors even known when this trial started. So if anything this is going to open us new pathways for those subgroups.
And yes degenerates I would put my money in. If I don’t see it, I’m ok knowing it went towards a noble fight.
Nobody is proclaiming anything on this board so shorts keep your shorts on.
Haha I hope so too. I want this trial to succeed and spark next wave of innovation. Ia
Until then, if you see or hear anything, keep on sharing.
@ex - i agree and understand what was the original goal and what not. Let’s focus on current state after many years into this study - cross over resulted in 90% as opposed to only 66% subjects getting the vaccine per randomization of 2:1.
Now somebody comes and tells me, this study sample is doing really well compared to baseline. I say ok since majority of subjects got the intervention (remaining 10% could be driving it higher - possible but unlikely)
I stop and say well tell me more about representativeness of this sample (did you just happen to enroll young people, males, mgmt yada yada) once I ensure that that’s not the case, I am golden and I stop. If somehow, that’s not enough I look at the qualitative data ie compassionate use cases (although I would like to know more and entirety of all such cases)
If this vaccine didn’t do anything, I would not see better than baseline numbers for sample (blinded) So if I then go on to separate 10% of control and compare *well*, where do you think it would go up or down? I want to remind myself that they had 2 interim read outs of this study sample.
Lastly, to the point why ain’t people buying this stock. There’s no end to human/market folly. You yourself need convincing and hard facts of trial data which is great thing as “investor” and just may be everyone is waiting for that. As for others who jumped in, they may be doing it for various reasons ranging from being true believers to humanitarians to degenerates... you take a pick.
I want to understand something - why the f*** is this shorted? I mean it’s a penny stock with no options. Please educate me. I really want to know why whoever the shorts are.
To be clear I am not in biostatistics but I do ab testing and data analysis. I do think it’s important to wait for the data and all the conjectures so far are favorably disposed. However, there’s always a chance that 10% of those pure control humans may be driving up the average. Can it happen - yes but unlikely that all 10% group is outliers only.
My motivation is for this study to succeed. We need better answers for fellow humans and loved ones. Don’t forget we are all in the queue to die and when it’s our turn it’s the impact of our actions - big or small - that would matter. Nothing against $ but I do think it’s incredibly arrogant to root against such efforts.
So yeah shorts hope you make money but just not here and I hope should you get tested with some disease that there’s hope for you and no shorts try to kill it.
Thanks for this Lykiri. This is what I was referring to in my reply to ex.
@ex - study will clearly lay out result with and without this comparison. And once the data is available, feel free to torture it the way you want. And yes theoretically I expect them to put up comparison of just true/pure treatment group with ECA discarding cross over altogether. But they may not have enough sample for statistically significant read ( or may be they do since effect size seems to be really off the charts. Amen!!!!)
Hey my friend, I think you are right only if they were doing that. Remember that after cross over 90% of study got the vaccine. And if the vaccine was not working then cross over would harm the study and not benefit it.
Also please keep in mind that synthetic control would be partial control + propensity matched additions. So, no they won’t present something like cross over vs non cross over. Let’s give them more credit than that ( presentation laid that out anyway)
Ps - this is what I do for living and it’s very commonplace to think and account about what you said even for beginners.
I think you’d have to shift and measure the metric since randomization since that’s when the experiment began if you involve Tx arm. But i do believe regardless curve should look better after the synthetic control is created ie taking out those 30ish data points which could be meaningfully driving the average down.
Positive TLD is the only thing world needs right now. If nwbo is sitting on it, they should do everything to get out there w/o worrying about $ (which will follow) Dont think once scientific opinion is formed, BP will be able to stop it especially with Biden at the top. Sooner they get it out there, better it would be for patients. I hope nwbo and all realize that every day lost is a human life that could be benefiting from it. Don’t forget fda, insurance etc would take its time for patients to actually start receiving this in clinic.
I want nothing less than best for nwbo including $ but this delay...
Yeah I would be interested in knowing this. Was there any hint that “I have solved this, I can save lives” and she looked a bit more calmer.
Ps - thank you dr bala for slides and service.
I hope there’s good tld but doubt any leak would happen. Just matter of controlling speculation and reading too much into things.
Thank you dr bala!
Btw I have been researching and reading all things NWBO. All of you who realize this is much bigger than just $, keep the faith. DCVax is hope and hope springs eternal. Amen!
Hey y’all - any word from LL’s talk today?
PS - praying for efficacious TLD!