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A post of mine from 2015. Notice the parallel to Journal of Nature article.
What about halting pathogenic cell division, in a natural way?
Bavi 2.0 + Statin = Spindle Checkpoint..
The genesis of checkpoints.. Take away the keys (pathways) Trigger the "something is wrong" checkpoint. Stop uncontrolled cell pathogenesis.
Common cold? Yes
Neoplasm? Yes
I'm still working on these scenarios and how.
All the best,
John
Now they're only a diagnostic company? What happened to "upstream" and the flavor of the day??
Before you had the list of cancers for bavi therapy. Now it's for diagnostic?
Btw,
What are the mechanics of this new exosome kit?
How will this work with elephants??
TIA,
John
Statin Theory
OHPSLSAE Theory.
Oxidative Hydrolyzed PS Lysis Species Associated Exosomes...
Ah yes shall we revisit my theory?
And AntiPS as we know it might be the next shelved Peregrine product? Just too many elephants?
The good news is that there closing in on my OHPSLSAE Theory..
All the best,
John
Dr. Wolchok seems to know candidates with less/no cross reactivity and elephants.
It's never real news about Bavituximab, IMO.
Common theme.
All the best and Happy Holidays!
John
"As the only PI3K-gamma inhibitor in clinical development, IPI-549 offers a unique approach to enhancing the anti-tumor immune response. Our preclinical findings suggest that IPI-549 remodels the immune-suppressive tumor microenvironment, primarily through its effects on myeloid cells, leading to enhanced anti-tumor T cell activity and cytokine production, all of which play critical roles in immune response," stated Jedd Wolchok, M.D., Ph.D., Chief of the Melanoma and Immunotherapeutics Service at Memorial Sloan Kettering Cancer Center (MSK), as well as Associate Director of the Ludwig Center for Cancer Immunotherapy and Director of the Parker Institute for Cancer Immunotherapy, both at MSK. Dr. Wolchok is also a scientific collaborator on the IPI-549 program and lead investigator for the Phase 1 clinical study. "Data also demonstrate that the effects of IPI-549 on the tumor microenvironment reverse resistance to checkpoint inhibition in multiple preclinical models, providing further rationale for evaluating this combination therapy in patients."
http://www.prnewswire.com/news-releases/infinity-presents-initial-clinical-and-new-preclinical-data-on-ipi-549-at-second-cri-cimt-eati-aacr-international-cancer-immunotherapy-conference-300333940.html
All the best,
John
PI3K-gamma inhibitor IPI-549
An orally bioavailable, highly selective small molecule inhibitor of the gamma isoform of phosphoinositide-3 kinase (PI3K-gamma) with potential immunomodulating and antineoplastic activities. Upon administration, IPI-549 prevents the activation of the PI3K-gamma-mediated signaling pathways, which may lead to a reduction in cellular proliferation in PI3K-gamma-expressing tumor cells. In addition, this agent is able to modulate anti-tumor immune responses and inhibit tumor-mediated immunosuppression. Unlike other isoforms of PI3K, the gamma isoform is overexpressed in certain tumor cell types and immune cells; its expression increases tumor cell proliferation and survival. By selectively targeting the gamma isoform, PI3K signaling in normal, non-neoplastic cells is minimally or not affected, which results in a reduced side effect profile.
https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=778361
https://clinicaltrials.gov/show/NCT02637531
Infinity Pharma.. Not Peregrine
All the best,
John
Complement activation.
This tells me that they've identified an inactive immune component protein, which becomes activated when Bavituximab is administered.
Why did we get Vienna Sausage in Vienna and not a poster?
No accountability with Peregrine. Happy Holiday's!
All the best,
John
That's because they've data mined, and confirmed a 2 ton elephant.
Hey, but let's keep moving forward with the same product and maybe the 2 ton elephant will magically disappear. NOT
Vienna Sausage.
All the best,
John
PRAN has failed, but they've scientifically contributed to the subject, as the metals theory was reasonable..
We will know in good time what ABeta's etiology is to AD..
Mercks BACE1 inhibitor Verubecestat has promising potential in reducing AB. However, will there be cognitive benefit?
I'm not thinking so, but hopeful.
All the best,
John
Correction noted. See PRAN's release.. Although, as shown below, they did have a significant reduction of "unaggregated soluable amyloid peptides" in previous studies. This is the information that I was alluding too.
What proof is there that brain amyloidosis correlates to AD anyway? Many inconsistencies in that theory.
All the best,
John
I agree. But a Momo play is what we've become, and where we will be, until the 2tonelephant is set free, IMO.
All the best,
John
I appreciate your efforts.. Coming from you I know it is real and not some bogus BS..
All the best,
John
Thanks for your efforts Wookie.
Truth.
Adjuvant.
In conjuntion to: Bavituximab & Statins
Biomarker: A provable antigen immune response as a result of.
Coming soon: Immunoantiphosphastatin (I'll have this provable and completed before next year)
You're welcome.
All the best,
John
And what's the point of speculating phase II anyway??
Sunrise was not sabotaged. It was stopped for futility, and even though the control arm exceeded history, Bavituximab performed below that and placebo.
Bavituximab wasn't making "healthier sick patients" healthier than placebo and control. It failed, no matter how you slice it.
They need to address the admitted 2tonelephant, as the data mining from Sunrise proved.. 70% of therapeutic lost at sea.
The focus should be on solving the riddle:
"the curve of diminishing returns", as related to b2gp1 and availability.
"Lets say you have to much antiPs bavi injected, and as a result less available b2gp1, or more usesless bavi with only one arm grabbing b2gp1, instead of two as required to bind to PS".
Or move on and stop wasting time with big clumsy product.
All the best,
John
This is real. and better than data mining's past.
I like this..
All the best,
John
Sulaco, RE: "CP, here's a post of mine from 5/14/2013"
Below is a post of mine from 1/5/13.. I didn't go back any further, but I believe MrsKatie and I had this discussion back in 2004/05.. Some of which were erased because of TOS violation.. Which btw is crazy..