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If they learn from globe and correct possible mistakes in ovarian it may have been worth the failure. I hope the failure was due to human mistake and not vb111 being weak drug
Top line is q3 although in some places in website it says q2
Davidal wss right. The refusal of spa ovarian plus other things....I will email the company about my opinion of failure which is changes from ph2 where vb111 was given first as monotherapy and the fact they treated the fever. I m not selling and will wait to see ovarian results
Very sad to see I made a huge mistake. Waiting 2 years to see ovarian
I own eyeg. They have ph3 that takes forever probably because hard to find participant. It's a gamble there but I still believe it will be successful . I m not running will update if Steven Siegel was right
Vb-111 will meet easily all endpoints. Avastin is not an anti cancer drug. I won't even give it to cows .I think the reason fda approved it is because it helps with some side effects . Avastin is a drug for eyes issue it's a fake cancer drug fake news
If vb-111 doesn't pass easily all endpoints major and minor then I need to learn again everything. From what I learn vb111 is an example of a very strong coley toxin. In order for something to be strong coley toxin 2 things should occur:
1. The coley toxin should be injected into tumor and not submuscular systemically or submuscular
2. The fever induced or cytokine storm cause a peak in as many as possible interleukins that destroy cancer cells. Every different coley toxin or every dead bacteria virus or DNA cause different effect. Dr coley knew for example that Tracy Mix was his strongest one.
VB-111 has the 2 above. It express itself only in tumor area this is why it equal to injected to tumor coley fluid and we know it's a strong coley (2nd condition) because single fever response of 1 administration only caused complete remission or some non durable CR other words the cytokine storm of vb111 consist of many anti tumor factor and it's not just fever.
Unfortunately VB111 should be part of an arsenal to cure cancer completely . You can take now all cancer free patients . I mean patients we wish to avoid recurrence and induce over 50 times fever in them. These people the cancer will never come back, zero recurrences. As far as I understand there is no hidden cancer that can fight with over 50 times fever event when cancer is in a latent mode. Coley toxin can easily cure every cancer if used properly and so far I never heard of using it as it should be . Coley was limited due to the time he worked and nowadays nobody do it except of some places that do it wrong and want your money. If you use an arsenal of coley toxin that vb111 is part of it ..toca is part of it. Tocagen is also coley toxin that should be part of the arsenal. That's the only way to cure cancer . It's on the table this simple cancer cure
You are wrong. The fda gives them the run around. It's obvious. The fda are the cancer best friends. If you check the guidance the history of meeting from Hart to biostage under different management. The fact wiggle from mayo clinic didn't publish biostage work on animals in mayo peer magazine...The fda piss on them . It has nothing to do with the management
Dror harats made the fda accept all the tricks. They try to help they like vbl. Expect a huge jump in company valuation.
Yes . Past failure is the trigger and motive here. Also past down trend before results is a motive. I believe vb111 will meet primary endpoint easily but I m in the minority 99% of people I spoke to think I m a dreamer
VB-111 will succeed to pass all primary and secondary endpoints. The market assume VB-111 will fail but the market assumption is only by using statistic based on past results. People here are surprised how come doctors are not investing....I gave in past many examples of wrong doing in this field of immunotherapy and lack of scientific world understanding. Doctors know that many immunotherapy drugs failed in rgbm and they also assume vb111 will fail like Optivo failed and so on. Even if they hear from their friends doctor that vb111 is a great success they will still think it's going to fail. When we as humans brain washed we don't know we are . Here is a case that fear together with brain washed plus the fact the company has zero attention and some other factors cause this predicting of failure in stock price. The market predicted 3 ph2 failures as well otherwise the spikes were not so prominent when it passed.
Very interesting
I was shocked to read htbx presentation where they use ox40 intradermally instead of injection to tumor. They will continue to fail even 1000 trials if they do that. Just another example of the lack of scientific community understanding of immunotherapy
The cure of cancer exist but it's not possible to do it because of regulation and FDA. I will write u here the recipe to cure cancer but it doesn't matter. You won't have doctor that will do it and you don't have patients willing to do it because they are brain washed. When patients agree to this treatment which is not available anywhere it will be only when they are already stage 4 so of course can't cure the cancer now. But I write u the recipe. All you have to do is surgery if possible and injection to tumor itself if possible or around it or submuscular or subcutaneous agents like dead bacteria modified viruses...And many more known agents that create fever. When you created fever don't treat it with fever reliever. If fever was not created raise the dose. If raise dose didn't help change the agent you inject. You need an arsenal of dozens of agent. This treatment will cure cancer if u do it after surgery or early cancers or to people who had cancer when they are clean to avoid recurrence. Try to reach 100 times fever. But 50 also should be enough. What I wrote you was never tried and will never be tried in our life time due to cancer best friend - fda doctors and countries regulations.
Yes . I think if you look at mbvax patent you will find they add in their coley toxin mixture similar DNA type adjuvant. Mbvax doesn't exist anymore - they went out of business. This is another scam. They had investors at the beginning but later on lost investor faith probably because investors figured coley toxin can't actually be patented because anybody else can come with similar thing but just a bit different (different dead bacteria...). The clinical results of around 89 patients they treated using their fluid were impressive considering the fact all of the patients were under compassionate care program in Canada. If u go to wayback archive machine website and click mbvax.com you can find their website and find there the chart with their results. They had many durable complete responders even a stage 4 lung cancer with metastases to liver and kidney who entered complete remission after 1 year treatment .
I just hope 1 day this company will get some respect. The CEO said many times that current valuation won't allow many things he would love to do like other collaborations
Spoke typo. I personally think they want to mark a V in earning call about lung cancer trial and it will happen only in February
In seeking alpha somebody spike to IR today and was told earning will be in March any thoughts why ? Expected was Feb
They used the word vaccine . Vaccine is dead bacteria or variation of virus or bacteria...
It's the same motive . It's a kind of coley toxin. Many agents injected to tumor can raise fever but some work better than the other. Coley for example found that Tracy mix was the best. Vb-111 is also a strong coley toxin because one fever event changed the plan of the tumor and affected future progression . There are better agents than the other because each agent affect different interleukin. They are proud about their success and mechanism. I tend to ignore their mechanism and enthusiasm from simple reason - I believe all the activity is being done by the immune system but it's cool for them and more flattering to think they found an agent that can do this or that wonderfully in tumor area and far from tumor... It's just systemic fever that killed also metastases but they will Give u the impression as if they found a sophisticated way to cure cancer. Again I wish these clowns were funny . It's possible to cure cancer . It's on the table but it won't happen due to human stupidity. Albert Einstein used to say there are 2 things that are infinite - the universe and human stupidity
To scare people to sell. The stock market is a scam . Same as they take bitcoin down now just to take it up later on. Stock market is managed by crooks . First step is to know who u are dealing with.
The time it will start to run is February earning conference call if he still announce results coming this quarter. Nvax pending ph2 and anth pending ph3 and it already started to run. Maybe here rgbm is not something they jump to buy due to past 82 out of 82 trial failures
It's a pump toward conference . May exceed 3 and expect a crash after. Usually it's what happening. I would wait and buy under 1.7 and not during pump
U have to decide market cap by 20. The one u see is wrong. There was 1:20 split and it's not updated yes to the market cap
I read this speculation in another forum but I wish to hear opinion. Last date to apply an abstract to this year ASCO is 13 Feb. Dror said he will want to show final data in an important meeting . Conclusion - there is a chance results published before 13 Feb.
The lung cancer trial is expected to be together with nano ? Correct ? Any chance nano pay for the trial and it considered milestone payment to vbl as part of the 100 mil deal ?
Last chance to join the train before it goes above 10. The start of lung trial end of month plus mid February conference call earning and coming phase 3 results won't let it be below 10. To all the skeptical I say give it a chance . Vbl is a good company. They have a great drug they know how to exploit around 5% of the drug potential but it's enough in the poor world we are at that we gave doctors to deal with cancer. Cancer fighting global war should be taken from them and be given to the public . The phase 3 results will be impressive. Dr dror read in his life thousands of trial and knows all the tricks. He is the head of Helsinki committee in israel and read many many trials. The adjustment he agreed with the fda to consider tumor size and severity in final calculation will make the result look great. Doctors failed big time with cancer but vbl stock will win big time
This 2 people get options correct ? Why do we need them . There is a drug that works and the rest of people we don't need. Why do we have to share success with these people ? Are they going to make vbl use the drug correctly ? No. All the directors should be fired and return options back. Vb111 does the work al9ne these people are there to milk money they don't think even 1 minute a day how to use vb111 or about killing the cancer
As a result of fda limitations and the fact all bio companies are designed to play the politic of fda we will see here and there lucky complete responders but not more than that. The durable ones we will also see but only minority of patients will benefit durable. There is no fight against cancer the fight is to extend overall survival the fight is no death during trial from side effect and the fight is to gain money . Killing cancer is not even in the list
Small example vbl in year 2000 invent vb111 CEO I m quoting "if I saw the cancer gone I would think something must be wrong" they invent another human idea which is called antiangiogenesis which is useless against cancer like all human substances because human can't win cancer so they say we try to make the cancer chronic disease by the way in most cases they failed even in that. Then by mistake they see something new they see in 2004 that the immune system create granoloma in cancer area and they see durable complete responders from first vb111 injections. You would expect that they change their mind and move to talk about cure - change the conception well we are at 2018 which is 14 years and their brain 14 years after it happened still think the old conception this is how they the fda doctors and scientist are losers and stupid. Scientists are losers before they been scientists u can't blame them winners goes to do other things
Don't worry as long as fda exist and as long as the current scientists lead there won't be complete responders especially not durable ones. Even vbl complete responders are by mistake they didn't plan to cure cancer. They planned and they said that 1000 times to make cancer chronic. Not only they are losers because they don't try even to win the cancers they also tell the data and immune system to change from destroying the cancer to make it chronic. They want the immune system to match their thoughts and they won't change their mind instead. The fda is the leader to make sure they limit the fight and the doctors and scientist are big losers
They start oval soon. The previous link I published shows data from 2004 to 2010. Patients who were not treated by paracetamol lived 16 months while patients who were treated lived 8 . Not treating the patient with paracetamol will make u rich because the market won't compare their result to chemo but to avastin. Although the trial is vs chemo the market will judge the results comparing to avastin and therefore I ask everybody to send an email to company and ask them not to treat the patients with fever reliever right now TOCA use it vblt use it they are all stupid and need to wake them up so we won't kill the patients kill vb111 and kill the trial.
https://www.ncbi.nlm.nih.gov/m/pubmed/25445814/
https://www.ncbi.nlm.nih.gov/m/pubmed/25445814/
If u treat the fever u cause early death.
I m not invested in toca but here is a question to ask toca. Are the 5 cr had fever as a side effect ? I personally believe all the hype and doctors proud of their achievement is silly it's only the fever that cause the cr or extended os I may be wrong
Ok so I see there is fever 2 out of 17 had fever in initial phase 1. Surprisingly the cr in the later update is 5 out of 58 not far from the fever rate. When I see fever I always suspect the fever caused the therapeutic factor and not their proposed mechanism that of course like all doctor books teachers forget to say the word proposed. It can be just viral fever attack like coley toxin specific to brain like vb111
Hello gr8. Did u find fever as a side effect in their treatment?
I think a girl named Claudia Castillo and a boy named Ciaran Finn Lynch are alive until today with a regenerated trachea made by biostage or similar tech as biostage . It's very interesting these 2 are alive with the implant . It was a partial success but again trachea was a challenge and was never tried in large animals . Look what happen now they neglected bronchus because probably large animals mean the pigs it didn't work well. I believe trachea wouldn't work well in pigs as well but the esophagus works. Anyway even the trachea was a partial success
The trachea implant worked partially. There was a regeneration but the new tissue lacked the ciliary cells . The absence of these cells caused the implant to fail overtime . In addition to that there was a doctor involved that many alleged was dishonest and he mislead probably all involved about the actual results.
Great news - the 75 years old patient is alive. A trusted person from stocktwit spoke to CFO
Bstg liquidation began few days ago according to stocktwit. Any comment ?
http://auctions.biosurplus.com/m/view-auctions/catalog/id/184