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To clarify on the the tumor resection aspect. In your realm when as stated
Eight Is Enough?* One of the many benefits of mRNA technology is it enables pivoting (adapting) vaccines to new variants quicker. Phase 1 is primarily testing for safety. Assuming phase 1 is successful expect some pivoting going forward. Said pivoting likely resulting in different mixes of epitopes and/or additional epitopes to attempt to achieve a level of efficacy (see Horseb4CarT post 606041). Any level of efficacy likely resulting in a suite of different vaccines.
*apologies for borrowing from title of late 70’s sitcom/drama (in this instance I’d bet the under of the current mix of eight being enough. While noting a successful phase 1 for. safety is attainable and will likely get some media attention….as the cool new stuff tends garner media attention.)
The “egg” (shaped) shipping container for the vaccine which they developed years ago uses liquid nitrogen.
I see Matt Williams is presenting on “brain tumor data accelerator project”. Hope accelerated data encompasses meaningful long-term survival data….
Thanks, an earlier post of yours corrected a misconception I had. Originally thought they were using dry ice in the shipping containers. Where in fact they are using liquid nitrogen.
Rhetorical question: What are the odds of it being a late night in Vegas?
Noted Mr. Sarola has a UNC poli sci undergraduate degree and a business and public policy certificate from Wharton while getting his JD at University of Pennsylvania. I’m thinking the poli sci background serves him well in his current profession pursuing justice…… perhaps the poli sci background is a bit of irony for the board. Could be some potential fans of irony here if administered in the appropriate dosages.
Along that vein could be interesting if participants in the cohort who were excluded from the trial and received DCVax-L If some in the cohort also received Poly-ICLC or other adjuvant(s).
Instigated by the “wary eye” perhaps? If so, petty.
Bottom line it doesn’t bode well for the niche purveyor of the NovoCure device in the UK whom is keeping a wary eye on emerging therapies…..but might explain the “wary eye”
Playing off your analogy. With commercialization challenges remain to take science (rocket/biologics) to the next level as SpaceX has just demonstrated. To be clear there were positives in today’s launch and yet some tweaking remains.
The dude is all about integrity trial or otherwise….
Per your DD (post 558547) below is the list of institutions involved in the pre-clinical study. Note there was a lot of work in and around Boston and at Children’s Hospital.
PM might agree to that being a good tactical position . And I feel certainly would agree to it being a good financial one…
I’m considering removing mine, so as not to appear as a conformist…
Competent response addressing Dr. Williams concerns. As a bonus, and I’m sure Dr. Williams noted, affiliations and conflicts of interest were openly disclosed*.
*Interesting Bosch’s pending patent is disclosed as a conflict…..
Does not the “A” in AF stand for Adonis*?
*at minimum in the Night King of the 16oz Photo-op Curl’s mind
Thanks. No doubt there is likely an abundance of overlap in doing multiple filings. Will be interesting as the fog starts to lift and we gain some clarity on the horizon.
Since they intend to file for marketing approval in multiple jurisdictions simultaneously(?), Perhaps one of the other jurisdictions requires established manufacturing capability (MIA)? And this was misconstrued (intentionally or not by LP) as MHRA requiring MIA before filing MAA.
Is it also fair to say that statement (excluding UHF*) is not made with a lot of frequency?
*Old school, analog, technology/terminology
Channel 20 resides in UHF* band……just saying.
*Ultra High Frequency
Knowing there’s a pool started on revenue estimates for 2023 it will be interesting to see how #3 MIA impacts the revenue stream going forward. Not sure the early entrants in the pool are making a MIA splash or ripple with their respective estimates(calculus).
Possible April Fools?
Wonder if any of SVB’s biotech accounts have been pimped by the notorious Night King Of The 16oz Photo-Op Curl*?
*Sporting an impressive finally tuned physique from the noted workout routine.
Typically need to keep clean rooms up and running 24/7. Whether you’re producing product or not.
Inflation or b and m are close.on keyboard? Or Siri*?
*to achieve detente with Siri is an admirable goal…..but is it attainable?
Not sure if anybody pointed out this additional connection. Evis has a seat on Cognate’s board.
Several individuals with smaller amounts spread over multiple trades… “Nothing to see here”
Nice of them to establish their AF connection with a tepid “independent observer” qualification……which virtually every poster on ihub, Reddit, etc meets.
Users don’t last long. They either get worn down or worse. Does make one wonder how much upfront payment (if any) is required? Might be a way to crunch Novocure’s financials to come up with swag on prepaid “subscriptions”*.
*noting upfront payment would be more likely where there is no insurance coverage as a confounding factor for a swag.
Since nobody else has bothered to this point, I’ll say I saw what you did there… as I’m sure others did.
How much is intent, ineptitude and intellect (intelligence gathering/learning/understanding/optimization)?…..major league tea leaf reading
Cool…Multiparametric Is to MRI what Doppler is to radar.
IMO as a parent of a couple of teenagers: No doubt social media is a factor and continues to be a factor (says poster on social media/financial site) contributing to the ills of adolescents and also adults. Many adolescents haven’t acquired and/or adequately fine tuned their BS filter. Some of the older crowd have not maintained their (now clogged) filters….
I’m aware of many people that have/had two phones(myself included). And even if Citadel was inclined to look at the phone the only phone that they could possibly look at is one that Citadel provides for exclusively for business. If they provide a stipend for mobile phone which many companies are moving towards. Then the phone is considered personal and Citadel has no purview for review on a personal device.
So yeah, if a hard look is performed, nothing untoward will be found on any cell phone.
Bio, just to clarify the submarine patent thing is old school stuff dating back to the day when the Patent clock started on the day of issuance. So what they were doing was delaying the issuance of the patent by adding subsequent claims over time.
At a high-level agree with your comments but I can tell you in practice many times when you decide to file a patent can be a game-time decision. As mentioned you have all year from introduction of a product. And the more you delay the more risk you assume of a competitor having documented prior art a year before your filing. In practice what you want to do documented internally as early as possible any potentially patentable art. If a competitor files a patent on the same intellectual art before you do and you can document prior art a year before their filing you can practice same art under the protection of the patent assigned to the competitor. Documenting art was something we became more disciplined on as it can’t be back of the napkin stuff. In that context I would argue documenting internally your art is more important than filing date.
In regards to the context* of my question I don’t think NWBO was running much risk as industry had given up on DC vaccines and they’re not toying with the Flaskworks system.
* invalidated by Ex and you
Ex, thanks. Yeah I knew the international filing would make domestic filing obvious and sensed your explanation would be the scenario (knowing the USPTO had done a lot of work to tighten things up with international offices). But, since we’ve always filed domestically first was not familiar in practice with the aspects of filing foreign first….and had to ask.
PM, i’ll try to quickly add my $0.02. I concur with a lot of dmb’s analysis and thoughts. Not that this is my area expertise but fortunately I have an ace in the hole who works in the same industry as dmb. I will add and I’ve stated this before the raw material for L is human tissue inducing the ultimate variability to start the manufacturing process which gives the industry reason pause. Also adding that Flip’s dd came up with an international Patent publication on appearance Northwest had/has been working on concurrently with the Flaskworks acquisition (probably incurring some Covid slack). With an impressive list of academic institutions I might add.
Need to provide a little context with what ultimately will be a question. I have over 20 patents but I am not a big fan of patents in general. You can take the number of patents I have and multiply that by two or three times the number of workarounds we Engineered to get around competitive patents. A larger competitor who is better resourced and was skilled in the art of “submarine” patents back in the day where you could add a clause to a patent already in the filing in process and the process would basically start over. It was something akin to Robert De Niro‘s character in the movie Casino changing job titles making his gambling license application will go back to the bottom of the pile. You could extend the prosecution of a patent for years. We had to be more nimble.
Present day the life of a patent starts at filing and you have a year to file once the product goes to market. Typically what I’ve seen parents will be filed within a few months of product on the market if not before. But, sometimes companies will string it out to the 11th month in order to extend the patent life.
We have many good posters with Patent and expertise (Roman, muee, Hmuny to name a few with possible SP errors) and since all of my parents were filled U.S. first with a fraction subsequently filed internationally here’s are the questions: Does the clock on the US application not start until the date of filing even though said application was filed first internationally? And is there a time constraint once filed internationally for same patent to be filed with U.S. patent office?
Asking for a friend if this is a way to game the system by filing internationally and getting some protection before starting the clock domestically. And not necessarily expecting the answer to come from PM.…
600 dpi resolution could take down the ATC (air traffic control) system…
Now that’s a shareable and/or shareholder (by many) image