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Funny, but my strongest reaction was to Dr. Steve saying he's not a medical doctor. Some time back I suggested that his (her?) graduate degree (if he/she even really has one) was in some sort of creative writing..
Regards
Dr Compost
Actually t-bo it was all started by a post on Yahoo by 'Dr Steve'. At that point I went looking for verification and came across the clinicaltrials.gov site.
Lord only knows this has been a roller coaster ride for the past decade +. You've probably never heard of Jerry Clower. He was a southern humorist some decades ago and one of his characters was a pulp wooder named Marcel Ledbetter. To make a long story short, in one of Marcel's adventures he ended up in a tree fighting with a wildcat. In the midst of the struggle he begged the hunters on the ground to 'shoot up here amongst us....one of us has got to get some relief'. That kind of sums up my feelings about Entemed. Either shoot us and get it over with or move on.....we need some relief from this misery.....
was that not thought out in advance ?
From the same outfit that forgot to pay their web domain fees a few months ago? I don't think there's a whole lot of in depth, forward thinkin' goin' on.
I hate it folks....but I'm bettin' that it was tox...and that'll surely delay the results...making it riskiest.
I'm sure we will know soon enough t-bo.
If toxicity were an issue at a higher dosage, how do they know the problem will go away at a lower dosage... I could see stopping or suspending the trial for reevaluation... but to simply lower the dosage and continue does not make sense...
This offers one potential positive. Imagine that the problem isn't imminently life threatening AND they're getting significant efficacy.
I, too, am inclined to believe that it is toxicity. It just isn't imminently life threatening. Any change in the protocol, in my opinion, isn't good news. If they are achieving a significant level of efficacy....then, at least the news is only bad but not awful.
Regards
It's hard for me to put a positive spin on today's news.
http://clinicaltrials.gov/archive/NCT01104675/2010_08_24/changes
Even if it's as DocA said on Yahoo, that it might be an adjustment because of the gender mix in the initial PI's.....they still don't make across the board changes like this without good cause.
Anybody?
the doctors were astounded at the length of her survival.
As long as we underand that she began taking 2076 quite late in the progression of her disease. After all of the reports from various ASCO posters and the like....one thing I haven't seen addressed is the durability of 2076's response. It makes this obituary a bit more unsettling.
It’d be funny (not really funny) if somebody(s) had a GTC sell order on their ENMD priced around $2.50 from the prereverse split….and today they’re unwittingly unloading. Ya know, those folks who believe that a sell order on their holdings lock up shares to keep them from being lent to shorts.
Just a curiousity Florham, who are the 'bashers' on the IHUB board?
why are more people dying of cancer in America today than ten years ago?
A larger population of older Americans?
Yeah Ken, I don't expect big movement from this press release. I am afraid that this may be what we can expect from our '4 peer reviewed' publications. I do hope I am wrong.
Yo ag...why do you try to engage him? Look closely and you'll see that no one else bothers. I'm telling you that if you'll just ignore all of his posts, you'll be happier for it.
More Lemron ‘That ws just a silly question.’
Not at all. You said this is how a company works its way into nonexistence. You’ve made a complaint…now what do you suggest? You just complain to criticize?
Further Lemron wrote ‘oh , I left something out, compost
, what would you do??’
First, you aren’t hearing me complain. But I will at least offer my opinion, not just some bs about being an exchange purchased investor. In my opinion management is doing the only things that they can. PERIOD. Their options are gone. They’ve made hard choices. I believe that our chances of success are low. If, somehow, we do get a partner for 2076 it will have been worth the misery. If we don’t get a partner, then it was money down the drain. It is just that simple.
I would ask you to leave the Yahoo insanity behind. Think, offer constructive opinions and take a moment to make sure your comments are lucid and that you've articulated your thoughts clearly before you press the enter key.
Regards
this is how a company works its way to non existence.
So Lemron....how does the reverse split cause the company to become nonexistant? And...what would you do if you were running the show to assure its continuation?
Ahhhh yes, I see VK. The issue now is will it remain above a buck long enough to get relisted? And if so, how long will it stay listed? It seems like an exercise in futility.
The next pipe?
Yes Paul it was 2076. There was a link to a written piece associated with the video and ENMD2076 was specifically mentioned.
I'll never understand it....if they thought it was necessary, why not go the whole enchilada? What the heck, why not 20 to 1?
Would you vote "no" to a buyout @ $10? or $5?
Actually, I would. If some big pharma was offering those prices it would only confirm that the value of the company was larger.
I want to see a partner and a revenue stream so that we can get back to the business of getting our other compounds approved. What do you suppose the value of Panzem, proven effective and approved for RA would be? There is too much at stake here, in my opinion, to have Entremed swallowed up by some conglomerate for 2076 alone.
In spite of the Yahoo's claims of poor management....I think Tarnow is doing the right thing. It's a 'hail Mary' pass and it might fall flat but I'm in for the duration.
Regards
if thats all you think we could get, the risk/reward says there's no reason to even be in it now.
This is why I qualified my statement by saying 'in our present circumstances'. Nobody is going to pay big bucks for those ifs today. And, frankly, if those ifs ever come to pass I'd hope that Entremed could capitalize on them and remain a viable, independent entity. I'd rather ride this out and see the company achieve its full potential than turn a quick buck on a good news buyout. Just my opinion.
Regards
Or... just wishfull thinking????
Last thing I'd hope for. What do you figure we'd bring in a buyout? $.75/share? Maybe, if we were lucky we get a buck. In my opinion, based on the present circumstances those are optimistic numbers. Would you really want to see that?
It looks 'on topic' to me silver bullet.
At first blush the fact that the AML and Multiple Myeloma PI studies continue to enroll/expand seems to run counter to Entremed’s efforts on cost containment and focus on getting 2076 to market quickly. Yet, in the background it makes sense. If 2076 gets approved for ovarian cancer and there is good clinical evidence of efficacy for these two indications, then the market value of the compound is much higher, immediately on approval, based on its off label potential. Tarnow may be brighter than he looks.
You know absolutely nothing about the drug business
From your posts over the past few months....I say that makes two of us.
$1 BILLION when ENMD-2076 gets approved by the FDA
Closer to reality than your original $1 billion up front demand.
But you're still dreaming. It's ok to dream but don't be surprised if someone doesn't temper those dreams with a small dose of reality.
Remember BIG business deals can be done over a weekend!!!
I would never have guessed. They can collect and evaluate the pertinent data, negotiate a deal and write a billion dollar plus check in just two days. Goes to show you just how dumb I am.
You just don't understand the drug business.
Thank goodness you're here to enlighten those of us who are unable to comprehend the basics.
I for one do NOT want Entremed to sign a partnership NOW
I dunno...the sooner they get some money coming in, the sooner they can get back to panzem, 1198 and MKC-1....etc.
at least $1 Billion upfront
Keep dreaming George.
Yeah t-bo, I agree, the reverse split may just happen. It seems totally pointless to me though.
I thought perhaps it would shut up some of the persistent bashing that goes on on that board.
That ain't gonna happen.
Celgene's two positions When did they exercise their right for the second seat? If they actually now have filled both....that would speak volumes.
At the time, ENMD was dealing with a huge collision between expectations and reality
A situation that has remained unsolved since, as well.
John resigned as Chairman and CEO as a necessary part of making this work. Why do you suppose this was necessary? Just curious. Earlier on I nearly sold my entire ENMD position because of a lack of confidence in Holladay. I'm sure he's a good guy but his expertise was clearly not business. When he started talking about going into the business of manufacturing the compound, I knew he was out of his element for sure. I wish now I had listened to my instincts.
Back to my original question....why would it be necessary for him to resign to get the deal done with Celegene?
But the deal was initiated by Entremed to Celgene
I'm not sure we know that. Regardless, we accepted the deal. We may have had a choice. We were close to folding but had a lawsuit filed against Celegene. It's possible that we could have gone into a survival mode, as we are currently, and waited out the suit. We might have owned Revlimid.
We will never know.
Regards
CELG would not take a seat now, after all these years, unless it meant something to them in a way that it didn't before. I can't argue with that. I'm still hoping it'll be someone else. I hardly think of Celegene as a 'white knight' after they acquired the rights to Thal analogs at the eleventh hour. They may have baied us out.....but there was no generosity in their spirit when they did it.
CA-125 testing for ovarian cancer
http://www.msnbc.msn.com/id/34276015/vp/37264010#37264010
George, I think your messages on the inspire board would have been more honest if you’d stated, up front, that you were an investor in Entremed. Your opinions expressed there are surely biased by that fact and in all fairness to Patti, I think you should have told her so.
why put 2076 in a bidding situation Why the heck not?
You are entitled to your opinion RRG. Historically our 'deals' with Celegene have left us impoverished and at the same time have fueled the 'great track record' of Celegene. As I've said, without Entremed Celegene wouldn't have ever made it beyond being a niche player in the pharma world. What would make you expect the next 'deal' to be any better for us?
Celegene's real expertise, in my opinion, is their ability to milk every last nickel from their sole product. They are a one horse show. If they don't do something to diversify their product portfolio soon, someone is going to get a superior product approved and that'll be the end for Celegene. Wall Street loves them because they have great revenue and margins. But with a single marketable compound that will surely end. The best candidate for a partnership?.....I suppose so if you own shares of Celegene.
Just my opinion.
Regards
I'm going to be so pis.......angry.... if Celegene gets 2076.....