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Might find this is pretty far gone but I believe or certainly hope that 273 or 371 work although I’m quite happy with my life as a blind person. It’s my Parkinson’s symptoms that caused me the most angst because I am very vain and the shaking makes me seem like an old person which I am of course but I’d rather not admit it. In general the blindness is a plus because people are just amazed how well I get around with my cane. A funny story is one day I was headed towards the stairs to the subway on market Street. I was searching with my cane for the banister as my left hand shock attempting to find it. There was a homeless man on the other side of the stairs who was sitting on the ground. He saw my rather pathetic approach and he said “man Alzheimer’s and Parkinson’s, you it is fucked up ! I replied… I greatly appreciate the diagnosis sir lol
I look forward to having a 273 help my Parkinson’s. I am used to my blindness but would probably welcome the return of my eyesight except for the fact that then I will be able to see in the mirror and because I own the stock I will be able to afford it the 273 that is, without any insurance. I have already put my neurologist on notice that I will be asking him to write me an off label prescription. I also have contacts in the Slovak Republic a part of the EU if the truck is available they are before it is available here please excuse Siri’s fuck ups
I have no idea what my post means but I can look at my post looking at my post looking at my post and sense the presence of a deep spirit that comes from the wisdom of TheDepok
Now I want you to look at yourself
Now I want you to look at yourself looking at yourself
Now I want to look at yourself looking at yourself with Parkinson’s
Now I want you to look at yourself looking at yourself with Parkinson’s after taking 8 to73 for five days
Sweetheart it on
But unlike Uber and Starbucks we get to participate before the public offering. Are we post coffee shop investors , post SI. ??????
My gut says it’s just high volume consolidation continuing in a band around three dollars
If 8 to73 can be shown to be more effective possibly by a factor of 10 in multiple measurements. Then some people especially at the Pharma decision level might run the numbers in the new Waze and find that our drug is better has proven with only nine patients versus their 100 patients. The author of the black swan in the seam tell him often says that in and of one can be more significant in and of 10,000
Let’s say there’s a small hamlet with three or four houses. A fire breaks out. Marine gets out a fire hose but he can only reach one of the houses. It saves that house. But now comes the great big fire truck. Finally released from its fire house it’s able to put out all the fires in the whole Hamlett
Now which would you rather have a little fire hose or the big fire truck? I am leash fire truck a 273!
Does the Rhett syndr I believe they have shown the bio chemistry of the mechanism of action and they are phase 2 study. Did that same downstream reaction mechanism of action show up in an hour article and sell magazine? Is this one of many processes at 273 effects? Should we thank them for helping prove our thesis?
2000 years of monarchy has left its mark or in the European mind. The American Revolution and the government that was founded on its principles emancipated the minds of the Citizen from the Tierney of the state or the monarch. But it only takes one generation for all this to be lost
I don’t understand. If big bloated fat medical insurance company Zulu was charging huge premiums above its payouts why wouldn’t lean smart company beta come in and undercut them? The only reason I could think of would be that corrupt insurance commissioner would get in the way of competition
The thieving lying self righteous trial lawyers in general have run amok largely because especially in certain states they control or have significant input into the political apparatus of certain states especially the ones that are colored blue
That said it is very important that the common wall check one fraudulent and dangerous medical malpractice be maintained. I have a very good friend who does this for a living makes a lot of money and is a decent person and earns what he gets
What is this the same Indian prime minister who basically overnight out called all currency notes worth more than five dollars that’s completely robbing all the people who had their money in cash which was largely be on banked masses of Poor
I would like in my lifetime for everyone to have affordable healthcare without somebody having a gun put to their head and forcing them to work for months to pay for other people stuff
Apologies for dictation errorsQAirline travel was only for the rich in the 1970s and Jimmy Carter do you regulated it in now everyone can fly. Trucking and transportation was tremendously expensive in the 70s and then Jimmy Carter do you regulated it and that has enabled tremendous economies in delivering any kind of thing medical care is been heavily regulated from the 1920s at an Exceller rating rate. Get the government out of it do you regulate every part of it and you have high quality affordable healthcare probably without even the necessity of insurance. My grandfather belong to a group called the Workmans Circle he was buried in the Workmans Circle cemetery to Workmans Circle was a group of Marxist ideologues you also were small business people people they formed a mutual aid society where they would all work together to bury each other to take care of each other when they got unemployed etc. by the 1950s most organizations such as my grandfathers hire their own doctors the AMA site regulations to prevent self-help organizations such as that from hiring their own doctors. I have a friend who is a doctor he refuses to take any insurance or any government program. His subscription rate is $150 a month regardless of your health. He sees people as needed and you get some admitted to the hospital when they need to go and he finds them the specialist as much as possible he tries to work with specialist to work on the same business model Walmart and others here in California have walk-in clinics so that for most minor illnesses and injuries people don’t have to go to the emergency room and for a modest fee they can walk out or fix stuff. This is America are used to believe in freedom it’s starting to believe in it again and maybe we can get this done wet the common wall regulate the medical industry this simple change that will punish fraud and abuse under the common law LA W is the mechanism under which much of the rest of society that is free works. It’s time to try it let freedom ring affordable healthcare for all
The consensus of the board here seems to be the bio is too sleazy. What about the culture of Pfizer versus Merc can some people weigh in
Cbt has saved my life. And the proof is that an insurance company bet that I was going to die within weeks and bought my old insurance policy at a 16% discount and now they’ve had to wait 20 years to get there 16% ha ha HaI have a live through the nasty divorce from the woman that I love even though I’m gay, I’m nasty employee lawsuit that was completely fabricated but it was meant to get in the pockets of my billionaire client, and in my real relationship with a client and most of my business then at the same time I had full-blown I aids and after that I had to have replacements and a gradual process where I am now totally blind. Cognitive behavior therapy during all of this got more and more affective with each punch in the gut. I can’t highly recommend enough the YouTube‘s of Albert Ellis and Michael edelstein@3minutestheyarep.com. He calls it three minute therapy because once you learn the principles you can sit down and write down your troubles and see where the distortion‘s are separate your practical problems from your emotional problems it’s all very good stuff and if you look at his podcasts I am a guest on one of the shows although not called grassy knoll I was his first non-professional guest. Anyway I’m happy as a clam but I’ll be even happier when the stock puts a few million in my pocket One should also search for the following words… Mental and emotional fitness… The guy has like 11 videos is very nerdy but the videos are transformative
Yes in the world of FDA we have to wait by the knowledge that the rest of the investing community is caught in a false paradigm can give us confidence to invest and hold we are a small and happy group having invested the equivalent of 15 McMansions can a company that will change the world make that 50
My dad was in a wonderful assisted living facility for his last 10 years of his life. And sometimes I would sleep over and actually they they let me stay over when he was in the hospital so that I didn’t have to get a hotel room well I left the door unlocked one night and one of the far gone Alzheimer’s patients slept walked into my room it was completely scary it was like the invasion of the body snatchers. My father told me that sometime he would walk into his room and poop in his closet it always amazes me how kind and understanding the staff was
The scientific world has a fetish for the normal distribution. There are many things in nature that do not follow this rule. This is the basis of the many books by Nascimento web the author of the black swan and fooled by randomness correctionNasinm Telab
I highly recommend Ed the YouTube of his talk at New York University NYU on the topics above. My favorite line from the The talk is as follows approximately…
Sometimes an N of one is significant
Sometimes an N of 10,000 carries no meaning
And this is why those of us who understand are supporting this little company through its infancy and will be rewarded handsomely for thinking outside of the box of stupidity. Well thank God for stupid because otherwise I would have to get my blind but out there and be a Walmart greeter or something
Will Lucy put the ball back at the last second?
Suppose I was a scientist in a drug company who would help discover that protease inhibitor‘s in and in RTI were incredibly effective against HIV. Suppose that I had become completely frustrated with the glacial speed of the FDA now supposed that I started making these drugs deep in bunkers under the Pinehills of our now suppose that I then tried to start distributing these drugs to desperate people near death from maids. What federal agency with the FDA call to have me arrested and to have my stock of drugs destroyed in my laboratory ransacked wouldn’t that agency be the drug enforcement agency just like the millions of bodies that have been buried due to type two errors by the FDA that are unseen. There is unseen muscle behind the white coats the muscle will be brought out if the white coats are not properly respected. I have talked to FDA employees about this and they go absolutely nuts they do not want to see that their authority comes at least in part not on the barrel of a pen but from the barrel of a gun. If the FDA was up private foundation that did not have its own private muscle to enforce its eat X and was accountable and could be ignored or competed with then we might get possibly even safer drugs and possibly an order of magnitude or multiple or order of magnitude is greater innovation. I am glad that the good doctor is not as outspoken as I am and is quite circumspect as he quietly sneaks around them
The unseen death is still a death. And this is the problem fundamentally with all government intervention. The scene versus the unseen. The deaths from the unforetold consequences of your actions or the unseen results of your actions are not counted The great philosopher and economist Frederick Bastiat promulgated this principl
The world is not full of dangerous and shoddy and fraudulent products because the government does not regulate refrigerators and water heaters and furnaces in a preempt to you in a preamp Tory manner. In fact Innovacion is rather wrap it in energy efficiency and in usefulness. Imagine how long it would’ve taken for a government agency to approve the first refrigerant where the frost free refrigerator etc. Underwriters by and large keeps us safe. As does a myriad of other private regulatory agencies including the national science foundation excuse me the national cemetery foundation I mean a national sanitary foundation sorry but Siri is an idiot The FDA has a deep deep deep culture of caring only about type one errors I E approving a dangerous drug and not caring about type two errors I’m not approving a safe truck. And that is because one death of a type one error is more obvious than 100,000 deaths of a type to error please do not excuse these people or that institution for their behavior fortunately we have such terrific management and has been able to skirt the FDA’s in humanity and callousness. Many of us are in very invested in another biotech it that has the potential to save much suffering and perhaps millions of lives from infections and cancer but was not able to plow through the mark that the FDA puts in the way of innovation in the name of safety or their interpretation of what safety should be. We are not serves we should not put up with this and this this agency should be cut loose from the government be reestablished as a private foundation and have its protection from liability be removed and it’s muscleman reassigned to the duty of protecting the public from rape murder Saft and fraud please excuse series errors but I am blind and not quite up to snuff with my computer abilities yet. I am passionate about this issue because not only did I lose my eyes to Siri excuse me to the food and drug in ministration‘s long delays in approving obviously effective HIV drugs but I lost loved ones and entire generation for no reason but they don’t care and people who defend the legitimacy of this organization cannot read them selves of the stain of guilt of the millions of deaths they have buried unseen unheard of and forgotten
Part of the FDA’s job is to protect the people taking experimental drugs from being exposed to drugs then maybe Toxic or that are most certainly will not work. Otherwise the FTA is in on the fraud itself please excuse errors and dictation but I am blind and I know I should sit down properly and do it but I’m just dictating
I’m kind of blind card here so please excuse some of the errors that Siri makes a dictation but I think you get the pointThe FDA has a few basic problems. First of all it’s agents in the DEA use coercion against innocence. See the movie Dallas buyers club for a vivid picture of the FDA enforcement alarm in action. Secondly the FDA has a severe problem in that it does all I can to ensure that there are no type one error is in regulation. A type one error is a failure to regulate a real hazard. However it has no incentive to avoid type two errors and type two hours or where it regulates a non-hazard. In my example I lost a friend to HIV during the five years that it took the FDA to approve drugs that had already shown to be 10,000 times more toxic to the virus then to human cells. People had to chain them selves to the gates of the FDA to get them moving. In my opinion the FDA should be released and disarmed from its federal connections. It should become like the underwriters laboratory The underwriters laboratory inspection approves thousands of appliances including some innately very dangerous appliances such as ovens and furnaces and water heaters. It is a completely private organization and Zhaz is subject to liability when it fails to protect the public. I see no reason why the FDA could not work on such a model. As for the thalidomide example I have a friend my best friend whose father was the first biostatistics PhD from UC Berkeley. He saw the desk of the FDA inspector who is in charge of the light of my. Her desk was piled high to the ceiling with unfinished paperwork. The delay in approvingthalodomide was due simply to procrastination bordering on incompetence. Years later the truck has been shown to be extremely effective in various developmental diseases and cancer with small derivations that’s my story and I’m sticking to it I believe system exemplified here is based on the nonaggression principle when should never spells violence against innocence finally the FTA’s behavior in the last two years where the good Doctor Gottlieb was basically resisted health and almost nothing got done to the dance the clear will of sign of excuse me of Congress to move the organization into a more proactive and scientific mode The R resistance cares nothing about science cares nothing about patients cares nothing about death and cares only about its retrograde communist politics it is my sincere hope that karma gets them perhaps soon and barely with a disease that could’ve been remedied had they been focused on reforming the agency and improving the drug approval process instead of resisting every step of the way
On the topic of being thorough I wonder if our MTA with bio included a clause preventing a hostile takeover?
I have a question about how cautious we should be in our expectations of time in price. The shorts are out there waiting waiting waiting circling circling circling. They seem to of gone gone away for a while. But the low volume makes us vulnerable. At what market cap are we vulnerable??? What market cap have the shorts attacked other phase 3 companies that have very promising prospects?? Just asking because if we get ahead of ourselves it could be just a set up for them. Patience is all that’s really needed
He thought his daughter was saying dada but actually she was trying to say “fake news“!
Did the boss say along time ago that he wanted to just have a manufacturing partner
So is the copy business
Wink
In evolutionary biology there is a concept called conservation. For example the gene that codes the protein that is the back bone for your DNA is very nearly identical in every thing from LG to lobsters to even God for bid cats. The gene has almost no variation throughout the whole living spectrum. This is the ultimate in conservation. The sigma one gene and it’s resulting protein is clearly ubiquitous in nature and has a similar function from worms to humans it is been tested now repeatedly in a petri dish in worms in mice and rats and him are humans now for what five years? The human study has even gotten statistically significant Lee different results from the usual progression in more than one measurement if I recall three measurements maybe more of this to D disease restorative or halting. The animal studies have been done with multiple models of epilepsy multiple models of Parkinson’s multiple animal models of Alzheimer’s and multiple models of various rare genetic diseases especially childhood diseases in every test that I know of there has been statistically significant improvement. I have been a biotech investor for 40 years and I have written many a roller coaster. But I have never seen a company amass such a mountain of pre-clinical evidence and A nice little plate of human evidence I also see a management that is navigating the murky waters of regulatory politics pretty well. Yes it got one leg beaten or bitten off by the short sharks but has still kept swimming in the shark tank of Wall Street it won’t be long now
Two real simple answers won the S***it works. And to The fact that it works was printed inCell . It’s like reading something in the New York Times back when the New York Times was the New York Times
The emoji described in the study is probably only part of what I have a vex dies. It fixes up all Pro Tien production at the point where it’s made by sending in a fire truck to clean up a fire in the protein factory.
The proteins describe it in the paper are basically the janitor crew that cleans up after the fire. If the fire is bad the janitor can’t stand the heat or even a better analogy the machine with and makes the janitor is on fire and so there’s no janitor to show up to work
The paper shows that the janitor has returned to work and is cleaning up the mess. But in my humble opinion and has George has shown by the previous links the MOS even deeper and has to do with the fact that every pro team including the janitors proteins are made correctly
Patience is all that’s required for this one in my humble opinion
This company could be big just on the rare diseases. Our company could price the drug at it 1/2 or 1/3 the usual astronomical prices for rare diseases and do quite well once the FDA gets rolling on streamlining approvals for baskets of drugs that have similar mechanism of action we could be a very nice rare disease company which alone could make us big Pharma. The FDA it’s a lot more willing to approve rare disease drugs because it doesn’t have to worry about weird unbeknownst side effects showing up in a large population.
The market is so Euge for a LZ and for Parkinson’s that and for epilepsy that our little baby can do quite well thank you even with a very low price for the consumer The cost of not treating a patient and instead treating the symptoms in a nursing home are astronomical. Once the word gets out there would be tremendous political costs and not covering the truck. Now the pricing for rare diseases is an interesting question. Will the company keep the Price low in hopes of jumpstarting an off label market or Kennett get it to eat the usual insane prices that are routinely paid by the insurance for rare diseases. Don’t forget the insurance have to deal with the lawyers and Jory’s if the drug fit you must convict
Patrick Byrne of overstock has written extensively on the problem of fraudulent short sales. In this case shares ours are sold that have not even been borrowed yet. The rules are such that they have three days to deliver those shares if they can’t come up with the shares in the three day time limit it is called a failure to deliver. Unfortunately the three day rule is rarely enforced. And the failure to deliver can go on for a very long time. The corruption is deep. The clearinghouse is a private Company set up by the five largest banks. It has a monopoly on the clearing function. And of course those banks on Congress and the state on the regulators. And now you know why the three day rule is not enforced or why can’t it can’t be just one day or 10 minutes
First you got to be really picky about the ones you get you want to make sure that they are meeting all the criteria. Then you’re in competition with a Scillion other pre-clinical drugs also trying to recruit patients damn you have the problem that if you have a placebo and you were up against candidates that have no placebo you’re going to have a tough time because who wants to take zero drug. Then you have a mountain ofFUD that you have to place in front of normal people. How in the you know what are they going to be able to tell what’s good and what’s not
But if they cure autism where will apple and google get their engineers?
Just speaking out of my proverbial you know what but maybe it’s a simple as 171 permanently alters the actual receptor. This is apparently what happens in meth addiction. The serotonin receptors I believe or permanently altered by being super activated. Once the usual have been flow of emotions I have been destroyed the person could no longer function
I will vote yes I hope you guys will too and Gail’s. Apologies for series misconstrued wordsThe company desperately needs protection from Wall Street. I will be voting yes. I have always been a risk taper excuse me a risk taker shooting for the fences but looking for the best possible risks. My experience in the chain your goal market is that I would find fantastic prospects and then watch them get hammered as the general golden market got hammered. Then one day while the market was at the bottom Big gold with swoop in and buy the company for 30% premium which was still 70% below its previous top. Don’t let this happened I had a vex. This is important protection especially if the general market filters and takes us down with it. Then big Pharma could swoop in and buy a sale
I have some friends who could buy and sell this company 10 times over but couldn’t get past the pathetic website.
In general science is the pursuit of truth through observation and experimentation. Make a hypothesis and then test to see if the hypothesis is correct in nature. Then the hypothesis becomes a theory. My theory is always open to more testing and then the hypothesis is proven wrong in theory and hypothesis disappear. In general and in the minds of most scientists as for self as a part of pursuing truth scientists use Arkansas razor… Please excuse series stupidity… Always looking for the simplest explanation. For example most physicists have been searching for a very long time for universal theory that unites all the forces of the universe and the Adam. Now that paradigm has moved to Madison. Understanding that each individual is different, individualized medicine attempts to isolate what factors will make a drug work in one person at night and another. This paradigm in testing and approval by the FDA is the opposite of trying to move a mountain of people. For example the Staten drugs attempt to move a whole bunch of people into a specific range for their fat intake and blood results instead of looking for specific individualized results that can be correlated with this particular markers in the individual. Now the case for an FX 273 is that science was used to identify the sigma one receptor and then experiment Tatian was used to find chemicals that would activate it in specific ways and out at the same time interact with muscarinic receptor. In a very specific way. The testing on nerve cell cultures helped to pick the best of many chemicals that were found two of the many chemicals that kind of work were chosen to move forward into animals, 271 and 273 or excuse me 371 and 273. Every single animal that has been tested in every disease that’s been tested has shown efficacy with 273 and efficacy at 371 at remarkably well doses. I should say every group of animals as compared to placebo. And now we have three years of ALC data with on average no progression of disease and many statistically significant maintenance of multiple measurements of the disease. Nasim tell of the author of the black swan and the author of the book full by randomness. Often says that in and of wine can be significant in and of 10,000 cannot be significant. In my humble eopinion The animal and now human evidence is pretty good pretty pretty good as Larry David would say
I bought 40 contracts of the July‘s this morning just to top off my actual equity holdings.