Connection? Mate I'm full on speculating that he was attending an Amarantus business meeting because he mentioned a meeting. Forgive me. please do clue me in...

Uhhh, I'll take your word for it!! Doesn't put his context in better context, for me personally, though. Lol! Thank you, at least, for attempting to assist me.

Ahhh, BH, you come in with a compliment that I said something well. I'll take it coming from the master of articulation.

You know,

should be all completely irrelevant, though, in this short term phase (2/12/2014) a profit has been made by hopefully most investors since a few months ago we were at 3C and hopefully future dealing/investor identities don't give a rats ass about this board's DD in my opinion.

I wish I was a better trader but currently, mostly an investor. Proof of concrete evidence that the pipeline is solid will bring better return...that goes without saying. Hopefully I can get a trading portion of this stock, separate from my core position, right...

WTF??!! Is he saying he as been sitting in on AMBS business meetings??? If that is the case, somebody needs to duct tape he/she's mouth the FFFFFFFFFF shut. Or Gerald needs to send out one of those filed 8k's to account for or we've got ourselves a lawsuit coming at us. Or our future JV partner will have...



Interesting...I didn't catch any cautiousness in Gerald's voice. I heard his usual ummmm's before saying something...didn't sound cautious to me though (no worries folk...I like Gerald and think he is a competent CEO).

Man, I wish I knew what an Islet was.

Need I going on?

I thought public couldn't read the posts until edit time of 15 minutes is up! Dang...

I hope you are right! Good luck to you too.

Challenge and counter til the cows home, I love it. But what some people think are views not supported by facts...be it lies, hidden agendas, whatever, just because it is in opposition to AMBS's progression...is seen as being "pulled out of their ass", which it very well might, yet on the flip side, many people can speculate, even pull future JV's with various big pharma with out being supported by facts...even allow Watsonhelper predictions that aren't supported by facts go uncontested isn't playing on even grounds. Being politically correct on this board is making assumptions regarding future contracts because of a smile Gerald gave them...that's all fine and good, I don't mind that either. But if Joboggi says he hears a strange tone in ones voice, that is just plain ludicrous (which it is...yet, I don't mind that either). And just because I ask Joboggi a question only because he claims to have a medical background and will probably give me an answer that doesn't fit this boards everyday pumping of AMBS stock(which I don't mind and is usually warmly received), I get loads of flack because of it. That is all BS.

No need to apologize because I agree with you 100%!! And that is why I'm invested, one of the reasons! Even better, a lot of posters on this board do in fact back up claims with links...like, the FDA coming out itself on record to say we need early detection, and I get to read it. This is why I read this board regularly...but the curtailing of what might possibly be an opposing view is BS.

True, and lies and accompanying agendas are, at least, I believe, easy to spot too. I like that he brings other products out there to this board and compares...and to his credit, though he is wishy washy regarding his opinion of Lympro, he has stated that there are uses for it, just doesn't agree they are that significant. I have talked to several people regarding Lympro in person and most of them, without reading anything on it, will dispute its significance for a similar reason that Joboggi does. Without a cure, what is the use? I know I know....please don't start posting me links, it isn't needed...my point is, counter arguments are healthy and severely lacking on this board. I'm only mentioning this because I feel like I need to defend myself for asking questions...and that's silly.

Yeah, I guess I do...actually, no not really, in fact, generally speaking, I struggle understanding any of the science I've invested into, and I put a lot of trust into AMBS management that they are confident in the science and that it's not a science fiction story. This is precisely why I'll listen to pretty much any view regarding the pipeline. And yes, I do recall that response you made...and recall thinking to myself after I read it, "Nice counter Zoomboom". I also recall that he didn't have a response to it...

Warp, save it mate. Most of your counter posts to Joboggi's in the past, if not all, were publicly posted on this board. I've probably already read them all at least two or three times and as much as I've agreed and even taken your side of the debate regarding most of the topics debated directly regarding AMBS and its pipeline, I still have found some of what Joboggi has posted intriguing...worth reading. I don't feel like I need to defend that. I'm sorry you feel the need to jerk his chain, too. It seems like a waste of time?

Who has BELIEVED it? I don't care if he was a 5 year high school biology teacher, I still would read what he has to say and welcome, if not solicit, his view.

AMBS management is largely why I have invested for over a year now and at times have added...but you sound as if you are posting to me as if you have made decisions what I believe just because I ask him questions?

I will always be curious about any counter argument regarding AMBS and counter arguments are hard to come by on this board. Until management makes statements such as MANF IS break through biology, or WILL be break through therapy based on concrete evidence, I will always welcome counter arguments and Lympro's long term accuracy is announced, my ears will always perk upon hearing opposing views. Actually, scratch that, I'll always be interested in hearing it...

As much as you go on about his psychology etc etc, makes me wonder about your own...why do you feel so attached to it? Give it up already.

Can you or anyone (yes, including Joboggi) explain, or post a link, preferably in layman's terms, the science behind this possibility? I interpreted this, Phenoguard, was used back in John's NIH days, as somewhat of a consultant tool. I'd like to understand this better.

and so quickly they show up on the scene...it's surprising.

Well, it makes me wonder because I sense you spend more time than he does letting everyone know of his 30 yrs medical experience telling everyone that his medical license has been revoked etc etc over and over again.

I don't know if anyone believes a message board poster with a revoked medical license has more credibility about the company's products etc etc...are you really worried about that!

You know, Joboggi just might be referring to that, I don't know because my inquiry hasn't been responded to. And, I'm not really trying to make a point.

You don't really think a potential JV partner or any significant investor might read these here posts and become instilled with fear do you? Or are you worried about potential investor's pizza monies failing to be used for purchasing of AMBS stock? I'm not worried about either, personally.

It's been reported that Eltoprazine, so far, has shown strong safety data. Why do you say it has too many side effects?

BH, I would like to know, what do you mean by "was always a two-edged sword", regarding BD and AMBS relationship? Vendor relationship, absolutely, but the rest is speculation, which makes me ask you why a two edge sword then? Meaning, AMBS must pay BD money to do the tests which sucks and that is the other edge of the sword? Are you of the understanding or belief that BD has or will or even interested in "staking a claim" for Lympro? It is assumed by many...including you? I may have missed an important PR along the way.

Joboggi, given the fact that AMBS is a penny stock would make it possible for any deep pocketed someone to significantly influence the share price! As with all penny stocks, as far as my shallow pocketed knowledge is concerned. What have you got to post in regards to AMBS for WF and the work DR. Urano is currently undergoing? Still a 1% chance of success?

This is something that could easily be clarified via phone or email to company asking, "which was it referring to, Eltoprazine that was recently acquired or is it actually something to be in-licensed at some future date"?

I plan to inquire about this. There shouldn't be any reason why it can't be answered.

It might just very well mean Eltoprazine, just worded badly in that statement?

oh...I didn't know the dictionary defines it as what you say it defines it as...

%100. It all looks good, with exceptions to the financials...as everyone knows. But that lottery ticket play could change all of that! And I'm wondering if I've married it or not. I'm struggling tonight to sort out plan with this stock! Thanks for your responses.

"the best test that is available when a treatment becomes available will win."

Absolutely. It'll be the standard. But when you say treatment are you saying a treatment to cure or prolong? or both? What do you know about treatments to prolong? Do-able? Easier? Something out there currently that looks as if it can be done given AD is diagnosed early?

I guess...I'm anxious to find out if I'm in this for the longhaul or..just a bit more above that dime that it is right now and believe me, I'm proud of that dime we sit at today! I do need a plan though but it's difficult in biotech land.

I would have to say, sorry for the late response, I am of the opinion that it is somewhat on hold...actually. I mean, what is really going on behind the scenes is anyone's guess, but it really does appear that orphans and diagnostics, diabetes, WF(am I missing anything?) have made their way to the forefront, pushing MANF for PD, you know, somewhere along the uh, back burner...to simmer for awhile. It really does bring out the flavor that way. I see the necessity and I think it is great, actually.

On hold does not by any definition mean abandoned. That's just silly.

I often hear speakers or educators say to audiences, "HOLD that thought, we'll come back to it"... and I'm assuming that is just what AMBS is doing with MANF for PD. MJFF didn't give them another grant. Where else were they supposed to obtain the funds? Come to think of it...why didn't they chose to dilute to raise the funds to further MANF for PD? Or did they?

I don't understand why the notion which blood test is better than the other and encompasses more detection properties isn't the point? And if there is a race to develop tests, I say, first to commercialize, manufacture, and aggressively sell it takes the lion share of the market!

Joboggi, I appreciate you taking the time to educate but I really don't grasp the science beyond a superficial level. I've invested based on the hype. Really that is what it comes down to. I've invested because of who the AMBS team players are and their rich backgrounds. The fact that AMBS pps went from sub penny to 19 cents in what, 3 or 4 months time? That certainly caught my attention, and I'm very pleased that I was able to purchase at 3 cents last summer and look at it holding at 10 cents today! AMBS pipeline of course appears plentiful in comparison to other biotechs but that may be just because I'm biased. We don't know if MANF will work, do we really know what Lympro specificity and sensitivity % are, even until now? What DD is one supposed to do with this one?? The company is broke, I mean, we may be in "good shape" as far as any other start up biotech company can be doing...without revenue but we're broke! Bottom line, proper DD being conducted should ask, how much money? Burn rate? I know, everything Rubber Duck posts, doesn't make for the best DD experience. Yet at the same time of all this unknowing, I'm week after week eagerly awaiting that elusive PR from Gerald announcing "we got money now folks"!

I see what you are saying about tests are way ahead of the treatments...but I still think that is irrelevant to the need for diagnostics in order to find treatments. A market is there for AD diagnostic tools, especially in 2014. It'd be cool to find that treatment sooner than later for the good of mankind but, in the meantime, a constant search to find it just means revenue for hopefully Lympro blood test. Can you really dispute that? And do you really doubt we can't be selling a few packaged Lympro tests via CLIA at the time management is hopeful we can?

All that competition you mention there will be. I recall a few months back going through about 6 or 7 AD diagnostics out there currently being developed...and none of them seemed any where near commercialization. but then again, I may be biased. DO you really believe Lumbar Puncture is a legitimate way of diagnosing disease when there is a blood test that is just as accurate?

Anyway, I value your posts, even though I question your motives at times (like, why in the hell are you even invested in AMBS??) but anytime anyone can offer their own medical experience and knowledge to this board, I find it intriguing so thank you.

Thank you for your response.

Historically speaking, there was a test...but, not much of a market,apparently. I'm not, however, convinced that this will not change and or isn't changing and or hasn't already changed completely. I personally do see a market, or at least earnestly HOPE there is a market for a diagnostic tool for AD, regardless of all past failures that I honestly know nothing about. Perhaps, ignorance truly is bliss but I do sense the tide is turning in regards to AD research and that more focus and interest is shifting towards finding a cure than before(the 1990's) which in turn would make great use of that E4 blood test these days. But of course I'm hoping, for the sake of my humble core of AMBS shares that E4 has already missed the boat and long since forgotten, that is, unless, Lympro isn't what we hope it cracks out to be!

Thanks for that Joboggi... I've got two questions I'd like to ask you, and forgive me, it is coming from a pure medical layman's perspective...

1) This very old but excellent E4 blood test, in your opinion, is it as excellent as we hope our Lympro blood test to be? I mean, same specificity and sensitivity percentage etc etc?

2) What you are saying is, if I understand you, to test out a single compound for AD without companion compounds to test simultaneously, is just a waste of time? If that really is the case, wouldn't that be common knowledge within the AD research community? And if so, wouldn't there still be a need for a diagnostic tool whether it be that E4 or Lympro or whatever else may be out there so all these compounds can be grouped up, allowing a possible 50 year revenue for such a diagnostic test until a cure is successfully found?

yes it does...simply because Japanese do mix Chinese characters in their writings adapted from Chinese script. This is why the Japanese can read Chinese literature and, unless they've studied the Chinese language, can't speak it.

Well, I can help with a small portion....my elementary Chinese reading ability can explain part of what it says directly under the written word "wolf". Translation- "big door". Don't believe me? Go ahead and take it to a Chinese restaurant and ask a native directly if I'm right...

Lympro detects at early to mild stages of AD. What exactly constitutes early to mild? Forgetting your anniversary or your spouse's name? This spinal tap may detect several years before the latter but how many people would want to undergo such a risky procedure?

"it wasn't about duplicating an actual clinical patient trial but rather about confirming that the testing process was valid and reproducible"

Valid regarding what? That it does in fact detects AD in the brain and we didn't buy a lemon? Or was this validation more about the technique used in conducting the blood test? How can they assess proper technique without checking resulted accuracy? Without a specificity and sensitivity figure, can we really feel at ease that we didn't "buy a lemon"? I honestly do not understand.

Within the past few days I've read up on a few articles regarding AD diagnostics currently being studied...from sniffing peanut butter to another spinal fluid diagnostic, and they are all several years away to market, yet, at some level ours is months away from making a few sales but not any kind of article anywhere can be read about it recently. Peanut butter diagnostics makes better news than a boring old blood test?

Hehehe.... let me have a go... Dumb ceo and his daddy haven't even sold any manf to a single aids patient! Incompetent board of directors, too. Alright, lets see if that works...

WOW! Incredible find. The NY Times! I wonder if the NY Times will print AMBS info on a daily basis? Or perhaps any listed company gets printed in the NY Times, too?

I'm not in disagreement with you on many of your ideas, especially, doing the research in China, particularly the preliminary type and FDA the dinasour. Developed products in China do not equal low grade, I do agree and I have expressed my opinion of the quality of research and development centers in China in a previous post.

Issue with patents...I disagree. Yes, USA probably isn't completely innocent of stealing intellectual property either. But...how can I say this, many of my Chinese friends openly admit that this concept is difficult for the Chinese to come to terms with. As they like to say, "it's a difference of culture". Intellectual property from "abroad" isn't viewed as stealing but as a gift! This is why you see foreign enterprises opening manufacturing facilities in China and then finding later on that the newly opened plant a couple miles down the road from them are selling the exact same products as they are but under different names. Using the same logistic company to distribute. They even share the same production manager. I've seen it! I've toured them! I've been asked to assist in selling the products!

What about knock off Chinese drugs? Yes, there are plenty of them too. Future knock off MANF catheter injections...it wouldn't surprise me.

I know AMBS pps is low, but that is expected from a start up biotech. I'm talking about future revenue. My experience is with government controlled enterprises in China, they are not concerned with making American shareholders rich. And JV contracts are set up accordingly.

I'm sorry, but China is the last country I'd ever go to for brain surgery! I know I know, they have modern facilities there...but they aren't run with care, there aren't even enough truly western skilled physicians anyway to handle an increased influx of patients. Mate, one can easily light up a smoke right outside a surgical room in most hospitals in China (at least 2 years ago you could you).

What are your thoughts regarding MJF working with the FDA to lower the bar for PD drugs and therapies evaluation and testing? I've read a few articles recently (NY Times...for one) that they are looking into making it easier for drugs and therapies to pass through quicker instead of facing the current situation of being placed on the back burner for 5 years wait.

I recall a few months ago when you first began suggesting oversea funding from Asian sources...I replied to your post, somewhat scoffing your idea, especially IF it meant from Chinese investors and you suggested I was ignorant to think that China was the only country in Asia.

I too have lived and worked in China (well over a decade), part owned a market research company which did work for most big pharma established there (most are). Hey, I'm even fluent in the language which means I can not only order a beer in Mandarin but can also read the local newspapers! In short, I most definitely agree with blackhawks points. I would like to add that I think Gerald may prosper personally in going your proposed Chinese route, but the shareholders!

Using Chinese facilities and scientists to conduct researches and other studies that may be more cost effective to begin in China, than in the states, I think is brilliant, but to try to side step the FDA by setting up shop in China is complete nonsense.

In the world of Biotech, Rubinfeld is un-doubtedly a legend. And many people have raised the point that if AMBS was merely a scam organization then why would he be on the board of directors? My question is, what is he doing for AMBS anyway? Is his involvement only on a behind the scenes basis? Apart from his famous quote of MANF might be a blockbuster drug of the decade upon decades of experience in the biotech field of study, what else has he said? Or done? Onemed forum he wasn't keen on getting into the science aspect of MANF where I personally was hoping he would.

Seriously, all this chatter today about studies done in China is ridiculous. And even more so, I think I read some about how MANF is going to be HUGE in China. Because testing was done there? Go figure?

Why isn't it? What's the connection? Because it's CHINA!? Every major pharmaceutical company has locations there, along with research and development centers. I spent over a decade there, several of those years doing market research for many of these major pharmaceutical companies. Much of the literature/data findings on MANF were done by Chinese scientists. My guess the same scientists that performed these latest studies were the same scientists that did them before... what's the big deal?

Might you know which method the other neurotrophic factors, CDNF and GDNF, used during pre-clinical studies?

Right on! And my participating whole life policy with an honest built up cash value that I can "borrow" from when needed for me is the best thing since sliced bread...

You might be right. I still reckon this stock does have the potential to climb past a dime on any given day though. How do we really know what is going on behind the scenes? The product seems to have support from plenty of people with scientific backgrounds that either are sold on it or do attest that it does appear promising. How much does the actual market it is being sold in and the present share price affect more investment from larger investors from big pharma or general scientific community? If I was flushed with cash ready to invest big dollars into a company, I wouldn't touch anything in this market! But if I had a neuroscience background and studied up on AMBS and MANF, might I feel more inclined to invest here? I do have a background in the pharmaceutical industry and I have seen lots of money thrown into researches and various projects that appear wasteful to me. Furthering MANF research seems like a worthy research to invest into IMO. This is why I have gambled already into MANF and hope to be able to gamble more when funds do come in!

Absolutely...unfortunately for me, with my luck, once fresh funds to invest more into with do finally arrive, I won't be able to purchase more for under 6 cents! Lesson for me is, be thankful with what I do have and don't get too greedy. Purchasing above a dime, while taking in all considerations regarding AMBS, I'm predicting would still be a profitable investment.