Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
that doesn't mean that much to me, too bad that we relapse every time
hahaha that with $ 3.5 they can put the stock so far back, it should be banned, lol
what would it be like with chardmaster
I am happy, TSOI is doing well, so I am too, and received my 3 pots of QuadraMune in good order, what more do you need as a person ))
I shared the video on FB and now just hope they copy it )) it's for their own good
subslover, that would be nice but I'm here for a long time so I'm not looking at a week or month ))
perfect answer sharky, if i would wear a hat on my head i would take it off now
hahaha you are right now but when i wrote it it was different and that he is now going up is because they felt sorry for me, have a nice day everyone else
bad news and very good news, the TSOI share is slowly decreasing so far, that's the bad news, the good news is that my QM has arrived in the Netherlands and I have to wait about 2 more days for it to be in my closet
new week, new opportunities, I hope for positive news this week, go TSOI
what a rest on the forum, I hope this afternoon is different, that we stumble with our opinions about the news
I'm already looking forward to tomorrow
thanks for sharing here on this forum
and that is exactly what most people think, you don't have to be a rocket scientist to understand this
ERNEMEN FARMA & BIOTECH
US inject record sum into candidate vaccine
TwitterFacebookWhatsappLinkedInE-mail Bookmark this pageDON THIS ARTICLE1
Full-frame playback
Under the code name Operation Warp Speed, the U.S. government is pumping billions in candidate vaccines to accelerate development and there are already hands on. © REUTERS
NICO SCHOOFS
July 31, 2020 4:44 PM
The United States is funding $ 2.1 billion in the clinical studies and production of the candidate vaccine that pharma giants GSK and Sanofi are developing together. In exchange, the US has already secured 100 million doses.
The geopolitical struggle to get as many corona vaccines as possible, even though they are still in full development, continues to rage in full force.
On Friday, the United States announced that it is pumping $ 2.1 billion into the candidate vaccine that British and French pharmaceutical giants GlaxoSmithKline and Sanofi, two of the world's largest vaccine manufacturers, have been preparing together. The money goes to the clinical studies and to scale up production.
With that billion-dollar investment - the largest to date in the United States - the Trump administration is already assured of 100 million doses if the vaccine actually comes. The United States also has an option to add an additional $ 500 million over the longer term, reports the Bloomberg news agency.
The Sanofi-GSK duo, which also closed a vaccine with the United Kingdom this week, announced on Friday that they hope to have positive results from the last phase of clinical studies by the end of this year, with the first half next year will apply for market authorization from the US regulator.
TIP
Start your day well informed.
Get The Time Today Now.
Every day (Mon-Sat) via email - Unsubscribe in one click
Operation Warp Speed
The US does not put all their eggs in one basket. The record investment is just one of many under the banner of Operation Warp Speed, with which the country is spurting the development of multiple promising candidate vaccines with billions of investments in the hoop to accelerate development and already anticipate possible doses.
For example, the US made a $ 1.95 billion deal last week with Pfizer and its partner BioNTech. AstraZeneca, which is preparing a vaccine with the University of Oxford, received $ 1.2 billion from the Americans.
On Friday, the Pfizer-BioNTech vaccine is also understood to have signed a deal with Japan to supply the country with 120 million doses in the first half of next year.
A little story: The elderly may have the least of COVID-19 vaccine
It is difficult to teach an old immune system something new, which makes the search for a new vaccine against COVID-19 difficult.
+ READ MORE
Tuesday, July 21, 2020 by Roxanne Khamsi
If you want to pinpoint one organ in your body that plays a key role in the fight against COVID-19 and you want to know why the disease affects older people so hard, put your index finger on the center of your chest, then slide it over your sternum up and stop just before you reach your neck. There, hidden behind the breastbone, is the gland that aroused Edith Boyd's curiosity in the 1930s: the thymus or thymus.
Boyd wanted to know why the thymus seemed to vary in size with age. At the University of Minnesota, where she was an assistant professor, she went through the data from 10,000 autopsies and also analyzed information gathered by scientists from European countries. She confirmed an interesting pattern: the thymus, which is about the size of a box of tictac in babies, continues to grow during puberty and then decreases in size.
It would be another thirty years before scientists figured out what the thymus actually did: the last major organ whose function was determined. The thymus turned out to be a very important source of T cells, a large group of disease fighters that help the immune system to develop additional defense mechanisms, for example by producing antibodies.
Together with the insights of anatomists such as Boyd, this discovery may explain why the elderly in particular are severely affected by diseases such as COVID-19. First, as the thymus fills with adipose tissue, the aging immune system can provide an ever-decreasing amount of flexible T cells. As a result, our immune system becomes less good at fighting new viruses. An analysis of more than 50,000 coronavirus deaths in the US in July found that eighty percent of cases involved people aged 65 or older.
Second, the development of a vaccine against this disease can also be complicated by the aging thymus. Vaccines give instructions to our immune system, which are also distributed throughout the body by T cells. By the forties or fifties, most of the stock of the type of T cells that can recognize unknown pathogens and "train" other immune cells to fight them, called T helper cells, has been used up in the thymus. But many vaccines rely on T helper cells.
Because of the outbreak of COVID-19, researchers are paying more attention than ever to the effect of vaccines on older people. For example, the company Moderna Therapeutics, which released the first results of the Phase 2 test of its new mRNA vaccine last week, has developed a special Phase 2 test for adults aged 55 and older.
"Until very recently, people in the vaccine world have focused on rescuing young children," said Martin Friede, World Health Organization (WHO) vaccine production and distribution coordinator. "The people who need the vaccine most now may be those whose vaccine is not working properly."
Testing among the elderly is also critical because not everyone ages the same way, Friede says. And this is not just about the thymus: some elderly people step onto the golf course energetically while others are too infirm to walk - and these individual differences in vitality can also cause a different response to a possible vaccine.
Pharmaceutical companies can adapt their vaccines to protect older people as well. But those kinds of adjustments are often complicated and difficult to "sell" to people who mistrust vaccines.
Stimulation of the older defense system
Vaccine developers have, in the context of their research on the flu virus, acquired the necessary experience with immunosensescence, the aging (and deterioration) of the immune system. As a result of this aging, people of age are often less well protected by the flu virus.
To solve that problem, vaccine manufacturer Sanofi Pasteur created the flu vaccine Fluzone for people 65 and older. Fluzone contains four times the amount of "antigen", a molecular component of the pathogen that triggers the body to produce protective antibodies. In 2014, research showed that the high-dose version was 24 times more effective than the normal version.
Another way to increase the efficacy of an influenza vaccine in older people is to use "immunological adjuvants," ingredients that help the immune system boost the immune response. The Fluad vaccine, for example, contains the adjuvant MF59, which is partly extracted from squalene, a natural oil produced by the skin and plants.
Adjuvants have been used in vaccines for a century, not just against the flu or for older people. But even highly proven adjuvants have been portrayed as "dangerous" by activists against the use of vaccines.
The squalene-based adjuvant AS03 was used by the pharmaceutical company GlaxoSmithKline (GSK) in a vaccine that was used against swine flu in 2009. However, when cases of narcolepsy were associated with the vaccine in Scandinavia, the drug was withdrawn from the market and no longer used in the US. A study conducted in 2014 by the U.S. Centers for Disease Control and Prevention (CDC) on one and a half million people found that there was no association between the vaccine and narcolepsy, but anti-vaccine activists continue to heap on this adjuvant, claiming it to be harmful would have triggered immune responses.
Doctors fear that this type of false information may make people hesitate to get vaccinated with a COVID-19 vaccine.
MOST POPULAR
SCIENCE
How long does the coronavirus remain in the body?
HISTORY AND CULTURE
COVID-19 disaster threatens Amazonian tribes
TO TRAVEL
9x The most beautiful places in the Netherlands
TO TRAVEL
Under the crust: 10 special geysers and volcanoes
PHOTOGRAPHY
Photographer climbs out of the deepest cave on earth for his life
SCIENCE
The elderly may have the least of COVID-19 vaccine
HISTORY AND CULTURE
11,000-year-old underwater cave in underwater cave surprises archaeologists
PHOTOGRAPHY
Photo of COVID-19 victim leads to fascination - and denial
TO TRAVEL
You will find most castles in this part of Europe
VIEW MORE
+ HOW SOLVING THIS MEDICAL MYSTERY SAVED LIVES
"Anti-vaxxers look for every reason they can think of to reject a vaccine," said Wilbur Chen, who leads clinical trials among adults at the Center for Vaccine Development and Global Health at the University of Maryland. "Now they're not talking about anything other than" those adjuvants are dangerous, "he says.
Chen warns vaccine developers not to let them get rid of them: “If we addressed those people's fears, we would inadvertently give legitimacy to their claims. Then they might say, "You see? It was a serious issue and they have adjusted it. ""
According to GSK, the company will produce large amounts of the adjuvant AS03 to be used in multiple optional COVID-19 vaccines. The company states that the narcolepsy diagnosed in some children after they were vaccinated with the swine flu vaccine was a response to the swine flu virus (H1N1) itself, which had spread to the population.
Old and new
Old age does not always determine how severely affected someone is by COVID-19. There are regular reports in the news about centenarians who have passed through the disease and teenagers who have succumbed to it. A new study in the journal Science describes a range of immune responses to COVID-19 that occur regardless of age, including a response with virtually no symptoms.
That lack of any response in some older adults in the study "may be related to immuno-senescence," said Michael Betts, an immunologist at the University of Pennsylvania's Perelman School of Medicine and co-author of the new study. "Some people respond better to the disease than others, and we currently don't really know what drives it."
Immunosensescence is not just about a shortage of T cells. Also, the body's innate immune response, the front line in defense against invading microbes, is weakened by aging, even before the body can produce antibodies to a particular antigen with its acquired immune response.
And immuno-senescence isn't the only challenge for researchers trying to develop a COVID-19 vaccine for the elderly. There is increasing evidence that many older people have another problem, namely that their immune system is mainly aimed at combating viruses that remain active in the body for a long time after infection, such as the generally benign cytomegalovirus (CMV).
"When you look at the elderly, you sometimes see that 20 percent of their immune system is focused on CMV," said David Kaslow, vice director of essential medicines for PATH, a Seattle NGO. "There is a price tag to suppress such viruses."
Scientists refer to this phenomenon as "inflammatory" - "inflammation" and "aging" - when the immune response is actually caught in a permanent inflammatory response. This makes it more difficult for the body to recognize new pathogens such as SARS-CoV-2 (which causes COVID-19) or to be stimulated by a vaccine against it.
"It's actually like being in a very noisy place and someone is shouting 'help,'" Friede explains. "You don't hear that."
+ HOW PANIC AND FEAR FORM A DRIVER IN THE EVOLUTION
SIGN UP FOR
NATIONAL GEOGRAPHIC
NEWSLETTERS
Researchers attempting to study the problem of immunological aging in the laboratory encounter a curious problem: a shortage of mice with age. Maintaining old mice is relatively expensive for companies that supply mice to laboratories, so this category of animals is not kept in stock.
"I wanted to place an order for older mice with our usual supplier late last week," said Byram Bridle, a viral immunologist at the Ontario Veterinary College at the University of Guelph in Canada. “But they don't have old mice and have just started a program where they let mice age a bit. Laboratory mice that are one and a half years old will not be available until January 2021. ”
And ultimately, as far as COVID-19 is concerned, scientists also encounter a fundamental problem: none of us have ever contracted this new coronavirus before. Other vaccines that have been developed specifically for the elderly, including flu and shingles vaccines, are, according to Friede, primarily `` stimulants '' that fuel the existing immune response to these viruses, because everyone has had the flu before and most older people have been on the varicella zoster before- virus, the virus that also causes shingles.
In addition, because the elderly have been exposed to a large number of cold viruses (including coronaviruses) throughout their lives, they may have built up a repertoire of antibodies to attack SARS-CoV-2. Oddly enough, that could prevent the body from producing even better antibodies to the new disease. "It could even be less good with an infection," says Betts.
But it is also possible that previous exposures to this type of bacillus are a good thing. There is new evidence that contact with the 2003 SARS virus or coronaviruses that have been passed from animals to humans has led to an improved T cell response to SARS-CoV-2 in some people. More extensive research is needed to further investigate the extent of this protection and what this means for the development of a vaccine, as the coronavirus is still completely new to most immune systems.
"In the case of COVID-19, we probably need to immunize the population against something they've never encountered before," Friede says.
This article was originally published in English on NationalGeographic.com
I only follow your lessons, my friends hang on my lips when I tell about you and what I have already learned in such a short time
yes 72, I had not seen it like that, thank you hahaha
you do not think about it when you are working to earn money for your daily groceries how hard they work for our health, I think this is a great advantage of having shares, you go much further in life, in the first place to make money and secondly understand the company and what they do, thank you for your comment and read pleasure
A pregnancy is a great excuse to leave the gardening and changing of the litter box to someone else. There is a reasonable chance that you will become infected with the parasite toxoplasmosis gondii. This parasite spreads through cat feces and meat. by this I actually mean how much we don't actually know, so I am also curious about what viruses and bacteria are released under the melting ice caps. it is quiet on both forums, I think something is brewing, I am ready
a very good morning / afternoon, and of course for the rest of the week, and that the cash register may ring like the carillon of New York
totally agree gint1, and i'm happy and proud to own a little piece of TSOI haha, see you tomorrow, good night
does not matter, it is Sunday, tomorrow we will have more discussion material, nice Sunday
hahaha Portugal doesn't care about that, they really need tourists like you, the Portuguese themselves don't really make such a mess, so the fewer tourists the less mess
Doctors and geneticists at Radboudumc in Nijmegen have discovered how mistakes in a specific gene cause some people to become sicker of the coronavirus than others. The researchers hope that their discovery can contribute to a better treatment of seriously ill corona patients. Doctors discovered the role of the gene after two infected young brothers within the same family were put on a ventilator in the intensive care unit of Radboud university medical center. One of them died from the infection and the other brother recovered. Because elderly people are particularly affected by the virus, geneticist Alexander Hoischen wondered whether genetic factors also played a role in the brothers. The research that followed indeed showed that they had a congenital defect in a so-called TLR7 gene. As a result, the virus is not properly recognized, so that the defense against the infection works less well than in other people. "It seems like the virus can just go ahead, because the immune system doesn't get a message that the virus has invaded," says Hoischen. This may explain why young corona patients get so sick The researchers were able to put it to the test after doctors at Radboud university medical center again had to deal with two seriously ill brothers. Geneticists also discovered a "clerical error" in the specific TLR7 gene. Suddenly we had four young people with a defect in the same gene, all of whom had become seriously ill from COVID-19, "said Hoischen. None of them had previously suffered from immune or immunity, according to the doctor. The defect in the TLR7 gene may explain why some young people become so seriously ill from the coronavirus. Men may also be more sensitive to the genetic defect than women. The TLR7 gene is located on the X chromosome, of which women have two and men have one. "If there is something wrong with that, then there is no second gene that can take over the role as in women," says trainee physician Cas van der Made. When the TLR7 gene works properly, it activates the production of all kinds of antibodies, including interferons. Radboud university medical center is currently investigating whether giving interferon can help treat COVID-19.
BDEZ, thank you I have another new app to look at
written very wisely, I don't know you personally but I love you
guys now you know what the Dutch language looks like hahaha and then you don't even hear whoehahaha, have a nice weekend or else until tomorrow
Radboud researchers find errors in a gene that worsen corona complaints
https://www.nu.nl/coronavirus/6066563/radboud-onderzoekers-vinden-foutjes-in-gen-die-coronaklachten-verergeren.html
good afternoon, I will post here what a doctors found in a university hospital why one gets sicker than another you have to translate it to English. https://www.nu.nl/coronavirus/6066563/radboud-onderzoekers-vinden-foutjes-in-gen-die-coronaklachten-verergeren.html
yes that's true then i have 3 pots for the price of 2 ) thanks i will pass it on to lynda i already ordered them today so will send a message after this this was my last post nice evening
I hope so for everyone
I am going to order 2 pots of QM again so it will end up green with this large order, to be honest, I feel very good with it, unbelievable what a difference, so what the share does does not really matter to me at the moment , I know that my zest for life is up again and that is the most important thing
I have QM and metformin but I certainly do not want a covid, but glad that it helps so well, gives me a calmer feeling
it may be weird what i'm telling now but i'm now taking QM for a few weeks and this is not an advertising talk but i'm much better next to my bed in the morning, first it was that i needed hours to wake up but now everything is much clearer in my head and less painful complaints of muscles and bones, really incredible when you consider what I have experienced and swallowed, I am even 100% disapproved for my work, thank you Tim and TSOI employees
good morning centsability4me, thanks again for the many reading stuff, hahaha I already feel like becoming a whole doctor, our company is doing well and the patients can benefit from this as well as I do, I am curious if we have a nice day It is nice to see the increase in the share, hope that many more days will follow, until later
Chartmaster, I think it is so good that you can see it like this, I try to read such a chart but do not understand it, thanks for sharing your knowledge, so this is not a day but there are more days like this On ?
72, is this the only hobby you have to try to break down a company to the ground (which you can not do anyway) have you had a bad childhood or maybe you are not feeling well, take a QM maybe it helps