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2 months ago (July 27) we received the 31 wk data from the trial--now 2 months later can we expect to get the 38 wk data update from the trial--perhaps tomorrow ?? Thoughts???
neiu--excellent reporting--thank you !
Outstanding post!! Thanks dado for your contributions to this board !
Nice coverage by Investopidia---"Significant Recovery"
ANAVEX 2-73 is an orally available drug candidate. Its daily use over a five-week period indicated significant recovery in the motor symptoms. Normal behavioral patterns were observed without any anomalies.
Read more: Annex Shows Positive Parkinson's Drug Data (AVXL) | Investopedia http://www.investopedia.com/news/annex-shows-positive-parkinsons-drug-data-avxl/#ixzz4LGpMl0K0
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Do note "SIGNIFICANT RECOVERY"
apostrophe...excellent post--thanks !!
What are the chances that we get some "new" news from the Dr. at Tuesdays upcoming conference ??
A little lesson about "patience"--I bought 1500 shares of Tesla stock back in the day when it traded in the $20-$30 range---I
paid around $28-ish--got tired of waiting around for things to pan out and sold my stock for around $30--and have been regretting that move Bigtime ever since(never did buy any shares back). Think I learned a lesson from that blunder--that being "have a little more patience"--I will have patience with Anavex--I do think The Science is the real deal---I've been an owner for over a year and will continue to hold---our day is coming !!!! GLTA !!
bas...are you thinking some positive stuff next week?? like 38 wk data perhaps ??
can't come soon enough !! hoping for good stuff !
So who is doing all the buying today ?? Do I hear "smart money" ? I say yes !!!!!!
bio...do you mean PD drug approval ??? you say "data"
Volume--big numbers---gotta be institutions buying in! nice !
From Dr Missling in today's release "ANAVEX 2-73, might accelerate the exploration of ANAVEX 2-73 as a potential therapeutic intervention in Parkinson’s disease.” I question "might accelerate"--is the Dr being super cautious in saying "might" ???? why not be more positive and say "will accelerate" just a bit concerned about him not being more positive !
likewise myself (will be pissed)
promises-hopes and dreams....where's the meat?? show me the money--I also dream about "winning the lottery"--how long does the dream go on ??????
Today's Conference in Boston--we gonna get anything of import at this event? The Dr. there to promote his co.? Any flies on the wall to let us know what the buzz is? Lots of questions-very few answers. The norm.
heavy volume today ---someone expecting positive reports from the conferences???
trying to stay confident here--wish the co. communicated with a bit more frequency--hope we get some "news" in the next week !
I'll settle for any kind of "new" news---38 wk data update--PK analysis--Rett--Parkinsens news---I think any positive "new" news would be sufficient to "move the needle" IMO !!! Throw us a bone please--not real fussy what kind of bone--just a bone !!!
methinks the Dr. will have some good positive things in his warchest ready to share!!
agree--and will hold for however long it takes for this to develop---developing drugs is a long slow process--and this is on the right track--patience !!!!
stock....look forward to this response--thanks
Ziggy...good stuff well said--thank you !!!!!!!!!!!
stockaesthetics...great post--appreciate your opinion--do stick around !!!!
The piano player,the painter,the golfer- regaining lost skills after taking 2-73----I'm still bewildered that these events weren't more in the public eye or more flaunted in the medical community as astonishing---were they not real?? were they some kind of hoax?? did these things really not happen ? were they just some kind of freak co-incidence??? puzzled why the co.(Avxl) didn't publicize this.
"This drug can’t get to market quick enough imo"---I'm sure the good DR. is doing his best to see that this happens--he is doing this right---doesn't want anything to go wrong !
tradeherpete....great response to my question and I concur 100%--I'm glad you mentioned the piano player and the artist--those reports on how they have regained lost skills after taking 2-73 seem not to be significant by most on this board.I think those reports are mind-boggleing especially emphasizing what Dr. MacFarlene discussed re: mood-quality of life-joy with being able to participate in life.Test scores on paper are one thing but how do you put a number on happiness-self-satisfaction-everyday mood improvement---PRICELESS---I truly believe Anavex is "quality merchandise" and hope one day all will recognize it as such. Thanks for shareing your experiences with your mom !!! Best of luck to you !
are you implying Anavex is "quality merchandise" ?
McMagyar--likewise myself (more jacked)--I'm not a medical guy with a whole lot of understanding of THE SCIENCE--yet recently I've been investigating the sigma 1 receptors area and WOW ! I really believe Anavex is in the center of this STORM re: MOA---this IS the real deal--all kinds of heavy medical info out there (google "sigma 1 receptors")--lots of info re: exactly what is in our pipeline--Alzheimer's-Parkinsens-Depression- Anxiety-Cancer-Retina-Epilepsy-etc.etc. I've been discouraged by the recent market action of our SP yet now I firmly realize we ARE on the right path---The Dr. is doing things right and these things do not happen overnite-they do take time--I do recall Dr.MacFarlane saying he was expecting ph 2/3 to commence in early '17---we just have to have patience and this Blockbuster will explode upward !
Lots going on that we are not aware of--the wheels are turning for our little dynamo--the "little engine that could" is on the way to the mountaintop--lots of irons in the fire----do stay onboard !!!!!!!!!!!!!
A great read from Michael J.Fox Foundation re:our grant:
Study Rationale:
In a previous MJFF-sponsored project, we evaluated PRE-084 (an experimental compound binding to the sigma-1 receptor) in pre-clinical models of Parkinson’s disease. Chronic treatment with PRE-084 produced a gradual improvement of motor deficits and activated molecules involved in brain repair. In this project, we will evaluate a sigma-1 receptor agonist (ANAVEX2-73) produced by Anavex, which is now being evaluated in patients with Alzheimer’s disease. In our experimental study, the efficacy of ANAVEX2-73 on Parkinson’s biology will be compared to that of PRE-084 and other Sig-1R ligands.
Hypothesis:
The overarching aims of the study are to find a dose of ANAVEX2-73 producing a pattern of neurorestorative effects comparable to that of PRE-084 and to translate this dose into an equivalent dose for human use.
Study Design:
We will test the biological activity of ANAVEX2-73 in pre-clinical models and compare to PRE-084, previously shown to promote recovery of forelimb use, up-regulation of trophic factors and anti-inflammatory effects in the brain in this model. We will assess target engagement by measuring the ability of the tested compounds to prevent a radioactive ligand from binding to brain sigma-1 receptors.
Impact on Diagnosis/Treatment of Parkinson’s Disease:
The present study holds potential to impact the way Parkinson’s disease is treated. We aim to develop a new pharmacological approach to boost repair mechanisms and dampen inflammation in the part of the brain that is most affected by Parkinson’s. If this treatment exerts the expected effects, it could slow the progression of the disease.
Next Steps for Development:
If successful, this study will accelerate the translation of pre-clinical findings into the first clinical trial of ANAVEX2-73 as a potential disease-modifying therapy for Parkinson’s disease. ANAVEX2-73 has already been tested for safety and tolerability in humans with positive results.
Hoping Missling will give a great pitch to listening welcome ears--we do have the goods--someone needs to be convinced !
Great read...thanks for posting...gives my confidence in the Science a boost
would be nice if they were interested in us !
I think it's taken way too long for things to develop here---did never imagine it would take this long !
agreed-to hell with the regulators--"we have this great Science that will benefit all these indications and we want the world to know about it"---why keep it hidden as they have been ?
basparks...glad to see we are on the same page re: the co.sprouting their wings a bit and letting the world know what they are all about--why all the hush hush secrecy? Are they ashamed of something?--they have such great,promising Science.Plant some seeds and get some positive publicity.You have to toot your own horn sometimes to get noticed.Nobody knows who we are--the co. needs to change this by communicating more effectively--sorry for rambling but getting very frustrated by the silence of the co. Shout it from the rooftops how great our science is !!!! The SP stuck here at $2.50 is a real shame!
I also e-mailed Dr.MacFarlane a couple of time awhile ago--he never did return an e-mail to me--I'm sure he has to be very careful what he discusses and with whom---hopefully you will get a response
the proof in "in the pudding"---the pudding is long over-due here---come'on good Dr. perform some magic !
don't consider myself a "whiner"--just have different expectations from management than you do--ever hear the expression "toot your own horn?"--sometimes management needs to "toot their own own"--let the investment community know what positive things are happening (when-if they are)