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Once again Phantom, Thanks for both your answers. CAR-T being approved makes sense. And the CD19 toxicity to healthy cells also makes complete sense.
in post 32208 I typed "WHY can we treat patients FIRST AND INSTEAD OF CAR-T???" , it was supposed to ask:
"WHY CAN'T we treat patients FIRST AND INSTEAD OF CAR-T???"
And here is a question I'm sure somebody can answer and I never thought to ask before, but, if our 6 antigens are PRAME, NY-ESO-1, Survivin, MAGE-A4, SSX2, WT1, why didn't marker just add CD19 to make it seven antigens?
Or back when we had our original 5 antigen mix (before WT1), why wasn't CD19 included to make that mix 6?
Sometimes, some things just make no sense to me, like the following:
"This contrasts strongly with the experience of CD-19 CAR-Ts, where up to 40% of patients are expected to relapse within 12 months of developing a complete response.”
OK, if 40% of CAR-T RELAPSE blah blah blah, then WHY are we limited to treating patients who have failed CAR-T?
WHY can we treat patients FIRST AND INSTEAD OF CAR-T???
WHY do they have to go through CAR-T first?
If we are better, then we are better, makes no freaking sense.
The repetition in the PR of things that WE ALL KNEW and that we all HAVE BEEN SAYING for years ........ such as "without the severe toxicities that commonly occur with other adoptive cell therapies, such as cytokine release syndrome or neurotoxicity." and "consistently drove an enhanced immunological response from the patient’s own immune system, which we believe was due to the lack of lymphodepletion which allowed the patient’s own immune system to play a part. We believe that this phenomenon, known as epitope spreading, was critical in driving more durable responses than have been observed with other cell therapies like TCRs and CAR-Ts." ..... is MEANINGLESS WORDS at this point as it is NOTHING NEW and have already been REPEATED MANY MANY TIMES.
WE NEED new data, not just repeated words and talking points.
The following from the PR ... " In addition, the FDA has cleared Marker to initiate its study at a dose level of 200 million cells per infusion, versus the dose range of 10-40 million cells per infusion used in the TACTAL study." ..... may be very good as it should results in much better outcomes and much more positive patient responses.
In the PR for the IND, it said: "who have failed or are ineligible to receive anti-CD19 CAR T cell treatment."
Is that wording new? I don't recall reading that before as a condition of a Marker IND?
Thanks for the info. I know it's just me talking into the wind but it would be nice if THEY would inform shareholders or ANSWER a simple email to IR.
so glad they reported AML data as planned.
Have not received an answer as of yet. Not really surprised. What's the point of paying for people in "investor relations"?
Marker building more confidence every day.
Figured I'd give a few days because of the Holiday. I just sent an email. Did you get any answer yet?
OK, so let's recap. MRKR was supposed to report AML trial data news by the end of JUNE.
Unless I am mistaken, it is JULY.
I would say something like "OH MY, what a suprise, I am shocked",
But I can't, seems to be par for the course, WHY that is I do not know.
Hopefully we hear something SOON.
I have GOTTAGET a whole bunch of money back just to break even.
weird price up with no news
Thank You Phantom. Well it's the end of Q2 and tomorrow is Friday, sooooooo we shall see.
If you can, whenever data does come out on active, just translate it into english.
I really don't want to wait a year for adjuvant but what I want or don't matters not.
Maybe they will offer some bits (of good news) sooner (I hope).
P.S. sorry this board went to hell, I kind of got over frustrated myself.
Waiting for AML news. I went back and read again the last press release and on the SAME subject, they said two DIFFERENT things???????
PR is dated May 13, 2022.
May being the 5th month is in the 2nd quarter. OK.
In one part of the MAY PR they say: "After completing enrollment of the first 20 patients in the Phase 2 AML trial last year, we anticipate reporting topline data from the active disease group in the main phase of the trial next quarter.”
OK, so, IF in May (the 2nd quarter) you say "next quarter", then "next" would mean the 3rd quarter.
BUT, then a bit later they say: "Enrollment of the first 20 patients of the main Phase 2 stage of the AML trial was completed in Q4 2021. Topline readout of Group 2 active disease is anticipated in Q2 2022."
SO, are we expecting AML trial data news in the 3rd quarter? or the 2nd quarter (which ends TODAY)?
WTF?
And in any case, this would be data for the "active" arm, which should by far be the least successful.
Does anyone know when we are supposed the get AML news from the "adjuvant" arm?
SELL SELL SELL it might be over $1 soon.
Nothing to be impressed or speechless about. Just look at your last post # 32138.
As of yet, nobody has put in a giant share sell order "at the market".
I've heard nothing but complaining about the share price for months, but it seems like nobody wants to just sell and ditch them "at the market".
big enough to have an open "good till cancel" BUY order for 500,000 shares, and that is still less than the value of just one of my Florida investment condo's.
I agree with everybody. This stock sucks. It will be worth ZERO pretty soon.
That is why all owners should enter a "market" order to sell all their shares.
I have an open "good till cancel" BUY order for 500,000 shares, but it seems like all the constant complainers just want to complain, but not sell.
As soon as they enter a "market" order to sell, they can stop constantly complaining.
and that is exactly why everybody who owns MRKR shares just just enter a "market" order to sell their shares.
My open "GTC" buy order will immediately take them out of their misery.
It is not so much the reverse split that is scary bad. It is the dilution that will really hurt investors. As I have said before, with a reverse split, (IN THEORY), the investor does not get hurt, in that they do not lose a single penny. Yes, in real life, most times, the price tends to drift down after the split, but the split itself is not bad and is done for a good reason, like to stay nasdaq listed. It also has the longer term benefit of IF, the stock later does do good, there are less shares on the market for the short sellers to short.
P.S. I still have my "good till cancel" open BUY order in. All anybody has to do is enter a "market" order to sell their shares and they will be sold instantaneously.
Any disgruntled MRKR owners who want to sell 50,000 or 100,000 shares or more.
I just entered a GTC open order to buy them.
All you have to do is enter the amount of shares that you want to sell, and enter it as a market order.
I will buy all that you want to sell, and then,
you can stop complaining about owning them.
Problem solved.
SELL NOW BEFORE THE DREADED REVERSE SPLIT.
SELL NOW BEFORE THE CATASTROPHIC DILUTION.
Gotta Get me some more shares ................................
after the reverse split and after the cash raise dilution,
THEN the share price should be at or near it's lowest.
GLTA
"There is nothing you or the management team can do without solid data."
Exactly, it would be nice if investors understood that.
Here is the best one:
On March 17, 2000 TPIV/MRKR stock price was a split adjusted $2,530,500.00 per share.
https://www.google.com/search?q=mrkr+stock+chart&ei=OAycYpG3KPbKwbkPv6CNsAk&oq=mrkr+stock+chart&gs_lcp=Cgdnd3Mtd2l6EAEYADIECAAQHjIFCAAQhgMyBQgAEIYDMgUIABCGAzoHCAAQRxCwAzoGCAAQHhAHOgcIABCxAxBDOgUIABCRAjoICAAQgAQQsQM6CggAEB4QCBAHEAo6BggAEB4QCEoECEEYAEoECEYYAFCCC1j9G2DfLmgBcAF4AIABeYgB5wWSAQM1LjOYAQCgAQHIAQTAAQE&sclient=gws-wiz
click on timaframe "MAX"
TGTX went from split adjusted $140,000 in 1997 to $4.40 current
CLSN went from split adjusted $120,000 in 2000 to $2.30 current
ONTX went from split adjusted $66,000 in 2013 to $1.44 current
AMRN went from split adjusted $1,400 in 1993 to $1.68 current
LXRX went from $330 to $1.80 current
SQNM went from $300 to 0
DNDN went from $56 to 0
ONCY went from $80 to $1 current
AVEO went from $200 to $4 current
ENZN went from $78 to 0.30 current
etc, etc, etc, etc, etc, etc, etc, etc, etc, etc, etc, etc, etc, etc, etc.
YES, HAPPENS ALL THE TIME. IT'S CALLED BIOTECH INVESTING.
IF TRIAL DATA IS NOT OVERWHELMINGLY POSITIVE ...
IT IS CONSIDERED NEGATIVE AND THE STOCK PRICE PLUMMETS
NO BIG SURPRISE
"From $13.50 four years ago to today's .28, a loss of 98%... why?"
Well, the most common sense, logical, realistic answer is ... because the FDA trials were NOT as successful as everybody hoped they would be ... and therefore, realistically, the market responded correspondingly negatively.
Not much of a surprise, that is how it generally works.
It is small cap biotech investing, that is how it goes, shall I list 100+ small cap biotech companies that have BOMBED BIG TIME after their trials failed?
"if BP'S did know (that the science is promising), guess where the price may be."
Absolutely correct ... and do you know how and WHEN Big Pharma KNOWS "that the science is promising"?
Well, the most common sense, logical, realistic answer is ... when MRKR HAS successful FDA trials that proves it to them and everybody else.
Not much of a surprise, that is how it generally works.
Thank You for posting the article about the CAR-T patient.
That article is EXACTLY why we held out so much hope for MRKR's Multi-TAA therapy. And also why we NEED MRKR's Multi-TAA to become successful.
Not so much "WE" the investors, but we, those patients who need it so much.
CAR-T, for all it's promises, has many flaws.
The main flaw, as expressed in the article, is that in order to get to the "CAR" part of it, the Chimeric Antigen Receptor part, the T cells HAVE TO BE genetically engineered.
Not easy, not quick, most hospitals have no means to do so, very expensive, and with many different genetically engineered therapies, whether CAR or RNAI or MRNA or CRISPR, many times the human body does not react well to genetically engineered products and the result is negative side effects that CAN and HAS killed patients, like cytokine release syndrome.
That is one of the MAJOR benefits of MRKR's Multi-TAA , it is NOT genetically engineered, can be done in days, at a MUCH LOWER cost, with NO cytokine release syndrome.
WE, the world, really needs a NOT genetically engineered therapy/potential cure.
For how many decades now have we tried "linker" technology, or "TIL" technology, or "kinase" technology, or "checkpoint" technology.
And YES, we have tried an "off the shelf" CAR-T product.
A CAR-T product that is NOT derived from the sick patients blood, but already made from random generic T cells.
Many years ago a French Company, Cellectis (CLLS) tried it and did not have much success that I could find.
ALSO, if you don't mind, may I please address the "dilutes their investors into oblivion" comment.
IF, in real life a company needs additional cash like Marker does, they have two choices.
#1, Do NOTHING, and therefore go out of business when cash runs out, and then everybody has NOTHING, ZERO.
#2, Dilute investors to raise cash so that they can continue operations and hopefully succeed in the future.
What would you prefer?
There is no magic solution, two options, option #1 of Do Nothing DOES lead to oblivion.
At least option #2 of Dilute holds out hope.
MRKR - Marker Therapeutics
PPHM - Peregrine Pharmaceuticals became CDMO - Avid Bioservices
BOTH TWO GIANT LOSSES FOR ME
OH WOE IS ME
VRTX - Vertex Pharmaceuticals
SGEN - Seattle Genetics became Seagen
EXEL - Exelixis
ALNY - Alnylam Pharmaceuticals
ARWR - Arrowhead Pharmaceuticals
MRTX - MethylGene became Mirati Therapeutics
AVXL - Anavex Life Sciences
PCYC - Pharmacyclics bought by AbbVie
CBST - Cubist bought by Merck
TRIL - Trillium bought by Pfizer
ALL WERE TINY MICROCAP BIOTECH of mine that did very very well for me.
MANY WERE the "penny players" that are supposed to be the scam stocks.
Thank God all of the Florida investment condo's they paid for didn't know they "HAD NO CHANCE TO MAKE IT" as they were all "SCAMS".
sad but true.
Howdy hanscott, Unfortunately it seems like this board has become ... I made a bad investment, as millions of other people do every single day ... but let me blame everybody else except the one person who was responsible for the decision ... let me point out a hundred reasons so that I can absolve myself from my own decision.
It is funny because I had the exact same response as you did, not only to the reply I got but also from a new post.
The reply, instead of addressing issues with facts, was just more empty meaningless words with no substance.
On the path to learning, it appears that some have not quite made it around the curve as of yet.
The new post, I can understand the frustration because I know they have A TON of money invested.
QUOTE: "I can safely say, that if there were honest IR communication, most would have sold put their position long ago."
It is not like we just woke up and realized this. Same person has said this A TON of times for years, but DID NOT SELL, if fact kept buying more.
SIX Years ago said:
"I have become very disappointed with the companies transparency and a lack of effective communication to shareholders and the public comparing these past six months with the previous six or more months. They have failed me as an investor.
I realize that my 24,000 shares has become not only " dead money ", but eroding investment capital."
But kept BUYING MORE for years. Who's fault is that? the companies? or the buyer?
OK, blame someone else ... it's management, it's Peter's fault.
But yet same person said four years ago:
"Peter is a gifted person and we are fortunate to have his leadership and experience.
I am a emotionally controlled person,but am excited beyond norms."
And yes you are correct that "many at MRKR have millions of $$$ invested themselves."
That matters not ... BAD PEOPLE!!!
OK, blame someone else ... it's the boosters fault, all those people like Phantom who kept telling us they believed.
Like Phantom FORCED anybody to buy anything.
But the same person said:
"At this successful stage of development and results, I suggest the share value should rise close to $40 based on the above and insignificant number of shares."
They have ALSO been a boosters all along, when they said $40 a share, when they said $50 a share, when they said a market cap of 2 billion, when they said a market cap of 3 billion.
No, but it's Phantom's fault, blame him .... and by the way (yes I had the same reaction as you did) ... because I am not a mind reader, I can state unequivocally why Phantom no longer posts.
I will finish with another quote from the same poster:
"To just " wallow" on any message board, is non productive, rather, just " pot stirring ".
I would suggest they take their own advice.
more on KRAS G12D.
One year ago: "FDA Approval of KRAS Inhibitor Sotorasib for Lung Cancer Hailed as Milestone"
https://www.cancer.gov/news-events/cancer-currents-blog/2021/fda-sotorasib-lung-cancer-kras
https://www.mdanderson.org/cancerwise/targeting-the-kras-mutation-for-more-effective-cancer-treatment.h00-159458478.html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126715/
Article states that this treatment is New and Historic.
It sounds like CAR-T targeting mutation, or Multi TAA targeting mutation as opposed to antigen, I don't believe targeting a specific mutation is anything new.
Article says T cells were reprogrammed to target a specific mutation of her cancer cells. Did not mention HOW.
The New England Journal of Medicine says T cells that had been genetically engineered to clonally express two allogeneic HLA-C*08:02–restricted T-cell receptors (TCRs) targeting mutant KRAS G12D expressed by the tumors.
https://www.msn.com/en-us/health/medical/portland-doctors-first-in-world-to-apply-new-cancer-therapy-resulting-in-tumor-reduction/ar-AAXYQmq?ocid=msedgdhp&pc=U531&cvid=ce885dae2a3847e285386f5d937b69be
HERE you can find 7 current clinical trials for KRAS G12D
https://ichgcp.net/clinical-trials-registry/research/list?term=KRAS%20G12D
ALSO see: https://www.mycancergenome.org/content/alteration/kras-g12d/
Let us continue with the lesson in logic and reason.
If your point was TRUE that "99% of publicly traded biotech isn't just a way to offload BP's cost for research" when "they never really had a chance."
Then that MUST mean that you are smarter than and more successful than multibillion dollars investors that have for decades invested in publicly traded biotech.
They must all be idiots for investing in publicly traded biotech because according to you, "99% of publicly traded biotech isn't just a way to offload BP's cost for research" when "they never really had a chance."
Baker Brothers
NEA
Vanguard
T Rowe Price
Blackrock
Renaissance
State Street
Bank of America
should I continue to list the hundreds of companies that you imply must be idiots for investing in publicly traded biotech because according to you, "99% of publicly traded biotech isn't just a way to offload BP's cost for research" when "they never really had a chance."
And herein lies the problem of easily said but empty words.
YOU SAID: "How do you know that 99% of publicly traded biotech isn't just a way to offload BP's cost for research?"
I KNOW that because I have a functioning brain and therefore I understand that when you generalize "99%" of anything into one group it is most likely not going to be accurate.
OK, How do you KNOW that what you said is TRUE?
PROVE to me and all on this board that 99% of public biotech companies are just being used to fund the research cost for big pharma at the expense of small investors.
That is what you are implying. How do you KNOW that? Back up to all of us and prove your words. Or are they just empty words with absolutely NOTHING of any meaning or importance to back them up?
They are just empty meaningless words solely for the sake of being negative.
YOU SAID: "Perhaps handsomely paid biotech executives are all in on the game of research for researches sake, paid for by naive retail where they never really had a chance."
That statement at least may be TRUE, in a small part, but the FOOLISH use of the word "ALL" in your statement again gets us back to empty meaningless words.
I will explain so that maybe you can understand logic and reason.
YES, there may be a SMALL percentage of biotech executives who are in it for "the game of research for researches sake" because they just want to do research or because they just want a paycheck or because they want to make a name for themselves or because they want to win the Nobel prize or for whatever reason ..., when they KNOW they have no chance of succeeding as you imply.
BUT to say "ALL" again is just asinine.
SO AGAIN, PROVE your empty words.
PROVE that NOT A SINGLE biotech executive is in it for a good cause, to try to save and cure patients.
PROVE that they are ALL in it just for the money.
AGAIN just negative nonsense for the sole purpose of being negative.
AGAIN just EMPTY MEANINGLESS WORDS just to spout something negative.
It is NOT that I have "some pretty low standards" for the company management, I just have REALISTIC standards because I understand they can only work with what they have to work with.
I am sure they all WISH the trial data was further along and was Much better, but again, in real life, they do not have a magic wand to wave to make it that way.
PLEASE tell me what YOU would have done differently with the trials that they have going on, that would have the share price so much higher than it is right now, which is based on what every other stock price is based on and that is what the market thinks it is currently worth.
PLEASE give us all your list of brilliant ideas that you would have executed differently and then tells us why you believe they would have resulted in a much higher stock price.
I believe most of the frustration investors are showing is, in reality, frustration with themselves for the bad investment that they made (as of now).
If a complainer really wants to be objective about management, then management is doing EXACTLY what they are supposed to do, which is the best they can with what they have to work with.
It is NOT the management's fault that the trial data has not been as positive as possible, they cannot wave a magic wand and make it better so the share price would be higher so investors can feel better about themselves.
They can whine and complain that management gets paid a decent salary and gets stock options ... but welcome to the real world of business.
Yes, they might have to do a reverse split, welcome to the real world of business and investing.
Yes, they might have to raise more cash that would be dilutive, welcome to the real world of business and investing.
They might wind up either going bankrupt or curing cancer, welcome to the real world.
Investing involves risk, those who come here week after week after week to just complain and whine and lament and blame others, should either understand and accept the risk of investing or just simply not invest in anything that involves any risk.
maybe me, you and a few others, I know gottagit has about 4 times more $'s invested than I do.
This is all setting up great:
First, do a reverse split, after which THAT stock price will continue to slowly drift downward.
Second, do a dilution offering at an even LOWER price, which will, of course cause the stock price to go down even further.
Third, invest another 150K to double my investment, RIGHT BEFORE they announce great trial data for adjuvant AML and Pancreatic.
Fourth, ............
FINANCIAL RESULTS about what was expected, nothing great but no surprise.
I don't expect anything GREAT from the Active arm data in 2Q/22.
Would like to know when Adjuvant arm data will be released. At least there, there might be some great news.
But after the last couple years, I'm not holding my breath.
You would think that if there was any kind of insider belief at all, they would be buying hand over fist at these levels ............ BUT NOOOOOOOOOOOO??????????