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Dopamine Receptor Antagonists, Radiation, and Cholesterol Biosynthesis in Mouse Models of Glioblastoma
Liau, Cloughesy, Nathanson, et al.
09-Feb-2021
"Our results indicate promising therapeutic efficacy with the triple combination of quetiapine, atorvastatin and radiation treatment against glioblastoma without increasing the toxicity of radiation. With both drugs readily available for clinical use our study could be rapidly translated into a clinical trial."
https://academic.oup.com/jnci/advance-article-abstract/doi/10.1093/jnci/djab018/6129263
Is this possibly related to the IDH mutation status data gathering that delayed data lock?
"Testing was performed on glioma samples as part of clinical care and analyzed up to 395 cancer-associated genes (including IDH1/2). Whole arm 1p19q codeletion status was predicted from the same assay using a custom research-use only algorithm, which was validated using 463 glioma samples with available FISH data. For 519 patients with available outcomes data, progression-free and overall survival were assessed based on whole arm 1p19q codeletion status derived from sequencing data."
https://academic.oup.com/noa/advance-article/doi/10.1093/noajnl/vdab017/6128601?login=true
Why would NWBO buy Flashworks and build Swaston just to rip off some retail investors? They wouldn't.
Why would UCLA use a drug that doesn't work? They wouldn't.
Why would Dr. LL ruin her reputation in order to make NWBO management earn paychecks for an extra few months or so? She wouldn't.
Again, TLD announcement day is 2/8.
Or 2/16. We'll see.
"Considering February 1, 2021 is tomorrow, I’d say you’re 100% correct :)"
Thanks. That makes me 1-for-1 in '21.
My lucky number is still 20,221, more recognizable as 020221.
I don't think we'll get TLD before February 2021.
NeWBrO -
"Hoping NWBO can participate / leverage awareness on this upcoming holiday ..."
Thinking 02/02/21 is as good a day as any to begin unveiling protocol 020221.
c
AE Kusterer,
Can you tell us who Joe Pratt is please?
ccie1024
Options that became exercisable on 06/13/2017, if I am reading that correctly. If so, anyone care to speculate if that was due to reaching a milestone and, if so, which one?
Edit: Disregard, 50% were immediately exercisable when granted and the other 50% over 24 months...
"...we will have to pay federal + state tax..."
For capital gains in taxable (non-qualified) accounts, the federal long-term capital gains tax(for a stock held over a year) in 2020 is 0.00% for married taxpayers filing jointly with Taxable Incomes under $80,000.00.
Preclinical advances in pediatric GBM
Congress of Neurological Surgeons
Merck's Disappointing 2020
"The spinoff will heighten Merck’s reliance on Keytruda, which grew sales 21% in the September quarter and accounted for 30% of the company’s revenue."
"Merck has said it would use its ample cash to build its oncology franchise by joining with firms like Seagen (SGEN) on drug-antibody combinations, and Moderna for messenger-RNA cancer therapies. It will also bring in oncology products through “bolt-on” acquisitions like the purchase of ArQule at the start of 2020.
Vaccines will remain a big business for Merck..."
https://www.barrons.com/articles/merck-had-a-disappointing-2020-why-its-strategy-could-pay-off-in-2021-51609347863
Hansm7777 -
It is in our best interests to follow the 5-year rule as failure to do so means you'll pay both income taxes and a 10% penalty on withdrawn earnings.
re: Roth a c c o u n t s.
As someone with a "traditional" pre-tax 401K, a Roth 401K, and a Roth IRA, and planning for what-ifs in 2020... er, 2021, I'd like to add to the conversation that for those between the ages of 55 and 59.5, a "traditional" 401K may offer an advantage in the scenario of early retirement. The "Rule of 55" permits one to withdraw from a 401K left at a former employer, without penalty. Taxes are still due since they were not paid at the time of funding.
When I look at my Roth IRA, I have penalty-free access to the contributions only before the age of 59.5.
Of course, consult a tax advisor (I am not) and/or consider any dissenting views you might see in reply to this post...
:)
I've been singing this song in my head today for some reason smile
Thanks ATL. Nice to get caught up on what Dr. Bosch is up to over there...
:)
Is it possible the changes at SNO for LTBK-02 is just a formatting change? If I recall correctly, there was a LTBK-01 - what does it look like today?
I cannot find it, which leads me to wonder if it's more website formatting changes than it is content-related.
annnddd.. BSB bought 110,000 shares approximately last week...
NWBio operates on the metric calendar and clock.
I just spoke with DI. He confirmed that TLD would be releases on September 37th
Why would anyone pay for DDAmanda?
CT1 - Working link to Dr. Siegel on Fox
Could our own bodies hold the key to the curing cancer?
Instead of providing a 9/12 update on what they have not done, how about something like this to give us something new to chew on for a couple of weeks?
"While the company remains blinded as we continue to work toward announcing trial results, I wanted to provide this update on the blinded results that we put together…
… regarding our long tail, here is a 2020 update on the KM-derived mOS figures for the top 100 in our 2020 look compared to the 2017 and 2018 interim results…
…to the 2017 and 2018 survival milestones for the entire intent to treat population we’ve not only added the 2020 figures, but we’ve also expanded the analysis to include 4-year and 5-year milestones...
The 2017 and 2018 results were previously reported at the SNO conference in 2018 by Principal Investigator Dr. Linda Liau, and we are pleased that Dr. Liau will again be presenting on this trial at the SNO conference in two months..."
re: SNO is Virtual
As public health safety concerns related to COVID-19 continue, the SNO leadership has concluded that the 2020 SNO Annual Meeting scheduled for November in Austin, Texas, cannot occur in person as planned.
dangit. I was hoping for a new conspiracy.
But, alas, facts are facts.
Thanks 'oldsocks.
This Chart
I usually pay no attention to these, but found this very odd..
* Posted by 'Gucci
* Timestamped 4:57a Thu
* (that's before market opened)
* msg 304025 falls in the sequence of messages posted at that time
* cannot be edited after 15 minutes
* Shows a high of .671 for the day, before the first share traded
* Shows a low of .531 for the day, before the first share traded
* Shows a low of .549 for the day, before the first share traded
* Shows a volume bar in the 15mm range, before the first share traded
What am I missing???
Gonna diss me? Bring it.
We also know the top 100 responding patients in the vaccine trial are cancer free at 5 years or greater.
One example: Details on something that starts with an "S" and ends with an "n". :)
Timeline just got more definite.
From the 10Q filed 08-10-2020:
trial results will be ready for reporting approximately sometime after Labor Day in the month of September. The Company will be consulting with its Principal Investigator and experts on the appropriate venue and manner of presenting the Trial results.
The Company currently continues to anticipate reporting topline trial data in September.
Today marks 36 months since first purchase. Numerous purchases have followed, and while I'm not all-in to the extent some seem to be, the balance in "cautiously optimistic" is less on the cautious side. I've broken my own rule of not investing more than 5% in risky investments. Regardless, I am 100% to plan at retiring in 6 years at 62.
I "anticipate" a "soft early retirement" as early as "approximately" 1/1/2021 after a "multi-month process", with "hard retirement" to follow. I'd be ecstatic to see "soft early retirement" on 7/13/2020, but I know that ain't gonna happen.
Perhaps it happens somewhere between now and 2026. Whether tomorrow or 6 years from tomorrow, I'll be content with having taken a calculated gamble.
Don't get caught up in the negativity. Decide what's important to you. Then embrace it. Literally or figuratively. But positively.
Today is July 12, 2020
And I've always believed luck has little to do with it, so best wishes. To all.
"Shouldn’t it be possible to... find the details of... milestones..."
A good point. I had started that today but there's more involved than I currently have the time for.
From the 03-02-18 8K:
The unvested portions of the Options are subject to full accelerated vesting upon any of the following events or milestones (i) a change of effective control of the Company, (ii) the filing of an application for any type of product approval in any jurisdiction, (iii) completion of any randomized clinical trial that meets its endpoint(s) (Phase II or Phase III), (iv) decision by the Board, in its discretion or (v) the death of the recipient.
The unvested portions of the Options are subject to partial accelerated vesting upon any of the following events or milestones (i) publication of a peer reviewed manuscript, (ii) initiation of a new Phase II trial, (iii) new orphan drug designation for any product in any jurisdiction or (iv) breakthrough status or equivalent designation for any product in any jurisdiction.
tryn2, please tell us you raised some funds to keep your lights on in June.
and a bit extra, for emergencies...
I've often wondered if the CFO/CIO move was a reluctant hire to get the SEC off their backs for a while. That's a lot of C-level positions for a company of less than 20 employees.
Now they can buy still more time with the SEC in a CFO search, which could be a multi-month process.
And they can tell the SEC all about what their Certified Sarbanes-Oxley Expert is doing with SOX Section 404 compliance.
06-08 8K
Jean Davis, who has been serving as Northwest Biotherapeutics, Inc.’s (the “Company”) Chief Financial Officer (“CFO”), Chief Accounting Officer (“CAO”), as well as the interim Chief Information Officer (“CIO”), has been appointed the CIO and is relinquishing her duties as CFO and CAO effective immediately, to focus on CIO duties and special projects such as the design of Sarbanes-Oxley controls. Linda Powers will resume acting as CFO and CAO, with accounting and financial reporting functions performed by an external firm and the Company’s Controller as has been the case historically, until a new CFO is hired.
https://www.facebook.com/Braintumor/videos/10158489085074485/
Also, in the comments:
Our daughter was diagnosed with GBM a month after her 21st birthday 8 years ago. She had another stable scan 2 weeks ago. We know how lucky and blessed we are. She completed the DC-Vax clinical trial after surgery, RT and Temodar.
Quarantine Game 4... Guess the closing pps on 4/17 & on 4/20.
Voting on Scott Gottlieb for a NWBO Board member.
Conspicuously quiet on twitter: Bigger, Rago.
Novocure bringing more public awareness of GBM today on CNBC:
https://www.cnbc.com/video/2020/01/07/how-novocures-electric-fields-cancer-therapy-works.html
Quality of Life is important...