Adam is irrelevant to NWBO's future... which is why LP ignores him.

That is my take too.

Here's the exact wording from the email (Bold/red emphasis added for emphasis):

Yes. We don't know when approval will come... but LP, via her actions, is sure approval will occur, imo.

Trocprofit,

We just learned from this morning's PR that "An automated system for the fill and finish of DCVax-L product has also been delivered, installed, validated and qualified". The email stated,

NO ONE was expecting full automation coming out of the gate. This automation adds infinite scalability to the manufacturing of the most successful brain cancer treatment, for which there will be a tremendous demand on day one. Furthermore, it positions NWBO now for DCVax-L's inevitable expansion to SOC. Just imagine, NWBO will be able to scale up to what ever levels necessary almost effortlessly.

You see this as "cart-before-the-horse spending". You, therefore, must believe LP would use non-existent resources to purchase land, build manufacturing facilities, purchase a company and develop, test and implement automation procedures, work with RAs in other countries and not KNOW DCVax-L would be approved--- though she has TLD in her hands!!!!

Does this make any sense to you?

Linda Powers, with TLD in her hands, KNOWS DCVax-L will be approved-- imo. But, what do I know.

Sorry Gus, I have no idea. I'm too excited about the following para from the PR release this morning:

An automated system for the fill and finish of DCVax-L product has also been delivered, installed, validated and qualified. “Fill and finish” is the final step of the process, after a batch of DCVax-L product has been manufactured, in which the batch is allocated into single doses in individual vials for cryopreservation and distribution.

Just received this email. Does this sound like the imminent failure of the DCVax-L trial? LMAO!

Dear William,

We are pleased to send you our most recent release regarding further progress made at our Sawston, UK facility. Northwest Biotherapeutics has announced that an application for a manufacturing license for commercial manufacturing of cellular therapies (after the therapies receive regulatory approval) has been submitted to the regulatory authorities. This manufacturing license is separate from any application for approval of DCVax-L itself.


Best,


Dave Innes
VP, Investor Relations
Northwest Bio?therapeutics, Inc.

Oh, boy. I didn't think about that. I'll do better next time. Don't want to give anyone a heart attack. GLTU

God damn it, NWBO trial was a failure, right? LMAO!

Northwest Biotherapeutics Announces Filing of Application for License for Commercial Manufacturing at Sawston, UK Facility

Press Release | 07/06/2022

https://www.otcmarkets.com/stock/NWBO/news?id=363861

I can definitely see that.

AF will still attack NWBO AFTER even after the journal article. Look at AMRN. He will have no impact after the journal article.

https://www.mdpi.com/1422-0067/23/13/7325

Exactly...

I hold a different point of view.

Though I understand and respect yours, nothing/no one can convince me that updating the trial data/endpoints was an oversight, that somehow this ivy-league trained lawyer-- who taught medical product development and commercialization (and-- I think, if memory serves me correctly-- merger and acquisitions at some point too) for more than six years at the National Institutes of Health and at Georgetown Law School as an adjunct professor-- forgot to update the data given all the bullshit her enemies have done to thwart her efforts. That conclusion would, imo, be untenable.

More than everyone on this board, combined, LP has a vested interest to succeed. She isn't incompetent nor does she lack knowledge of what she is doing. The likely "problem" (from some investor's pov) is DCVax-L is changing the treatment of all cancers. Powerful entities could lose huge fortunes while some could gain fortunes. Some are likely jockeying for position. Others are wreaking havoc to thwart or slow down the inevitable. LP is majoring on the majors, sort of speak, dealing with issues that can derail her main objectives... not the day-to-day stock swing bullshit.

Some of us may be uncomfortable with the silence. But you can bet your sweet @zz, LP is not silent behind the scenes... but what do I know?

https://nwbio.com/company-management/#:~:text=Linda%20F.,Powers&text=Powers%20has%20served%20as%20the,therapies%2C%20from%202001%20to%202010.

Incorrect! These people would have attacked NWBO no matter what. If they didn't have a reason, they would have made one up. Remember Phase5? Came out of nowhere dropped a damning report and a few months later disappeared to never be seen again. Had NWBO updated the clincialtrial.gov website they would have said NWBO changed the data endpoints after-the-fact and added some additional bs.

These people will hit NWBO with everything they have until they can't-- journal article. But enough data is out (to the extent that we KNOW DCVAX-L works) that we, imo, should be more at ease than ever before with our investment in NWBO. Yet, based on posts, many are not. Go figure.

NWBO won, period. NO OTHER TREATMENT PRODUCED THESE RESULTS IN THE LAST DECADE OR TWO (ALMOST THREE) for GBM!

The complete success of NWBO is not absolutely guaranteed, but as of May 10th (based on the data) the risk is very, very low compared to what it was in any period in the past.

Approval/commercialization is, imo, a formality.

That is THE billion $$$ question. She isn't incompetent and damn sure isn't stupid. There are only a few explanations now that we KNOW DCVAX-L works, imo.

Exactly...

Lmao.....

Hear! Hear!

great question...

Thx for the reply.

I have heard that some hedge funds short a stock without closing the position but use the position for collateral, enabling them to free up the cash for additional investment/leverage avoiding taxes (that come with closing out the position).

Have absolutely no idea if this is true or not but it would be nice if there were a shit load of short positions on NWBO prior to the expected run-up.

Wishful thinking, I know...

Fireman (or anyone else who has an opinion),
Is it your position that these shorts hold recent positions when the stock ran up last month (5/10) or do you think shorts are still holding positions from years ago when NWBO's pps was $12?

Just curious...

Hear! Hear!

https://insiderfinancial.com/feuersteins-flab-on-northwest-bio-nwbo-dives-stock-on-meritless-claims-after-nailing-primary-endpoint/183278/

ByChris Sandburg
Posted on June 12 2022

AF and those of his ilk create fig leaves out of thin air. We know they have been doing it for damn near a decade. Yes, the trial data should have been updated but that wouldn't have stopped AF. They would have just yelled about the change in endpoints being an LP slight-of-hand trick or some other bs (I am sure they have a list).

LP shouldn't be chasing AF's bullshit like a wac-a-mole game or focusing on him at all. When the data peer review is shared, he will be known as the fool he is. The TLD data proves we've won already. LP needs to focus on manufacturing/automation, partnering, approval and perhaps other critical objectives.

Maybe that "some reason" has to do with his humanity. He has enough to do that and invest with NWBO. Perhaps now that trial info is out, it may be possible for him and others like him to invest.

Hear! Hear!

Hear! Hear!

Now you know: . size doesn't matter!

Twitter/NWBO post of the day (courtesy of The Danish Dude)!

$NWBO

No matter how hard, how long and how insistent mean creatures hammers at NWBO, I can assure you Linda Powers will be last (wo)man standing.

You have the opportunity of a lifetime in front of you.

Results are known.

Fear keeps you from grasping it.

Snap out of it. pic.twitter.com/fojm92ZIda

— 🇩🇰 The Danish Dude 🇩🇰 (@FlemmingBruce) June 1, 2022

The Presentation title/description doesn't look like it will include phase3 trial info. Are we getting ahead of ourselves... again? No clarifying/detail info will come out BEFORE the journal article. The presentation will likely be a general discussion to rehash exactly what was discussed previously, imo.

That's crazy but way more often than not it is true!!!!

Exactly.

Hear! Hear!

Thx. Exwannabe.

OK, I see... on the summary or landing page of the portal, the status does say "Non-Final Action". But when you click on the "Image File Wrapper" it says "Non-Final Rejection". Here one can read the details as to why claims were rejected. The details are too far over my head but I did notice some of the rejected claims "would be allowable if...".

If you look at the transaction history of any patent application, this back-in-forth takes place for a while. I think, NWBO is close to finishing up this applications but it may take a bit longer.

I agree those news channels report mostly bs. No doubt politically/socially, lying has become mainstream where even "the righteous" are leading the way toward, if not directly bringing about, serious societal decay. Facts don't seem to matter anymore.

But lying about a GBM trial with unprecedented results, purporting that the trial failed, when facts directly and completely prove the very opposite, I think, is different and beyond the pale. I just don't think AF will get away with it much longer. The stakes in terms of human life, and amount of $$$ (to be lost and to be made) are too high to let it go. Furthermore, the legal risk of AF and media who prints these lies may be too, too high for the bs to continue (though, I am not an attorney). For the first time, the indisputable full facts regarding the p3 DCVax-L trial are available to fight AF's bs. Perhaps my optimism is misplaced.

I do believe AF should have been dealt with but with everything else on management's plate, did AF rise to a top priority compared to other issues NWBO management has been dealing with at the time? Because I am not privy to that answer, I am not comfortable saying management is incompetent and choose to defer to management. We may find that given the bs management has been dealing with in bring a disruptive product to market, LP far, far, far from incompetent.

But what do I know?

Don't know if this Combo-patent (14/533879) update has been posted.

https://portal.uspto.gov/pair/PublicPair (enter 14/533879)

On 5/11/2022 a non-final rejection was issued/documented. It appears that combo-patent saga continues… Although, I think NWBO will prevail as a number of the new rejected claims “would be allowable if…”, I admit these patent arguments are way above my pay grade.

Curious in what others think.

From SMITHonSTOCKS:

https://smithonstocks.com/northwest-biotherapeutics-debunking-silly-fictitious-adam-feuerstein-article-falsely-claiming-phase-3-trial-of-dcvax-l-in-glioblastoma-multiforme-was-a-failure/