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I find these numbers hard to believe. Out of 15 billion only 500 million was spent on dogs. Did u mean 1 billion not 15 billion?
100 million for the start of phase 1 WOW, lol. Sure hope your are right
Blue, how much of a milestone payment are you expecting from Amgen? 10 million or 100 million?
If you're referring to the AZN trial then yes I believe we are still collaborating. Advaxis has made no public statement that it has ended but going off the latest presentations/webcast it seems that AZN is an afterthought and Dan did publicly state that they think BMY is a stronger fit. So time will tell!!
No they haven't!! Clinical trials. gov still has it recruiting but hasn't been updated since January 2017 so that doesn't help but bringing Bristol Meyers in this late and going straight into a phase 3 has to make you think that
1. Either AZN decided to walk away from its right for first refusal
2. One of the parties did not like the combo data to date
3. Advaxis stated that BMY was a stronger fit(but then why are we paying)
4. If they already had patients enrolled(which we know they did) I don't think they can just stop the trial at this point. They can stop recruiting new patients but don't think they can stop treating enrolled patients!
Anybody else have any theories of what might be going on?
First we don't even know if there is or will be a EU partner so there is your first NO. Next we can only assume and hope that there is a milestone payment for start of NEO phase 1. You speak of the ongoing phase 3 that is being partially paid for by some of our partners but we have agreed to start another phase3 with BMY that we are responsible for and PETX revenues will be small if/whenever they happen
This is what I'm talking about!!! Now we have a cure for cancer!!!! What else people?
When they state they have enough cash until a certain date that also comes with fine print stating as long as nothing changes which we all know that spending is going to increase as of now
My goal for ADXS was always $70 but I'm getting tired/worried of waiting. So $40 to $50 would still make me happy. I would not be happy with $20 to $25 like some are saying but I guess it's better than failure and still profits in my pocket
Ok thanks
Short interest, did these numbers just come out? 10.2 mil
Well we are just about there if not already but everyone keeps forgetting that our expenses are going to increase in the near future with more trials slated to start. I'm not sure where Dan thought all this money was coming from when they agreed to pay for an additional phase 3 study.
Look how fast Anthony Lambardo was brought in right after the shareholders meeting. They have been planning on removing Dan since April!!!!
Lol, let me respond for her. Everything is on track and moving forward. We will also continue to make shareholder value one of our top goals. Blah blah blah blah
$20 to $25 BO you've got to be kidding me. Anything less then $40 is just unacceptable!!
If I had to guess Dan was already on his way out after the votes were in. I don't think the 4 BOD members were happy with the against votes they received. While Dan received so many for votes. I would guess David S. chairman of the board wasn't going to wait until next years vote. Where he was the one being forced out!!!
Dr. David Sidransky 12,324,390 6,540,383 14,532,686
Sorry, just starting to worry a little bit. A lot of years vested here and I would hate to see it all wasted on poor deal making after all this time.
You definitely are special but no you don't know anymore insight then I do. That's the point!!!! Most of that money could be a ways down the road.
Lol, ok so when do these several payments starting . My guess is you won't see a large amount of this money until much later in development. Which could be years
Let's try this again!!! When will we receive our first milestone payment, how much will it be and for what?
Wow thanks for reminding me of that. Now tell me what the milestone payments look like going forward. Since you seem to know
Blue, I hope your right but a couple million won't make much of a dent. When you have all these other trials slated to start and one being a very large phase 3. How much are we burning right now per quarter $20 million+ that could increase to 30 million. I can only hope a deal is near with a nice upfront payment
I hope so because with the start of another phase 3 and I believe a phase 2. Cash burn will increase. Did you read how Aduro received a 2 million milestone payment for completion of IND. what did we get from Amgen? Nothing Dan rewarded himself with shares. So I at least hope if we start the NEO phase 1 by year end we receive a 5 million milestone payment
The thought of an offering at these levels makes me want to throw up but don't think it can't happen. We are burning a lot of cash now and that is only going to increase by year end. We are going to need money!!!!!!
It also takes MONEY!!!!
Who said anything about news this week?
Yes! Actually 3 days I think but that doesn't mean Dan didn't mess up a potential deal before being shown the door. Which could have set us back. Nothing to do but sit and wait some more
Try me! Let me hear what you got
Lol, we can all dream! Would still love to know why our great CEO just up and left us. Now we all have to sit here with our fingers crossed hoping everything is ok.
$70 a share would definitely work for me! Dan made sure he had plenty of shares before he was shown the door this time
James Salmon, you must be heartbroken.
I had read a while back that Merck had about 70 combo trials going but I didn't think it was as high as 250
From an article today.
"Meanwhile, Keytruda is also being studied for more than 30 types of cancer in 500 trials. Almost 50% of these trials are in combination with other cancer drugs."
This should give you an idea of how many studies BP companies are running and how many shots on goal it gives them. So great! We got a deal with BMY but we will be paying most of the bill for a phase 3 never the less and everyone wonders why our pps got hammered.
Wow that is encouraging news but thanks for the info. Learned something new!
Yes the the deal with GBP seems to be ongoing and I believe part of the deal with them was they would pay for up to 150 patients for our ongoing phase3 trial in cervical cancer. So I would assume that is what the payment is for. On another note they were also going to start a trial for Small Cell Lung Cancer which hasn't happened but probably for the best.
lol that's great! Someone actually says it like it is, thank you and by the way Dan will be in the office until 10 tonight and go to church 3 times on Sunday
I sure hope we are not waiting another year. I've said it before 2017 should be the do or die year. There should be plenty of data read outs by the end of this year and new trials starting to tell us if we are going to make it or not.
I was the first to bring up that Astra seemed to be a second thought at the conference but they definitely didn't dump Advaxis and I don't think Advaxis dumped Astra but I do believe BMY has the stronger PD1. Not to mention that I believe it was Bristol who won a patent dispute with Merck and Merck I believe has to pay a portion of their profits going forward to Bristol. So which PD1 would you want in your corner. If we can jump right to phase 3 then I'm ok with the decision. Otherwise it feels like we have wasted a lot of time.
So what's everyone's guess on short volume. Increase or decrease? We know share volume was up over 1 million per day for a while. The increase in volume for that many days definitely was something going on but what?
WOW!!!! Now we know why Dan kept talking about how he couldn't believe they got the NEO IND done as quickly as they did and he thought it might not go through at all. So he was thinking " just remember everyone when you see my shares I got rewarded even though the pps/MC are garbage. We did successfully complete the IND