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You obviously don’t understand that retrospective studies are not strong evidence.
Here is uptodate
Hydroxychloroquine/chloroquine — We suggest not using hydroxychloroquine or chloroquine in hospitalized patients given the lack of clear benefit and potential for toxicity. In June 2020, the US FDA revoked its emergency use authorization for these agents in patients with severe COVID-19, noting that the known and potential benefits no longer outweighed the known and potential risks [54].
Both chloroquine and hydroxychloroquine may inhibit SARS-CoV-2 in vitro [55]. However, accumulating data from controlled trials suggest that they do not provide a clinical benefit for patients with COVID-19 [56-60]. According to a preliminary, unpublished report from a large randomized trial evaluating a number of potential therapies for hospitalized patients with COVID-19, there was no difference in 28-day mortality among 1561 patients who were randomly assigned to receive hydroxychloroquine compared with 3155 patients who received standard care (26.8 versus 25 percent, rate ratio 1.09, 95% CI 0.96-1.23); hydroxychloroquine also did not decrease length of hospital stay [56]. Based on these data, the hydroxychloroquine arm of the trial was closed. The World Health Organization also terminated the hydroxychloroquine arm of its large SOLIDARITY trial, and the United States National Institutes of Health terminated its trial of hydroxychloroquine in hospitalized patients; each cited a lack of benefit based on preliminary data from the trials [57,58,61]. In another open-label trial of hospitalized patients who required no or only low-flow oxygen supplementation (≤4 L/min), hydroxychloroquine (with or without azithromycin) did not improve clinical status at 15-day follow-up compared with standard of care [60].
Observational data are somewhat mixed and have methodologic limitations, but also suggest no benefit with hydroxychloroquine or chloroquine [62-67]. As an example, in an observational study of nearly 1400 patients with COVID-19 admitted to a hospital in New York, hydroxychloroquine use was reported in 811 patients and was associated with a higher risk of intubation or death (HR 2.37) [64]. Patients who received hydroxychloroquine were older, were more likely to have comorbidities, and had more severe illness than those who did not, which were likely confounding variables; in a multivariate analysis comparing those patients with a propensity score-matched subset of 274 patients who did not receive hydroxychloroquine, there was no association between hydroxychloroquine use and intubation or death (adjusted HR 1.04).
In contrast, in one retrospective study of over 2500 patients hospitalized with COVID-19 in Michigan, protocol-driven hydroxychloroquine administration for severe disease with close telemetry monitoring was associated with decreased mortality (propensity-score adjusted HR 0.34) [67]. However, potential confounders (including substantially more glucocorticoid administration among those who received hydroxychloroquine and uncertain reasons why some patients with severe disease did not receive hydroxychloroquine per protocol) limit confidence in these findings, particularly in light of randomized trial results.
Studies have highlighted the toxicity of hydroxychloroquine or chloroquine [66,68]. One trial comparing two doses of chloroquine for COVID-19 was stopped early because of a higher mortality rate in the high-dose group [68]. QTc prolongation, arrhythmias, and other adverse effects associated with hydroxychloroquine and chloroquine are discussed in detail elsewhere.
So that is an RCT published in Newsweek? Please stop embarrassing yourself
As long as you show me a positive RCT, i will become a believer.
Yes she believes in witchcraft too
— Alina 🌻 (@alinamercedes) July 28, 2020
Know a physician who has been taking Vascepa for a year.
His wife got sick and is COVID positive. Hopefully she will do well. However he is negative for covid.
Not sure if his resistance to covid could be ascribed to Vascepa but it is interesting.
Yes it will but amarin needs patent back
Yet for some patients on medicare Vascepa copay is super high or it is not covered at all.
This is a month old news
You need to check website every day. The masks move in and out very quickly but everone should be able to buy them easily. Also buy F1 replacement filters.
No i don’t have an N95 handed to me every day by the hospital. Are you kidding me?
USA can make F35s, MOABS, have space force unit, 8,000 nuclear heads but cannot ensure 10 cent N95 (real cost of N95) for every doctor and why not for every citizen.
That’s why this crisis will go on and will get worse and worse. Compare us to Germany and see the difference.
Saves my butt every day even from China. All of our docs wear it. They are all happy with it.
I think they would wear it if in red color with MAGA logo and with bonus 90 days supply of HCQ
As i said, i purchased N99 at https://rzmask.com/
These are super awsome. Better than N95
Instead of stimulus check, the goverment should get every American this mask and mandate wearing it in public. The infection rates would decline significantly.
These cloth masks may protect you from Faucci in terms of slowing the spit but if he gets near the virus that masks is useless.
Sure i agree but that is not enough
Only N95 and N99 masks work
I bought multiple n99 masks and have no issue touching multiple covid patients every day.
N99 means that 99 percent of particles are filtered out.
Regular surgical masks and cloth masks do not work.
The mask issue
Only N95 and N99 work
I bought 20 N99 masks and have been touching covid patients every day
Regular surgical mask or self made masks do not work.
Shop for your mask at rzmasks.com
They profited at least $1,000 on my orders.
Vascepa has no chance against dexa. Are you serious?
The worst part of working for a hospital system:
You have to kiss Administrators’ asses and if you don’t, and god forbid you criticize them, they put a target on you and quickly fire you stating that you don fit their culture. This same scenario happened to multiple physicians at my previous health system. This system bought all 4 hospitals and all private practices in the county and have total monopoly over every physician.
I blame doctors for self-destruction.
I worked for 3 hospital systems and finally got out last year to be on my own. The best decision ever. Make more money as well, which I did not expect. My own boss and glad that i am not supporting bunch of administrators who write useless emails all day and bullshit, but have every weekend off, while docs put over 100 hours week.
Because they signed with devil hospital systems and destroyed private practice.
I guess. ??
He is not a doctor but a PA
Is generic lipitor substitute for brand Crestor?
Of course not
Generic lovaza is not identical to generic vascepa, thus pharmacists cannot substitute without a new prescription for generic lovaza. Geez.
Looking to double value on oli approval
If ards works then probably above $10 or more
I am talking of 2 different drugs
Opiate is one drug. Olicidrine
Only use in hospitals
Safer than morphine
Trvn 27 is Angiotensin receptor blocker
TRV027 is a novel AT1 receptor selective agonist with the potential to treat acute lung injury and ARDS
Robust clinical development history with well-characterized PK and demonstrated safety in ~700 individuals
https://markets.businessinsider.com/news/stocks/trevena-announces-collaboration-with-imperial-college-london-to-evaluate-trv027-in-covid-19-patients-1029271761?op=1
Pay attention to TRVN
Olicidrine to be approved in August (new synthetic opioid (iv only, to be used in hospitals). Less nausea, vomiting, less CND depression.
TRVN 27 to be tested for ARDS in covid.
That’s is the only way. I sell covered calls on half of my shares
No. I will just collect 12k credit and still keep my shares.
That is a big gamble and a lot of money. Hopefully they don’t need it.
So i can sell September covered calls at 11
As I understand injunction requires large cash deposit by amarin in case of appeal loss.
Give Guinness some rest for few days. Pleasantly surprise your brain and liver. :)
Stating known facts is nothing negative.
The only thing that can help in the case of appeal loss, is after generic gets on the market, for amarin to examine their product and find out if there is patent infringement. Anyone?
Fda approved Hikma generic. They can start selling tomorrow
Don’t have that info
So no hidden strategy behind this move?