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Do we have such an expanded
phase 1? Are you sure?
Best Ingo
All is possible, if a phase 2 gives rock solid results.
Dont know if the currently running phase 1 is sufficient.
Anyone?
Best Ingo
Breakthrough therapy - a possible way for Kevetrin?
Innovative Drugs May Win U.S. Approval After Early Trials
http://mobile.bloomberg.com/news/2013-02-11/innovative-drugs-may-win-u-s-approval-after-early-trials.html?cmpid=yhoo
Let us hope that our management is looking into such an option.
Best, Ingo
We may see a start of similar action, as soon as we have safety and strong efficacy signals.
Building then value on multiple smart partnerships, that will move valuation massively, until a gorilla takes us out
Starting point in about 6 months, then hopefully zooooom!!!
All imho.
Best, Ingo
Will be interesting to learn what compound is the basis for Prurisol
and in which indications it is already used.
We never got info about if they could develop Prurisol into other indications than psoriasis.
We should hear soon about the filed patent - this should shed more light on this story.
Best, Ingo
Even more exciting if there are signals from c1 or c2
Best, Ingo
Why would he say this and give a kind of schedule?
But still it is my guess.
Best, Ingo
So Dr Menon expects first signs of efficacy happening at cohort 3
Guess, that is in line with preclinical data.
Interesting times ahead, but then also prurisol will kick in.
Best, Ingo
Any idea why they did not put a quality like primary endpoint met into their pr like kerx...
GL Pix
Xcellent find
You just saved my night....
Best Pix
They are talking of in vivo results
But then refer to a cell line...
What do you think of it?
Best, Ingo
TOB - it is quite easy to predict - the next coil is forming
All the best for all CTIXers
Ingo
Just get back to me in case....
In summer we have superb lakes, in winter perfect alps....
Let us make the HIT with CTIX
Best, I
Hi citxers
Just let science & clinic speak!
Merry Xmas from Austria
Best, Ingo
Chart of CTIX reminds me on Pcyc three years ago...
http://finance.yahoo.com/q/ta?t=5y&s=PCYC&l=on&z=l&q=l&c=Ctix&ql=1
Hope it works out accordingly.
Best Ingo
Bioman - so we Need early signs of efficacy in our PH 1, then they could Apply for.
Best, Ingo
There is a Good probability, that they get Report on the Data this friday;
Best Case scenario, that we get Updated a Second Time today...
Cheers Ingo
Not necessarily, as the dilution will take Place over several months @ different SP.
I expect just a small dip until the next PR comes in.
What i Wonder is, if they have installed an anti Shorting clause...
Best Ingo
Dr F, pls advise as soon as you found that.
Thx, Ingo
Well said
Pix
P21 Expression will be encouraging
Clinical positive outcome will be rewarding
Same for prurisol
We have to wait....
I am all in
Pix
Real Time pcr just means that the amplicon is displayed via fluorescence immedeately...
The blood Samples of course can be stabilized and amalyzed later
Pix
Dr. F.:
Placebo in this Case of course possible, SOC difficult Because
MTX or Mab go IV
What do you think?
Best, Pix
Agree.
Hope that they can dose High enough to get kev into the Cancer cells - this will be the Key...
Ingo
Thx a Lot.
BTW: i am Long 50k
Talked to a Top Researcher Last week - he just Said transcription Factors are by Pharma Definition not drugable.
We will have to wait and See.
Ingo
I would like to See the correlation of p21 upregulation of PBMCs and p53 activation from Fine Needle aspirates from the solid Tumors of preclinical Experiments...
DrF: any idea if These Data are here?
Has CTIX validated p21 as a biomarker in PBMCs
Perfect
Best Ingo
Good points, may be it would be a more acceptable Approach, just to Point at the Posters and preclinical results and Not to Stress the Stock...
Best, ingo
Hi Drano,
Pls put me in at 4.91
Thx Ingo
What about the autism drug.
Leo wanted to update several months ago...
This could also be a nice push in not to far distance.
Best, ingo
Are there any preclinical Data available on Leukemia?
Best Ingo
Nice SA article: Pfizer @ Kevetrin
Look it up
Best Ingo
I am quite nice invested into ctix, and Cant wait for the start of dosing.
The last pr of ctix was essentially very encouraging,
As they stated that DF is basially mapping the individuals tumors-
Which means, that they know about the p53 status of each patient.
So ctix is dealing with a theragnostic approach.
As well very interesting will Be the appearence of the potential biomarker p21,
Which could give a pretty fast signal, that the Basic concept of kevetrin is working
In patients.
Exciting Times ahead!!!!
All the Best,
Ingo
Hi Kelt,
you asked me for the "handle".
I do not post often, mainly following the Board...
Looking forward to get your updates.
All the best,
Ingo
Port,
i got this info from a reliable source.
i also was thinking that 200mg/kg would be quite high...but they do a volumetric upscale, so they will work in the range of 60mg/kg
hopefully this works out, without too many side effects.
anyway, DF would not have chosen the drug, without taking this quite high dose into consideration. they have done for sure a lot of due dilligence...
in a way, despite excellent preclinical results, it is still a gamble - you never know how a drug works in humans - that is what is all about wright now.
hoping for the best,
pix
Port - they will Start with 60mg/kg in human trials
I agree - Value will massively come in, if good results in Placebo Controlled Phase ii Data.
The Same is valid for prurisol.
All imho,
Best purifix
Does anybody have an idea what happened
to the Salesconx project? Are there any activities going on?
PIX
Either tactics my MM
or simply no more buying orders...