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huge.... Now let's enjoy the ride!
Banned Anti-Vax ‘Menace’ Is Back and Selling ‘Vaccine Cures’ -clown-
https://www.thedailybeast.com/banned-anti-vax-menace-larry-page-is-back-on-elon-musks-twitter-and-selling-vaccine-cures
Moderna is on track to become a multi-product company, and that means it's likely to have many revenue sources down the road.
The company's goal is to capture as much as half of the $30 billion respiratory vaccines market in 2027
next catalyst:
(Nasdaq:MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, today announced positive topline data from its ConquerRSV Phase 3 pivotal efficacy trial of mRNA-1345, an investigational mRNA vaccine targeting respiratory syncytial virus (RSV) in older adults. Following review by an independent Data and Safety Monitoring Board (DSMB), the primary efficacy endpoints have been met, including vaccine efficacy (VE) of 83.7% (95.88% CI: 66.1%, 92.2%; p<0.0001) against RSV-associated lower respiratory tract disease (RSV-LRTD) as defined by two or more symptoms. Based on these results, Moderna intends to submit for regulatory approval in the first half of 2023.
Moderna to test mpox vaccine in humans this summer
https://www.fiercebiotech.com/biotech/bio-moderna-test-mpox-vaccine-humans-summer
$RAIN 3.42 in cash per share = MULTIBAGGER$
just waiting for news from Tang. Price will stay in this channel until he is done loading or news breaks on a take over bid.
I don’t see why this man would invest millions & not do nothing. He did a takeover bid in JNCE 3 months ago with fire results for shareholders. Expecting a pop here very soon
last arrived-great signal: https://fintel.io/so/us/rain/tang-capital-partners-lp
deep hands.
Slow and steady! a potential game changer for so many patients! The treatment still has a ways to go but the interim data has been incredible!
This is just a waste of time! adios
we have two different ideas!
Distant metastasis-free survival results from the randomized, phase 2 mRNA-4157-P201/KEYNOTE-942 trial.
https://meetings.asco.org/abstracts-presentations/218505
go back to the cave!
your words mean nothing
Moderna said during its investor call that it was starting a Phase 3 confirmatory study, which it hoped to open in the third quarter of this year.
Scientists have been chasing the dream of vaccines to treat cancer for decades with few successes. Experts say mRNA vaccines, which can be produced in as little as eight weeks, paired with drugs that rev up the immune system may lead to a new generation of cancer therapies--------
cancer- mRNA-4157 (V940) in combination with KEYTRUDA reduced the risk of distant metastasis or death by 65%
Moderna and Merck Announce mRNA-4157 (V940) in Combination With KEYTRUDA(R) (pembrolizumab) Demonstrated a Statistically Significant and Clinically Meaningful Improvement in Distant Metastasis-Free Survival in Patients with High-Risk Stage III/IV Melanoma Following Complete Resection Versus KEYTRUDA
Adverse events reported with mRNA-4157 (V940) in KEYNOTE-942 were consistent with those previously observed in a Phase 1 clinical trial. The safety profile of KEYTRUDA was consistent with findings from previous studies. The number of patients reporting treatment related Grade = 3 adverse events were similar between the arms (25% vs 18%, respectively). The most common adverse events of any grade attributed to either mRNA-4157 (V940) or the combination of mRNA-4157 (V940) and KEYTRUDA were fatigue (60.6%), injection site pain (55.8%) and chills (50.0%).
https://investors.modernatx.com/news/news-details/2023/Moderna-and-Merck-Announce-mRNA-4157-V940-in-Combination-With-KEYTRUDAR-pembrolizumab-Demonstrated-a-Statistically-Significant-and-Clinically-Meaningful-Improvement-in-Distant-Metastasis-Free-Survival-in-Patients-with-High-Risk-Stage-IIIIV-Melanoma-F/default.aspx
Tang bought 30% of the float...
Planned MANTRA-2 clinical update at a medical conference in 4Q 2023
PHASE 2- it works very well
Milademetan Shows Early Activity in MDM2-Amplified Advanced Solid Tumors
Notably, activity with the MDM2 inhibitor was observed in patients with heavily pretreated, refractory disease.
more news to come:
Evaluate avenues to enhance the pipeline through precision oncology program acquisition-
$RAIN 36.4 million shares of common stock outstanding
Year-end 2023 cash guidance of $75-$80 million, and cash runway to year-end 2026
There's one piece left-- Rain Therapeutics Provides Interim Analysis of Phase 2 Basket Trial of Milademetan for MDM2-Amplified Advanced Solid Tumors (MANTRA-2)
- Two patients exhibited an unconfirmed partial response at their first scan, and two additional patients saw promising tumor regression activity out of ten efficacy evaluable patients, demonstrating monotherapy activity of milademetan in MDM2-amplified patients -
At the data cutoff of October 26, 2022, 17 patients were enrolled. Two unconfirmed partial responses were observed in patients with pancreatic and lung cancer with a tumor regression of 34% and 30% with lung cancer, respectively. Additionally, there was promising tumor regression of 29% in a patient with biliary tract cancer and 27% in a patient with breast cancer; both are receiving continued investigational therapy.
https://www.rainoncology.com/news-press-releases/rain-therapeutics-provides-interim-analysis-of-phase-2-basket-trial-of-milademetan-for-mdm2-amplified-advanced-solid-tumors-mantra-2
NEW$$$$-Tang Capital Partners Lp ownership in RAIN / Rain Oncology Inc
2023-06-01 - Tang Capital Partners Lp has filed an SC 13D form with the Securities and Exchange Commission (SEC) disclosing ownership of 3,740,341 shares of Rain Oncology Inc (US:RAIN). This represents 14.1 percent ownership of the company.
https://fintel.io/so/us/rain/tang-capital-partners-lp
Oxford Properties Completes US$91M Sale of Newly Constructed, 140,000 Square Foot Boston GMP Facility to Pioneering Biotechnology Firm Moderna
https://www.bldup.com/posts/oxford-properties-completes-us-91m-sale-of-newly-constructed-140-000-square-foot-boston-gmp-facility-to-pioneering-biotechnology-firm-moderna
Doctors say this is the most important virus you’ve never heard of-there's no vaccine for HMPV, nor is there an antiviral drug to treat it.
https://edition.cnn.com/2023/05/29/health/human-metapneumovirus-explainer-wellness/index.html
Moderna Announces Phase 2 Data on mRNA-4157 (V940), an Investigational Individualized Neoantigen Therapy, to be Presented at the 2023 ASCO Annual Meeting
https://investors.modernatx.com/news/news-details/2023/Moderna-Announces-Phase-2-Data-on-mRNA-4157-V940-an-Investigational-Individualized-Neoantigen-Therapy-to-be-Presented-at-the-2023-ASCO-Annual-Meeting/default.aspx
BEIJING, May 26 (Reuters) - U.S. vaccine maker Moderna said on Friday it was looking for opportunities in China after confirming that it had registered a legal entity in the world's second largest economy.
The U.S. pharmaceutical and biotech firm registered a unit called Moderna (China) Biotech Limited in Shanghai on May. 24 with capital of $100 million, according to Chinese data providers including company database Qichacha.
"We are exploring opportunities to engage in the market and bring the power of Moderna’s mRNA platform to the people of China," a spokesperson said in response to a query from Reuters.
The company prior to this had no presence in mainland China. It opened an office in Hong Kong last year as part of an Asia expansion.
Its establishment of a mainland China unit comes as its revenue growth slows sharply due to waning global demand for its COVID vaccine, the U.S. company's only approved product.
The company in February forecast a possible net loss for 2023, calling it a transition year before it starts to see sales from experimental vaccines for respiratory syncytial virus (RSV) and flu.
Those vaccines, based on the same mRNA platform as its COVID shot, have yet to be filed for regulatory approval decisions.
Moderna has said that it was keen to sell its mRNA vaccine to China but the company and its foreign peers have so far been kept out as Beijing has insisted on using only Chinese-made COVID-19 vaccines for its population.
CEO Stephane Bancel visited Shanghai last month during which he said Moderna will accelerate its investment in Shanghai and work with Chinese partners on local research, development, according to local media Yicai Global.
Globe-trotting Moderna is investing $322M in new manufacturing site close to home:
The move comes as Moderna is rapidly growing. The company plans to add 2,000 employees this year, bringing its head count to 6,000.
https://www.fiercepharma.com/manufacturing/globetrotting-moderna-investing-322m-new-manufacturing-site-close-home
your extinction as a human being, you are living in the world of fairy tales!
$MRNA
Moderna has early clinical evidence that its mRNA technology can treat a rare disease by replacing intracellular proteins. Participants in the phase 1/2 trial experienced a 66% overall relative risk reduction in the frequency of life-threatening events, encouraging the biotech to keep studying the candidate.
The phase 1/2 trial marks the first time a biotech has reported clinical data on an mRNA therapeutic for intracellular protein replacement. In the study, children with propionic acidemia (PA), a rare inherited metabolic disorder, received multiple doses of a lipid nanoparticle-encapsulated dual mRNA therapy.
Moderna’s therapy, mRNA-3927, encodes two subunit proteins, PCCA and PCCB, that form the enzyme that is deficient in patients with PA. By triggering production of the subunit proteins, Moderna could fix the root cause of the disease and prevent the buildup of harmful compounds that cause PA symptoms.
https://www.fiercebiotech.com/biotech/moderna-looking-past-vaccines-guides-first-mrna-protein-replacement-therapy-past-early
Moderna,Inc. a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, reported on interim data from the Phase 1/2 trial of mRNA-3927, an investigational mRNA therapy for propionic acidemia (PA), presented at the 2023 American Society of Gene + Cell Therapy (ASGCT) Annual Meeting.
More than 280 doses of mRNA-3927 were administered. Five patients have more than a year of dosing
https://investors.modernatx.com/news/news-details/2023/Phase-12-Interim-Data-on-Modernas-mRNA-3927-an-Investigational-mRNA-Therapy-for-Propionic-Acidemia-PA-Presented-at-the-2023-ASGCT-Annual-Meeting/default.aspx
AI dramatically improved mRNA vaccines in just 11 minutes:
https://www.freethink.com/health/mrna-sequence
Is Moderna Building a Respiratory Vaccine Empire: I agree 1000%
https://www.fool.com/investing/2023/05/06/is-moderna-building-a-respiratory-vaccine-empire/?source=eptyholnk0000202&utm_source=yahoo-host&utm_medium=feed&utm_campaign=article
Moderna rakes in surprise profits ahead of 400% vaccine price hike
Moderna made about $680 million more than expected in the first quarter.
https://arstechnica.com/science/2023/05/moderna-rakes-in-surprise-profits-ahead-of-400-vaccine-price-hike/
Moderna Jumps On Unexpected First-Quarter Profit Amid Plummeting Covid Sales
Moderna Announces Phase 1/2 Data on mRNA-3927, an Investigational mRNA Therapy for Propionic Acidemia (PA) to be Presented at the 2023 ASGCT Annual Meeting
https://investors.modernatx.com/news/news-details/2023/Moderna-Announces-Phase-12-Data-on-mRNA-3927-an-Investigational-mRNA-Therapy-for-Propionic-Acidemia-PA-to-be-Presented-at-the-2023-ASGCT-Annual-Meeting/default.aspx
"We are pleased to expand our footprint into the Philipines by establishing an Enterprise Solutions Hub and commercial operations. The Philippines has a critical mix of talent and global business service expertise, which makes it an excellent location to scale efficiently and provide regional support," said Stéphane Bancel, Chief Executive Officer of Moderna."The Asia Pacific region is integral to Moderna's business, with established subsidiaries in Australia, Hong Kong, Japan, Singapore, South Korea, and Taiwan. We look forward to further solidifying our presence. The addition of the Philippines site completes our strategy to provide regional solutions across the business, complementing our existing locations in Atlanta, Georgia, which services the Americas, and Warsaw, Poland, which covers Europe, the Middle East, and Africa."
https://investors.modernatx.com/news/news-details/2023/Moderna-Announces-Establishment-of-an-Enterprise-Solutions-Hub-and-Commercial-Operations-in-The-Philippines/default.aspx
shrimp for everyone!