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Amanita Muscaria Antibiotics and Epilepsy
by Ivan S | Nov 30, 2013 | Blog, homeopathy | 0 comments
Amanita Muscaria Antibiotics and Epilepsy
There are several compounds in Amanita Muscaria that exhibit antibiotic action and other medicinal effects, which are known to science. The following short excerpts are from Mycol. Res. 107 (2): 131-146 (February 2003) © The British Mycological Society DOI: 10.1017/8095376203007305 Review Amanita Muscaria: Chemistry, Biology, Toxicology, and Ethnomycology. By Didier Michelot and Leda Maria Melendez-Howell
amenita-muscaria-vancouver“Ibotenic acid, and particularly muscimol, have to be regarded as the substances responsible for the psychotropic action of Amanita Muscaria. The effects of both substances are similar but not identical to the effect of the fungus in toto.”
Ibotenc acid “Ibotenic acid (pantherin, agarin), i.e. a-amino-3-hydroxy-5-isoxazoloacetic acid, is colorless (crystals, C5H6N2O4, mol. wt. 158.11, mp. 150-152 deg. C decomposition), readily soluble in cold water. Any attempt of dehydration leads to decarboxilation yielding quantitatively muscimol.”
Muscimol “Muscimol, i.e. 5-(aminomethyl)-3-hydroxyisoxazole, isolated from Amanita Muscaria, is colorless (crystals, C4H6N2O2, mol. wt.114.10, mp. 175 deg. C decomposition) readily soluble in cold water.” “Interestingly, cycloserine (myxomycin, seromycin, D-4-amino-3isoxazolidone) is an antimicrobial tuberculostatic agent that exhibits a similar carbon backbone as muscimol.”
“(-)-R-4-hydroxy-pyrrolidone-(2) “(-)-R-4-hydroxy-pyrrolidone-(2), whose structure is closely related to ibotenic acid and muscimol, was found in Amanita Muscaria (Matsumoto et al. 1969a). This chemical frame is common in some micromycetes; they generally exhibit a potent biological activity against bacteria and other fungi (e.g. aureothrycin, equisetin).” “A; B-(1->6) branched (1->3)-beta-D-glucan (AM-ASN) was isolated from A. muscaria. AM-ASN exhibited antitumor activity against Sarcoma 180 in mice (Kiho et al. 1992).”
As you can see, the two major chemicals Ibotenic acid and Muscimol found in Amanita Muscaria, are closely related to known antibiotics. Plus, the chemically related hydroxypyrollidone derivative found in Amanita Muscaria is a known antibiotic and antifungal; also found in micromycetes. The chemical AM-ASN a Beta-glucan is extremely interesting for its antitumor activity; Sarcoma 180 is a standard cancer cell line that is used in cancer research all over the world. AM-ASN may in fact be the antiviral compound we are searching for but that testing has yet to be performed. No specifically antiviral compounds are found in this paper; that doesn’t mean that they do not exist in the mushroom; it simply means that no research has been done in this area. This is the basic research on the antibiotic properties of Amanita Muscaria however there are other medicinal properties that are very interesting concerning ibotenic acid and muscimol in this paper.
“Ibotenic acid and muscimol are respectively conformationally restricted derivatives of glutamic acid and gamma-aminobutyric acid (GABA).” “Glutamic acid is a major excitatory neurotransmitter in mammalian central nervous systems and its receptors are implicated in neurological disorders such as epilepsy and Huntington’s disease. Inhibitory glutamate receptors (IGluRs) constitute a class of ion channel proteins equivalent to glycine and GABA receptors. Ibotenic acid acts on IGluRs (Cleland 1996).” “AMPA, a synthetic analogue of ibotenic acid, displays the same typical moiety and was found to be more effective and specific glutamate agonist than the parent compound (Watkins, Krogsgaard-Larsen & Honore 1990).” “There is evidence that damaged function of GABA mediated inhibitory synapses is implied in experimental and clinical seizure disorders. Decreased concentration, and then activity of GABA, may have a role in human epilepsy. Muscimol is a potent conformational analogue and biologically active biosostere (Krogsgaard et. el. 2000).” “This toxin tightly binds with the gamma-aminobutyrate receptor (de Feudis 1980). Moreover, it is also an inhibitor of neuronal and glial GABA uptake and a substrate for the GABA- metabolizing enzyme: GABA transaminase. Subsequently, some research teams tried to improve the potency of drugs. Lipophilicity is of considerable interest for the prediction of the transport, adsorption and distribution properties of molecules, and so is an important factor in drug design. More lipophilic bioisosteres of muscimol and GABA have been synthesized, such as Tiagabine. This drug was marketed as a therapeutic agent for the treatment of epilepsy, Gabatril ® (Krogsgaard-Larsen 1977, KrogsgaardLarsen et. el. 1994, Krogsgaard-Larsen, Frolund& Frydenvang 2000).”
Here we have ibotenic acid and muscimol both having beneficial effects on human epilepsy and perhaps Huntington’s ....
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We're hard at work on a new look for our website and many other exciting changes for Psyched Wellness in 2022, including a product rebrand.
Happy Holidays everyone! Enjoy this wonderful time with friends and family. Let's get festive!
We're hard at work on a new look for our website and many other exciting changes for Psyched Wellness in 2022, including a product rebrand.
— Psyched Wellness (@PsychedWellness) December 24, 2021
Happy Holidays everyone! Enjoy this wonderful time with friends and family. Let's get festive! pic.twitter.com/dnhRISWBXp
Happy Holidays:
Just wondering if you have a time frame for when it will start moving? Dead money right now, could be used in other places until then.
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Generally Recognized As Safe (GRAS) is a US FDA designation that a substance added to food is considered safe by experts.
Caffeine, for example, is considered GRAS by the FDA. And soon, our Amanita Muscaria extract will be too.
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Generally Recognized As Safe (GRAS) is a US FDA designation that a substance added to food is considered safe by experts.
— Psyched Wellness (@PsychedWellness) December 16, 2021
Caffeine, for example, is considered GRAS by the FDA. And soon, our Amanita Muscaria extract will be too.
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Some confirmation https://db.koreascholar.com/article?code=348644
Anti-cancer research is piling up re: A. Muscaria recently https://www.sciencedirect.com/science/article/abs/pii/S0144861721010341
A. Muscaria Research link https://www.genome.jp/db/pcidb/kna_species/3261#interaction
THE MIGHTY AMANITA - cancer treatment https://www.researchgate.net/publication/350208179_Defining_a_Role_of_Amanita_phalloides_Toxins_in_Cancer_Research_and_Therapy
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